DE69836747D1 - Zielgerichtetes system zur entfernung von tumorzellen aus zellpopulationen - Google Patents

Zielgerichtetes system zur entfernung von tumorzellen aus zellpopulationen

Info

Publication number
DE69836747D1
DE69836747D1 DE69836747T DE69836747T DE69836747D1 DE 69836747 D1 DE69836747 D1 DE 69836747D1 DE 69836747 T DE69836747 T DE 69836747T DE 69836747 T DE69836747 T DE 69836747T DE 69836747 D1 DE69836747 D1 DE 69836747D1
Authority
DE
Germany
Prior art keywords
cells
removal
mixture
tumor cells
cell populations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69836747T
Other languages
English (en)
Other versions
DE69836747T2 (de
Inventor
Bernhard O Palsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69836747D1 publication Critical patent/DE69836747D1/de
Application granted granted Critical
Publication of DE69836747T2 publication Critical patent/DE69836747T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0093—Purging against cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0088—Inverse microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Multimedia (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE69836747T 1997-03-27 1998-03-27 Zielgerichtetes system zur entfernung von tumorzellen aus zellpopulationen Expired - Lifetime DE69836747T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/824,968 US5874266A (en) 1997-03-27 1997-03-27 Targeted system for removing tumor cells from cell populations
US824968 1997-03-27
PCT/US1998/006125 WO1998042356A1 (en) 1997-03-27 1998-03-27 Targeted system for removing tumor cells from cell populations

Publications (2)

Publication Number Publication Date
DE69836747D1 true DE69836747D1 (de) 2007-02-08
DE69836747T2 DE69836747T2 (de) 2007-10-04

Family

ID=25242769

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69836747T Expired - Lifetime DE69836747T2 (de) 1997-03-27 1998-03-27 Zielgerichtetes system zur entfernung von tumorzellen aus zellpopulationen

Country Status (11)

