DE69729182T2 - Prozess zur chromatographischen trennung von peptiden und nucleinsaure und neue ionentauschermatrix mit hoher affinität - Google Patents
Prozess zur chromatographischen trennung von peptiden und nucleinsaure und neue ionentauschermatrix mit hoher affinität Download PDFInfo
- Publication number
- DE69729182T2 DE69729182T2 DE69729182T DE69729182T DE69729182T2 DE 69729182 T2 DE69729182 T2 DE 69729182T2 DE 69729182 T DE69729182 T DE 69729182T DE 69729182 T DE69729182 T DE 69729182T DE 69729182 T2 DE69729182 T2 DE 69729182T2
- Authority
- DE
- Germany
- Prior art keywords
- chohch
- anion exchanger
- group
- hydrogen
- nhch
- Prior art date
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- Expired - Lifetime
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- 150000004651 carbonic acid esters Chemical class 0.000 description 1
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- 150000004676 glycans Chemical class 0.000 description 1
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- 230000003301 hydrolyzing effect Effects 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-N hydroperoxyl Chemical compound O[O] OUUQCZGPVNCOIJ-UHFFFAOYSA-N 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- JGJLWPGRMCADHB-UHFFFAOYSA-N hypobromite Inorganic materials Br[O-] JGJLWPGRMCADHB-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
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- 238000001764 infiltration Methods 0.000 description 1
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- 238000011835 investigation Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- RUUFMHUAHUPZSS-UHFFFAOYSA-N oxido-oxo-sulfinophosphanium Chemical group P(=O)(=O)S(=O)O RUUFMHUAHUPZSS-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
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- 229920000193 polymethacrylate Polymers 0.000 description 1
- 210000004896 polypeptide structure Anatomy 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
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- 238000003860 storage Methods 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
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- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/04—Processes using organic exchangers
- B01J41/07—Processes using organic exchangers in the weakly basic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600590 | 1996-02-19 | ||
| SE9600590A SE9600590D0 (sv) | 1996-02-19 | 1996-02-19 | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| PCT/SE1997/000237 WO1997029825A1 (en) | 1996-02-19 | 1997-02-14 | Process for chromatographic separation of peptides and nucleic acid, and new high affinity ion exchange matrix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69729182D1 DE69729182D1 (de) | 2004-06-24 |
| DE69729182T2 true DE69729182T2 (de) | 2005-01-27 |
Family
ID=20401430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69729182T Expired - Lifetime DE69729182T2 (de) | 1996-02-19 | 1997-02-14 | Prozess zur chromatographischen trennung von peptiden und nucleinsaure und neue ionentauschermatrix mit hoher affinität |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6090288A (enExample) |
| EP (1) | EP0888157B1 (enExample) |
| JP (1) | JP4422797B2 (enExample) |
| AT (1) | ATE267037T1 (enExample) |
| AU (1) | AU713635B2 (enExample) |
| DE (1) | DE69729182T2 (enExample) |
| SE (1) | SE9600590D0 (enExample) |
| WO (1) | WO1997029825A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103314290A (zh) * | 2011-01-12 | 2013-09-18 | 积水医疗株式会社 | 离子交换色谱法用洗脱液以及核酸链的分析方法 |
