DE69828330T2 - Aktiviertes Protein C Formulierungen - Google Patents
Aktiviertes Protein C Formulierungen Download PDFInfo
- Publication number
- DE69828330T2 DE69828330T2 DE69828330T DE69828330T DE69828330T2 DE 69828330 T2 DE69828330 T2 DE 69828330T2 DE 69828330 T DE69828330 T DE 69828330T DE 69828330 T DE69828330 T DE 69828330T DE 69828330 T2 DE69828330 T2 DE 69828330T2
- Authority
- DE
- Germany
- Prior art keywords
- formulation according
- formulation
- activated protein
- apc
- sucrose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4525597P | 1997-04-28 | 1997-04-28 | |
| US45255P | 1997-04-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69828330D1 DE69828330D1 (de) | 2005-02-03 |
| DE69828330T2 true DE69828330T2 (de) | 2005-10-13 |
Family
ID=21936854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69828330T Expired - Lifetime DE69828330T2 (de) | 1997-04-28 | 1998-04-28 | Aktiviertes Protein C Formulierungen |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US6159468A (Direct) |
| EP (2) | EP0875252B1 (Direct) |
| JP (2) | JP4383546B2 (Direct) |
| KR (2) | KR100564189B1 (Direct) |
| CN (2) | CN1235638C (Direct) |
| AR (2) | AR012010A1 (Direct) |
| AT (1) | ATE285788T1 (Direct) |
| AU (2) | AU743531B2 (Direct) |
| BR (2) | BR9809292A (Direct) |
| CA (2) | CA2287267C (Direct) |
| CO (2) | CO4940438A1 (Direct) |
| CZ (1) | CZ298429B6 (Direct) |
| DE (1) | DE69828330T2 (Direct) |
| DK (1) | DK0875252T3 (Direct) |
| EA (2) | EA002149B1 (Direct) |
| EG (1) | EG23685A (Direct) |
| ES (1) | ES2234072T3 (Direct) |
| HU (2) | HUP0003401A3 (Direct) |
| ID (2) | ID23172A (Direct) |
| IL (2) | IL132502A0 (Direct) |
| IN (2) | IN187157B (Direct) |
| MY (2) | MY118591A (Direct) |
| NO (2) | NO995134L (Direct) |
| NZ (2) | NZ337828A (Direct) |
| PE (2) | PE84799A1 (Direct) |
| PL (2) | PL195642B1 (Direct) |
| PT (1) | PT875252E (Direct) |
| SI (1) | SI0875252T1 (Direct) |
| SV (2) | SV1998000051A (Direct) |
| TR (2) | TR199902631T2 (Direct) |
| TW (2) | TW585871B (Direct) |
| UA (2) | UA73071C2 (Direct) |
| WO (2) | WO1998048818A1 (Direct) |
| ZA (2) | ZA983496B (Direct) |
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| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
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| JP2002529515A (ja) * | 1998-11-13 | 2002-09-10 | イーライ・リリー・アンド・カンパニー | ヘパリンにより誘発される血小板減少症の処置法 |
| BR9915460A (pt) * | 1998-11-20 | 2001-07-17 | Lilly Co Eli | Método de tratamento de febre hemorrágica virótica |
| WO2000030676A1 (en) * | 1998-11-23 | 2000-06-02 | Eli Lilly And Company | Method of treating sickle cell disease and thalassemia |
| CN1329503A (zh) * | 1998-12-10 | 2002-01-02 | 伊莱利利公司 | 治疗血小板减少性紫癜和溶血性尿毒综合征的方法 |
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| PT2283856T (pt) | 2002-06-21 | 2017-12-26 | Novo Nordisk Healthcare Ag | Composições sólidas estabilizadas de polipéptidos do fator viia |
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| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
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| BRPI0508992A (pt) * | 2004-03-17 | 2007-09-04 | Chiron Corp | tratamento de pneumonia severa pela administração de tfpi |
| CA2574598A1 (en) * | 2004-07-23 | 2006-02-09 | The University Of Rochester | Activated protein c inhibits undesirable effects of plasminogen activator in the brain |
