DE69729392T2 - Krampfhemmende enantiomere Aminosäurederivate - Google Patents

Krampfhemmende enantiomere Aminosäurederivate Download PDF

Info

Publication number
DE69729392T2
DE69729392T2 DE69729392T DE69729392T DE69729392T2 DE 69729392 T2 DE69729392 T2 DE 69729392T2 DE 69729392 T DE69729392 T DE 69729392T DE 69729392 T DE69729392 T DE 69729392T DE 69729392 T2 DE69729392 T2 DE 69729392T2
Authority
DE
Germany
Prior art keywords
compound
mmol
compounds
liver
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69729392T
Other languages
German (de)
English (en)
Other versions
DE69729392D1 (de
Inventor
Harold Kohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21760388&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69729392(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Application granted granted Critical
Publication of DE69729392D1 publication Critical patent/DE69729392D1/de
Publication of DE69729392T2 publication Critical patent/DE69729392T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69729392T 1996-03-15 1997-03-17 Krampfhemmende enantiomere Aminosäurederivate Expired - Lifetime DE69729392T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1352296P 1996-03-15 1996-03-15
US13522P 1996-03-15

Publications (2)

Publication Number Publication Date
DE69729392D1 DE69729392D1 (de) 2004-07-08
DE69729392T2 true DE69729392T2 (de) 2005-06-02

Family

ID=21760388

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69729392T Expired - Lifetime DE69729392T2 (de) 1996-03-15 1997-03-17 Krampfhemmende enantiomere Aminosäurederivate
DE69705210T Expired - Lifetime DE69705210T2 (de) 1996-03-15 1997-03-17 Krampflösende, enantiomere aminosäure-derivate
DE122009000010C Active DE122009000010I2 (de) 1996-03-15 1997-03-17 Krampflösende, enantiomere aminosäure-derivate

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69705210T Expired - Lifetime DE69705210T2 (de) 1996-03-15 1997-03-17 Krampflösende, enantiomere aminosäure-derivate
DE122009000010C Active DE122009000010I2 (de) 1996-03-15 1997-03-17 Krampflösende, enantiomere aminosäure-derivate

Country Status (12)

Country Link
EP (2) EP1038522B1 (https=)
JP (1) JP3145414B2 (https=)
AT (2) ATE268169T1 (https=)
AU (1) AU718577B2 (https=)
CA (1) CA2248317C (https=)
DE (3) DE69729392T2 (https=)
DK (2) DK1038522T3 (https=)
ES (2) ES2218024T3 (https=)
FR (1) FR09C0006I2 (https=)
NL (1) NL300376I1 (https=)
PT (2) PT1038522E (https=)
WO (1) WO1997033861A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
EP1873527A1 (en) 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
US8093426B2 (en) * 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
DE102008059155A1 (de) 2008-11-27 2010-06-02 Ratiopharm Gmbh Trockenverarbeitung und neue Formen von Lacosamid
WO2011015617A1 (en) 2009-08-06 2011-02-10 Medichem, S.A. Solid forms of an n-(phenylmethyl)propanamide derivative and processes of preparation
EP2480524A1 (en) * 2009-09-25 2012-08-01 Cadila Healthcare Limited Processes for the preparation of lacosamide and intermediates thereof
IT1398044B1 (it) * 2010-01-29 2013-02-07 Archimica Srl Processo per la preparazione della lacosamide
CA2788451A1 (en) 2010-02-08 2011-08-11 Natco Pharma Limited A process for the preparation of lacosamide
US8907132B2 (en) 2010-02-09 2014-12-09 Msn Laboratories Private Limited Process for preparing (R)-2-acetamido-N-benzyl-3-methoxy-propionamide
EP2399901A1 (en) 2010-06-23 2011-12-28 Archimica GmbH Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide
EP2621893A1 (en) 2010-10-01 2013-08-07 UCB Pharma GmbH Process for the preparation of amino acid derivatives
WO2012051551A1 (en) * 2010-10-15 2012-04-19 Nektar Therapeutics N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides
HUE031138T2 (en) 2010-10-19 2017-06-28 Euticals Gmbh A method of producing lacosamide
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
BR112013013525A2 (pt) 2010-12-02 2016-10-18 Ucb Pharma Gmbh formulação de liberação controlada sólida de lacosamida para administração oral, composição farmacêutica sólida, e, método para a prevenção, alívio e/ou tratamento de uma doença do sistema nervoso central
CN104771356A (zh) * 2014-01-09 2015-07-15 山东方明药业集团股份有限公司 一种拉科酰胺注射液及其制备方法
US11278634B1 (en) 2021-02-12 2022-03-22 Extrovis Ag Stable parenteral composition of lacosamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
ATE62222T1 (de) * 1985-02-15 1991-04-15 Res Corp Technologies Inc Aminosaeure-derivate und ihre anwendung zur herstellung eines antikrampfmittels.

