DE69821002T2 - Verbesserte lager- und haltbarkeit von blutprodukten - Google Patents

Verbesserte lager- und haltbarkeit von blutprodukten Download PDF

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Publication number
DE69821002T2
DE69821002T2 DE69821002T DE69821002T DE69821002T2 DE 69821002 T2 DE69821002 T2 DE 69821002T2 DE 69821002 T DE69821002 T DE 69821002T DE 69821002 T DE69821002 T DE 69821002T DE 69821002 T2 DE69821002 T2 DE 69821002T2
Authority
DE
Germany
Prior art keywords
carnitine
alkanoyl
mixtures
hemolysis
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69821002T
Other languages
German (de)
English (en)
Other versions
DE69821002D1 (de
Inventor
Secondo Dottori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of DE69821002D1 publication Critical patent/DE69821002D1/de
Publication of DE69821002T2 publication Critical patent/DE69821002T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet [UV] radiation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A61L2103/09—Blood or products thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Packages (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DE69821002T 1997-04-16 1998-04-15 Verbesserte lager- und haltbarkeit von blutprodukten Expired - Lifetime DE69821002T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/840,765 US6482585B2 (en) 1997-04-16 1997-04-16 Storage and maintenance of blood products including red blood cells and platelets
PCT/IT1998/000086 WO1998046073A1 (en) 1997-04-16 1998-04-15 Improved storage and maintenance of blood products
US840765 2001-04-23

Publications (2)

Publication Number Publication Date
DE69821002D1 DE69821002D1 (de) 2004-02-12
DE69821002T2 true DE69821002T2 (de) 2004-07-08

Family

ID=25283169

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69821002T Expired - Lifetime DE69821002T2 (de) 1997-04-16 1998-04-15 Verbesserte lager- und haltbarkeit von blutprodukten

Country Status (20)

Country Link
US (2) US6482585B2 (https=)
EP (1) EP0975214B1 (https=)
JP (1) JP4467649B2 (https=)
KR (1) KR100508408B1 (https=)
CN (2) CN1698430A (https=)
AT (1) ATE257326T1 (https=)
AU (1) AU739842B2 (https=)
BR (1) BR9808911B1 (https=)
CA (1) CA2286721A1 (https=)
CZ (1) CZ298671B6 (https=)
DE (1) DE69821002T2 (https=)
DK (1) DK0975214T3 (https=)
ES (1) ES2212288T3 (https=)
HU (1) HUP0001936A3 (https=)
IL (1) IL132271A (https=)
NZ (1) NZ500534A (https=)
PL (1) PL192684B1 (https=)
PT (1) PT975214E (https=)
SK (1) SK284688B6 (https=)
WO (1) WO1998046073A1 (https=)

Families Citing this family (42)