| US9447460B2 (en) | 2011-01-12 | 2016-09-20 | Sekisui Medical Co., Ltd. | Method for detecting single nucleotide polymorphisms |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| DE19520398B4 (de) | 1995-06-08 | 2009-04-16 | Roche Diagnostics Gmbh | Magnetisches Pigment |
| KR100463475B1 (ko) | 1995-06-08 | 2005-06-22 | 로셰 디아그노스틱스 게엠베하 | 자기성피그먼트 |
| US6027945A (en) | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
| SE9700769D0 (sv) | 1997-03-04 | 1997-03-04 | Pharmacia Biotech Ab | Matriser för separation och separation som utnyttjar matriserna |
| DE19736366A1 (de) * | 1997-08-21 | 1999-02-25 | Ernst Prof Dr Bayer | Verfahren zur Isolierung von anionischen organischen Verbindungen aus wäßrigen Systemen mit kationischen Polymernanopartikeln |
| US6914137B2 (en) * | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids |
| ES2177093T3 (es) * | 1997-12-06 | 2002-12-01 | Dna Res Innovations Ltd | Aislamiento de acidos nucleicos. |
| US7078224B1 (en) | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
| SE9802214D0 (sv) * | 1998-06-18 | 1998-06-18 | Amersham Pharm Biotech Ab | Jonbytare och användning därav |
| WO2000034521A1 (en) * | 1998-12-08 | 2000-06-15 | Boston Probes, Inc. | Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices |
| WO2000044928A2 (en) * | 1999-01-27 | 2000-08-03 | Halaka Folim G | Materials and methods for the purification of polyelectrolytes |
| US6270970B1 (en) | 1999-05-14 | 2001-08-07 | Promega Corporation | Mixed-bed solid phase and its use in the isolation of nucleic acids |
| US6310199B1 (en) | 1999-05-14 | 2001-10-30 | Promega Corporation | pH dependent ion exchange matrix and method of use in the isolation of nucleic acids |
| SE9904197D0 (sv) * | 1999-11-22 | 1999-11-22 | Amersham Pharm Biotech Ab | A method for anion exchange adsorption on matrices carrying mixed mode ligands |
| SE9904272D0 (sv) * | 1999-11-25 | 1999-11-25 | Amersham Pharm Biotech Ab | A method for selective removal of a substance from samples containing compounds having nucleic acid structure |
| GB9927904D0 (en) * | 1999-11-25 | 2000-01-26 | Amersham Pharm Biotech Ab | A method fro obtaining a nucleic acid variant |
| ATE346856T1 (de) * | 2000-02-08 | 2006-12-15 | Upfront Chromatography As | Neue harze und ihre verwendung zur rückgewinnung von proteinen oder peptiden |
| US20030066336A1 (en) * | 2000-12-19 | 2003-04-10 | Showa Denko K.K. | Method for measuring anions |
| US20020194901A1 (en) * | 2000-12-19 | 2002-12-26 | Showa Denko K.K. | Porous polymer particle, alkali-resistant anion exchanger, producing method thereof, column for ion chromatography, and method for measuring anions |
| SE0004932D0 (sv) * | 2000-12-31 | 2000-12-31 | Apbiotech Ab | A method for mixed mode adsorption and mixed mode adsorbents |
| EP1267169B1 (en) * | 2001-05-21 | 2004-12-15 | Fuji Photo Film Co., Ltd. | Biochemical analysis unit and method for its production |
| SE0103084D0 (sv) * | 2001-09-14 | 2001-09-14 | Amersham Pharm Biotech Ab | Generation of ion exchange media |
| GB0127809D0 (en) * | 2001-11-20 | 2002-01-09 | Dna Res Innovations Ltd | Purification of nucleic acid |
| CN1617938A (zh) | 2002-01-16 | 2005-05-18 | 戴诺生物技术有限公司 | 从单个样品中分离核酸和蛋白质的方法 |
| AU2003217837A1 (en) * | 2002-02-28 | 2003-09-16 | Keck Graduate Institute | Cationic polyelectrolytes in biomolecule purification and analysis |
| US20060035224A1 (en) * | 2002-03-21 | 2006-02-16 | Johansen Jack T | Purification methods for oligonucleotides and their analogs |
| GB0207975D0 (en) * | 2002-04-05 | 2002-05-15 | Genovision As | Isolating nucleic acid |
