DE69842019D1 - Transgene vögel und proteinproduktion - Google Patents

Transgene vögel und proteinproduktion

Info

Publication number
DE69842019D1
DE69842019D1 DE69842019T DE69842019T DE69842019D1 DE 69842019 D1 DE69842019 D1 DE 69842019D1 DE 69842019 T DE69842019 T DE 69842019T DE 69842019 T DE69842019 T DE 69842019T DE 69842019 D1 DE69842019 D1 DE 69842019D1
Authority
DE
Germany
Prior art keywords
exogenous
protein production
transgenic birds
bird
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69842019T
Other languages
English (en)
Inventor
Robert D Ivarie
Alex J Harvey
Julie A Morris
Guodong Liu
Jeffrey C Rapp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Georgia
University of Georgia Research Foundation Inc UGARF
Synageva Biopharma Corp
Original Assignee
University of Georgia
University of Georgia Research Foundation Inc UGARF
Synageva Biopharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Georgia, University of Georgia Research Foundation Inc UGARF, Synageva Biopharma Corp filed Critical University of Georgia
Application granted granted Critical
Publication of DE69842019D1 publication Critical patent/DE69842019D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/77—Ovalbumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
    • C12N2740/11041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/11043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/40—Vector systems having a special element relevant for transcription being an insulator
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Animal Husbandry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69842019T 1997-10-16 1998-10-15 Transgene vögel und proteinproduktion Expired - Lifetime DE69842019D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6217297P 1997-10-16 1997-10-16
PCT/US1998/021975 WO1999019472A1 (en) 1997-10-16 1998-10-15 Vectors comprising a magnum-specific promoter for avian transgenesis

Publications (1)

Publication Number Publication Date
DE69842019D1 true DE69842019D1 (de) 2011-01-05

Family

ID=22040673

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69842019T Expired - Lifetime DE69842019D1 (de) 1997-10-16 1998-10-15 Transgene vögel und proteinproduktion

Country Status (14)

