NZ511808A - Transgenic bovine that produce the heterologous protein in milk - Google Patents

Transgenic bovine that produce the heterologous protein in milk

Info

Publication number
NZ511808A
NZ511808A NZ511808A NZ51180899A NZ511808A NZ 511808 A NZ511808 A NZ 511808A NZ 511808 A NZ511808 A NZ 511808A NZ 51180899 A NZ51180899 A NZ 51180899A NZ 511808 A NZ511808 A NZ 511808A
Authority
NZ
New Zealand
Prior art keywords
milk
produce
heterologous protein
animals
transgenic
Prior art date
Application number
NZ511808A
Inventor
Robert D Bremel
Gregory T Bleck
Original Assignee
Gala Design Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gala Design Inc filed Critical Gala Design Inc
Publication of NZ511808A publication Critical patent/NZ511808A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Methods and compositions are described for the generation of transgenic non-human animals, i.e., bovines. The method involves the introduction of exogenous nucleic acid sequences into the genome of unfertilised eggs (e.g., pre-maturation oocytes and pre-fertilisation oocytes) by microinjection of an infectious retrovirus into the perivitelline space of the egg. Such methods provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals that are mosaic for the presence of the transgene.
NZ511808A 1998-11-19 1999-11-17 Transgenic bovine that produce the heterologous protein in milk NZ511808A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19667098A 1998-11-19 1998-11-19
PCT/US1999/026848 WO2000030437A1 (en) 1998-11-19 1999-11-17 Transgenic animals

Publications (1)

Publication Number Publication Date
NZ511808A true NZ511808A (en) 2004-01-30

Family

ID=22726354

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ511808A NZ511808A (en) 1998-11-19 1999-11-17 Transgenic bovine that produce the heterologous protein in milk

Country Status (5)

Country Link
EP (1) EP1130960A4 (en)
AU (1) AU772439B2 (en)
CA (1) CA2351553C (en)
NZ (1) NZ511808A (en)
WO (1) WO2000030437A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9150880B2 (en) 2008-09-25 2015-10-06 Proteovec Holding, L.L.C. Vectors for production of antibodies
WO2010036978A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of growth hormone
WO2010118360A1 (en) 2009-04-09 2010-10-14 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Production of proteins using transposon-based vectors
WO2011163446A2 (en) * 2010-06-24 2011-12-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Pan-lyssavirus vaccines against rabies
CN108070617A (en) * 2016-11-16 2018-05-25 中国科学院海洋研究所 A kind of exopalaemon carinicauda embryo micro-injection method and Application way structure mRNA are overexpressed model
CN112342238A (en) * 2020-10-21 2021-02-09 复旦大学 Ovum function restoring preparation for inducing ovum maturation disorder by TRIP13 gene mutation and using method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8901778D0 (en) * 1989-01-27 1989-03-15 Univ Court Of The University O Manipulatory technique
US5453366A (en) * 1990-07-26 1995-09-26 Sims; Michele M. Method of cloning bovine embryos
US5550034A (en) * 1992-12-04 1996-08-27 Arch Development Corp. Apolipoprotein B mRNA editing protein compositions and methods
WO1994018834A1 (en) * 1993-02-16 1994-09-01 Virginia Tech Intellectual Properties, Inc. Polyelectrolyte dna conjugation and genetic transformation of an animal
US6080912A (en) * 1997-03-20 2000-06-27 Wisconsin Alumni Research Foundation Methods for creating transgenic animals

Also Published As

Publication number Publication date
CA2351553C (en) 2007-01-30
AU1721000A (en) 2000-06-13
CA2351553A1 (en) 2000-06-02
WO2000030437A1 (en) 2000-06-02
WO2000030437A8 (en) 2001-04-19
EP1130960A1 (en) 2001-09-12
AU772439B2 (en) 2004-04-29
WO2000030437A9 (en) 2001-05-17
EP1130960A4 (en) 2003-07-30

Similar Documents

Publication Publication Date Title
DE69839905D1 (en) METHOD FOR CREATING TRANSGENIC NON-HUMAN ANIMALS
Wall Pronuclear microinjection
Wall New gene transfer methods
US20060191025A1 (en) Method for the rapid selection of homozygous primary cell lines for the production of transgenic animals by somatic cell nuclear transfer
DK0748386T4 (en) Generation of fibrinogen in transgenic animals
AU2002341746A1 (en) Production of a transgenic avian by cytoplasmic injection
Zou et al. Generation of cloned goats (Capra hircus) from transfected foetal fibroblast cells, the effect of donor cell cycle
CA2436754A1 (en) Production of a monoclonal antibody by a transgenic avian
IL135604A0 (en) Vectors comprising a magnum-specific promoter for avian transgenesis
Echelard Recombinant protein production in transgenic animals
DE59712068D1 (en) METHOD FOR PRODUCING MAMMALS WITH DEFINED GENETIC PROPERTIES
Watanabe et al. The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer
Galli et al. Genetic engineering including superseding microinjection: new ways to make GM pigs
Garrels et al. Cytoplasmic injection of murine zygotes with Sleeping Beauty transposon plasmids and minicircles results in the efficient generation of germline transgenic mice
Kanatsu-Shinohara et al. Production of transgenic rats via lentiviral transduction and xenogeneic transplantation of spermatogonial stem cells
NZ511808A (en) Transgenic bovine that produce the heterologous protein in milk
US20090228999A1 (en) Process of Making Transgenic Mammals That Produce Exogenous Proteins in Milk and Transgenic Mammals Produced Thereby
Yuan et al. Expression of Recombinant Human Alpha‐Lactalbumin in the Milk of Transgenic Goats Using a Hybrid Pomoter/Enhancer
US20210345592A1 (en) Genetically modified sterile avians and method for the reconstitution thereof
Galli Animal engineering for xenotransplantation
US11464216B2 (en) Production method for conditional knockout animal
EP3120700A1 (en) Microinjection into a cell's nucleus following somatic cell nuclear transfer
Nottle et al. Transgenic perspectives in xenotransplantation, 2001.
Sato et al. Recent Advances in the Production of Genome-Edited Animals Using i-GONAD, a Novel in vivo Genome Editing System, and Its Possible Use for the Study of Female Reproductive Systems
DEYKIN et al. RESEARCH RESULTS IN PHARMACOLOGY

Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: GALA DESIGN, US

Free format text: OLD OWNER(S): WISCONSIN ALUMNI RESEARCH FOUNDATION

PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)