ATE393571T1 - Aviäres expressionssystem für fremdproteine - Google Patents
Aviäres expressionssystem für fremdproteineInfo
- Publication number
- ATE393571T1 ATE393571T1 AT02796854T AT02796854T ATE393571T1 AT E393571 T1 ATE393571 T1 AT E393571T1 AT 02796854 T AT02796854 T AT 02796854T AT 02796854 T AT02796854 T AT 02796854T AT E393571 T1 ATE393571 T1 AT E393571T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- aviary
- expression system
- foreign proteins
- bird
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 241000271566 Aves Species 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 210000001161 mammalian embryo Anatomy 0.000 abstract 1
- 210000004940 nucleus Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L15/00—Egg products; Preparation or treatment thereof
- A23L15/20—Addition of proteins, e.g. hydrolysates, fats, carbohydrates, natural plant hydrocolloids; Addition of animal or vegetable substances containing proteins, fats, or carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/30—Bird
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/32—Vector systems having a special element relevant for transcription being an silencer not forming part of the promoter region
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/90—Vector systems having a special element relevant for transcription from vertebrates avian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0115111A FR2832423B1 (fr) | 2001-11-22 | 2001-11-22 | Systeme d'expression de proteines exogenes dans un systeme aviaire |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE393571T1 true ATE393571T1 (de) | 2008-05-15 |
Family
ID=8869671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02796854T ATE393571T1 (de) | 2001-11-22 | 2002-11-21 | Aviäres expressionssystem für fremdproteine |
Country Status (7)
Country | Link |
---|---|
US (1) | US20050227315A1 (de) |
EP (1) | EP1446004B1 (de) |
AT (1) | ATE393571T1 (de) |
AU (1) | AU2002361327A1 (de) |
DE (1) | DE60226335T2 (de) |
FR (1) | FR2832423B1 (de) |
WO (1) | WO2003043415A1 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60233049D1 (de) | 2001-01-26 | 2009-09-03 | Selexis Sa | Matrix-anheftungsregionen und verfahren zu deren verwendung |
US7145057B2 (en) | 2002-02-01 | 2006-12-05 | Origen Therapeutics, Inc. | Chimeric bird from embryonic stem cells |
US20060191026A1 (en) | 2005-02-18 | 2006-08-24 | Origen Therapeutics, Inc. | Tissue specific expression of antibodies in chickens |
US20050090001A1 (en) * | 2003-10-07 | 2005-04-28 | Parker Stephen H. | Cell lines and methods for producing proteins |
IN2014DN02484A (de) | 2003-10-24 | 2015-05-15 | Selexis Sa | |
GB2408980B (en) * | 2003-12-09 | 2006-06-07 | Nat Biolog Standards Board | Genetic reference materials |
ES2647491T3 (es) | 2004-05-21 | 2017-12-21 | Novartis Vaccines And Diagnostics, Inc. | Vectores del alfavirus para las vacunas del virus de la gripe |
AU2006310337B9 (en) | 2005-11-04 | 2013-11-28 | Novartis Ag | Adjuvanted influenza vaccines including cytokine-inducing agents |
BRPI0618254A2 (pt) | 2005-11-04 | 2011-08-23 | Novartis Vaccines & Diagnostic | emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido |
JP2009514850A (ja) | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | アジュバントとして減少した量の水中油型エマルションを有するインフルエンザワクチン |
JP2009514838A (ja) | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 細胞培養物において増殖されたインフルエンザウイルスから調製された非ビリオン抗原を含むアジュバントワクチン |
