CA2227806A1 - Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use - Google Patents

Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use Download PDF

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Publication number
CA2227806A1
CA2227806A1 CA002227806A CA2227806A CA2227806A1 CA 2227806 A1 CA2227806 A1 CA 2227806A1 CA 002227806 A CA002227806 A CA 002227806A CA 2227806 A CA2227806 A CA 2227806A CA 2227806 A1 CA2227806 A1 CA 2227806A1
Authority
CA
Canada
Prior art keywords
ion
ions
transmission device
spectrometer
damp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002227806A
Other languages
French (fr)
Other versions
CA2227806C (en
Inventor
Andrew N. Krutchinsky
Alexandre Loboda
Victor L. Spicer
Erich W. Ens
Kenneth G. Standing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manitoba
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4162020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2227806(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to CA002227806A priority Critical patent/CA2227806C/en
Priority to DE69919325.7T priority patent/DE69919325T3/en
Priority to PCT/CA1999/000034 priority patent/WO1999038185A2/en
Priority to EP99900849.3A priority patent/EP1050061B2/en
Priority to DK99900849.3T priority patent/DK1050061T4/en
Priority to AU20428/99A priority patent/AU745866B2/en
Priority to JP2000528992A priority patent/JP4331398B2/en
Priority to AT99900849T priority patent/ATE273561T2/en
Priority to DE1050061T priority patent/DE1050061T1/en
Publication of CA2227806A1 publication Critical patent/CA2227806A1/en
Priority to US09/989,882 priority patent/US6680475B2/en
Priority to US10/236,514 priority patent/USRE39099E1/en
Priority to US10/758,511 priority patent/US6833543B2/en
Priority to US10/919,859 priority patent/US7189963B2/en
Publication of CA2227806C publication Critical patent/CA2227806C/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Electron Sources, Ion Sources (AREA)

Abstract

A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by an ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet or matrix molecules and ions, which is non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can substantially spread out the generated ions along an ion axis. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the spectrometer.
CA002227806A 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use Expired - Lifetime CA2227806C (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA002227806A CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
AT99900849T ATE273561T2 (en) 1998-01-23 1999-01-25 PULSE ION SOURCE SPECTROMETER, COUPLING DEVICE FOR DAMPING ION MOVEMENT, AND METHOD OF USING THE SAME
DE1050061T DE1050061T1 (en) 1998-01-23 1999-01-25 SPECTROMETER WITH PULSED ION SOURCE, COUPLING DEVICE FOR DAMPING ION MOVEMENT, AND METHOD FOR USE THEREOF
PCT/CA1999/000034 WO1999038185A2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
EP99900849.3A EP1050061B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
DK99900849.3T DK1050061T4 (en) 1998-01-23 1999-01-25 Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof
AU20428/99A AU745866B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
JP2000528992A JP4331398B2 (en) 1998-01-23 1999-01-25 An analyzer with a pulsed ion source and a transport device for damping ion motion and method of use thereof
DE69919325.7T DE69919325T3 (en) 1998-01-23 1999-01-25 Pulsed ion source spectrometer, coupling device for damping ion motion, and method of using same
US09/989,882 US6680475B2 (en) 1998-01-23 2001-11-21 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/236,514 USRE39099E1 (en) 1998-01-23 2002-09-06 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/758,511 US6833543B2 (en) 1998-01-23 2004-01-15 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/919,859 US7189963B2 (en) 1998-01-23 2004-08-17 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002227806A CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Publications (2)

Publication Number Publication Date
CA2227806A1 true CA2227806A1 (en) 1999-07-23
CA2227806C CA2227806C (en) 2006-07-18

Family

ID=4162020

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002227806A Expired - Lifetime CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Country Status (8)

