DE60012500D1 - Antikörper und antikörperfragmente mit spezifität für tgfbeta1 - Google Patents
Antikörper und antikörperfragmente mit spezifität für tgfbeta1Info
- Publication number
- DE60012500D1 DE60012500D1 DE60012500T DE60012500T DE60012500D1 DE 60012500 D1 DE60012500 D1 DE 60012500D1 DE 60012500 T DE60012500 T DE 60012500T DE 60012500 T DE60012500 T DE 60012500T DE 60012500 D1 DE60012500 D1 DE 60012500D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- antibodies
- tgfbeta1
- specificity
- antibody fragments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13198399P | 1999-04-30 | 1999-04-30 | |
US131983P | 1999-04-30 | ||
PCT/GB2000/001679 WO2000066631A1 (en) | 1999-04-30 | 2000-05-02 | SPECIFIC ANTIBODIES AND ANTIBODY FRAGMENTS FOR TGFβ¿1? |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60012500D1 true DE60012500D1 (de) | 2004-09-02 |
DE60012500T2 DE60012500T2 (de) | 2005-08-11 |
Family
ID=22451886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60012500T Expired - Lifetime DE60012500T2 (de) | 1999-04-30 | 2000-05-02 | Antikörper und antikörperfragmente mit spezifität für tgfbeta1 |
Country Status (15)
Country | Link |
---|---|
US (3) | US6492497B1 (de) |
EP (1) | EP1175445B1 (de) |
JP (1) | JP2003501348A (de) |
AT (1) | ATE272073T1 (de) |
AU (1) | AU768554B2 (de) |
BR (1) | BR0010162A (de) |
CA (1) | CA2370304A1 (de) |
DE (1) | DE60012500T2 (de) |
ES (1) | ES2225132T3 (de) |
GB (1) | GB2350612B (de) |
IL (1) | IL145813A0 (de) |
MX (1) | MXPA01010739A (de) |
NO (1) | NO20015261L (de) |
NZ (1) | NZ514759A (de) |
WO (1) | WO2000066631A1 (de) |
Families Citing this family (75)
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US7368111B2 (en) * | 1995-10-06 | 2008-05-06 | Cambridge Antibody Technology Limited | Human antibodies specific for TGFβ2 |
US6683156B1 (en) * | 1996-08-27 | 2004-01-27 | University Of South Florida | Method for diagnosing selected adenocarcinomas |
US7211644B1 (en) * | 1996-08-27 | 2007-05-01 | University Of South Florida | Diagnostic markers of human female infertility |
US8106001B2 (en) * | 1996-08-27 | 2012-01-31 | University Of South Florida | Diagnostic markers of human female infertility |
US6294662B1 (en) | 1996-08-27 | 2001-09-25 | University Of South Florida | Nucleic acids encoding an endometrial bleeding associated factor (ebaf) |
WO2001066754A1 (en) | 2000-03-03 | 2001-09-13 | Cambridge Antibody Technology Limited | Human antibodies against eotaxin and their use |
US6946546B2 (en) | 2000-03-06 | 2005-09-20 | Cambridge Antibody Technology Limited | Human antibodies against eotaxin |
EP1572937B1 (de) * | 2002-04-09 | 2012-02-08 | The Scripps Research Institute | Hybrid-polypeptide mit eingefügten sequenzmotiven und ihre verwendungen |
CA2494367A1 (en) * | 2002-07-25 | 2004-02-05 | Scios Inc. | Methods for improvement of lung function using tgf-.beta. inhibitors |
US20060286105A1 (en) * | 2003-04-30 | 2006-12-21 | Steven Ledbetter | Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency |
US20070172446A1 (en) | 2003-05-16 | 2007-07-26 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
AU2004259398A1 (en) | 2003-06-27 | 2005-02-03 | Amgen Fremont Inc. | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
EP1646655A2 (de) * | 2003-07-09 | 2006-04-19 | Eli Lilly And Company | Tgf-beta1 liganden |
GB0407315D0 (en) | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
RU2386638C2 (ru) | 2004-03-31 | 2010-04-20 | Дженентек, Инк. | Гуманизированные анти-тфр-бета-антитела |
EP1789074A4 (de) * | 2004-08-09 | 2009-08-12 | Alios Biopharma Inc | Synthetische hyperglycosylierte, protease-resistente polypeptid-varianten, orale formulierungen und anwendungsverfahren dafür |
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WO2006044433A2 (en) * | 2004-10-13 | 2006-04-27 | The Ohio State University Research Foundation | Methods to treat or prevent viral-associated lymphoproliferative disorders |
ES2711213T3 (es) * | 2005-02-08 | 2019-04-30 | Genzyme Corp | Anticuerpos de TGFbeta |
EP1874818B1 (de) * | 2005-04-22 | 2011-04-13 | Eli Lilly And Company | Tgf-beta-1-spezifische antikörper |
