DE69833973D1 - Elektrode und vorrichtung zur messung von zellpotentialen - Google Patents

Elektrode und vorrichtung zur messung von zellpotentialen

Info

Publication number
DE69833973D1
DE69833973D1 DE69833973T DE69833973T DE69833973D1 DE 69833973 D1 DE69833973 D1 DE 69833973D1 DE 69833973 T DE69833973 T DE 69833973T DE 69833973 T DE69833973 T DE 69833973T DE 69833973 D1 DE69833973 D1 DE 69833973D1
Authority
DE
Germany
Prior art keywords
microelectrodes
electrode
measuring cell
cell potentials
monitored sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69833973T
Other languages
English (en)
Other versions
DE69833973T2 (de
Inventor
Hirokazu Sugihara
Hirakata Oka
Ken Shimono
Ryuta Ogawa
Makoto Taketani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panasonic Corp
Original Assignee
Matsushita Electric Industrial Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsushita Electric Industrial Co Ltd filed Critical Matsushita Electric Industrial Co Ltd
Application granted granted Critical
Publication of DE69833973D1 publication Critical patent/DE69833973D1/de
Publication of DE69833973T2 publication Critical patent/DE69833973T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G01N33/4836—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
DE69833973T 1997-12-25 1998-12-22 Elektrode und vorrichtung zur messung von zellpotentialen Expired - Lifetime DE69833973T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP35860197 1997-12-25
JP9358601A JPH11187865A (ja) 1997-12-25 1997-12-25 細胞電位測定電極及びこれを用いた測定装置
PCT/US1998/027489 WO1999034202A1 (en) 1997-12-25 1998-12-22 Cell potential measuring electrode and measuring apparatus using the same

Publications (2)

Publication Number Publication Date
DE69833973D1 true DE69833973D1 (de) 2006-05-11
DE69833973T2 DE69833973T2 (de) 2006-12-14

Family

ID=18460162

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69833973T Expired - Lifetime DE69833973T2 (de) 1997-12-25 1998-12-22 Elektrode und vorrichtung zur messung von zellpotentialen

Country Status (9)

Country Link
EP (1) EP1040345B1 (de)
JP (2) JPH11187865A (de)
KR (1) KR100433913B1 (de)
CN (1) CN1192231C (de)
AT (1) ATE321267T1 (de)
CA (1) CA2316213C (de)
DE (1) DE69833973T2 (de)
TW (1) TW424026B (de)
WO (1) WO1999034202A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682649B1 (en) 1999-10-01 2004-01-27 Sophion Bioscience A/S Substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
GB9929892D0 (en) * 1999-12-20 2000-02-09 Secr Defence Biological sensor
JP3909738B2 (ja) * 2000-07-13 2007-04-25 松下電器産業株式会社 細胞外記録用一体化複合電極
JP3570715B2 (ja) * 2001-06-05 2004-09-29 松下電器産業株式会社 マルチ電極を備えた信号検出用センサ
US7041492B2 (en) 2001-06-20 2006-05-09 Matsushita Electric Industrial Co., Ltd. Extracellular recording electrode
CN100344960C (zh) * 2001-12-17 2007-10-24 清华大学 刺激动物细胞并记录其生理信号的装置及其生产使用方法
WO2003096002A1 (fr) * 2002-05-13 2003-11-20 Matsushita Electric Industrial Co., Ltd. Instrument et procede de mesure du signal d'action d'un echantillon biologique
JP3925439B2 (ja) * 2003-03-07 2007-06-06 松下電器産業株式会社 細胞外電位測定デバイスおよびその製造方法
ES2221528B1 (es) * 2002-07-03 2006-02-16 Universidad De Sevilla Electrodo de succion flotante.
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
WO2005047482A2 (en) 2003-11-12 2005-05-26 Xiao Xu Real time electronic cell sensing systems and applications for cell-based assays
AU2003254789A1 (en) * 2002-07-31 2004-02-16 Japan Science And Technology Agency Automatic culture apparatus for cell or tisse with biological origin
JP4370082B2 (ja) * 2002-08-26 2009-11-25 独立行政法人科学技術振興機構 神経細胞培養マイクロチャンバー
KR100552115B1 (ko) * 2002-11-14 2006-02-14 주식회사 뉴로바이오시스 전력선 잡음이 제거되는 신경신호 기록용 반도체 미세전극
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US9709548B2 (en) 2008-05-05 2017-07-18 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
WO2005001018A1 (ja) 2003-06-27 2005-01-06 Matsushita Electric Industrial Co., Ltd. 薬理測定装置およびシステム並びにそれに用いるウェル容器
EP1749203A4 (de) * 2004-02-09 2009-05-06 Xiao Xu Elektronisches echtzeit-zellenerfassungssystem und anwendungen für die cytotoxizitätsprofilierung und zusammengesetzte assays
JP4895345B2 (ja) * 2005-10-25 2012-03-14 セイコーインスツル株式会社 生細胞観察用セル
JP4748451B2 (ja) * 2006-02-08 2011-08-17 凸版印刷株式会社 ハイブリダイゼーションの検出方法
US8398443B2 (en) * 2006-04-21 2013-03-19 Roche Diagnostics Operations, Inc. Biological testing system and connector therefor
WO2009116271A1 (ja) * 2008-03-18 2009-09-24 株式会社ニコン 容器運搬ケースおよび培養処理装置
JP5047878B2 (ja) * 2008-05-27 2012-10-10 株式会社アルバック 微小電極アレイデバイス、その製造方法及びバイオアッセイ法
WO2010129725A1 (en) * 2009-05-05 2010-11-11 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
CN101713757B (zh) * 2009-11-19 2012-09-26 浙江大学 检测细胞生理参数的光电复合一体式传感器及其制备方法
CN103417205B (zh) * 2012-05-23 2015-05-06 中国科学院电子学研究所 一种神经信息检测系统
US20150260675A1 (en) * 2012-11-06 2015-09-17 Panasonic Intellectual Property Management Co., Ltd. Inspection device for biologically derived material
CN103630579A (zh) * 2013-02-27 2014-03-12 中国科学院电子学研究所 细胞阻抗分析的芯片及仪器
US9279801B2 (en) * 2013-07-26 2016-03-08 Axion Biosystems, Inc. Devices, systems and methods for high-throughput electrophysiology
CN104132976A (zh) * 2014-06-11 2014-11-05 中国科学院长春应用化学研究所 Ito导电玻璃表面电沉积超稳定金属薄膜原位构建电极的方法
CN104789443B (zh) * 2014-06-23 2020-01-17 格子生物科技(上海)有限公司 一种细胞定位单元、阵列、器件及其形成方法
WO2016025646A1 (en) 2014-08-12 2016-02-18 Axion Biosystems, Inc. Cell-based biosensor array and associated methods for manufacturing the same
JP6074671B2 (ja) 2015-01-30 2017-02-08 パナソニックＩｐマネジメント株式会社 電気化学測定デバイス
KR101863816B1 (ko) * 2016-05-26 2018-06-01 울산과학기술원 세포자극 측정장치 및 이를 이용한 세포자극 측정방법
JP6919651B2 (ja) * 2016-06-21 2021-08-18 ソニーグループ株式会社 半導体装置および細胞電位測定装置
JP6739028B2 (ja) * 2016-07-13 2020-08-12 パナソニックＩｐマネジメント株式会社 生物組織または微生物の培地および電位測定装置
CN107758605B (zh) * 2016-08-16 2020-01-31 中国科学院上海微系统与信息技术研究所 一种微电极阵列芯片及其制作方法
GB201615140D0 (en) * 2016-09-06 2016-10-19 Quanta Dialysis Tech Ltd Liquid conductivity measurement pin
JP2018143144A (ja) 2017-03-03 2018-09-20 パナソニック株式会社 ヒト由来ｉＰＳ細胞から分化した心筋細胞においてβミオシン重鎖を効率的に産生させる方法
CN110582569B (zh) 2017-03-03 2024-04-02 安捷伦科技有限公司 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统
JP2019062869A (ja) * 2017-10-05 2019-04-25 ソニーセミコンダクタソリューションズ株式会社 細胞電位検出装置、細胞電位検出装置の製造方法、及び、情報処理システム
WO2019069707A1 (ja) * 2017-10-05 2019-04-11 ソニーセミコンダクタソリューションズ株式会社 細胞電位検出装置、細胞電位検出装置の製造方法、及び、情報処理システム
JP2020022407A (ja) * 2018-08-08 2020-02-13 ソニーセミコンダクタソリューションズ株式会社 計測装置および計測システム
JP2020051882A (ja) * 2018-09-27 2020-04-02 ソニーセミコンダクタソリューションズ株式会社 電位測定装置
CN110187088B (zh) * 2019-05-05 2020-09-29 浙江大学 用于电位信号测量的细胞微球阵列芯片装置及其方法
JP7229110B2 (ja) * 2019-06-25 2023-02-27 株式会社Ｓｃｒｅｅｎホールディングス 細胞電位測定装置
WO2021095393A1 (ja) * 2019-11-14 2021-05-20 Nok株式会社 細胞外電位測定装置
JP7474161B2 (ja) 2020-09-15 2024-04-24 株式会社Ｓｃｒｅｅｎホールディングス 細胞計測プレート
JP7312288B2 (ja) * 2021-08-05 2023-07-20 シャープ株式会社 電位測定装置
JP7312289B2 (ja) * 2021-08-05 2023-07-20 シャープ株式会社 電位測定装置
CN113789263A (zh) * 2021-08-30 2021-12-14 东南大学 一种用于体外神经细胞网络多参数实时监测的多通道系统
JP2023042881A (ja) * 2021-09-15 2023-03-28 株式会社Ｓｃｒｅｅｎホールディングス 細胞外電位計測プレート

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
JP3204875B2 (ja) * 1994-06-13 2001-09-04 松下電器産業株式会社 細胞電位測定装置
US5563067A (en) * 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
DE19529371C3 (de) * 1995-08-10 2003-05-28 Nmi Univ Tuebingen Mikroelektroden-Anordnung
EP0823483A4 (de) * 1996-01-24 2001-04-18 Matsushita Electric Ind Co Ltd Verfahren zur messung physikochemischer eigenschaften von geweben oder zellen, verfahren zur prüfung von chemikalien und vorrichtung dafür
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors

Also Published As

Publication number Publication date
ATE321267T1 (de) 2006-04-15
EP1040345A1 (de) 2000-10-04
KR20010033620A (ko) 2001-04-25
CA2316213C (en) 2004-07-27
CA2316213A1 (en) 1999-07-08
CN1284166A (zh) 2001-02-14
DE69833973T2 (de) 2006-12-14
EP1040345B1 (de) 2006-03-22
JPH11187865A (ja) 1999-07-13
JP3577459B2 (ja) 2004-10-13
KR100433913B1 (ko) 2004-06-04
JP2002523726A (ja) 2002-07-30
TW424026B (en) 2001-03-01
CN1192231C (zh) 2005-03-09
WO1999034202A1 (en) 1999-07-08

Similar Documents

Publication Publication Date Title
DE69833973D1 (de) Elektrode und vorrichtung zur messung von zellpotentialen
US4571292A (en) Apparatus for electrochemical measurements
CA2377813A1 (en) Extracellular recording multiple electrode
ATE269666T1 (de) Anordnung zur mehrfachen nutzung von elektrokardiogramm-elektroden und-wandlern
CA2072885A1 (en) Polarographic chemical sensor with external reference electrode
DE60220035D1 (de) Sensor-array-vorrichtung sowie ein verfahren zur überwachung von elektrochemischer korrosion
DE60324182D1 (de) Verfahren und vorrichtung zur darstellung von hautwunden
BR9612395A (pt) Instrumento eletrocirúrgico e um conjunto de eltrodo eletrocirúrgico
ATE167794T1 (de) Vorrichtung zur messung der elektrischen impedanz von organischen und biologischen stoffen
NO894085D0 (no) Instrument for maaling av fysikalske proever, f.eks. en urindraapes ledningsevne.
DE69913153D1 (de) Gerät zum zusammendrücken einer gel/sensor-einheit
DE3582532D1 (de) Vorrichtungen zur verwendung in chemischen analyseverfahren.
DK373086A (da) Elektrode til anbringelse i aerekanalen i naerheden af trommehinden
JP2002031617A5 (de)
ATE395865T1 (de) Störungsfreie elektromyographische sonde
DE50213056D1 (de) Sensoranordnung, vorrichtung und verfahren zur ampologischen wirkort- und/oder wirkstofftestung
ATE150174T1 (de) Sensor zur messung der aktivität von ionen und dessen verwendung
JPS6168028A (ja) 電気化学的測定器
DE69804935D1 (de) Instrument zur messung der spannung einzelner batteriezellen
WO2003087802A3 (en) Electrochemical sensor system and sensing method
DE68919426D1 (de) Enzymelektrode zur Messung von Malto-Oligosacchariden und Messapparat dafür.
JPS6166957A (ja) 電気化学的測定器
GR1003489B (el) Μεθοδος προσδιορισμου βιολογικων και χημικων παραγοντων μεσω της μετρησης των μεταβολων των ηλεκτρικων ιδιοτητων ακινητοποιημενων κυτταρων ή συστατικων αυτων (βιοηλεκτρικη μεθοδος αναγνωρισης)
RU17428U1 (ru) Устройство для выявления биологически активных точек
Ferrer et al. A Minilaboratory for use in the field of teaching and the biomedical research

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PANASONIC CORP., KADOMA, OSAKA, JP