EP1951299B1 (de) | 2005-11-04 | 2012-01-04 | Novartis Vaccines and Diagnostics S.r.l. | Grippeimpfstoffe mit kombinationen aus teilchenförmigen adjuvantien und immunverstärkern |
EP1976559B3 (de) | 2006-01-27 | 2020-02-19 | Seqirus UK Limited | Influenzaimpfstoffe mit hämagglutinin und matrixproteinen |
EP2004226A1 (de) | 2006-03-24 | 2008-12-24 | Novartis Vaccines and Diagnostics GmbH & Co. KG | Lagerung von grippeimpfstoffen ohne kühlung |
FR2898909A1 (fr) | 2006-03-24 | 2007-09-28 | Agronomique Inst Nat Rech | Combinaison de marqueurs de cellules aviaires |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
BRPI0716536A2 (pt) | 2006-09-11 | 2013-09-24 | Novartis Ag | produÇço de vacinas de vÍrus influenza, sem a utilizaÇço de ovos |
CA2671629C (en) | 2006-12-06 | 2017-08-15 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
EP1995309A1 (de) * | 2007-05-21 | 2008-11-26 | Vivalis | Rekombinante Proteinproduktion in EBx -Vogelzellen |
WO2009001217A2 (en) | 2007-06-27 | 2008-12-31 | Novartis Ag | Low-additive influenza vaccines |
GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
CN101971030A (zh) | 2007-12-24 | 2011-02-09 | 诺华有限公司 | 流感吸附疫苗的试验 |
ES2535101T3 (es) | 2008-03-18 | 2015-05-05 | Novartis Ag | Mejoras en la preparación de antígenos en vacuna de virus de la gripe |
CA2726862A1 (en) * | 2008-06-30 | 2010-01-21 | Atgcell Inc. | Mammalian cell expression vectors and utilization |
ES2552383T3 (es) | 2009-02-10 | 2015-11-27 | Novartis Ag | Regímenes de vacuna de la gripe para cepas asociadas a pandemias |
US20120093860A1 (en) | 2009-02-10 | 2012-04-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
ES2608841T3 (es) | 2009-02-10 | 2017-04-17 | Seqirus UK Limited | Vacunas contra la gripe con cantidades reducidas de escualeno |
CN102548577A (zh) | 2009-04-27 | 2012-07-04 | 诺华有限公司 | 用于抵抗流感的佐剂疫苗 |
US8815242B2 (en) | 2009-05-27 | 2014-08-26 | Synageva Biopharma Corp. | Avian derived antibodies |
WO2011008974A2 (en) | 2009-07-15 | 2011-01-20 | Novartis Ag | Rsv f protein compositions and methods for making same |
JP2013504556A (ja) | 2009-09-10 | 2013-02-07 | ノバルティス アーゲー | 気道疾患に対する組み合わせワクチン |
WO2011110955A2 (en) | 2010-03-08 | 2011-09-15 | Novartis Ag | Methods of testing for intracellular pathogens |
EP2556151A1 (de) | 2010-04-07 | 2013-02-13 | Novartis AG | Verfahren zur erzeugung von virusähnlichen parvovirus-b19-partikeln |
JP6072677B2 (ja) | 2010-05-06 | 2017-02-01 | ノバルティス アーゲー | 微生物の不活化のための有機ペルオキシド化合物 |
JP5876036B2 (ja) | 2010-05-21 | 2016-03-02 | ノバルティス アーゲー | インフルエンザウイルス再集合方法 |
BR112012030619A2 (pt) | 2010-06-01 | 2019-09-24 | Novartis Ag | concentração de antígenos de vacina influenza sem liofilização. |
AU2011262312B2 (en) | 2010-06-01 | 2015-05-28 | Novartis Ag | Concentration and lyophilization of influenza vaccine antigens |
AU2011276328C1 (en) | 2010-07-06 | 2016-01-21 | Novartis Ag | Norovirus derived immunogenic compositions and methods |
WO2012023044A1 (en) | 2010-08-20 | 2012-02-23 | Novartis Ag | Soluble needle arrays for delivery of influenza vaccines |
PT2667892T (pt) | 2011-01-26 | 2019-06-07 | Glaxosmithkline Biologicals Sa | Regime de imunização contra o vsr |
EP2707385B1 (de) | 2011-05-13 | 2017-09-20 | GlaxoSmithKline Biologicals SA | Rsv-f-präfusionsantigene |
CA2840989A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Immunogenic combination compositions and uses thereof |
JP2014520807A (ja) | 2011-07-06 | 2014-08-25 | ノバルティス アーゲー | 免疫原性組成物およびその使用 |