| GB0212826D0 (en) | 2002-05-31 | 2002-07-10 | Dna Res Innovations Ltd | Materials and methods relating to polyions and substance delivery |
| US6989442B2 (en) * | 2002-07-12 | 2006-01-24 | Sirna Therapeutics, Inc. | Deprotection and purification of oligonucleotides and their derivatives |
| DE602004018616D1 (de) | 2003-03-05 | 2009-02-05 | Ge Healthcare Bio Sciences Ab | Verfahren zur herstellung von multimodalen anionenaustauschliganden |
| SE0302911D0 (sv) * | 2003-10-31 | 2003-10-31 | Amersham Biosciences Ab | Novel separation matrix |
| US20050106589A1 (en) * | 2003-11-17 | 2005-05-19 | Hashem Akhavan-Tafti | Compositions and methods for releasing nucleic acids from solid phase binding materials |
| SE0303532D0 (sv) * | 2003-12-23 | 2003-12-23 | Amersham Biosciences Ab | Purification of immunoglobulins |
| US7479222B2 (en) * | 2004-02-05 | 2009-01-20 | Millipore Corporation | Porous adsorptive or chromatographic media |
| EP1693108A1 (en) * | 2004-12-04 | 2006-08-23 | MERCK PATENT GmbH | Mixed-modal anion-exchange type separation material |
| KR100668337B1 (ko) | 2005-05-21 | 2007-01-12 | 삼성전자주식회사 | 단백질에 비하여 핵산에 대한 결합력이 선택적으로 높은ｐＨ 의존성 이온 교환물질, 그가 고정화되어 있는 고체기판, 및 상기 물질 및 고체 기판을 이용하여 핵산을분리하는 방법 |
| CN101258175B (zh) | 2005-08-03 | 2011-11-16 | 默克专利股份公司 | 亲水交联聚合物 |
| EP1754534A1 (de) | 2005-08-03 | 2007-02-21 | MERCK PATENT GmbH | Hydrophiles vernetztes Polymer |
| GB2445442A (en) * | 2006-09-26 | 2008-07-09 | Ge Healthcare Bio Sciences | Nucleic acid purification using anion exchange |
| GB2443505B (en) * | 2006-09-26 | 2008-12-31 | Ge Healthcare Bio Sciences | Nucleic acid purification method |
| GB2445441B (en) | 2006-09-26 | 2010-06-30 | Ge Healthcare Bio Sciences | Nucleic acid purification method |
| US9433922B2 (en) | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| DE202008017854U1 (de) | 2007-08-14 | 2010-08-19 | Millipore Corp., Billerica | Mittel zur Ionenaustausch-Membranchromatographie auf der Basis von primären polymerischen Aminen, Sorptionsvorrichtung mit diesem Mittel, Chromatographieverfahren und Reinigungsverfahren unter dessen Verwendung |
| US20090130738A1 (en) * | 2007-11-19 | 2009-05-21 | Mikhail Kozlov | Media for membrane ion exchange chromatography |
| WO2009100172A1 (en) | 2008-02-07 | 2009-08-13 | Ge Healthcare Bio-Sciences Corp. | Isolation of dna, rna and protein from a single sample |
| WO2009126603A1 (en) | 2008-04-08 | 2009-10-15 | Bio-Rad Laboratories, Inc. | Chromatography purification of antibodies |
| WO2009145722A1 (en) * | 2008-05-30 | 2009-12-03 | Ge Healthcare Bio-Sciences Ab | Separation method utilizing polyallylamine ligands |
| CN105911183B (zh) * | 2011-02-10 | 2019-03-22 | 积水医疗株式会社 | 离子交换色谱法用填充剂以及核酸链的分离检测方法 |
| CN104812491B (zh) | 2012-03-08 | 2018-06-19 | 生物辐射实验室股份有限公司 | 阴离子交换-疏水性混合模式 |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| MY195756A (en) * | 2012-09-17 | 2023-02-09 | Grace W R & Co | Functionalized Particulate Support Material and Methods of Making and Using the Same |
| MY178616A (en) | 2012-09-17 | 2020-10-19 | Grace W R & Co | Chromatography media and devices |
| EP2925432A4 (en) * | 2012-11-29 | 2016-08-31 | Affigel Ab | SUPER-HYDROXYLATED ADSORBENTS AND USES THEREOF |
| JP6853670B2 (ja) | 2014-01-16 | 2021-04-07 | ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ | 親和性クロマトグラフィー媒体及びクロマトグラフィーデバイス |
| WO2015137860A1 (en) * | 2014-03-14 | 2015-09-17 | Ge Healthcare Bio-Sciences Ab | Separation matrices for purification of biological particles |
