DK1050061T3 - Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof - Google Patents
Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereofInfo
- Publication number
- DK1050061T3 DK1050061T3 DK99900849T DK99900849T DK1050061T3 DK 1050061 T3 DK1050061 T3 DK 1050061T3 DK 99900849 T DK99900849 T DK 99900849T DK 99900849 T DK99900849 T DK 99900849T DK 1050061 T3 DK1050061 T3 DK 1050061T3
- Authority
- DK
- Denmark
- Prior art keywords
- ion
- ions
- transmission device
- source
- spectrometer
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
- H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Electron Sources, Ion Sources (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by a pulsed ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet of matrix molecules and ions, which is substantially non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can have a number of effects, including: substantially spreading out the generated ions along an ion axis to generate a quasi-continuous beam; reducing the energy spread of ions emitted from the source; and at least partially suppressing unwanted fragmentation of analyte ions. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the ion generation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002227806A CA2227806C (en) | 1998-01-23 | 1998-01-23 | Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use |
PCT/CA1999/000034 WO1999038185A2 (en) | 1998-01-23 | 1999-01-25 | Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1050061T3 true DK1050061T3 (en) | 2004-11-22 |
DK1050061T4 DK1050061T4 (en) | 2017-01-23 |
Family
ID=4162020
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99900849.3T DK1050061T4 (en) | 1998-01-23 | 1999-01-25 | Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1050061B2 (en) |
JP (1) | JP4331398B2 (en) |
AT (1) | ATE273561T2 (en) |
AU (1) | AU745866B2 (en) |
CA (1) | CA2227806C (en) |
DE (2) | DE1050061T1 (en) |
DK (1) | DK1050061T4 (en) |
WO (1) | WO1999038185A2 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965884A (en) * | 1998-06-04 | 1999-10-12 | The Regents Of The University Of California | Atmospheric pressure matrix assisted laser desorption |
US6849847B1 (en) | 1998-06-12 | 2005-02-01 | Agilent Technologies, Inc. | Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis |
GB9820210D0 (en) * | 1998-09-16 | 1998-11-11 | Vg Elemental Limited | Means for removing unwanted ions from an ion transport system and mass spectrometer |
DE60044899D1 (en) | 1999-06-11 | 2010-10-14 | Applied Biosystems Llc | MALDI ION SOURCE WITH GAS PULSE, DEVICE AND METHOD FOR DETERMINING THE MOLECULAR WEIGHT LABILES MOLECULES |
DE10010204A1 (en) | 2000-03-02 | 2001-09-13 | Bruker Daltonik Gmbh | Conditioning ion beam for flight time mass spectrometer involves damping ion movements in conducting system with gas pules, feeding ions to system end and extracting ions via lens system |
DE10010902A1 (en) | 2000-03-07 | 2001-09-20 | Bruker Daltonik Gmbh | Tandem mass spectrometer consisting of two quadrupole filters |
US6586727B2 (en) * | 2000-06-09 | 2003-07-01 | Micromass Limited | Methods and apparatus for mass spectrometry |
CA2340150C (en) * | 2000-06-09 | 2005-11-22 | Micromass Limited | Methods and apparatus for mass spectrometry |
US6642514B2 (en) | 2000-11-29 | 2003-11-04 | Micromass Limited | Mass spectrometers and methods of mass spectrometry |
CA2364158C (en) | 2000-11-29 | 2003-12-23 | Micromass Limited | Mass spectrometers and methods of mass spectrometry |
US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
US6617577B2 (en) | 2001-04-16 | 2003-09-09 | The Rockefeller University | Method and system for mass spectroscopy |
CA2460567C (en) * | 2001-09-17 | 2010-11-02 | Mds Inc. | Method and apparatus for cooling and focusing ions |
WO2003052399A2 (en) * | 2001-12-14 | 2003-06-26 | Mds Inc., D.B.A. Mds Sciex | Method of chemical of ionization at reduced pressures |
CA2479872C (en) | 2002-03-21 | 2009-06-23 | Thermo Finnigan Llc | Ionization apparatus and method for mass spectrometer system |
