DE69719557T2 - Verbesserte erkennung von spezifischen nukleinsäuren - Google Patents
Verbesserte erkennung von spezifischen nukleinsäuren Download PDFInfo
- Publication number
- DE69719557T2 DE69719557T2 DE69719557T DE69719557T DE69719557T2 DE 69719557 T2 DE69719557 T2 DE 69719557T2 DE 69719557 T DE69719557 T DE 69719557T DE 69719557 T DE69719557 T DE 69719557T DE 69719557 T2 DE69719557 T2 DE 69719557T2
- Authority
- DE
- Germany
- Prior art keywords
- probe
- target
- function
- sequence
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9601676 | 1996-04-30 | ||
| SE9601676A SE9601676D0 (sv) | 1996-04-30 | 1996-04-30 | Improved probing of specific mucleic acids |
| PCT/SE1997/000737 WO1997041254A1 (en) | 1996-04-30 | 1997-04-30 | Improved probing of specific nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69719557D1 DE69719557D1 (de) | 2003-04-10 |
| DE69719557T2 true DE69719557T2 (de) | 2004-02-26 |
Family
ID=20402429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69719557T Expired - Lifetime DE69719557T2 (de) | 1996-04-30 | 1997-04-30 | Verbesserte erkennung von spezifischen nukleinsäuren |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20010007742A1 (enExample) |
| EP (1) | EP0951565B1 (enExample) |
| JP (1) | JP2000508920A (enExample) |
| AT (1) | ATE233826T1 (enExample) |
| CA (1) | CA2252817C (enExample) |
| DE (1) | DE69719557T2 (enExample) |
| SE (1) | SE9601676D0 (enExample) |
| WO (1) | WO1997041254A1 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994003624A1 (en) | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
| US6261808B1 (en) * | 1992-08-04 | 2001-07-17 | Replicon, Inc. | Amplification of nucleic acid molecules via circular replicons |
| US20050053957A1 (en) * | 2002-11-19 | 2005-03-10 | Applera Corporation | Polynucleotide sequence detection assays |
| AU2003294417A1 (en) * | 2002-11-19 | 2004-06-15 | Applera Corporation | Polynucleotide sequence detection assays and analysis |
| EP1641936B1 (en) | 2003-06-17 | 2010-08-04 | Human Genetic Signatures PTY Ltd. | Methods for genome amplification |
| JP4714148B2 (ja) * | 2003-09-04 | 2011-06-29 | ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド | 核酸検出アッセイ |
| US8168777B2 (en) | 2004-04-29 | 2012-05-01 | Human Genetic Signatures Pty. Ltd. | Bisulphite reagent treatment of nucleic acid |
| EP1756307A1 (en) * | 2004-05-20 | 2007-02-28 | Trillion Genomics Limited | Use of mass labelled probes to detect target nucleic acids using mass spectrometry |
| WO2006026828A1 (en) | 2004-09-10 | 2006-03-16 | Human Genetic Signatures Pty Ltd | Amplification blocker comprising intercalating nucleic acids (tna) containing intercalating pseudonucleotides (ipn) |
| KR101293713B1 (ko) | 2004-12-03 | 2013-08-12 | 휴먼 제네틱 시그너처스 피티와이 엘티디 | 시토신의 화학적 변형에 의한 미생물 핵산의 단순화 방법 |
| AU2006251866B2 (en) | 2005-05-26 | 2007-11-29 | Human Genetic Signatures Pty Ltd | Isothermal strand displacement amplification using primers containing a non-regular base |
| US8343738B2 (en) | 2005-09-14 | 2013-01-01 | Human Genetic Signatures Pty. Ltd. | Assay for screening for potential cervical cancer |
| EP1879377A3 (en) * | 2006-07-13 | 2010-06-16 | Panasonic Corporation | Portable Device |
| EP2215250B1 (en) | 2007-11-27 | 2013-02-27 | Human Genetic Signatures Pty Ltd | Enzymes for amplification and copying bisulphite modified nucleic acids |
| WO2009121021A1 (en) * | 2008-03-28 | 2009-10-01 | Life Technologies Corporation | Degradable arrays for preventing reuse |
| US20110159499A1 (en) * | 2009-11-25 | 2011-06-30 | Quantalife, Inc. | Methods and compositions for detecting genetic material |
| WO2010065568A2 (en) | 2008-12-01 | 2010-06-10 | Laboratory Corporation Of America Holdings | METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95 |