| JP6914189B2 (ja) | 2014-05-02 | 2021-08-04 | ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ | 官能化担体材料並びに官能化担体材料を作製及び使用する方法 |
| SG11201609908VA (en) | 2014-05-28 | 2016-12-29 | Agency Science Tech & Res | Virus reduction method |
| EP3286172B1 (en) | 2015-04-23 | 2019-06-12 | Constellation Pharmaceuticals, Inc. | Lsd1 inhibitors and uses thereof |
| CN107921407B (zh) | 2015-06-05 | 2022-07-05 | 格雷斯公司 | 生物处理吸附澄清剂及其制备和使用方法 |
| US11059856B2 (en) * | 2016-09-15 | 2021-07-13 | Klawego Gmbh & Co. Kg | Use of a polymeric mesh for the purification of macromolecules |
| LT3532459T (lt) | 2016-10-26 | 2023-11-10 | Constellation Pharmaceuticals, Inc. | Lsd1 inhibitoriai ir jų medicininis panaudojimas |
| EP3644055B1 (en) * | 2017-06-22 | 2022-04-13 | Showa Denko K.K. | Separation/analysis method for mixture of oligonucleotides |
| CN111683976B (zh) | 2018-02-05 | 2022-11-18 | 生物辐射实验室股份有限公司 | 具有阴离子交换-疏水混合模式配体的色谱树脂 |
| CN111818980B (zh) | 2018-03-08 | 2022-10-11 | 生物辐射实验室股份有限公司 | 阴离子交换-疏水混合模式色谱树脂 |
| CN114040815B (zh) | 2019-09-05 | 2024-06-28 | 生物辐射实验室股份有限公司 | 阴离子交换-疏水混合模式色谱树脂 |
| WO2021111418A1 (en) | 2019-12-05 | 2021-06-10 | Waters Technologies Corporation | Polyphosphonic acids for improving recovery and minimizing system loss |
| US20220017887A1 (en) * | 2020-07-14 | 2022-01-20 | Waters Technologies Corporation | Compositions, kits and methods useful for separating oligonucleotides from matrix components |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767670A (en) * | 1987-01-21 | 1988-08-30 | E. I. Du Pont De Nemours And Company | Chromatographic supports for separation of oligonucleotides |
| SE8902315D0 (sv) * | 1989-06-27 | 1989-06-27 | Pharmacia Ab | Anjonbytare |
| US5087359A (en) * | 1989-08-07 | 1992-02-11 | J. T. Baker Inc. | Quaternized PEI silica solid supports for chromatography |
| EP0416748B1 (en) * | 1989-08-07 | 1994-03-30 | J.T. Baker Inc. | Quaternised pei silica solid supports for chromatography |
| SE9004129D0 (sv) * | 1990-12-21 | 1990-12-21 | Pharmacia Lkb Biotech | Anion exchanger |
-
1996
- 1996-02-19 SE SE9600590A patent/SE9600590D0/xx unknown
-
1997
- 1997-02-14 AU AU18180/97A patent/AU713635B2/en not_active Ceased
- 1997-02-14 DE DE69729182T patent/DE69729182T2/de not_active Expired - Lifetime
- 1997-02-14 EP EP97903706A patent/EP0888157B1/en not_active Expired - Lifetime
- 1997-02-14 US US09/117,678 patent/US6090288A/en not_active Expired - Lifetime
- 1997-02-14 WO PCT/SE1997/000237 patent/WO1997029825A1/en not_active Ceased
- 1997-02-14 AT AT97903706T patent/ATE267037T1/de not_active IP Right Cessation
- 1997-02-14 JP JP52927797A patent/JP4422797B2/ja not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103314290A (zh) * | 2011-01-12 | 2013-09-18 | 积水医疗株式会社 | 离子交换色谱法用洗脱液以及核酸链的分析方法 |
| CN103314290B (zh) * | 2011-01-12 | 2015-07-01 | 积水医疗株式会社 | 核酸链的分离方法 |
| US9447460B2 (en) | 2011-01-12 | 2016-09-20 | Sekisui Medical Co., Ltd. | Method for detecting single nucleotide polymorphisms |
| US9481881B2 (en) | 2011-01-12 | 2016-11-01 | Sekisui Medical Co., Ltd. | Eluent for ion-exchange chromatography, and method of analyzing nucleic acid chains |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0888157A1 (en) | 1999-01-07 |
| ATE267037T1 (de) | 2004-06-15 |
| DE69729182D1 (de) | 2004-06-24 |
| WO1997029825A1 (en) | 1997-08-21 |
| AU713635B2 (en) | 1999-12-09 |
| SE9600590D0 (sv) | 1996-02-19 |
| US6090288A (en) | 2000-07-18 |
| EP0888157B1 (en) | 2004-05-19 |
| JP2000504625A (ja) | 2000-04-18 |
| AU1818097A (en) | 1997-09-02 |
| JP4422797B2 (ja) | 2010-02-24 |
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