ES2157567T3 - Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo. - Google Patents

Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo.

Info

Publication number
ES2157567T3
ES2157567T3 ES97916897T ES97916897T ES2157567T3 ES 2157567 T3 ES2157567 T3 ES 2157567T3 ES 97916897 T ES97916897 T ES 97916897T ES 97916897 T ES97916897 T ES 97916897T ES 2157567 T3 ES2157567 T3 ES 2157567T3
Authority
ES
Spain
Prior art keywords
derivatives
amino acids
enantiomeric amino
anticonvulsive effect
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97916897T
Other languages
English (en)
Spanish (es)
Inventor
Harold Kohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21760388&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157567(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Application granted granted Critical
Publication of ES2157567T3 publication Critical patent/ES2157567T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES97916897T 1996-03-15 1997-03-17 Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo. Expired - Lifetime ES2157567T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1352296P 1996-03-15 1996-03-15

Publications (1)

Publication Number Publication Date
ES2157567T3 true ES2157567T3 (es) 2001-08-16

Family

ID=21760388

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97916897T Expired - Lifetime ES2157567T3 (es) 1996-03-15 1997-03-17 Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo.
ES00109377T Expired - Lifetime ES2218024T3 (es) 1996-03-15 1997-03-17 Derivados de aminoacido enantiomerico anticonvulsionante.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00109377T Expired - Lifetime ES2218024T3 (es) 1996-03-15 1997-03-17 Derivados de aminoacido enantiomerico anticonvulsionante.

Country Status (12)

Country Link
EP (2) EP0888289B1 (https=)
JP (1) JP3145414B2 (https=)
AT (2) ATE268169T1 (https=)
AU (1) AU718577B2 (https=)
CA (1) CA2248317C (https=)
DE (3) DE69729392T2 (https=)
DK (2) DK0888289T3 (https=)
ES (2) ES2157567T3 (https=)
FR (1) FR09C0006I2 (https=)
NL (1) NL300376I1 (https=)
PT (2) PT888289E (https=)
WO (1) WO1997033861A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
EP1873527A1 (en) 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
US8093426B2 (en) 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
DE102008059155A1 (de) 2008-11-27 2010-06-02 Ratiopharm Gmbh Trockenverarbeitung und neue Formen von Lacosamid
AR080275A1 (es) 2009-08-06 2012-03-28 Medichem Sa Formas solidas de un derivado de n-( fenilmetil) propanamida y procedimientos de preparacion
JP5564570B2 (ja) * 2009-09-25 2014-07-30 カディラ・ヘルスケア・リミテッド ラコサミドおよびその中間体の調製方法
IT1398044B1 (it) * 2010-01-29 2013-02-07 Archimica Srl Processo per la preparazione della lacosamide
KR20120128667A (ko) 2010-02-08 2012-11-27 낫코 파마 리미티드 라코사미드의 제조방법
WO2011099033A1 (en) * 2010-02-09 2011-08-18 Msn Laboratories Limited Process for preparing (r)-2-acetamido-n-benzyl-3-methoxy-propionamide
EP2399901A1 (en) 2010-06-23 2011-12-28 Archimica GmbH Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide
EP2621893A1 (en) 2010-10-01 2013-08-07 UCB Pharma GmbH Process for the preparation of amino acid derivatives
WO2012051551A1 (en) * 2010-10-15 2012-04-19 Nektar Therapeutics N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides
PL2444390T3 (pl) 2010-10-19 2017-06-30 Euticals Gmbh Sposób wytwarzania Lakozamidu
MX2013005974A (es) 2010-12-02 2013-07-29 Ucb Pharma Gmbh Formulacion de lacosamida de administracion una vez al dia.
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
CN104771356A (zh) * 2014-01-09 2015-07-15 山东方明药业集团股份有限公司 一种拉科酰胺注射液及其制备方法
US11278634B1 (en) 2021-02-12 2022-03-22 Extrovis Ag Stable parenteral composition of lacosamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
EP0194464B1 (en) * 1985-02-15 1991-04-03 Research Corporation Technologies, Inc. (a Delaware corp.) Amino acid derivatives and use thereof for the preparation of an anticonvulsant