| KR20110120891A (ko) | 2009-01-15 | 2011-11-04 | 래버러토리 코포레이션 오브 아메리카 홀딩스 | Her-3의 측정에 의한 환자 반응의 결정 방법 |
| BRPI1007048A2 (pt) * | 2009-01-15 | 2016-02-10 | Lab Corp America Holdings | método e kit para correlacionar os níveis relativos da quantidade de pelo menos um de her-2 ou homodímeros de her-2 em uma amostra biológica de um indivíduo, e , método para prognosticar se um indivíduo com câncer e que é tratado com um agente que atua em her-2 é provável ter um evento significante. |
| CA2760439A1 (en) | 2009-04-30 | 2010-11-04 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
| US12129514B2 (en) | 2009-04-30 | 2024-10-29 | Molecular Loop Biosolutions, Llc | Methods and compositions for evaluating genetic markers |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| WO2012109500A2 (en) | 2011-02-09 | 2012-08-16 | Bio-Rad Laboratories, Inc. | Analysis of nucleic acids |
| US8551708B2 (en) | 2011-02-15 | 2013-10-08 | Leica Biosystems Newcastle Ltd. | Methods for localized in situ detection of mRNA |
| US9556473B2 (en) | 2011-02-15 | 2017-01-31 | Leica Biosystems Newcastle Ltd | Methods for identifying nucleic acid sequences |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| US8932819B2 (en) | 2011-07-06 | 2015-01-13 | Affymetrix, Inc. | Assays for affinity profiling of nucleic acid binding proteins |
| BR112014005253B1 (pt) | 2011-09-07 | 2019-11-05 | Human Genetic Signatures Pty Ltd | método de detecção molecular |
| US9228233B2 (en) | 2011-10-17 | 2016-01-05 | Good Start Genetics, Inc. | Analysis methods |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
| AU2014248759B2 (en) | 2013-03-13 | 2020-02-27 | Meso Scale Technologies, Llc. | Improved assay methods |
| US8778609B1 (en) | 2013-03-14 | 2014-07-15 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| BR112015023775B1 (pt) | 2013-03-15 | 2022-08-16 | Lubrizol Advanced Materials, Inc | Composições de cpvc isentas de metal pesado |
| EP3005200A2 (en) | 2013-06-03 | 2016-04-13 | Good Start Genetics, Inc. | Methods and systems for storing sequence read data |
| WO2015013681A1 (en) | 2013-07-25 | 2015-01-29 | Bio-Rad Laboratories, Inc. | Genetic assays |
| US11041203B2 (en) | 2013-10-18 | 2021-06-22 | Molecular Loop Biosolutions, Inc. | Methods for assessing a genomic region of a subject |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| WO2015175530A1 (en) | 2014-05-12 | 2015-11-19 | Gore Athurva | Methods for detecting aneuploidy |
| KR20250011724A (ko) | 2014-05-15 | 2025-01-21 | 메소 스케일 테크놀러지즈, 엘엘시 | 개선된 분석 방법 |
| CA2949732C (en) | 2014-06-13 | 2023-01-17 | Q-Linea Ab | Method for detecting and characterising a microorganism |
| US20160048608A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
| WO2016048829A1 (en) | 2014-09-24 | 2016-03-31 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
| EP3209798B1 (en) | 2014-10-23 | 2022-07-27 | Ricardo Mancebo | Reagents and methods for isothermal chain reaction |
| US10066259B2 (en) | 2015-01-06 | 2018-09-04 | Good Start Genetics, Inc. | Screening for structural variants |
| GB201507026D0 (en) | 2015-04-24 | 2015-06-10 | Linea Ab Q | Medical sample transportation container |
| US10465245B2 (en) | 2015-07-29 | 2019-11-05 | Progenity, Inc. | Nucleic acids and methods for detecting chromosomal abnormalities |
| US20170298427A1 (en) | 2015-11-16 | 2017-10-19 | Progenity, Inc. | Nucleic acids and methods for detecting methylation status |
| GB2554767A (en) | 2016-04-21 | 2018-04-11 | Q Linea Ab | Detecting and characterising a microorganism |
| EP4614155A3 (en) | 2016-12-01 | 2025-10-15 | Nautilus Subsidiary, Inc. | Methods of assaying proteins |
| CA3056650A1 (en) | 2017-03-30 | 2018-10-04 | Pioneer Hi-Bred International, Inc. | Methods of identifying and characterizing gene editing variations in nucleic acids |