EP2766385A2 (de) | 2011-10-12 | 2014-08-20 | Novartis AG | Cmv-antigene und verwendungen davon |
GB201216121D0 (en) | 2012-09-10 | 2012-10-24 | Novartis Ag | Sample quantification by disc centrifugation |
EP2768528A1 (de) | 2011-10-20 | 2014-08-27 | Novartis AG | Adjuvierte influenza-b-viren-impfstoffe für kinder |
CN104853770A (zh) | 2012-07-06 | 2015-08-19 | 诺华股份有限公司 | 免疫原性组合物及其应用 |
GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
EP2922570A1 (de) | 2012-11-20 | 2015-09-30 | GlaxoSmithKline Biologicals SA | Präfusionierte rsv-f-trimere |
EP2974739A1 (de) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF-Trimerisierungsdomänen |
EP3031822A1 (de) | 2014-12-08 | 2016-06-15 | Novartis AG | Cytomegalovirus-Antigene |
EP3047856A1 (de) | 2015-01-23 | 2016-07-27 | Novartis AG | Cmv-antigene und ihre verwendungen |
WO2016207853A2 (en) | 2015-06-26 | 2016-12-29 | Seqirus UK Limited | Antigenically matched influenza vaccines |
JP6830070B2 (ja) | 2015-07-07 | 2021-02-17 | セキラス ユーケー リミテッドSeqirus UK Limited | インフルエンザ効力アッセイ |
CN110506060B (zh) | 2017-03-30 | 2024-05-07 | 昆士兰大学 | 嵌合分子及其用途 |
CN109182533B (zh) * | 2018-09-04 | 2021-01-22 | 华南农业大学 | IGF1基因启动子区的(CA)n微卫星位点的应用 |
WO2021013798A1 (en) | 2019-07-21 | 2021-01-28 | Glaxosmithkline Biologicals Sa | Therapeutic viral vaccine |
WO2021014385A1 (en) | 2019-07-24 | 2021-01-28 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
KR20220128613A (ko) | 2019-11-18 | 2022-09-21 | 세퀴러스 피티와이 리미티드 | 재배열 인플루엔자 바이러스의 제조 방법 |
EP4032547A1 (de) | 2021-01-20 | 2022-07-27 | GlaxoSmithKline Biologicals S.A. | Hsv1 fce abgeleitete fragemente zur hsv therapie |
WO2023144665A1 (en) | 2022-01-28 | 2023-08-03 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6825396B2 (en) * | 1996-06-12 | 2004-11-30 | Board Of Trustees Operating Michigan State University | Methods for tissue specific synthesis of protein in eggs of transgenic hens |
CA2282791A1 (en) * | 1997-02-28 | 1998-09-03 | University Of Guelph | Methods for selecting germ-line competent cells in chicken embryos, and the use of the cells in the production of chimeras |
EP2133421A1 (de) * | 1997-10-16 | 2009-12-16 | University Of Georgia Research Foundation, Inc. | Transgene Vögel und Proteinherstellung im Eiweiss |
US20040040050A1 (en) * | 2000-05-10 | 2004-02-26 | West Michael D | Production of agricultural animals from embryonic stem (es) cells |
US20020028488A1 (en) * | 2000-06-19 | 2002-03-07 | Sujay Singh | Transgenic avian species for making human and chimeric antibodies |
-
2001
- 2001-11-22 FR FR0115111A patent/FR2832423B1/fr not_active Expired - Fee Related
-
2002
- 2002-11-21 AT AT02796854T patent/ATE393571T1/de not_active IP Right Cessation
- 2002-11-21 US US10/496,397 patent/US20050227315A1/en not_active Abandoned
- 2002-11-21 AU AU2002361327A patent/AU2002361327A1/en not_active Abandoned
- 2002-11-21 WO PCT/FR2002/003992 patent/WO2003043415A1/fr active IP Right Grant
- 2002-11-21 DE DE60226335T patent/DE60226335T2/de not_active Expired - Lifetime
- 2002-11-21 EP EP02796854A patent/EP1446004B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60226335D1 (en) | 2008-06-12 |
DE60226335T2 (de) | 2009-09-24 |
AU2002361327A1 (en) | 2003-06-10 |
WO2003043415A1 (fr) | 2003-05-30 |
FR2832423B1 (fr) | 2004-10-08 |
US20050227315A1 (en) | 2005-10-13 |
EP1446004B1 (de) | 2008-04-30 |
EP1446004A1 (de) | 2004-08-18 |
FR2832423A1 (fr) | 2003-05-23 |
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