Country Link
US (7) US6730822B1 (de)
EP (2) EP1023442B1 (de)
JP (5) JP2001520009A (de)
KR (1) KR20010031190A (de)
AT (1) ATE489461T1 (de)
AU (1) AU752946B2 (de)
CA (1) CA2307840C (de)
CY (1) CY1111267T1 (de)
DE (1) DE69842019D1 (de)
DK (1) DK1023442T3 (de)
ES (1) ES2357495T3 (de)
IL (2) IL135604A0 (de)
PT (1) PT1023442E (de)
WO (1) WO1999019472A1 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563803B2 (en) * 1997-10-16 2013-10-22 Synageva Biopharma Corp. Method of making protein in an egg of a transgenic chicken
ES2357495T3 (es) * 1997-10-16 2011-04-27 University Of Georgia Research Foundation, Inc. Aves transgénicas y producción de proteína.
US20040019923A1 (en) * 1997-10-16 2004-01-29 Ivarie Robert D. Exogenous proteins expressed in avians and their eggs
AU5690799A (en) * 1998-08-25 2000-03-14 Avigenics, Inc. Direct oviduct transgenesis
WO2000075300A2 (en) * 1999-06-04 2000-12-14 Tranxenogen, Inc. Methods for manipulating the avian genome
AU7491800A (en) * 1999-09-15 2001-04-17 Therapeutic Human Polyclonals, Inc. Immunotherapy with substantially human polyclonal antibody preparations purifiedfrom genetically engineered birds
US7049480B1 (en) * 2000-09-01 2006-05-23 Avigenics, Inc. Methods of enucleating an avian oocyte or zygote using two-photon laser scanning microscopy
JP2002176880A (ja) * 2000-12-12 2002-06-25 Kanegafuchi Chem Ind Co Ltd 効率的な遺伝子導入鳥類の作製法及びそれによって得られる遺伝子導入鳥類
US7339090B2 (en) 2001-02-13 2008-03-04 Avigenics, Inc. Microinjection devices and methods of use
US7541512B2 (en) 2001-03-30 2009-06-02 Synageva Biopharma Corp. Avians containing a lysozyme promoter transgene
WO2002079447A2 (en) 2001-03-30 2002-10-10 Avigenics, Inc. Avian lysozyme promoter
US7176300B2 (en) 2001-03-30 2007-02-13 Avigenics, Inc. Avian lysozyme promoter
GB0119497D0 (en) * 2001-08-10 2001-10-03 Viragen Inc Expression of modified antibodies in avian cells
WO2003025159A1 (en) 2001-08-13 2003-03-27 Embrex, Inc. Methods for injecting avian eggs
EP1438401B1 (de) 2001-09-18 2011-06-15 Synageva BioPharma Corp. Produktion eines transgenen vogels mittels cytoplasmainjektion
US7550650B2 (en) 2001-09-18 2009-06-23 Synageva Biopharma Corp. Production of a transgenic avian by cytoplasmic injection
DE10147439B4 (de) * 2001-09-26 2014-01-30 Qiagen Gmbh Verfahren zur Isolierung von DNA aus biologischen Proben
FR2832423B1 (fr) * 2001-11-22 2004-10-08 Vivalis Systeme d'expression de proteines exogenes dans un systeme aviaire
US6875588B2 (en) * 2001-11-30 2005-04-05 Avigenics, Inc. Ovomucoid promoter and methods of use
US7294507B2 (en) 2001-11-30 2007-11-13 Avigenics, Inc. Ovomucoid promoters and methods of use
AU2007201063B2 (en) * 2001-11-30 2007-11-08 Synageva Biopharma Corp. Ovomucoid promoter and methods of use
US7335761B2 (en) 2001-11-30 2008-02-26 Avigenics, Inc. Avian gene expression controlling regions
US7323618B2 (en) * 2002-02-01 2008-01-29 Origen Therapeutics, Inc. Tissue specific expression of exogenous proteins in transgenic chickens
US20060191026A1 (en) 2005-02-18 2006-08-24 Origen Therapeutics, Inc. Tissue specific expression of antibodies in chickens
US7145057B2 (en) * 2002-02-01 2006-12-05 Origen Therapeutics, Inc. Chimeric bird from embryonic stem cells
US7135562B2 (en) 2002-03-14 2006-11-14 University Of Cincinnati Avian iFABP gene expression controlling region
US20050246782A1 (en) * 2002-03-22 2005-11-03 Origen Therapeutics Transgenic aves producing human polyclonal antibodies
US7527966B2 (en) * 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
US20040235011A1 (en) * 2002-06-26 2004-11-25 Cooper Richard K. Production of multimeric proteins
