DE69928776T2 - Nanopartikel die polyisobutylcyanoacrylate und cyclodextrine enthalten - Google Patents

Nanopartikel die polyisobutylcyanoacrylate und cyclodextrine enthalten Download PDF

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Publication number
DE69928776T2
DE69928776T2 DE69928776T DE69928776T DE69928776T2 DE 69928776 T2 DE69928776 T2 DE 69928776T2 DE 69928776 T DE69928776 T DE 69928776T DE 69928776 T DE69928776 T DE 69928776T DE 69928776 T2 DE69928776 T2 DE 69928776T2
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DE
Germany
Prior art keywords
nanoparticles
active ingredient
polymer
hpβcd
progesterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69928776T
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German (de)
English (en)
Other versions
DE69928776D1 (de
Inventor
Airton Monza Da Silveira
Gilles Ponchel
Dominique Duchene
Patrick Couvreur
Francis Puisieux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioalliance Pharma SA
Original Assignee
Bioalliance Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioalliance Pharma SA filed Critical Bioalliance Pharma SA
Application granted granted Critical
Publication of DE69928776D1 publication Critical patent/DE69928776D1/de
Publication of DE69928776T2 publication Critical patent/DE69928776T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69928776T 1998-02-27 1999-02-24 Nanopartikel die polyisobutylcyanoacrylate und cyclodextrine enthalten Expired - Lifetime DE69928776T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9802429A FR2775435B1 (fr) 1998-02-27 1998-02-27 Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs
FR9802429 1998-02-27
PCT/FR1999/000418 WO1999043359A1 (fr) 1998-02-27 1999-02-24 Nanoparticules comprenant polyisobutylcyanoacrylate et cyclodextrines

Publications (2)

Publication Number Publication Date
DE69928776D1 DE69928776D1 (de) 2006-01-12
DE69928776T2 true DE69928776T2 (de) 2006-09-07

Family

ID=9523473

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928776T Expired - Lifetime DE69928776T2 (de) 1998-02-27 1999-02-24 Nanopartikel die polyisobutylcyanoacrylate und cyclodextrine enthalten

Country Status (12)

Country Link
US (1) US6881421B1 (https=)
EP (1) EP1056477B1 (https=)
JP (1) JP4651192B2 (https=)
AT (1) ATE311906T1 (https=)
AU (1) AU753573B2 (https=)
CA (1) CA2320928C (https=)
DE (1) DE69928776T2 (https=)
DK (1) DK1056477T3 (https=)
ES (1) ES2255246T3 (https=)
FR (1) FR2775435B1 (https=)
IL (2) IL137882A0 (https=)
WO (1) WO1999043359A1 (https=)

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Also Published As

Publication number Publication date
AU2628799A (en) 1999-09-15
US6881421B1 (en) 2005-04-19
FR2775435A1 (fr) 1999-09-03
JP2002504526A (ja) 2002-02-12
FR2775435B1 (fr) 2000-05-26
WO1999043359A1 (fr) 1999-09-02
EP1056477A1 (fr) 2000-12-06
CA2320928C (fr) 2009-12-15
IL137882A (en) 2006-12-31
DE69928776D1 (de) 2006-01-12
IL137882A0 (en) 2001-10-31
DK1056477T3 (da) 2006-04-18
JP4651192B2 (ja) 2011-03-16
AU753573B2 (en) 2002-10-24
ATE311906T1 (de) 2005-12-15
ES2255246T3 (es) 2006-06-16
CA2320928A1 (fr) 1999-09-02
EP1056477B1 (fr) 2005-12-07

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