Country Link
EP (1) EP1050061B2 (en)
JP (1) JP4331398B2 (en)
AT (1) ATE273561T2 (en)
AU (1) AU745866B2 (en)
CA (1) CA2227806C (en)
DE (2) DE69919325T3 (en)
DK (1) DK1050061T4 (en)
WO (1) WO1999038185A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
GB9820210D0 (en) 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
DE60044899D1 (en) 1999-06-11 2010-10-14 Applied Biosystems Llc MALDI ION SOURCE WITH GAS PULSE, DEVICE AND METHOD FOR DETERMINING THE MOLECULAR WEIGHT LABILES MOLECULES
DE10010204A1 (en) 2000-03-02 2001-09-13 Bruker Daltonik Gmbh Conditioning ion beam for flight time mass spectrometer involves damping ion movements in conducting system with gas pules, feeding ions to system end and extracting ions via lens system
DE10010902A1 (en) 2000-03-07 2001-09-20 Bruker Daltonik Gmbh Tandem mass spectrometer consisting of two quadrupole filters
GB2364168B (en) * 2000-06-09 2002-06-26 Micromass Ltd Methods and apparatus for mass spectrometry
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
GB2370685B (en) 2000-11-29 2003-01-22 Micromass Ltd Mass spectrometers and methods of mass spectrometry
CA2364158C (en) 2000-11-29 2003-12-23 Micromass Limited Mass spectrometers and methods of mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6617577B2 (en) * 2001-04-16 2003-09-09 The Rockefeller University Method and system for mass spectroscopy
US6849848B2 (en) 2001-09-17 2005-02-01 Mds, Inc. Method and apparatus for cooling and focusing ions
WO2003052399A2 (en) * 2001-12-14 2003-06-26 Mds Inc., D.B.A. Mds Sciex Method of chemical of ionization at reduced pressures
WO2003081205A2 (en) 2002-03-21 2003-10-02 Thermo Finnigan Llc Ionization apparatus and method for mass spectrometer system
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
US7388194B2 (en) 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
CA2477835C (en) * 2002-03-28 2011-11-22 Mds Sciex Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US6977371B2 (en) 2003-06-10 2005-12-20 Micromass Uk Limited Mass spectrometer
DE102004025841B4 (en) * 2004-05-24 2015-07-09 Bruker Daltonik Gmbh Method and apparatus for mass spectroscopic analysis of analytes
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
DE102004051785B4 (en) * 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Protein profiles with air MALDI
ES2389111T3 (en) 2005-12-02 2012-10-23 Sirtris Pharmaceuticals, Inc. Mass spectrometry assays for acetyltransferase / deacetylase activity
WO2008076139A1 (en) 2006-03-10 2008-06-26 Tethys Bioscience, Inc. Multiplex protein fractionation
DE102007043456B4 (en) 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrix-assisted laser desorption with high ionization efficiency
KR20200118841A (en) 2018-02-13 2020-10-16 바이오메리욱스, 인코포레이티드. Methods and related devices for verifying the generation of charged particles in a device

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535235A (en) † 1983-05-06 1985-08-13 Finnigan Corporation Apparatus and method for injection of ions into an ion cyclotron resonance cell
EP0409362B1 (en) † 1985-05-24 1995-04-19 Finnigan Corporation Method of operating an ion trap
JPH03503815A (en) † 1987-12-24 1991-08-22 ユニサーチ　リミテッド mass spectrometer
CA1307859C (en) † 1988-12-12 1992-09-22 Donald James Douglas Mass spectrometer and method with improved ion transmission
DE4202123C2 (en) † 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Device for the mass spectrometric analysis of fast organic ions
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
DE19511333C1 (en) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer
DE19629134C1 (en) † 1996-07-19 1997-12-11 Bruker Franzen Analytik Gmbh Device for transferring ions and measuring method carried out with the same
WO1999030350A1 (en) * 1997-12-05 1999-06-17 University Of British Columbia Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap

Also Published As

Publication number Publication date
EP1050061A2 (en) 2000-11-08
ATE273561T2 (en) 2004-08-15
WO1999038185A2 (en) 1999-07-29
CA2227806C (en) 2006-07-18
WO1999038185A3 (en) 1999-10-21
JP2002502084A (en) 2002-01-22
EP1050061B1 (en) 2004-08-11
DE69919325D1 (en) 2004-09-16
AU2042899A (en) 1999-08-09
DE69919325T2 (en) 2005-02-17
DE1050061T1 (en) 2001-06-07
AU745866B2 (en) 2002-04-11
DK1050061T4 (en) 2017-01-23
EP1050061B2 (en) 2016-10-19
JP4331398B2 (en) 2009-09-16
DK1050061T3 (en) 2004-11-22
DE69919325T3 (en) 2017-03-02

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Effective date: 20180123