| WO2006136033A1 (en) * | 2005-06-23 | 2006-12-28 | The University Of British Columbia | Coagulation factor iii polymorphisms associated with prediction of subject outcome and response to therapy |
| PT2029740E (pt) * | 2006-05-31 | 2012-07-06 | Genzyme Corp | Utilização de polissacáridos para promoção de actividade enzimática |
| CA2654761A1 (en) * | 2006-06-09 | 2007-12-13 | The University Of British Columbia | Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects |
| ATE512660T1 (de) * | 2007-03-05 | 2011-07-15 | Cadila Healthcare Ltd | Zusammensetzungen mit peg-interferon-alpha- konjugaten und raffinose als kryoschutzmittel |
| NZ580379A (en) * | 2007-03-29 | 2012-10-26 | Abbott Lab | Crystalline anti-human il-12 antibodies |
| TW200938221A (en) * | 2007-11-30 | 2009-09-16 | Abbott Lab | Protein formulations and methods of making same |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| CA2712057A1 (en) * | 2008-01-15 | 2009-07-23 | The University Of British Columbia | Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound |
| KR20110096553A (ko) * | 2008-11-28 | 2011-08-30 | 아보트 러보러터리즈 | 안정한 항체 조성물 및 이의 안정화 방법 |
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| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP2834635A4 (en) | 2012-04-03 | 2015-09-02 | Smiths Medical Asd Inc | COMPOSITIONS WITH A HEPARINE ACCUMULATIVE AND METHOD THEREFOR |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| BR112015000051A2 (pt) | 2012-07-04 | 2017-06-27 | Univ Sydney | tratamento de distúrbios inflamatórios da pele |
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| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| EP3137102B1 (en) | 2014-04-16 | 2021-07-14 | ZZ Biotech LLC | Apc for use in the treatment of abnormal cutaneous scarring |
| PL3131572T3 (pl) | 2014-04-16 | 2022-02-07 | Zz Biotech Llc | Analog apc do zastosowania w zaleczaniu rany |
| US11058750B2 (en) | 2015-12-03 | 2021-07-13 | Mor Research Applications Ltd. | Compositions and methods for treatment of ocular diseases |
| AU2017299374B2 (en) * | 2016-06-01 | 2021-05-27 | Servier IP UK Limited | Formulations of polyalkylene oxide-asparaginase and methods of making and using the same |
| CN108159399B (zh) * | 2017-12-29 | 2020-07-24 | 华中科技大学同济医学院附属同济医院 | 一种凝血蛋白酶aPC在防治糖尿病心肌病药物中的应用 |
| WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
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| US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
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| HUP0001237A3 (en) | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
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1998
- 1998-04-24 HU HU0003401A patent/HUP0003401A3/hu unknown
- 1998-04-24 BR BR9809292-8A patent/BR9809292A/pt not_active Application Discontinuation
- 1998-04-24 PE PE1998000311A patent/PE84799A1/es not_active Application Discontinuation
- 1998-04-24 TR TR1999/02631T patent/TR199902631T2/xx unknown
- 1998-04-24 PL PL98336420A patent/PL195642B1/pl unknown
- 1998-04-24 HU HU0100284A patent/HU224826B1/hu not_active IP Right Cessation
- 1998-04-24 JP JP54721998A patent/JP4383546B2/ja not_active Expired - Fee Related
- 1998-04-24 CN CNB988045672A patent/CN1235638C/zh not_active Expired - Fee Related
- 1998-04-24 US US09/065,975 patent/US6159468A/en not_active Expired - Lifetime