US20040172667A1 (en) * 2002-06-26 2004-09-02 Cooper Richard K. Administration of transposon-based vectors to reproductive organs
JP5468719B2 (ja) * 2002-08-13 2014-04-09 株式会社カネカ レトロウイルスベクターによる遺伝子導入鳥類での遺伝子発現法およびそれによって得られる遺伝子導入烏類
GB0227645D0 (en) * 2002-11-27 2003-01-08 Viragen Inc Protein production in transgenic avians
US7803362B2 (en) * 2003-01-24 2010-09-28 Synageva Biopharma Corp. Glycosylated interferon alpha
US20050034186A1 (en) * 2003-03-07 2005-02-10 Harvey Alex J. Site specific nucleic acid integration
US20080222744A1 (en) * 2003-05-09 2008-09-11 Avigenics, Inc. In vivo transfection in avians
US7381712B2 (en) * 2003-05-09 2008-06-03 Avigenics, Inc. In vivo transfection in avians
EP1633781A2 (de) * 2003-06-06 2006-03-15 Avigenics, Inc. Ovomucoid-promotor und verwendungsverfahren
US20050090001A1 (en) 2003-10-07 2005-04-28 Parker Stephen H. Cell lines and methods for producing proteins
MXPA06004858A (es) 2003-10-31 2007-04-16 Univ British Columbia Factores de virulencia bacteriana y sus usos.
US8071364B2 (en) 2003-12-24 2011-12-06 Transgenrx, Inc. Gene therapy using transposon-based vectors
ATE540580T1 (de) * 2004-01-08 2012-01-15 Kaneka Corp Verfahren zur herstellung eines transgenen vogels.
US20090313712A1 (en) * 2004-08-25 2009-12-17 Leandro Christmann RNA interference and disease resistance in avians
US20060046248A1 (en) * 2004-08-25 2006-03-02 Avigenics, Inc. RNA interference in avians
US20060046247A1 (en) * 2004-08-25 2006-03-02 Rapp Jeffrey C Protecting avians from pathogens
US20080222743A1 (en) * 2004-08-25 2008-09-11 Avigenics, Inc. RNA interference and disease resistance in avians
WO2006079121A2 (en) * 2005-01-19 2006-07-27 Avigenics, Inc. Methods of treating disease with glycosylated interferon
US20090064351A1 (en) * 2005-03-30 2009-03-05 Kaneka Corporation Transgenic bird producing erythropoietin and method of constructing the same
US7351582B2 (en) * 2005-06-17 2008-04-01 Avigenics, Inc. Cell lines
EP2380435B1 (de) 2005-08-31 2016-05-25 Kaneka Corporation Von Katzen stammendes Erythropoietin und Herstellungsverfahren dafür
EP1931698B1 (de) * 2005-10-05 2019-05-29 Alexion Pharmaceuticals, Inc. Schnelle produktion von virus mit hohem titer
US20090180989A1 (en) * 2005-10-05 2009-07-16 Synageva Biopharma Corp. Compositions and methods for delivering nucleotide sequences to vertebrates
US20080171696A1 (en) * 2005-10-21 2008-07-17 Avigenics, Inc. Pharmacodynamically enhanced therapeutic proteins
CN101291684A (zh) * 2005-10-21 2008-10-22 阿维季尼克斯股份有限公司 甘醇化和糖基化的禽类来源的治疗性蛋白
US20100166700A1 (en) 2006-02-28 2010-07-01 Oligasis Corporation Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates and Their Preparation
WO2007108882A2 (en) * 2006-03-17 2007-09-27 Avigenics, Inc. Glycosylated g-csf
US7812127B2 (en) 2006-03-17 2010-10-12 Synageva Biopharma Corp. Glycosylated human G-CSF
US7663019B2 (en) * 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
US20080124792A1 (en) * 2006-08-07 2008-05-29 Avigenics, Inc. Hybrid promoters
US20080071067A1 (en) * 2006-09-20 2008-03-20 Avigenics, Inc. Methods of purifying proteins from egg white
AU2007318209A1 (en) * 2006-11-09 2008-05-15 Synageva Biopharma Corp Avian derived erythropoietin
US20090105462A1 (en) * 2006-11-09 2009-04-23 Ivarie Robert D Glycosylated erythropoietin
EP2126071A4 (de) 2007-01-26 2010-12-08 Synageva Biopharma Corp Transgenexpression in vögeln
ES2439954T3 (es) * 2007-02-23 2014-01-27 Her Majesty The Queen, In Right Of Canada, As Represented By The Minister Of National Defence Vectores víricos recombinantes para la prevención y la protección contra la infección por alfavirus