Also Published As

Publication number Publication date
EP0888289A1 (en) 1999-01-07
ES2157567T3 (es) 2001-08-16
FR09C0006I2 (fr) 2009-12-18
CA2248317A1 (en) 1997-09-18
DE69705210T2 (de) 2001-09-20
DE122009000010I2 (de) 2010-10-21
ES2218024T3 (es) 2004-11-16
DE69705210D1 (de) 2001-07-19
EP0888289B1 (en) 2001-06-13
ATE268169T1 (de) 2004-06-15
NL300376I1 (nl) 2009-05-06
EP1038522B1 (en) 2004-06-02
EP1038522A3 (en) 2003-01-15
PT1038522E (pt) 2004-10-29
AU2539497A (en) 1997-10-01
CA2248317C (en) 2003-12-02
JP3145414B2 (ja) 2001-03-12
DE122009000010I1 (de) 2009-05-20
EP1038522A2 (en) 2000-09-27
FR09C0006I1 (https=) 2009-04-17
ATE202079T1 (de) 2001-06-15
DK0888289T3 (da) 2001-09-03
JP2000505476A (ja) 2000-05-09
DE69729392D1 (de) 2004-07-08
AU718577B2 (en) 2000-04-13
WO1997033861A1 (en) 1997-09-18
DK1038522T3 (da) 2004-10-11
PT888289E (pt) 2001-09-28

Similar Documents

Publication Publication Date Title
DE69729392T2 (de) Krampfhemmende enantiomere Aminosäurederivate
USRE38551E1 (en) Anticonvulsant enantiomeric amino acid derivatives
DE3885889T2 (de) (r)5-pentylamino-5-oxopentanesäure-derivate mit anticholecystokininwirkung.
DE69909818T2 (de) Pyrazolopyimidinon-derivate zur behandlung von impotenz
DE69816280T2 (de) Inhibitoren des impdh-enzyms
EP0400011B1 (de) Neue phenylethanolamine
EP0163965B1 (de) Pyridazinone, ihre Herstellung und Verwendung, Pyridazinone enthaltende Arzeimittel
EP0916679B1 (de) Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DD291560A5 (de) Verfahren zum herstellen von racemischen oder optisch aktiven pyrido [1,2-a] pyrazin-derivaten
DE69533194T2 (de) PYRAZOLO(3,4-g)CHINOXALINE ALS PDGF-REZEPTOR PROTEIN TYROSIN-KINASE INHIBITOREN
DE69028605T2 (de) Aminocarbonylcarbamate verwandt mit Physostigmin, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE3347867C2 (https=)
DE60003911T2 (de) Heteroaryl-diazacycloalkane, ihre herstellung und verwendung
CN107468690B (zh) 4-氧-烷基化特特拉姆酸类化合物及其制备方法与应用
DE69317399T2 (de) Aminocycloalkanobenzodioxole als beta-3 selektive adrenergische Wirkstoffe
EP0161599A2 (de) Neue Benzazepinderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
CN107353239A (zh) 4‑氧‑烷基化特特拉姆酸类化合物及其制备方法
DE69734594T2 (de) Nmda (n-methyl-d-aspartate) antagonists
DE10048715A1 (de) Verwendung von Aminosäure zur Behandlung von Schmerz
EP0508370B1 (de) Kondensierte Diazepinone, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Mittel zur Behandlung von Erkrankungen des Zentralnervensystems und zur Förderung der cerebralen Durchblutung
DE3786865T2 (de) Aminosäurederivate enthaltende antikonvulsive Zusammensetzungen und Verwendung dieser Aminosäurederivate.
DE69114405T2 (de) 3-(1,2-Benzisoxazol-3-yl)-4-Pyridinamine und Derivate.
DE69413333T2 (de) Benzospiroalken-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE69812599T2 (de) Imino-aza-anthracyclonderivate zur behandlung von amyloidosis
EP0085893B1 (de) Pyridobenzodiazepinone, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition