DE69922159D1 - Mehrzweck-antikörperderivate - Google Patents

Mehrzweck-antikörperderivate

Info

Publication number
DE69922159D1
DE69922159D1 DE69922159T DE69922159T DE69922159D1 DE 69922159 D1 DE69922159 D1 DE 69922159D1 DE 69922159 T DE69922159 T DE 69922159T DE 69922159 T DE69922159 T DE 69922159T DE 69922159 D1 DE69922159 D1 DE 69922159D1
Authority
DE
Germany
Prior art keywords
heterodimerization
molecules
vhch1
chosen
class
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69922159T
Other languages
English (en)
Other versions
DE69922159T2 (de
Inventor
Reinhilde Schoonjans
Nico Mertens
Walter Fiers
Roland Contreras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vlaams Instituut voor Biotechnologie VIB
Original Assignee
Vlaams Instituut voor Biotechnologie VIB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Instituut voor Biotechnologie VIB filed Critical Vlaams Instituut voor Biotechnologie VIB
Application granted granted Critical
Publication of DE69922159D1 publication Critical patent/DE69922159D1/de
Publication of DE69922159T2 publication Critical patent/DE69922159T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69922159T 1998-01-23 1999-01-25 Mehrzweck-antikörperderivate Expired - Lifetime DE69922159T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98200193 1998-01-23
EP98200193 1998-01-23
PCT/EP1999/000477 WO1999037791A1 (en) 1998-01-23 1999-01-25 Multipurpose antibody derivatives

Publications (2)

Publication Number Publication Date
DE69922159D1 true DE69922159D1 (de) 2004-12-30
DE69922159T2 DE69922159T2 (de) 2005-12-01

Family

ID=8233317

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69922159T Expired - Lifetime DE69922159T2 (de) 1998-01-23 1999-01-25 Mehrzweck-antikörperderivate

Country Status (10)

Country Link
US (1) US6809185B1 (de)
EP (1) EP1049787B1 (de)
AT (1) ATE283364T1 (de)
AU (1) AU2719099A (de)
CA (1) CA2317727C (de)
DE (1) DE69922159T2 (de)
DK (1) DK1049787T3 (de)
ES (1) ES2234241T3 (de)
PT (1) PT1049787E (de)
WO (1) WO1999037791A1 (de)

Families Citing this family (230)

* Cited by examiner, † Cited by third party
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