JP5173218B2 (ja) * 2007-03-09 2013-04-03 株式会社カネカ オボアルブミンプロモーターによる卵白特異的物質生産
PL2164862T3 (pl) 2007-06-08 2015-12-31 Australian Poultry Crc Pty Ltd Toksyna netb z clostridium
US20100138946A1 (en) * 2008-08-14 2010-06-03 Origen Therapeutics Transgenic chickens with an inactivated endogenous gene locus
WO2009023800A1 (en) * 2007-08-14 2009-02-19 Origen Therapeutics Transgenic chickens with an inactivated endogenous gene locus
WO2010036978A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of growth hormone
WO2010036979A2 (en) * 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of interferon
US9150880B2 (en) 2008-09-25 2015-10-06 Proteovec Holding, L.L.C. Vectors for production of antibodies
WO2010118360A1 (en) 2009-04-09 2010-10-14 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Production of proteins using transposon-based vectors
US8815242B2 (en) * 2009-05-27 2014-08-26 Synageva Biopharma Corp. Avian derived antibodies
WO2010142017A1 (en) * 2009-06-09 2010-12-16 Defyrus, Inc . Administration of interferon for prophylaxis against or treatment of pathogenic infection
US8765432B2 (en) 2009-12-18 2014-07-01 Oligasis, Llc Targeted drug phosphorylcholine polymer conjugates
WO2012125182A1 (en) 2011-03-11 2012-09-20 Synageva Biopharma Corp Npp1 fusion proteins
WO2011113027A2 (en) 2010-03-12 2011-09-15 Synageva Biopharma Corp Npp1 fusion proteins
US20110247091A1 (en) * 2010-03-26 2011-10-06 The Governors Of The University Of Alberta Transgenic Cells and Chickens Expressing RIG-I
ES2905690T3 (es) 2010-04-15 2022-04-11 Kodiak Sciences Inc Polímeros que contienen zwitteriones de alto peso molecular
KR20140108519A (ko) 2011-10-12 2014-09-11 시나게바 바이오파르마, 코포레이션 재조합 인간 naglu 단백질 및 이의 용도
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
US20140298503A1 (en) * 2013-04-01 2014-10-02 Synageva Biopharma Corp. Glycosylation in Avians
EP3125685A4 (de) * 2014-04-02 2017-11-08 Alexion Pharmaceuticals, Inc. Herstellung von therapeutischen proteinen
AU2015323966A1 (en) 2014-09-29 2017-03-16 Alexion Pharmaceuticals, Inc. Methods of treating mucopolysaccharidosis IIIB (MPSIIIB)
EP3504222A1 (de) 2016-08-23 2019-07-03 Alexion Pharmaceuticals, Inc. Verfahren zur reinigung eines heterologen proteins aus einem eiweiss
US11519005B2 (en) 2017-09-28 2022-12-06 The Governors Of The University Of Alberta Retinoic acid-inducible gene I promoter and compositions and methods relating to same
KR102207951B1 (ko) * 2019-07-12 2021-01-27 대한민국 오브뮤신 알파 유전자의 프로모터 영역 및 오브알부민 유전자의 프로모터 영역을 포함하는 재조합 프로모터
KR102159050B1 (ko) * 2019-07-12 2020-09-24 대한민국 오보뮤코이드 유전자의 프로모터 영역 및 오브알부민 유전자의 프로모터 영역을 포함하는 재조합 프로모터
KR102159051B1 (ko) * 2019-07-12 2020-09-24 대한민국 라이소자임 유전자의 프로모터 영역 및 오브알부민 유전자의 프로모터 영역을 포함하는 재조합 프로모터
EP3782465B1 (de) 2019-08-23 2023-08-30 Universität Potsdam Transgenes zebrafischmodell für schlaganfall
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296134A (en) * 1974-05-13 1981-10-20 Boldt Wayne A Liquid egg blend
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US5322837A (en) * 1985-01-11 1994-06-21 Genetics Institute, Inc. Homogeneous erythropoietin compositions and methods of using same
IL79176A (en) * 1985-06-20 1992-06-21 Kirin Amgen Inc Process for the recovery of erythropoietin from a fluid
CA1293460C (en) 1985-10-07 1991-12-24 Brian Lee Sauer Site-specific recombination of dna in yeast
US4903635A (en) * 1986-07-02 1990-02-27 Embrex, Inc. High speed automated injection system for avian embryos
EP0832981A1 (de) 1987-02-17 1998-04-01 Pharming B.V. DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten
GB8714426D0 (en) 1987-06-19 1987-07-22 Agricultural & Food Res Culture technique
US4997763A (en) 1987-07-31 1991-03-05 The United States Of America As Represented By The Secretary Of Agriculture Vectors for gene insertion into avian germ line
US5378618A (en) 1988-04-15 1995-01-03 E. I. Du Pont De Nemours And Company Vitro headful packaging system for cloning DNA fragments as large as 95kb
US5162215A (en) 1988-09-22 1992-11-10 Amgen Inc. Method of gene transfer into chickens and other avian species
GB8906214D0 (en) 1989-03-17 1989-05-04 Nat Res Dev Introducing an exogenous gene into birds
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
EP0424027A1 (de) 1989-10-16 1991-04-24 Merck & Co. Inc. Vektoren zur Erzeugung von Transgen-Hühnern
EP0424044A1 (de) 1989-10-16 1991-04-24 Merck & Co. Inc. Rinderwachstumshormone exprimierende Transgen-Hühner
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5056464A (en) * 1990-01-18 1991-10-15 Embrex, Inc. Automated injection system for avian embryos with advanced fluid delivery system
US5364783A (en) * 1990-05-14 1994-11-15 Massachusetts Institute Of Technology Retrovirus promoter-trap vectors
US6027722A (en) * 1990-10-25 2000-02-22 Nature Technology Corporation Vectors for gene transfer
ATE169061T1 (de) * 1990-10-25 1998-08-15 Clague Pitman Hodgson Methode des gentransfers mittels retrotransposons
WO1992015694A1 (en) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
BR9305795A (pt) * 1992-01-27 1997-02-18 Univ North Carolina State Transferéncia de genes em aves por introdução de dna em musculo in ovo
EP0688358A4 (de) * 1993-03-12 1997-10-01 Univ Creighton Verbesserte vektoren für die gentherapy
US5367054A (en) * 1993-04-12 1994-11-22 Stolle Research & Development Corp. Large-scale purification of egg immunoglobulin
US5897567A (en) * 1993-04-29 1999-04-27 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
US5885567A (en) 1993-10-22 1999-03-23 University Of Connecticut Treatment of infection in fowl by oral administration of avian interferon proteins
JP4216350B2 (ja) * 1994-09-19 2009-01-28 大日本住友製薬株式会社 動物細胞感染用の組換えｄｎａウイルスベクター
US5639635A (en) * 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
JPH08140527A (ja) * 1994-11-21 1996-06-04 Kanagawa Kagaku Gijutsu Akad Ｔｒｅｂ５遺伝子欠損動物、及びその作出方法
US6287663B1 (en) * 1995-10-31 2001-09-11 Kabushiki Kaisha Ohara Glass-ceramic substrate for a magnetic information storage medium
WO1997025413A1 (en) * 1996-01-09 1997-07-17 The Regents Of The University Of California Ungulate embryonic stem-like cells, making and using the cells to produce a transgenic ungulate
CA2248538A1 (en) * 1996-03-14 1997-09-18 The Immune Response Corporation Targeted delivery of genes encoding interferon
US6825396B2 (en) * 1996-06-12 2004-11-30 Board Of Trustees Operating Michigan State University Methods for tissue specific synthesis of protein in eggs of transgenic hens
US6563017B2 (en) 1996-07-08 2003-05-13 Dnavec Research Inc. In vivo electroporation method for early stage embryo of chickens
US6410220B1 (en) * 1997-02-28 2002-06-25 Nature Technology Corp Self-assembling genes, vectors and uses thereof
US5897998A (en) * 1997-08-04 1999-04-27 The University Of Georgia Research Foundation, Inc. Method for manipulating avian eggs
ES2357495T3 (es) * 1997-10-16 2011-04-27 University Of Georgia Research Foundation, Inc. Aves transgénicas y producción de proteína.
EP1438401B1 (de) * 2001-09-18 2011-06-15 Synageva BioPharma Corp. Produktion eines transgenen vogels mittels cytoplasmainjektion
US6875588B2 (en) * 2001-11-30 2005-04-05 Avigenics, Inc. Ovomucoid promoter and methods of use

