DE69910227T2 - Pyrrolobenzodiazepine - Google Patents
Pyrrolobenzodiazepine Download PDFInfo
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- DE69910227T2 DE69910227T2 DE69910227T DE69910227T DE69910227T2 DE 69910227 T2 DE69910227 T2 DE 69910227T2 DE 69910227 T DE69910227 T DE 69910227T DE 69910227 T DE69910227 T DE 69910227T DE 69910227 T2 DE69910227 T2 DE 69910227T2
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- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 114
- 238000000034 method Methods 0.000 claims abstract description 54
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 24
- 238000010914 gene-directed enzyme pro-drug therapy Methods 0.000 claims abstract description 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 14
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 11
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 10
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000010913 antigen-directed enzyme pro-drug therapy Methods 0.000 claims abstract description 4
- 102000004190 Enzymes Human genes 0.000 claims description 59
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- -1 hydroxy, amino Chemical group 0.000 claims description 40
- 239000000539 dimer Substances 0.000 claims description 28
- 229910052757 nitrogen Inorganic materials 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000001424 substituent group Chemical group 0.000 claims description 22
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
- 102000004459 Nitroreductase Human genes 0.000 claims description 20
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 12
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- 208000018408 tumor of duodenum Diseases 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 208000026533 urinary bladder disease Diseases 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9818731 | 1998-08-27 | ||
| GBGB9818731.3A GB9818731D0 (en) | 1998-08-27 | 1998-08-27 | Compounds |
| PCT/GB1999/002837 WO2000012507A2 (en) | 1998-08-27 | 1999-08-27 | Pyrrolobenzodiazepines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69910227D1 DE69910227D1 (de) | 2003-09-11 |
| DE69910227T2 true DE69910227T2 (de) | 2004-06-17 |
Family
ID=10837953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69910227T Expired - Lifetime DE69910227T2 (de) | 1998-08-27 | 1999-08-27 | Pyrrolobenzodiazepine |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6562806B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1109811B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4669611B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE246687T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2341968C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69910227T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1109811T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2205872T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB9818731D0 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ510492A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1109811E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000012507A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (143)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB9818731D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
| GB9818732D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
| ES2260570T3 (es) | 1998-08-27 | 2006-11-01 | Spirogen Limited | Pirrolobenziodiazepinas dimericas. |
| GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| FR2844273B1 (fr) | 2002-09-05 | 2008-04-04 | Aventis Pharma Sa | Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens. |
| GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
| DE602004023183D1 (de) * | 2003-03-07 | 2009-10-29 | Univ Texas | Gegen antikörper gerichtete photodynamische therapie |
| GB0321295D0 (en) * | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
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| US3524849A (en) | 1967-10-27 | 1970-08-18 | Hoffmann La Roche | Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein |
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-
1998
- 1998-08-27 GB GBGB9818731.3A patent/GB9818731D0/en not_active Ceased
-
1999
- 1999-08-27 DE DE69910227T patent/DE69910227T2/de not_active Expired - Lifetime
- 1999-08-27 AT AT99941766T patent/ATE246687T1/de active
- 1999-08-27 EP EP99941766A patent/EP1109811B1/en not_active Expired - Lifetime
- 1999-08-27 JP JP2000571053A patent/JP4669611B2/ja not_active Expired - Lifetime
- 1999-08-27 US US09/763,814 patent/US6562806B1/en not_active Expired - Lifetime
- 1999-08-27 ES ES99941766T patent/ES2205872T3/es not_active Expired - Lifetime
- 1999-08-27 WO PCT/GB1999/002837 patent/WO2000012507A2/en not_active Ceased
- 1999-08-27 NZ NZ510492A patent/NZ510492A/en not_active IP Right Cessation
- 1999-08-27 DK DK99941766T patent/DK1109811T3/da active
- 1999-08-27 CA CA002341968A patent/CA2341968C/en not_active Expired - Lifetime
- 1999-08-27 PT PT99941766T patent/PT1109811E/pt unknown
-
2003
- 2003-03-04 US US10/379,049 patent/US20030195196A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| WO2000012507A2 (en) | 2000-03-09 |
| GB9818731D0 (en) | 1998-10-21 |
| PT1109811E (pt) | 2003-12-31 |
| US20030195196A1 (en) | 2003-10-16 |
| ES2205872T3 (es) | 2004-05-01 |
| WO2000012507A3 (en) | 2000-08-31 |
| US6562806B1 (en) | 2003-05-13 |
| DE69910227D1 (de) | 2003-09-11 |
| CA2341968A1 (en) | 2000-03-09 |
| CA2341968C (en) | 2009-04-07 |
| WO2000012507A8 (en) | 2000-10-19 |
| DK1109811T3 (da) | 2003-11-24 |
| ATE246687T1 (de) | 2003-08-15 |
| EP1109811A2 (en) | 2001-06-27 |
| NZ510492A (en) | 2003-08-29 |
| JP2002525284A (ja) | 2002-08-13 |
| JP4669611B2 (ja) | 2011-04-13 |
| EP1109811B1 (en) | 2003-08-06 |
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