US7388194B2 (en) | 2002-03-28 | 2008-06-17 | Mds Sciex Inc. | Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring |
US7405397B2 (en) * | 2002-03-28 | 2008-07-29 | Mds Sciex Inc. | Laser desorption ion source with ion guide coupling for ion mass spectroscopy |
CA2477835C (en) * | 2002-03-28 | 2011-11-22 | Mds Sciex | Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring |
GB0210930D0 (en) | 2002-05-13 | 2002-06-19 | Thermo Electron Corp | Improved mass spectrometer and mass filters therefor |
GB0305796D0 (en) | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
US6977371B2 (en) | 2003-06-10 | 2005-12-20 | Micromass Uk Limited | Mass spectrometer |
DE102004025841B4 (en) * | 2004-05-24 | 2015-07-09 | Bruker Daltonik Gmbh | Method and apparatus for mass spectroscopic analysis of analytes |
GB0420408D0 (en) * | 2004-09-14 | 2004-10-20 | Micromass Ltd | Mass spectrometer |
DE102004051785B4 (en) | 2004-10-25 | 2008-04-24 | Bruker Daltonik Gmbh | Protein profiles with air MALDI |
ES2389111T3 (en) | 2005-12-02 | 2012-10-23 | Sirtris Pharmaceuticals, Inc. | Mass spectrometry assays for acetyltransferase / deacetylase activity |
WO2008076139A1 (en) | 2006-03-10 | 2008-06-26 | Tethys Bioscience, Inc. | Multiplex protein fractionation |
DE102007043456B4 (en) | 2007-07-31 | 2012-02-09 | Bruker Daltonik Gmbh | Matrix-assisted laser desorption with high ionization efficiency |
CA3090697A1 (en) * | 2018-02-13 | 2019-08-22 | Biomerieux, Inc. | Methods for confirming charged-particle generation in an instrument, and related instruments |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4535235A (en) † | 1983-05-06 | 1985-08-13 | Finnigan Corporation | Apparatus and method for injection of ions into an ion cyclotron resonance cell |
DE3688215T3 (en) † | 1985-05-24 | 2005-08-25 | Thermo Finnigan Llc, San Jose | Control method for an ion trap. |
WO1989006044A1 (en) † | 1987-12-24 | 1989-06-29 | Unisearch Limited | Mass spectrometer |
CA1307859C (en) † | 1988-12-12 | 1992-09-22 | Donald James Douglas | Mass spectrometer and method with improved ion transmission |
DE4202123C2 (en) † | 1992-01-27 | 1995-04-06 | Bruker Franzen Analytik Gmbh | Device for the mass spectrometric analysis of fast organic ions |
US5689111A (en) * | 1995-08-10 | 1997-11-18 | Analytica Of Branford, Inc. | Ion storage time-of-flight mass spectrometer |
DE19511333C1 (en) * | 1995-03-28 | 1996-08-08 | Bruker Franzen Analytik Gmbh | Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer |
DE19629134C1 (en) † | 1996-07-19 | 1997-12-11 | Bruker Franzen Analytik Gmbh | Device for transferring ions and measuring method carried out with the same |
CA2312806A1 (en) * | 1997-12-05 | 1999-06-17 | University Of British Columbia | Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap |
-
1998
- 1998-01-23 CA CA002227806A patent/CA2227806C/en not_active Expired - Lifetime
-
1999
- 1999-01-25 AU AU20428/99A patent/AU745866B2/en not_active Expired
- 1999-01-25 WO PCT/CA1999/000034 patent/WO1999038185A2/en active IP Right Grant
- 1999-01-25 AT AT99900849T patent/ATE273561T2/en active
- 1999-01-25 EP EP99900849.3A patent/EP1050061B2/en not_active Expired - Lifetime
- 1999-01-25 DK DK99900849.3T patent/DK1050061T4/en active
- 1999-01-25 DE DE1050061T patent/DE1050061T1/en active Pending
- 1999-01-25 DE DE69919325.7T patent/DE69919325T3/en not_active Expired - Lifetime
- 1999-01-25 JP JP2000528992A patent/JP4331398B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE273561T2 (en) | 2004-08-15 |
WO1999038185A2 (en) | 1999-07-29 |
DK1050061T4 (en) | 2017-01-23 |
AU745866B2 (en) | 2002-04-11 |
CA2227806C (en) | 2006-07-18 |
DE69919325T3 (en) | 2017-03-02 |
JP4331398B2 (en) | 2009-09-16 |
AU2042899A (en) | 1999-08-09 |
EP1050061B2 (en) | 2016-10-19 |
DE1050061T1 (en) | 2001-06-07 |
DE69919325D1 (en) | 2004-09-16 |
CA2227806A1 (en) | 1999-07-23 |
WO1999038185A3 (en) | 1999-10-21 |
EP1050061A2 (en) | 2000-11-08 |
JP2002502084A (en) | 2002-01-22 |
EP1050061B1 (en) | 2004-08-11 |
DE69919325T2 (en) | 2005-02-17 |
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