Country Link
US (3) US5874266A (de)
EP (1) EP1011697B1 (de)
JP (2) JP4512206B2 (de)
KR (1) KR20000075758A (de)
CN (1) CN1251528A (de)
AT (1) ATE349220T1 (de)
AU (1) AU743239B2 (de)
BR (1) BR9808068A (de)
CA (1) CA2281112A1 (de)
DE (1) DE69836747T2 (de)
WO (1) WO1998042356A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040139A (en) * 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
JP4323571B2 (ja) 1997-01-31 2009-09-02 エックスワイ， インコーポレイテッド 光学装置
US6469779B2 (en) * 1997-02-07 2002-10-22 Arcturus Engineering, Inc. Laser capture microdissection method and apparatus
WO1998041158A1 (en) * 1997-03-19 1998-09-24 Lucid Technologies, Inc. Cellular surgery utilizing confocal microscopy
US6534308B1 (en) 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6642018B1 (en) * 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
EP1073716B1 (de) * 1998-04-28 2004-04-28 Amersham Health AS Verbesserung von trennungsverfahren
DE19916749B4 (de) * 1999-04-14 2004-02-12 Carl Zeiss Jena Gmbh Verfahren zur Untersuchung von Proben
AU2922701A (en) * 1999-11-04 2001-05-14 Arcturus Engineering, Inc. Automated laser capture microdissection
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
EP2281879B1 (de) * 1999-11-30 2016-01-27 Intrexon Corporation Vorrichtung zur Bestimmung eines morphologischen oder physiologischen Merkmals von individuellen Zellen in einer biologischen Probe
CA2404431C (en) * 2000-03-27 2011-06-07 Thomas Jefferson University Guanylyl cyclase c in the detection of stomach and esophageal cancers
WO2002019594A2 (en) * 2000-08-02 2002-03-07 Arizona Board Of Regents, Acting On Behalf Of Arizona State University Scanning fluorescence lifetime microscope: directed evolution
WO2002022774A1 (en) * 2000-09-12 2002-03-21 Oncosis Llc Chamber for laser-based processing
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
EP2363828A1 (de) 2000-10-24 2011-09-07 Cyntellect, Inc. Vorrichtung zur gezielten Bestimmung von Zellen in einer dreidimensionalen Probe
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
AU2002220018A1 (en) * 2000-11-29 2002-06-11 Colorado State University System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US20050143791A1 (en) * 2001-07-09 2005-06-30 Stuart Hameroff Process of treating a cell
US10156501B2 (en) 2001-11-05 2018-12-18 Life Technologies Corporation Automated microdissection instrument for determining a location of a laser beam projection on a worksurface area
US8722357B2 (en) 2001-11-05 2014-05-13 Life Technologies Corporation Automated microdissection instrument
WO2003089901A2 (en) * 2002-04-19 2003-10-30 Palsson Bernhard O Methods for preparing libraries of unique tags and related screening methods
WO2004009237A2 (en) * 2002-07-22 2004-01-29 Xy, Inc. Sperm cell process system
MX337304B (es) * 2002-08-01 2016-02-24 Xy Llc Sistema de separacion de baja presion para celulas de esperma.
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
WO2004017041A2 (en) * 2002-08-15 2004-02-26 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP2306174B1 (de) 2003-03-28 2016-05-11 Inguran, LLC Durchflusszytometriedüse zur Orientierung von Partikeln und entsprechendes Verfahren
NZ544103A (en) * 2003-05-15 2010-10-29 Xy Llc Efficient haploid cell sorting for flow cytometer systems
US7776584B2 (en) * 2003-08-01 2010-08-17 Genetix Limited Animal cell colony picking apparatus and method
WO2005022147A1 (en) 2003-08-28 2005-03-10 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
US7425426B2 (en) * 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
CN104974983A (zh) 2004-03-29 2015-10-14 英格朗公司 用于授精的精子悬浮液
JP2005333889A (ja) * 2004-05-27 2005-12-08 Cybox Co Ltd 細胞壊死方法及び細胞壊死装置
AU2005266930B2 (en) * 2004-07-22 2010-09-16 Inguran, Llc Process for enriching a population of sperm cells
CA2580025A1 (en) 2004-09-09 2006-03-23 Molecular Devices Corporation Laser microdissection apparatus and method
JPWO2006088154A1 (ja) * 2005-02-18 2008-07-03 株式会社ＡＢｓｉｚｅ 細胞分離方法及び装置
US20070178067A1 (en) * 2005-11-09 2007-08-02 John Maier System and method for cytological analysis by raman spectroscopic imaging
DK2304020T3 (en) * 2008-06-30 2019-02-04 Microbix Biosystems Inc Method and apparatus for sorting cells
EP2385993B1 (de) * 2009-01-09 2016-03-30 Intrexon Corporation Genetische analyse von zellen
WO2010081171A2 (en) 2009-01-12 2010-07-15 Cyntellect, Inc. Laser mediated sectioning and transfer of cell colonies
US8665439B2 (en) * 2009-06-30 2014-03-04 Microbix Biosystems, Inc. Method and apparatus for limiting effects of refraction in cytometry
US9877644B2 (en) 2009-11-10 2018-01-30 Illumigyn Ltd. Optical speculum
US9271640B2 (en) 2009-11-10 2016-03-01 Illumigyn Ltd. Optical speculum
US8638995B2 (en) 2009-11-10 2014-01-28 Illumigyn Ltd. Optical speculum
DE102009060490A1 (de) 2009-12-22 2011-06-30 Carl Zeiss Microlmaging GmbH, 07745 Hochauflösendes Mikroskop und Bildteileranordnung
US9134301B2 (en) * 2010-11-22 2015-09-15 Bio-Rad Laboratories, Inc. Sorting of adherent cells by selective transformation of labels
EP2676121A1 (de) 2011-02-15 2013-12-25 Microbix Biosystems Inc. Verfahren, systeme, und vorrichtung für durchflusszytometrie
JP5333538B2 (ja) 2011-07-27 2013-11-06 株式会社デンソー 弾性表面波センサ
WO2013046980A1 (ja) * 2011-09-27 2013-04-04 株式会社島津製作所 細胞選別器及び細胞選別方法
TWI588199B (zh) 2012-05-25 2017-06-21 羅門哈斯公司 光擴散聚合物組成物、製造該光擴散聚合物組成物的方法以及由之製得的物品
US8808644B2 (en) * 2012-08-20 2014-08-19 Biochemical Diagnostics, Inc. Methods for dispensing fluids into microplates utilizing microwell covers
WO2015040570A1 (en) * 2013-09-18 2015-03-26 Illumigyn Ltd. Optical speculum
WO2015142923A1 (en) * 2014-03-17 2015-09-24 Carnegie Mellon University Methods and systems for disease classification
CN107072716A (zh) 2014-05-30 2017-08-18 托德.F.奥沃凯蒂斯 用于产生和使用活化的干细胞的方法和系统
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
WO2015187974A1 (en) 2014-06-06 2015-12-10 Ovokaitys Todd Frank Methods and compositions for increasing the bioactivity of nutrients
US10384985B2 (en) 2014-06-06 2019-08-20 B.K. Consultants, Inc. Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants
US11291931B2 (en) 2014-12-15 2022-04-05 Akadeum Life Sciences, Inc. Method and system for buoyant separation
US10324080B2 (en) * 2015-11-17 2019-06-18 Purdue Research Foundation Systems and methods for automated image-guided patch-clamp electrophysiology in vitro
JP6033980B1 (ja) * 2016-06-01 2016-11-30 株式会社片岡製作所 細胞処理システム
JP6532063B2 (ja) * 2017-02-13 2019-06-19 株式会社片岡製作所 細胞処理装置
JP6541160B2 (ja) 2017-02-13 2019-07-10 株式会社片岡製作所 細胞処理装置および対象物の処理方法
KR102034244B1 (ko) * 2017-09-01 2019-10-18 주식회사 코어파마 순환암세포를 선택적으로 사멸시키는 시스템
US11427804B2 (en) 2018-06-15 2022-08-30 Abs Global, Inc. Apparatus and method for cell kill confirmation
JP6574028B1 (ja) * 2018-06-29 2019-09-11 株式会社片岡製作所 細胞処理装置および細胞のレーザ処理方法
CN112437692B (zh) 2018-07-09 2022-06-24 爱卡德姆生命科学公司 用于有浮力颗粒处理的系统和方法
WO2022269389A1 (en) * 2021-06-21 2022-12-29 Evolution Optiks Limited Electromagnetic energy directing system, and method using same
WO2023028329A1 (en) 2021-08-26 2023-03-02 Akadeum Life Sciences, Inc. Method and system for buoyant separation