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US6403124B1 (en) * 1997-04-16 2002-06-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
ATE336243T1 (de) * 1999-10-11 2006-09-15 Sigma Tau Ind Farmaceuti Verwendung von l-carnitin und seinen alkanoyl- derivaten als osmotisches mittel in lösungen für medizinische verwendung
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
RU2245145C1 (ru) * 2003-10-01 2005-01-27 Российский государственный медицинский университет Средство нормализации агрегационных свойств тромбоцитов и эритроцитов и морфоденситометрических характеристик эритроцитов
US20070077237A1 (en) * 2003-10-09 2007-04-05 Udi Damari Method for freezing, thawing and transplantation of viable cartilage
WO2005072790A1 (en) * 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Device for directional cooling of biological matter
EP1711053A2 (en) * 2004-02-02 2006-10-18 I.M.T. Interface Multigrad Technology Ltd. Biological material and methods and solutions for preservation thereof
US7892726B2 (en) * 2004-06-07 2011-02-22 Core Dynamics Limited Method for sterilizing lyophilized eukaryotic anuclear cells with gamma irradiation
US8037696B2 (en) * 2004-08-12 2011-10-18 Core Dynamics Limited Method and apparatus for freezing or thawing of a biological material
WO2006090372A2 (en) * 2005-02-22 2006-08-31 I.M.T. Interface Multigrad Technology Ltd. Preserved viable cartilage, method for its preservation, and system and devices used therefor
FR2884717B1 (fr) * 2005-04-25 2009-07-03 Erytech Pharma Soc Par Actions Erythrocytes renfermant de l'arginine deiminase
US8198085B2 (en) * 2005-08-03 2012-06-12 Core Dynamics Limited Somatic cells for use in cell therapy
US7462485B2 (en) * 2005-10-07 2008-12-09 Glaser Lawrence F Modified erythrocytes and uses thereof
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US20090202978A1 (en) * 2008-02-13 2009-08-13 Ginadi Shaham Method and apparatus for freezing of a biological material
US8968992B2 (en) * 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
US8871434B2 (en) * 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
CN102905522A (zh) 2009-10-12 2013-01-30 新健康科学股份有限公司 用于从红细胞中除去氧的氧消耗装置和方法
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
CA2781866C (en) 2009-10-12 2019-12-03 New Health Sciences, Inc. Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US11864553B2 (en) 2009-10-23 2024-01-09 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
US9339025B2 (en) 2010-08-25 2016-05-17 New Health Sciences, Inc. Method for enhancing red blood cell quality and survival during storage
PT2635114T (pt) 2010-11-05 2020-06-16 New Health Sciences Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
CA2826969C (en) 2010-11-29 2019-02-19 New York Blood Center, Inc. Method of blood pooling and storage
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
EP3662750A1 (en) 2011-04-07 2020-06-10 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
EP2729000B1 (en) * 2011-07-05 2022-12-14 Hemanext Inc. A method for extended storage of red blood cells
ES2984863T3 (es) 2011-08-10 2024-10-31 Hemanext Inc Dispositivo integrado de filtrado de leucocitos, oxígeno y/o agotamiento de CO2, y separación de plasma
ES2900298T3 (es) 2013-02-28 2022-03-16 Hemanext Inc Dispositivo de agotamiento de gas para productos sanguíneos
PT3970731T (pt) 2015-03-10 2026-02-24 Hemanext Inc Kits descartáveis de redução de oxigénio, dispositivos e métodos de utilização dos mesmos
WO2016172645A1 (en) 2015-04-23 2016-10-27 New Health Sciences, Inc. Anaerobic blood storage containers
CA2985799A1 (en) 2015-05-18 2016-11-24 New Health Sciences, Inc. Methods for the storage of whole blood, and compositions thereof
KR20240132129A (ko) 2016-05-27 2024-09-02 헤마넥스트 인코포레이티드 혐기성 혈액 저장 및 병원체 불활성화 방법
DE102017218847A1 (de) 2017-10-23 2019-04-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Verbesserung der Stabilität von Blut und Blutprodukten
EP4064837A4 (en) * 2019-11-29 2023-01-04 Rutgers, the State University of New Jersey COMPOSITIONS, KITS AND METHODS FOR STORING BLOOD PRODUCTS AND METHODS OF USE THEREOF
EP4065690A4 (en) 2019-11-29 2022-10-05 Rutgers, the State University of New Jersey METHODS OF ISOLATING UMBRELLA PLASMA PRODUCTS, TISSUE AND CELL EXOSOMES AND COMPOSITIONS AND METHODS OF USE THEREOF
CN116115753A (zh) * 2021-11-15 2023-05-16 上海循曜生物科技有限公司 一种新的改善血小板质量的方法
CN114600872A (zh) * 2022-04-13 2022-06-10 西安北光医学生物技术有限公司 一种细胞、组织或器官的抗损伤保存的方法及保存系统
EP4687868A1 (en) * 2023-03-31 2026-02-11 Hemerus Medical, LLC Formulations and methods for collecting and storing blood and blood products

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US5120649A (en) * 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
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IT1261695B (it) * 1993-06-02 1996-05-29 Sigma Tau Ind Farmaceuti Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono.
US5362442A (en) * 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
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US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6010890A (en) * 1997-04-29 2000-01-04 New York Blood Center, Inc. Method for viral inactivation and compositions for use in same

Also Published As

Publication number Publication date
PT975214E (pt) 2004-05-31
ATE257326T1 (de) 2004-01-15
EP0975214A1 (en) 2000-02-02
IL132271A (en) 2005-12-18
BR9808911B1 (pt) 2010-09-21
NZ500534A (en) 2001-05-25
US6482585B2 (en) 2002-11-19
DK0975214T3 (da) 2004-05-10
SK142799A3 (en) 2000-05-16
AU7078198A (en) 1998-11-11
CZ298671B6 (cs) 2007-12-19
CN1698430A (zh) 2005-11-23
KR20010006464A (ko) 2001-01-26
CZ368199A3 (cs) 2000-04-12
IL132271A0 (en) 2001-03-19
US6960428B2 (en) 2005-11-01
WO1998046073A1 (en) 1998-10-22
BR9808911A (pt) 2000-08-01
AU739842B2 (en) 2001-10-18
HUP0001936A3 (en) 2001-03-28
HK1025477A1 (en) 2000-11-17
CN1252687A (zh) 2000-05-10
CA2286721A1 (en) 1998-10-22
PL192684B1 (pl) 2006-11-30
PL336294A1 (en) 2000-06-19
SK284688B6 (sk) 2005-09-08
US20010049089A1 (en) 2001-12-06
DE69821002D1 (de) 2004-02-12
ES2212288T3 (es) 2004-07-16
JP2001523225A (ja) 2001-11-20
US20030022228A1 (en) 2003-01-30
JP4467649B2 (ja) 2010-05-26
EP0975214B1 (en) 2004-01-07
KR100508408B1 (ko) 2005-08-17
HUP0001936A2 (hu) 2000-10-28

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