Also Published As

Publication number Publication date
FR09C0006I2 (fr) 2009-12-18
PT888289E (pt) 2001-09-28
AU2539497A (en) 1997-10-01
FR09C0006I1 (https=) 2009-04-17
DE69705210T2 (de) 2001-09-20
ATE202079T1 (de) 2001-06-15
JP3145414B2 (ja) 2001-03-12
DE69705210D1 (de) 2001-07-19
DE122009000010I2 (de) 2010-10-21
WO1997033861A1 (en) 1997-09-18
EP1038522B1 (en) 2004-06-02
EP0888289B1 (en) 2001-06-13
EP1038522A2 (en) 2000-09-27
NL300376I1 (nl) 2009-05-06
CA2248317A1 (en) 1997-09-18
DK1038522T3 (da) 2004-10-11
DK0888289T3 (da) 2001-09-03
DE69729392T2 (de) 2005-06-02
ATE268169T1 (de) 2004-06-15
JP2000505476A (ja) 2000-05-09
ES2218024T3 (es) 2004-11-16
PT1038522E (pt) 2004-10-29
EP0888289A1 (en) 1999-01-07
DE69729392D1 (de) 2004-07-08
EP1038522A3 (en) 2003-01-15
DE122009000010I1 (de) 2009-05-20
AU718577B2 (en) 2000-04-13
CA2248317C (en) 2003-12-02

Similar Documents

Publication Publication Date Title
ES2157567T3 (es) Derivados de aminoacidos enantiomericos que tienen efecto anticonvulsivo.
AR002705A1 (es) Un nuevo compuesto de indolina, un proceso para su preparacion y composiciones farmaceuticas que lo contienen.
BG102999A (bg) Нови 2,3 дизаместени-4(3н)-хиназолинони
BR0309875A (pt) métodos e composições para tratamento de distúrbios do sistema nervoso periférico e novos compostos úteis para isto
ES2126122T3 (es) Nitrato-aminoacido-disulfuros para la terapia de enfermedades del sistema cardio-circulatorio.
BR9713186A (pt) Inibidores de metaloprotease 1,3-diheterocìclicos
ATE203019T1 (de) Neue (r)-5-carbamoyl-8-fluor-3-n,n- disubstituierte-amino-3,4-dihydro-2h-1- benzopyrane
BR9714517A (pt) Cicloalquila, lactama, lactona e compostos correlatos, composições farmacêuticas compreendendo os mesmos e processos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese por uso de tais compostos
BR9713404A (pt) ésteres de n-(aril/heteroarilacetil) aminoácidos, composições farmacêuticas compreendendo os mesmos, e métodos para a inibição da liberação de peptìdeo beta-amilóide e/ou de sua sìntese por uso de tais compostos.
BR9406613A (pt) Composto éster ou amida metabolicamente lábil do mesmo processo para a preparação de um composto e composição farmacêutica
PA8442201A1 (es) Derivados de 6-fenilpiridil-2-amina
ES2184960T3 (es) Nuevas pirimidin-4-onas-(5,6)-heteroaril condensadas 2,3 disustituidas.
ATE223399T1 (de) Quinazolin-4-on ampa antagonisten
BR9708815A (pt) Composições farmacêuticas para prevenção e tratamento de desordens do sistema nervoso central.
BR9713178A (pt) Inbidores espirocìclicos da metaloprotease.
EA200300807A1 (ru) Лечение нарушений центральной нервной системы с использованием антагонистов оксидазы d-аминокислот и d-аспартатоксидазы
PA8457001A1 (es) Derivados del 2-(4-aril o heteroaril-piperazin-i-ilmetil)-1h-indol
ZA947957B (en) Substituted 1-naphthyl-3-pyrazolecarboxamides which are active in neurotensin their preparation and pharmaceutical compositions containing them
DE69838882D1 (de) Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung
BR9911917A (pt) Composições compreendendo análogos de gaba e cafeìna
DE69830450D1 (de) Neue Atropisomere von 2,3-Disubstituierten-(5,6)-heteroarylkondensierten-pyrimidin-4-onen
ES2184300T3 (es) Derivados de aminoacidos utiles para tratar el accidente vascular encefalico.
ES2189956T3 (es) Derivados de quinolina, procedimientos para su preparacion y su uso como medicamentos.
ES2153842T3 (es) Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central.
BR0112131A (pt) Composições farmacêuticas e métodos para uso

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 888289

Country of ref document: ES