DE69928006T2 - Lagerstabile flüssige zusammensetzungen von glucagon-ähnlichem peptid-1 - Google Patents
Lagerstabile flüssige zusammensetzungen von glucagon-ähnlichem peptid-1 Download PDFInfo
- Publication number
- DE69928006T2 DE69928006T2 DE69928006T DE69928006T DE69928006T2 DE 69928006 T2 DE69928006 T2 DE 69928006T2 DE 69928006 T DE69928006 T DE 69928006T DE 69928006 T DE69928006 T DE 69928006T DE 69928006 T2 DE69928006 T2 DE 69928006T2
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- Prior art keywords
- glp
- gly
- glu
- serine
- ala
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
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- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Immunology (AREA)
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- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11349998P | 1998-12-22 | 1998-12-22 | |
| US113499P | 1998-12-22 | ||
| PCT/US1999/030395 WO2000037098A1 (en) | 1998-12-22 | 1999-12-21 | Shelf-stable formulation of glucagon-like peptide-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69928006D1 DE69928006D1 (de) | 2005-12-01 |
| DE69928006T2 true DE69928006T2 (de) | 2006-07-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69928006T Expired - Lifetime DE69928006T2 (de) | 1998-12-22 | 1999-12-21 | Lagerstabile flüssige zusammensetzungen von glucagon-ähnlichem peptid-1 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1140148B1 (https=) |
| JP (1) | JP4689833B2 (https=) |
| AT (1) | ATE307603T1 (https=) |
| AU (1) | AU2373400A (https=) |
| CA (1) | CA2358107C (https=) |
| DE (1) | DE69928006T2 (https=) |
| DK (1) | DK1140148T3 (https=) |
| ES (1) | ES2249933T3 (https=) |
| WO (1) | WO2000037098A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| EP2213743A1 (en) | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| CA2430934C (en) | 2000-12-01 | 2011-06-21 | Takeda Chemical Industries, Ltd. | A method of producing sustained-release preparations of a bioactive substance using high-pressure gas |
| WO2003002136A2 (en) | 2001-06-28 | 2003-01-09 | Novo Nordisk A/S | Stable formulation of modified glp-1 |
| EP1432430A4 (en) | 2001-08-28 | 2006-05-10 | Lilly Co Eli | PREMIXTURES OF GLP-1 AND BASALINSULIN |
| MXPA04003569A (es) | 2001-10-19 | 2004-07-23 | Lilly Co Eli | Mezclas bifasicas de glp-1 e insulina. |
| WO2005003296A2 (en) | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| KR101198346B1 (ko) | 2003-04-08 | 2012-11-06 | 노보 노르디스크 에이/에스 | 크로마토그래피 고정상의 재생 |
| WO2004089985A1 (en) * | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Stable pharmaceutical compositions |
| ES2375056T3 (es) * | 2003-06-03 | 2012-02-24 | Novo Nordisk A/S | Composiciones pept�?dicas farmacéuticas estabilizadas. |
| EP1633390B1 (en) * | 2003-06-03 | 2012-01-18 | Novo Nordisk A/S | Stabilized pharmaceutical glp-1 peptide compositions |
| PL1633391T3 (pl) * | 2003-06-03 | 2012-03-30 | Novo Nordisk As | Stabilizowane farmaceutycznie kompozycje peptydowe |
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| EA201992502A1 (ru) | 2017-06-20 | 2020-04-22 | Эмджен Инк. | Способ лечения или уменьшения интенсивности метаболических нарушений с применением белков, связывающих рецептор гастроингибиторного пептида (gipr), в комбинации с агонистами glp-1 |
| EP3642238A1 (en) | 2017-06-21 | 2020-04-29 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins |
| KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
| WO2020208541A1 (en) * | 2019-04-08 | 2020-10-15 | Enzene Biosciences Limited | Composition comprising glp-1 analogue |
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| WO2021142733A1 (en) * | 2020-01-16 | 2021-07-22 | Shanghai Benemae Pharmaceutical Corporation | Combinational therapy comprising glp-1 and/or glp-1 analogs, and insulin and/or insulin analogs |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118666A (en) * | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| JP2583257B2 (ja) * | 1986-05-05 | 1997-02-19 | ザ・ジェネラル・ホスピタル・コーポレーション | インシュリン向性ホルモン |
| DK36492D0 (da) * | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Praeparat |
| US5705483A (en) * | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| GB9409496D0 (en) * | 1994-05-12 | 1994-06-29 | London Health Ass | Method for improving glycaemic control in diabetes |
| ATE234625T1 (de) * | 1994-12-23 | 2003-04-15 | Novo Nordisk As | Glp-1 zusammensetzungen mit verlängerter wirkdauer |
-
1999
- 1999-12-21 DE DE69928006T patent/DE69928006T2/de not_active Expired - Lifetime
- 1999-12-21 ES ES99967463T patent/ES2249933T3/es not_active Expired - Lifetime
- 1999-12-21 CA CA2358107A patent/CA2358107C/en not_active Expired - Fee Related
- 1999-12-21 JP JP2000589208A patent/JP4689833B2/ja not_active Expired - Fee Related
- 1999-12-21 EP EP99967463A patent/EP1140148B1/en not_active Expired - Lifetime
- 1999-12-21 AT AT99967463T patent/ATE307603T1/de active
- 1999-12-21 AU AU23734/00A patent/AU2373400A/en not_active Abandoned
- 1999-12-21 DK DK99967463T patent/DK1140148T3/da active
- 1999-12-21 WO PCT/US1999/030395 patent/WO2000037098A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4689833B2 (ja) | 2011-05-25 |
| JP2002532557A (ja) | 2002-10-02 |
| DE69928006D1 (de) | 2005-12-01 |
| EP1140148A1 (en) | 2001-10-10 |
| EP1140148B1 (en) | 2005-10-26 |
| ATE307603T1 (de) | 2005-11-15 |
| AU2373400A (en) | 2000-07-12 |
| CA2358107A1 (en) | 2000-06-29 |
| DK1140148T3 (da) | 2006-01-30 |
| WO2000037098A1 (en) | 2000-06-29 |
| ES2249933T3 (es) | 2006-04-01 |
| CA2358107C (en) | 2011-08-23 |
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