DE69820449T2 - T-zell-membranprotein (tirc7), davon abgeleitete peptide und antikörper und ihre verwendungen - Google Patents

T-zell-membranprotein (tirc7), davon abgeleitete peptide und antikörper und ihre verwendungen Download PDF

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Publication number
DE69820449T2
DE69820449T2 DE69820449T DE69820449T DE69820449T2 DE 69820449 T2 DE69820449 T2 DE 69820449T2 DE 69820449 T DE69820449 T DE 69820449T DE 69820449 T DE69820449 T DE 69820449T DE 69820449 T2 DE69820449 T2 DE 69820449T2
Authority
DE
Germany
Prior art keywords
cell
tirc7
protein
antibody
membrane protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69820449T
Other languages
German (de)
English (en)
Other versions
DE69820449D1 (de
Inventor
Nalan Utku
R. Steven GULLANS
L. Edgar MILFORD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Utku Nalan Dr 10719 Berlin De
Brigham and Womens Hospital Inc
Original Assignee
Utku Nalan Dr
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19738710A external-priority patent/DE19738710A1/de
Application filed by Utku Nalan Dr, Brigham and Womens Hospital Inc filed Critical Utku Nalan Dr
Priority to DE69820449T priority Critical patent/DE69820449T2/de
Application granted granted Critical
Publication of DE69820449D1 publication Critical patent/DE69820449D1/de
Publication of DE69820449T2 publication Critical patent/DE69820449T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69820449T 1997-08-29 1998-08-28 T-zell-membranprotein (tirc7), davon abgeleitete peptide und antikörper und ihre verwendungen Expired - Lifetime DE69820449T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69820449T DE69820449T2 (de) 1997-08-29 1998-08-28 T-zell-membranprotein (tirc7), davon abgeleitete peptide und antikörper und ihre verwendungen

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19738710 1997-08-29
DE19738710A DE19738710A1 (de) 1997-08-29 1997-08-29 Verwendung von TIRC7 zur Herstellung von Mitteln zur Inhibition der Immunantwort
DE29802653U 1998-02-12
DE29802653 1998-02-12
PCT/EP1998/005462 WO1999011782A1 (en) 1997-08-29 1998-08-28 T-cell membrane protein (tirc7), peptides and antibodies derived therefrom and uses thereof
DE69820449T DE69820449T2 (de) 1997-08-29 1998-08-28 T-zell-membranprotein (tirc7), davon abgeleitete peptide und antikörper und ihre verwendungen

Publications (2)

Publication Number Publication Date
DE69820449D1 DE69820449D1 (de) 2004-01-22
DE69820449T2 true DE69820449T2 (de) 2005-03-10

Family

ID=26039678

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820449T Expired - Lifetime DE69820449T2 (de) 1997-08-29 1998-08-28 T-zell-membranprotein (tirc7), davon abgeleitete peptide und antikörper und ihre verwendungen

Country Status (10)

Country Link
EP (2) EP0996726B1 (https=)
JP (1) JP4459435B2 (https=)
AT (1) ATE256185T1 (https=)
AU (1) AU751151C (https=)
CA (1) CA2301499C (https=)
DE (1) DE69820449T2 (https=)
DK (1) DK0996726T3 (https=)
ES (1) ES2213295T3 (https=)
PT (1) PT996726E (https=)
WO (1) WO1999011782A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL134830A0 (en) * 2000-03-01 2001-05-20 Chay 13 Medical Res Group N V Peptides and immunostimulatory and anti-bacterial pharmaceutical compositions containing them
WO2001082948A2 (en) * 2000-05-03 2001-11-08 Genpat77 Pharmacogenetics Ag Uses of tgap7 for the modulation of leucocyte activation
AU2002221775B2 (en) * 2000-10-30 2006-11-23 Genpat77 Pharmacogenetics Ag Methods for obtaining inhibitors of t-cell membrane protein (TIRC7) ligand binding and uses thereof
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
EP1430084A2 (en) * 2001-09-17 2004-06-23 GenPat77 Pharmacogenetics AG Peptides capable of modulating immune response
AU2002360946A1 (en) * 2001-11-27 2003-06-10 Genpat77 Pharmacogenetics Ag Use of T-cell immune response cDNA 7 (TIRC7) for modulation of angiogenesis and/or neovascularization
WO2003054018A2 (en) * 2001-12-21 2003-07-03 Genpat77 Pharmacogenetics Ag Anti-tirc7 antibodies in therapy of inflammatory diseases
US20060165684A1 (en) 2001-12-21 2006-07-27 Nalan Utku Therapeutic anti-tirc7 antibodies for use in immune related and other diseases
US20060165689A1 (en) * 2002-02-04 2006-07-27 Nalan Utku Compositions and methods for modulation of effects on phagocyte and lymphoid cell populations employing tirc7
US20050221424A1 (en) * 2002-04-26 2005-10-06 Nalan Utku Bispecific molecules for use in therapy and diagnosis of immune related and other diseases
CA2484182A1 (en) * 2002-04-29 2003-11-13 Genpat77 Pharmacogenetics Ag Novel antibody binding tcr and tirc7 and its use in therapy and diagnosis
EP1931371A1 (en) * 2005-05-17 2008-06-18 CellAct Pharma GmbH Peptides capable of modulating the function of tirc7
US8642512B2 (en) * 2005-05-17 2014-02-04 Cellact Pharma Gmbh Method of detecting early immune activation
DE202011103324U1 (de) 2011-07-12 2012-01-02 Nekonal S.A.R.L. Therapeutische anti-TIRC7 Antikörper für die Verwendung in Immun und anderen Krankheiten
JP2019532303A (ja) 2016-08-09 2019-11-07 ネコナル エス．ア．エール．エル． Ｔｉｒｃ７を基礎とする癌の診断及び治療
AU2017309985A1 (en) 2016-08-10 2019-02-28 Nekonal S.A.R.L. TIRC7 based diagnostic and therapy of solid cancer
EP4013781A1 (en) 2019-08-14 2022-06-22 Nekonal S.a.r.l. Method for producing engineered tirc7 specific t-regulatory cells (tregs)

Also Published As

Publication number Publication date
JP4459435B2 (ja) 2010-04-28
EP1350848A3 (en) 2004-02-04
ATE256185T1 (de) 2003-12-15
AU9265498A (en) 1999-03-22
WO1999011782A1 (en) 1999-03-11
CA2301499C (en) 2010-01-26
EP0996726B1 (en) 2003-12-10
PT996726E (pt) 2004-04-30
ES2213295T3 (es) 2004-08-16
EP1350848A2 (en) 2003-10-08
DE69820449D1 (de) 2004-01-22
EP0996726A1 (en) 2000-05-03
DK0996726T3 (da) 2004-04-13
AU751151B2 (en) 2002-08-08
JP2001514852A (ja) 2001-09-18
AU751151C (en) 2006-09-14
CA2301499A1 (en) 1999-03-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: THE BRIGHAM AND WOMEN'S HOSPITAL INC., BOSTON, MAS

Owner name: UTKU, NALAN, DR., 10719 BERLIN, DE

8328 Change in the person/name/address of the agent

Representative=s name: KOENIG SZYNKA TILMANN VON RENESSE, 40549 DUESSELDO