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674926A (en) * 1968-10-15 1972-07-04 Reynolds Metals Co Feature counter with improved masking and grey level detection
JPS53135660A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
US4803992A (en) * 1980-10-28 1989-02-14 Lemelson Jerome H Electro-optical instruments and methods for producing same
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US5272081A (en) * 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
IL68507A (en) * 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US4624915A (en) * 1982-07-29 1986-11-25 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4532402A (en) * 1983-09-02 1985-07-30 Xrl, Inc. Method and apparatus for positioning a focused beam on an integrated circuit
JPS6083584A (ja) * 1983-10-13 1985-05-11 Rikagaku Kenkyusho 生細胞内への物質移入法
US5103660A (en) * 1984-04-23 1992-04-14 Johnson Virgil T Removable steering wheel device, and methods of constructing and utilizing same
JP2522773B2 (ja) * 1986-09-08 1996-08-07 新技術事業団 細胞識別・定量方法
JP2774796B2 (ja) * 1986-11-13 1998-07-09 フードコ・コーポレーション 食品保存のための方法および装置
US5188633A (en) * 1987-03-16 1993-02-23 Michael Kratzer Device for selective destruction of cells
DE3708511A1 (de) * 1987-03-16 1988-09-29 Kratzer Michael Einrichtung zur selektiven zerstoerung von zellen
JPH07122902B2 (ja) 1987-04-17 1995-12-25 株式会社日立製作所 細胞位置検出装置
HU204856B (en) * 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
JPH074222B2 (ja) * 1988-05-20 1995-01-25 農業生物資源研究所長 細胞破砕選別装置及び選択的遺伝子導入装置
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
JPH02168160A (ja) * 1988-12-22 1990-06-28 Omron Tateisi Electron Co 細胞選別装置
JP2700702B2 (ja) * 1989-11-20 1998-01-21 浜松ホトニクス株式会社 医療装置用レーザ発生装置
EP0433824B1 (de) * 1989-12-22 1994-03-02 Asea Brown Boveri Ag Faseroptischer Sensor
US5622853A (en) * 1990-05-01 1997-04-22 Becton Dickinson And Company T lymphocyte precursor
US5202230A (en) * 1990-09-07 1993-04-13 Kamentsky Louis A Methods of detecting cut cells in a tissue section
EP0501688A1 (de) * 1991-02-27 1992-09-02 Hitachi, Ltd. Apparat und Methode zur Einspiegelung eines Laserstrahls in einen Mikroskopstrahlengang
US5298963A (en) * 1992-02-26 1994-03-29 Mitsui Mining & Smelting Co., Ltd. Apparatus for inspecting the surface of materials
US6007814A (en) * 1992-06-15 1999-12-28 Sloan-Kettering Institute For Cancer Research Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof
RU2054486C1 (ru) 1992-09-01 1996-02-20 Валерий Георгиевич Петухов Способ идентификации микроорганизмов
US6315772B1 (en) * 1993-09-24 2001-11-13 Transmedica International, Inc. Laser assisted pharmaceutical delivery and fluid removal
CA2102884A1 (en) * 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
US5422720A (en) * 1993-07-21 1995-06-06 Becton Dickinson And Company Blood culture sensor station utilizing two distinct light sources
US5381224A (en) * 1993-08-30 1995-01-10 A. E. Dixon Scanning laser imaging system
EP0662512A3 (de) * 1993-12-20 1997-01-15 Becton Dickinson Co Menschliche hämatopoietische Stammzellen.
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
US5795755A (en) * 1994-07-05 1998-08-18 Lemelson; Jerome H. Method of implanting living cells by laser poration at selected sites
US5523543A (en) * 1994-09-09 1996-06-04 Litel Instruments Laser ablation control system and method
DE69530072T2 (de) * 1994-12-08 2004-03-04 Molecular Dynamics, Sunnyvale System zur fluoreszenzabbildung unter verwendung eines objektivs mit makroabtastung
JP3077539B2 (ja) * 1994-12-22 2000-08-14 松下電器産業株式会社 レーザ加工方法
US6148096A (en) * 1995-09-15 2000-11-14 Accumed International, Inc. Specimen preview and inspection system
US6040139A (en) 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
US5646411A (en) * 1996-02-01 1997-07-08 Molecular Dynamics, Inc. Fluorescence imaging system compatible with macro and micro scanning objectives
CN1102877C (zh) * 1996-04-25 2003-03-12 格里森工场 用于带齿物件的切削工具
US6122396A (en) * 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
CA2287947A1 (en) 1997-05-09 1998-11-19 Ryan S. Raz Multi-spectral imaging system and method for cytology
US6005256A (en) * 1998-02-12 1999-12-21 Raytheon Company Method and apparatus for performing cell analysis based on simultaneous multiple marker emissions from neoplasia (CASMMEN)
US6642018B1 (en) * 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
WO2000057951A1 (en) * 1999-03-26 2000-10-05 Flock Stephen T Delivery of pharmaceutical compounds and collection of biomolecules using electromagnetic energy and uses thereof
US6381224B1 (en) * 1999-03-31 2002-04-30 Motorola, Inc. Method and apparatus for controlling a full-duplex communication system
EP2281879B1 (de) * 1999-11-30 2016-01-27 Intrexon Corporation Vorrichtung zur Bestimmung eines morphologischen oder physiologischen Merkmals von individuellen Zellen in einer biologischen Probe

