DE69919325T3 - Spektrometer mit gepulster Ionenquelle, Kopplungsvorrichtung zur Dämpfung der Ionenbewegung, und Methode zur Verwendung derselben - Google Patents

Spektrometer mit gepulster Ionenquelle, Kopplungsvorrichtung zur Dämpfung der Ionenbewegung, und Methode zur Verwendung derselben Download PDF

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Publication number
DE69919325T3
DE69919325T3 DE69919325.7T DE69919325T DE69919325T3 DE 69919325 T3 DE69919325 T3 DE 69919325T3 DE 69919325 T DE69919325 T DE 69919325T DE 69919325 T3 DE69919325 T3 DE 69919325T3
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DE
Germany
Prior art keywords
ion
ions
mass spectrometer
ion source
mass
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69919325.7T
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German (de)
English (en)
Other versions
DE69919325T2 (de
DE69919325D1 (de
Inventor
Andrew Krutchinsky
Alexandre Loboda
Victor Spicer
Erich ENS
Kenneth Standing
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University of Manitoba
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University of Manitoba
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Publication date
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Publication of DE69919325T2 publication Critical patent/DE69919325T2/de
Publication of DE69919325T3 publication Critical patent/DE69919325T3/de
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Electron Sources, Ion Sources (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
DE69919325.7T 1998-01-23 1999-01-25 Spektrometer mit gepulster Ionenquelle, Kopplungsvorrichtung zur Dämpfung der Ionenbewegung, und Methode zur Verwendung derselben Expired - Lifetime DE69919325T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA2227806 1998-01-23
CA002227806A CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
EP99900849.3A EP1050061B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
PCT/CA1999/000034 WO1999038185A2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Publications (3)

Publication Number Publication Date
DE69919325D1 DE69919325D1 (de) 2004-09-16
DE69919325T2 DE69919325T2 (de) 2005-02-17
DE69919325T3 true DE69919325T3 (de) 2017-03-02

Family

ID=4162020

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69919325.7T Expired - Lifetime DE69919325T3 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster Ionenquelle, Kopplungsvorrichtung zur Dämpfung der Ionenbewegung, und Methode zur Verwendung derselben
DE1050061T Pending DE1050061T1 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster ionenquelle, kopplungsvorrichting zur dämpfung der ionenbewegung, und methode zur verwendung derselben

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1050061T Pending DE1050061T1 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster ionenquelle, kopplungsvorrichting zur dämpfung der ionenbewegung, und methode zur verwendung derselben

Country Status (8)

Country Link
EP (1) EP1050061B2 (enExample)
JP (1) JP4331398B2 (enExample)
AT (1) ATE273561T2 (enExample)
AU (1) AU745866B2 (enExample)
CA (1) CA2227806C (enExample)
DE (2) DE69919325T3 (enExample)
DK (1) DK1050061T4 (enExample)
WO (1) WO1999038185A2 (enExample)