Also Published As

Publication number Publication date
US20060185024A1 (en) 2006-08-17
EP1023442B1 (de) 2010-11-24
US6730822B1 (en) 2004-05-04
US8519214B2 (en) 2013-08-27
US20060075513A1 (en) 2006-04-06
US8507749B2 (en) 2013-08-13
EP1023442A1 (de) 2000-08-02
WO1999019472A9 (en) 1999-10-21
JP2001520009A (ja) 2001-10-30
IL135604A (en) 2008-06-05
US7521591B2 (en) 2009-04-21
IL135604A0 (en) 2001-05-20
JP6078451B2 (ja) 2017-02-08
US20060123488A1 (en) 2006-06-08
ES2357495T3 (es) 2011-04-27
AU752946B2 (en) 2002-10-03
DK1023442T3 (da) 2011-03-14
PT1023442E (pt) 2011-02-25
CA2307840C (en) 2014-07-15
US20140065690A1 (en) 2014-03-06
JP2016119913A (ja) 2016-07-07
US20040158882A1 (en) 2004-08-12
US7875762B2 (en) 2011-01-25
KR20010031190A (ko) 2001-04-16
AU1189999A (en) 1999-05-03
JP6377095B2 (ja) 2018-08-22
JP2014023537A (ja) 2014-02-06
EP2133421A1 (de) 2009-12-16
JP2009118852A (ja) 2009-06-04
US20060185029A1 (en) 2006-08-17
CA2307840A1 (en) 1999-04-22
ATE489461T1 (de) 2010-12-15
JP2017121263A (ja) 2017-07-13
WO1999019472A1 (en) 1999-04-22
CY1111267T1 (el) 2015-08-05

Similar Documents

Publication Publication Date Title
ATE489461T1 (de) Transgene vögel und proteinproduktion
WO2003025146A3 (en) Production of a transgenic avian by cytoplasmic injection
Sang Prospects for transgenesis in the chick
EP0663952A4 (de) Transgene nicht-humane tiere mit zielgerichtet unterbrochenen transduktionsgenen in lymphozyten.
Wang et al. Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection
DE69839905D1 (de) Verfahren zur erschaffung transgener nicht-menschlicher tiere
ATE393571T1 (de) Aviäres expressionssystem für fremdproteine
WO2004067713A3 (en) Exogenous proteins expressed in avians and their eggs
AU2003303830A8 (en) Production of multimeric proteins
DK0986640T3 (da) Transgene fisk med væsspecifik ekspression
DK1218504T3 (da) GL50 molekyler og anvendelser deraf
NZ598769A (en) Transgenic chickens
WO2000011151A3 (en) Direct oviduct transgenesis
WO2000075300A3 (en) Methods for manipulating the avian genome
Houdebine Transgenesis to improve animal production
WO2003024200A8 (en) Production of transgenic birds using stage x primordial germ cells
ATE319822T1 (de) Verfahren und materialien zur vorbeugung und behandlung von autoimmunkrankheiten
US20210345592A1 (en) Genetically modified sterile avians and method for the reconstitution thereof
ATE449173T1 (de) 32144, eine humane fettsäureamid-hydrolase und deren verwendungen
ATE433489T1 (de) 16836, ein mitglied der humanen phospholipase c familie und seine verwendungen
ATE466089T1 (de) Positionsunabhängige und gewebespezifische expression eines transgens in der milch eines transgen-tieres
NZ511808A (en) Transgenic bovine that produce the heterologous protein in milk
ATE455176T1 (de) Transgene expressionskassetten zur expression von nukleinsäuren in nicht-reproduktiven blütengeweben von pflanzen
ATE509108T1 (de) Regulation der translation von heterolog exprimierten genen
Verrinder Gibbins Transgenic poultry technology and food production