- 1998-04-24 IL IL13250298A patent/IL132502A0/xx unknown
- 1998-04-24 ZA ZA9803496A patent/ZA983496B/xx unknown
- 1998-04-24 ID IDW991254A patent/ID23172A/id unknown
- 1998-04-24 CZ CZ0381099A patent/CZ298429B6/cs not_active IP Right Cessation
- 1998-04-24 AR ARP980101908A patent/AR012010A1/es active IP Right Grant
- 1998-04-24 CA CA002287267A patent/CA2287267C/en not_active Expired - Fee Related
- 1998-04-24 BR BRPI9809304-5A patent/BR9809304B1/pt not_active IP Right Cessation
- 1998-04-24 AU AU72589/98A patent/AU743531B2/en not_active Ceased
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- 1998-04-24 UA UA99105788A patent/UA73071C2/uk unknown
- 1998-04-24 US US09/065,872 patent/US6162629A/en not_active Expired - Lifetime
- 1998-04-24 NZ NZ337828A patent/NZ337828A/en unknown
- 1998-04-24 KR KR10-1999-7009933A patent/KR100450856B1/ko not_active Expired - Fee Related
- 1998-04-24 NZ NZ500346A patent/NZ500346A/en unknown
- 1998-04-24 CA CA2288143A patent/CA2288143C/en not_active Expired - Fee Related
- 1998-04-24 PL PL98336889A patent/PL195090B1/pl not_active IP Right Cessation
- 1998-04-24 WO PCT/US1998/008386 patent/WO1998048818A1/en not_active Ceased
- 1998-04-24 UA UA99105884A patent/UA55448C2/uk unknown
- 1998-04-24 ID IDW991133A patent/ID22933A/id unknown
- 1998-04-24 EA EA199900979A patent/EA004881B1/ru not_active IP Right Cessation
- 1998-04-24 WO PCT/US1998/008384 patent/WO1998048822A1/en not_active Ceased
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- 1998-04-24 IL IL13232598A patent/IL132325A/xx not_active IP Right Cessation
- 1998-04-24 CN CNB988063824A patent/CN1227025C/zh not_active Expired - Fee Related
- 1998-04-24 JP JP54722198A patent/JP4383547B2/ja not_active Expired - Lifetime
- 1998-04-26 EG EG45198A patent/EG23685A/xx active
- 1998-04-27 MY MYPI98001900A patent/MY118591A/en unknown
- 1998-04-27 SV SV1998000051A patent/SV1998000051A/es not_active Application Discontinuation
- 1998-04-27 IN IN752CA1998 patent/IN187157B/en unknown
- 1998-04-27 MY MYPI98001899A patent/MY120984A/en unknown
- 1998-04-27 IN IN751CA1998 patent/IN183798B/en unknown
- 1998-04-27 SV SV1998000050A patent/SV1998000050A/es not_active Application Discontinuation
- 1998-04-28 PT PT98303311T patent/PT875252E/pt unknown
- 1998-04-28 AT AT98303311T patent/ATE285788T1/de not_active IP Right Cessation
- 1998-04-28 DK DK98303311T patent/DK0875252T3/da active
- 1998-04-28 SI SI9830752T patent/SI0875252T1/xx unknown
- 1998-04-28 TW TW087106549A patent/TW585871B/zh not_active IP Right Cessation
- 1998-04-28 ES ES98303311T patent/ES2234072T3/es not_active Expired - Lifetime
- 1998-04-28 EP EP98303311A patent/EP0875252B1/en not_active Expired - Lifetime
- 1998-04-28 EP EP98303312A patent/EP0875563A3/en not_active Withdrawn
- 1998-04-28 DE DE69828330T patent/DE69828330T2/de not_active Expired - Lifetime
- 1998-04-28 TW TW087106558A patent/TWI242443B/zh not_active IP Right Cessation
-
1999
- 1999-10-21 NO NO995134A patent/NO995134L/no not_active Application Discontinuation
- 1999-10-25 NO NO995198A patent/NO995198D0/no not_active Application Discontinuation
-
2000
- 2000-09-14 US US09/662,232 patent/US6395270B1/en not_active Expired - Lifetime
- 2000-09-21 US US09/667,570 patent/US6436397B1/en not_active Expired - Lifetime
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