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US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
GB9820210D0 (en) * 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
DE60044899D1 (de) 1999-06-11 2010-10-14 Applied Biosystems Llc Maldi ionenquelle mit gasimpuls, vorrichtung und verfahren zur ermittlung des molekulargewichtes labilen moleküle
DE10010204A1 (de) 2000-03-02 2001-09-13 Bruker Daltonik Gmbh Konditionierung eines Ionenstrahls für den Einschuss in ein Flugzeitmassenspektrometer
DE10010902A1 (de) 2000-03-07 2001-09-20 Bruker Daltonik Gmbh Tandem-Massenspektrometer aus zwei Quadrupolfiltern
GB2364168B (en) * 2000-06-09 2002-06-26 Micromass Ltd Methods and apparatus for mass spectrometry
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
US6891153B2 (en) 2000-11-29 2005-05-10 Micromass Uk Limited Mass spectrometers and methods of mass spectrometry
US6642514B2 (en) 2000-11-29 2003-11-04 Micromass Limited Mass spectrometers and methods of mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6617577B2 (en) 2001-04-16 2003-09-09 The Rockefeller University Method and system for mass spectroscopy
US20040238754A1 (en) 2001-09-17 2004-12-02 Baranov Vladimir I. Method and apparatus for cooling and focusing ions
WO2003052399A2 (en) * 2001-12-14 2003-06-26 Mds Inc., D.B.A. Mds Sciex Method of chemical of ionization at reduced pressures
CA2479872C (en) 2002-03-21 2009-06-23 Thermo Finnigan Llc Ionization apparatus and method for mass spectrometer system
US7388194B2 (en) 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
US7405397B2 (en) 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
JP2005521874A (ja) * 2002-03-28 2005-07-21 エムディーエス シエックス レーザ脱離およびマルチプルリアクションモニタリングを用いる小分子のハイスループット定量のための方法およびシステム
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
CA2431603C (en) 2003-06-10 2012-03-27 Micromass Uk Limited Mass spectrometer
DE102004025841B4 (de) * 2004-05-24 2015-07-09 Bruker Daltonik Gmbh Verfahren und Vorrichtung zur massenspektroskopischen Untersuchung von Analyten
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
DE102004051785B4 (de) * 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
ES2389111T3 (es) 2005-12-02 2012-10-23 Sirtris Pharmaceuticals, Inc. Ensayos de espectrometría de masas para la actividad acetiltransferasa/desacetilasa
WO2008076139A1 (en) 2006-03-10 2008-06-26 Tethys Bioscience, Inc. Multiplex protein fractionation
DE102007043456B4 (de) 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrixunterstützte Laserdesorption hoher Ionisierungsausbeute
AU2019220546A1 (en) * 2018-02-13 2020-08-27 Biomerieux, Inc. Methods for confirming charged-particle generation in an instrument, and related instruments
US12205807B2 (en) 2020-04-01 2025-01-21 Mstm, Llc Multi-mode ionization apparatus and uses thereof

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Publication number Priority date Publication date Assignee Title
US4535235A (en) † 1983-05-06 1985-08-13 Finnigan Corporation Apparatus and method for injection of ions into an ion cyclotron resonance cell
EP0202943B2 (en) † 1985-05-24 2004-11-24 Thermo Finnigan LLC Method of operating an ion trap
WO1989006044A1 (en) † 1987-12-24 1989-06-29 Unisearch Limited Mass spectrometer
CA1307859C (en) † 1988-12-12 1992-09-22 Donald James Douglas Mass spectrometer and method with improved ion transmission
DE4202123C2 (de) † 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Vorrichtung für die massenspektrometrische Untersuchung schneller organischer Ionen
US5689111A (en) † 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
DE19511333C1 (de) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtung für orthogonalen Einschuß von Ionen in ein Flugzeit-Massenspektrometer
DE19629134C1 (de) † 1996-07-19 1997-12-11 Bruker Franzen Analytik Gmbh Vorrichtung zur Überführung von Ionen und mit dieser durchgeführtes Meßverfahren
DE69806415T2 (de) * 1997-12-05 2003-02-20 The University Of British Columbia, Vancouver Verfahren zur untersuchung von ionen in einem apparat mit einem flugzeit-spektrometer und einer linearen quadrupol-ionenfalle

Also Published As

Publication number Publication date
JP4331398B2 (ja) 2009-09-16
DK1050061T3 (da) 2004-11-22
DE69919325T2 (de) 2005-02-17
DE1050061T1 (de) 2001-06-07
EP1050061B2 (en) 2016-10-19
CA2227806C (en) 2006-07-18
DK1050061T4 (en) 2017-01-23
DE69919325D1 (de) 2004-09-16
EP1050061B1 (en) 2004-08-11
AU2042899A (en) 1999-08-09
WO1999038185A3 (en) 1999-10-21
JP2002502084A (ja) 2002-01-22
AU745866B2 (en) 2002-04-11
EP1050061A2 (en) 2000-11-08
ATE273561T2 (de) 2004-08-15
WO1999038185A2 (en) 1999-07-29
CA2227806A1 (en) 1999-07-23

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