EP2230252A1 (de) | 2006-03-13 | 2010-09-22 | The Johns Hopkins University | Erhöhung der endothelialen Thromboresistenz |
EP3254696A1 (de) | 2006-10-03 | 2017-12-13 | Genzyme Corporation | Verwendung von tgf-beta-antagonisten zur behandlung von kleinkindern mit dem risiko des ausbruchs von bronchopulmonaler dysplasie |
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US20120071628A1 (en) * | 2009-03-13 | 2012-03-22 | Nihon University | Topical therapeutic agent for ophthalmic diseases comprising compound capable of binding specifically to dna sequence |
EP3560503B1 (de) | 2010-03-24 | 2021-11-17 | Phio Pharmaceuticals Corp. | Rna-interferenz bei dermalen und fibrotischen erkrankungen |
EP2550001B1 (de) | 2010-03-24 | 2019-05-22 | Phio Pharmaceuticals Corp. | Rna-interferenz bei augenerkrankungen |
KR102051014B1 (ko) | 2011-06-03 | 2019-12-04 | 조마 테크놀로지 리미티드 | Tgf-베타에 특이적인 항체 |
WO2013014262A1 (en) | 2011-07-27 | 2013-01-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating myhre syndrome |
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EP2799537B1 (de) | 2011-12-28 | 2021-09-22 | Kyoto Prefectural Public University Corporation | Normalisierung der züchtung von hornhautendothelzellen |
US9518112B2 (en) | 2012-03-08 | 2016-12-13 | Ludwig Institute For Cancer Research Ltd | TGF-β1 specific antibodies and methods and uses thereof |
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TWI664979B (zh) | 2013-03-11 | 2019-07-11 | 健臻公司 | 經生物工程之抗-TGF-β抗體及抗原結合片段 |
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EP3064222B1 (de) | 2013-10-31 | 2020-10-21 | Kyoto Prefectural Public University Corporation | Therapeutikum enthaltend einen tgf-beta signalblocker für erkrankungen im zusammenhang mit endoplasmatischem retikulumszelltod im hornhautendothel |
CN107073042A (zh) | 2014-09-03 | 2017-08-18 | 布里格海姆妇女医院公司 | 用于产生内耳毛细胞来治疗听力损失的组合物、系统和方法 |
CA3008162A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
WO2016100233A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
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-
2000
- 2000-04-28 US US09/560,198 patent/US6492497B1/en not_active Expired - Lifetime
- 2000-05-02 JP JP2000615659A patent/JP2003501348A/ja active Pending
- 2000-05-02 ES ES00927483T patent/ES2225132T3/es not_active Expired - Lifetime
- 2000-05-02 MX MXPA01010739A patent/MXPA01010739A/es active IP Right Grant
- 2000-05-02 EP EP00927483A patent/EP1175445B1/de not_active Expired - Lifetime
- 2000-05-02 AT AT00927483T patent/ATE272073T1/de not_active IP Right Cessation
- 2000-05-02 GB GB0010568A patent/GB2350612B/en not_active Expired - Lifetime
- 2000-05-02 AU AU45886/00A patent/AU768554B2/en not_active Ceased
- 2000-05-02 DE DE60012500T patent/DE60012500T2/de not_active Expired - Lifetime
- 2000-05-02 IL IL14581300A patent/IL145813A0/xx unknown
- 2000-05-02 NZ NZ514759A patent/NZ514759A/en unknown
- 2000-05-02 BR BR0010162-1A patent/BR0010162A/pt not_active IP Right Cessation
- 2000-05-02 WO PCT/GB2000/001679 patent/WO2000066631A1/en active IP Right Grant
- 2000-05-02 CA CA002370304A patent/CA2370304A1/en not_active Abandoned
-
2001
- 2001-10-26 NO NO20015261A patent/NO20015261L/no not_active Application Discontinuation
-
2002
- 2002-09-13 US US10/243,308 patent/US7151169B2/en not_active Expired - Lifetime
- 2002-09-13 US US10/243,265 patent/US20030091566A1/en not_active Abandoned
Also Published As
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NZ514759A (en) | 2003-10-31 |
AU768554B2 (en) | 2003-12-18 |
NO20015261L (no) | 2001-12-21 |
NO20015261D0 (no) | 2001-10-26 |
CA2370304A1 (en) | 2000-11-09 |
DE60012500T2 (de) | 2005-08-11 |
EP1175445A1 (de) | 2002-01-30 |
ATE272073T1 (de) | 2004-08-15 |
JP2003501348A (ja) | 2003-01-14 |
ES2225132T3 (es) | 2005-03-16 |
US6492497B1 (en) | 2002-12-10 |
US7151169B2 (en) | 2006-12-19 |
GB2350612A (en) | 2000-12-06 |
IL145813A0 (en) | 2002-07-25 |
GB2350612B (en) | 2002-01-09 |
EP1175445B1 (de) | 2004-07-28 |
GB0010568D0 (en) | 2000-06-21 |
BR0010162A (pt) | 2002-02-05 |
US20030091566A1 (en) | 2003-05-15 |
AU4588600A (en) | 2000-11-17 |
MXPA01010739A (es) | 2003-08-20 |
WO2000066631A1 (en) | 2000-11-09 |
US20030064069A1 (en) | 2003-04-03 |
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