CA2227806C - Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use - Google Patents

Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use Download PDF

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Publication number
CA2227806C
CA2227806C CA002227806A CA2227806A CA2227806C CA 2227806 C CA2227806 C CA 2227806C CA 002227806 A CA002227806 A CA 002227806A CA 2227806 A CA2227806 A CA 2227806A CA 2227806 C CA2227806 C CA 2227806C
Authority
CA
Canada
Prior art keywords
ions
ion
ion source
source
spectrometer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002227806A
Other languages
English (en)
French (fr)
Other versions
CA2227806A1 (en
Inventor
Andrew N. Krutchinsky
Alexandre Loboda
Victor L. Spicer
Erich W. Ens
Kenneth G. Standing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manitoba
Original Assignee
University of Manitoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4162020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2227806(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Manitoba filed Critical University of Manitoba
Priority to CA002227806A priority Critical patent/CA2227806C/en
Priority to JP2000528992A priority patent/JP4331398B2/ja
Priority to DE1050061T priority patent/DE1050061T1/de
Priority to PCT/CA1999/000034 priority patent/WO1999038185A2/en
Priority to DE69919325.7T priority patent/DE69919325T3/de
Priority to AT99900849T priority patent/ATE273561T2/de
Priority to AU20428/99A priority patent/AU745866B2/en
Priority to EP99900849.3A priority patent/EP1050061B2/en
Priority to DK99900849.3T priority patent/DK1050061T4/en
Publication of CA2227806A1 publication Critical patent/CA2227806A1/en
Priority to US09/989,882 priority patent/US6680475B2/en
Priority to US10/236,514 priority patent/USRE39099E1/en
Priority to US10/758,511 priority patent/US6833543B2/en
Priority to US10/919,859 priority patent/US7189963B2/en
Publication of CA2227806C publication Critical patent/CA2227806C/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Electron Sources, Ion Sources (AREA)
CA002227806A 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use Expired - Lifetime CA2227806C (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA002227806A CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
EP99900849.3A EP1050061B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
DK99900849.3T DK1050061T4 (en) 1998-01-23 1999-01-25 Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof
DE1050061T DE1050061T1 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster ionenquelle, kopplungsvorrichting zur dämpfung der ionenbewegung, und methode zur verwendung derselben
PCT/CA1999/000034 WO1999038185A2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
DE69919325.7T DE69919325T3 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster Ionenquelle, Kopplungsvorrichtung zur Dämpfung der Ionenbewegung, und Methode zur Verwendung derselben
AT99900849T ATE273561T2 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster ionenquelle, kopplungsvorrichtung zur dämpfung der ionenbewegung, und methode zur verwendung derselben
AU20428/99A AU745866B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
JP2000528992A JP4331398B2 (ja) 1998-01-23 1999-01-25 パルスイオン源及びイオン運動を制動するための輸送デバイスを備えた分析計並びにその使用方法
US09/989,882 US6680475B2 (en) 1998-01-23 2001-11-21 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/236,514 USRE39099E1 (en) 1998-01-23 2002-09-06 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/758,511 US6833543B2 (en) 1998-01-23 2004-01-15 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/919,859 US7189963B2 (en) 1998-01-23 2004-08-17 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002227806A CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Publications (2)

Publication Number Publication Date
CA2227806A1 CA2227806A1 (en) 1999-07-23
CA2227806C true CA2227806C (en) 2006-07-18

Family

ID=4162020

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002227806A Expired - Lifetime CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Country Status (8)