Also Published As

Publication number Publication date
JP2010029193A (ja) 2010-02-12
AU743239B2 (en) 2002-01-24
JP2002511843A (ja) 2002-04-16
US7129070B2 (en) 2006-10-31
EP1011697B1 (de) 2006-12-27
ATE349220T1 (de) 2007-01-15
JP4512206B2 (ja) 2010-07-28
WO1998042356A1 (en) 1998-10-01
EP1011697A1 (de) 2000-06-28
US20030138923A1 (en) 2003-07-24
CN1251528A (zh) 2000-04-26
EP1011697A4 (de) 2002-11-20
AU6782698A (en) 1998-10-20
DE69836747T2 (de) 2007-10-04
US6143535A (en) 2000-11-07
BR9808068A (pt) 2000-03-08
CA2281112A1 (en) 1998-10-01
KR20000075758A (ko) 2000-12-26
US5874266A (en) 1999-02-23

Similar Documents

Publication Publication Date Title
DE69836747D1 (de) Zielgerichtetes system zur entfernung von tumorzellen aus zellpopulationen
DE68919856D1 (de) Nachrichtenvermittlungselement zur übertragung von zellen unterteilt in teilzellen.
BR0207775A (pt) Lipossomos anfotéricos métodos para carregamento dos mesmos com ingredientes ativos e sua utilização
BRPI0412845A (pt) herpes-vìrus, uso de um vìrus, composição farmacêutica, e, método de tratamento de um tumor em um indivìduo em necessidade do mesmo
ES2109924T3 (es) Metodo rapido, versatil y simple de expresion de genes en celulas eucarioticas.
DE68913962D1 (de) Bioreaktor und vorrichtung zur kultivierung von tierischen zellen.
ATE319855T1 (de) Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
ATE216426T1 (de) Verfahren zur isolierung und fusion von zellen
EP1055479A3 (de) Laserbestrahlungsvorrichtung
DE60026299D1 (de) Vorrichtung zur züchtung von zellkulturen
ATE250426T1 (de) Verwendung von verbindungen die an ein zytoplasmatischen dipeptidase binden zur potenzierung des immunantworts
CY1105439T1 (el) Κυτταρα, μεθοδοι καλλιεργειας και η χρηση τους στη θepαπεια με αυτολογη μεταμοσχευση
DE69009318D1 (de) Vorrichtung zur Extraktion von Antigenen.
ATE519536T1 (de) Methode zum trennen von zellen
DE3781004D1 (de) Vorrichtung zur begrenzung von stromstoessen.
WO2002093129A3 (en) Methods for analyzing interactions between proteins in live and intact cells
ATE267396T1 (de) Identifizierung von zellen während kinetischer versuchsreihen
ES2141249T3 (es) Procedimiento para la identificacion de celulas humanas y animales que presentan la capacidad para una proliferacion ilimitada o para una formacion de tumores.
FR2774785B1 (fr) Procede de gestion d'application et appareil de traitement d'information utilisant le procede
ES2175095T3 (es) Marcadores de adn respecto al tamaño de una camada de cerdos.
DE69529642D1 (de) Vorrichtung zur Emission von Elektronen
DE68911507D1 (de) Vorrichtung zur Umwandlung von extrinsieken Schwingungsbewegungen in nutzbare Energie.
ES2144604T3 (es) Inmunosubstraccion electroforetica capilar para clasificar y determinar las proteinas m.
TR199900596T2 (xx) Otoim�n hastal�klara kar�� maddeler olarak proteinlerin kullan�m�.
DE69216434D1 (de) Vorrichtung zur kultivierung von zellen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R082 Change of representative

Ref document number: 1011697

Country of ref document: EP

Representative=s name: PATENTANWALTSKANZLEI VIEL & WIESKE, 66119 SAARBRUE