Country Link
EP (1) EP1050061B2 (enExample)
JP (1) JP4331398B2 (enExample)
AT (1) ATE273561T2 (enExample)
AU (1) AU745866B2 (enExample)
CA (1) CA2227806C (enExample)
DE (2) DE1050061T1 (enExample)
DK (1) DK1050061T4 (enExample)
WO (1) WO1999038185A2 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
GB9820210D0 (en) 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
EP1181707B8 (en) 1999-06-11 2011-04-27 DH Technologies Development Pte. Ltd. Maldi ion source with a pulse of gas, apparatus and method for determining molecular weight of labile molecules
DE10010204A1 (de) 2000-03-02 2001-09-13 Bruker Daltonik Gmbh Konditionierung eines Ionenstrahls für den Einschuss in ein Flugzeitmassenspektrometer
DE10010902A1 (de) 2000-03-07 2001-09-20 Bruker Daltonik Gmbh Tandem-Massenspektrometer aus zwei Quadrupolfiltern
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
GB2364168B (en) * 2000-06-09 2002-06-26 Micromass Ltd Methods and apparatus for mass spectrometry
CA2419866C (en) 2000-11-29 2005-02-01 Micromass Limited Mass spectrometers and methods of mass spectrometry
US6642514B2 (en) 2000-11-29 2003-11-04 Micromass Limited Mass spectrometers and methods of mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6617577B2 (en) 2001-04-16 2003-09-09 The Rockefeller University Method and system for mass spectroscopy
EP1430508A1 (en) * 2001-09-17 2004-06-23 MDS Inc., doing business as MDS Sciex Method and apparatus for cooling and focusing ions
AU2002349241A1 (en) * 2001-12-14 2003-06-30 Mds Inc., D.B.A. Mds Sciex Method of chemical of ionization at reduced pressures
AU2003220320A1 (en) 2002-03-21 2003-10-08 Thermo Finnigan Llc Ionization apparatus and method for mass spectrometer system
US7388194B2 (en) 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
AU2003230093A1 (en) * 2002-03-28 2003-10-13 Mds Sciex Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
CA2431603C (en) 2003-06-10 2012-03-27 Micromass Uk Limited Mass spectrometer
DE102004025841B4 (de) * 2004-05-24 2015-07-09 Bruker Daltonik Gmbh Verfahren und Vorrichtung zur massenspektroskopischen Untersuchung von Analyten
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
DE102004051785B4 (de) * 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
ES2389111T3 (es) 2005-12-02 2012-10-23 Sirtris Pharmaceuticals, Inc. Ensayos de espectrometría de masas para la actividad acetiltransferasa/desacetilasa
US8097425B2 (en) 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
DE102007043456B4 (de) 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrixunterstützte Laserdesorption hoher Ionisierungsausbeute
CA3090697A1 (en) * 2018-02-13 2019-08-22 Biomerieux, Inc. Methods for confirming charged-particle generation in an instrument, and related instruments
US12205807B2 (en) 2020-04-01 2025-01-21 Mstm, Llc Multi-mode ionization apparatus and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535235A (en) † 1983-05-06 1985-08-13 Finnigan Corporation Apparatus and method for injection of ions into an ion cyclotron resonance cell
DE3688215T3 (de) † 1985-05-24 2005-08-25 Thermo Finnigan Llc, San Jose Steuerungsverfahren für eine Ionenfalle.
WO1989006044A1 (en) † 1987-12-24 1989-06-29 Unisearch Limited Mass spectrometer
CA1307859C (en) † 1988-12-12 1992-09-22 Donald James Douglas Mass spectrometer and method with improved ion transmission
DE4202123C2 (de) † 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Vorrichtung für die massenspektrometrische Untersuchung schneller organischer Ionen
US5689111A (en) † 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
DE19511333C1 (de) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtung für orthogonalen Einschuß von Ionen in ein Flugzeit-Massenspektrometer
DE19629134C1 (de) † 1996-07-19 1997-12-11 Bruker Franzen Analytik Gmbh Vorrichtung zur Überführung von Ionen und mit dieser durchgeführtes Meßverfahren
AU1329899A (en) * 1997-12-05 1999-06-28 University Of British Columbia, The Method of analyzing ions in an apparatus including a time of flight mass spectrometer and a linear ion trap

Also Published As

Publication number Publication date
JP4331398B2 (ja) 2009-09-16
DE69919325T2 (de) 2005-02-17
DE69919325T3 (de) 2017-03-02
WO1999038185A2 (en) 1999-07-29
DE69919325D1 (de) 2004-09-16
CA2227806A1 (en) 1999-07-23
EP1050061B1 (en) 2004-08-11
EP1050061B2 (en) 2016-10-19
DE1050061T1 (de) 2001-06-07
JP2002502084A (ja) 2002-01-22
ATE273561T2 (de) 2004-08-15
DK1050061T4 (en) 2017-01-23
AU745866B2 (en) 2002-04-11
WO1999038185A3 (en) 1999-10-21
DK1050061T3 (da) 2004-11-22
EP1050061A2 (en) 2000-11-08
AU2042899A (en) 1999-08-09

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