| AU2018395430B2 (en) | 2017-12-29 | 2024-05-23 | Nautilus Subsidiary, Inc. | Decoding approaches for protein identification |
| WO2019195346A1 (en) | 2018-04-02 | 2019-10-10 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
| AU2020232954A1 (en) | 2019-03-01 | 2021-09-09 | Meso Scale Technologies, Llc. | Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same |
| EP3947718A4 (en) | 2019-04-02 | 2022-12-21 | Enumera Molecular, Inc. | METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES |
| JP7727628B2 (ja) | 2019-12-03 | 2025-08-21 | アラマー バイオサイエンシーズ, インク. | 核酸結合免疫サンドイッチアッセイ(nulisa) |
| EP4165549A1 (en) | 2020-06-11 | 2023-04-19 | Nautilus Biotechnology, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
| WO2022061305A1 (en) | 2020-09-21 | 2022-03-24 | Progenity, Inc. | Compositions and methods for isolation of cell-free dna |
| US12092642B2 (en) | 2021-01-20 | 2024-09-17 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule quantitation |
| US20220227890A1 (en) | 2021-01-21 | 2022-07-21 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| EP4405683A1 (en) | 2021-09-22 | 2024-07-31 | Nautilus Subsidiary, Inc. | Methods and systems for determining polypeptide interactions |
| US20230149883A1 (en) | 2021-11-03 | 2023-05-18 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| WO2023192917A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
| US20230360732A1 (en) | 2022-04-25 | 2023-11-09 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| EP4630816A1 (en) | 2022-12-09 | 2025-10-15 | Nautilus Subsidiary, Inc. | A method comprising performing on a single-analyte array at least 50 cycles of a process |
| EP4634285A1 (en) | 2022-12-15 | 2025-10-22 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| WO2024206122A1 (en) | 2023-03-24 | 2024-10-03 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| US20240394902A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| US20250066841A1 (en) | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| WO2025128588A1 (en) | 2023-12-11 | 2025-06-19 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| WO2025137166A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| WO2025199236A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5427930A (en) * | 1990-01-26 | 1995-06-27 | Abbott Laboratories | Amplification of target nucleic acids using gap filling ligase chain reaction |
| SE9400522D0 (sv) * | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US5643724A (en) * | 1994-06-06 | 1997-07-01 | Roche Molecular Systems, Inc. | Methods and reagents for Glycophorin A typing |
| GB9414934D0 (en) * | 1994-07-25 | 1994-09-14 | Raggio Italgene Spa | Method and reagents for the detection of target nuceic acid sequences |
| DE69527444T3 (de) | 1995-07-11 | 2007-08-16 | Forfas (Trading As Bioresearch Ireland) | Glycosylase verwendende detektion von bestimmten nukleinsäuresequenzen |
-
1996
- 1996-04-30 SE SE9601676A patent/SE9601676D0/xx unknown
-
1997
- 1997-04-30 DE DE69719557T patent/DE69719557T2/de not_active Expired - Lifetime
- 1997-04-30 AT AT97921072T patent/ATE233826T1/de not_active IP Right Cessation
- 1997-04-30 CA CA002252817A patent/CA2252817C/en not_active Expired - Lifetime
- 1997-04-30 WO PCT/SE1997/000737 patent/WO1997041254A1/en not_active Ceased
- 1997-04-30 EP EP97921072A patent/EP0951565B1/en not_active Expired - Lifetime
- 1997-04-30 JP JP9538820A patent/JP2000508920A/ja not_active Ceased
- 1997-04-30 US US09/171,935 patent/US20010007742A1/en not_active Abandoned
-
2001
- 2001-12-31 US US10/029,913 patent/US7351528B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0951565A1 (en) | 1999-10-27 |
| US7351528B2 (en) | 2008-04-01 |
| DE69719557D1 (de) | 2003-04-10 |
| US20010007742A1 (en) | 2001-07-12 |
| CA2252817C (en) | 2009-07-07 |
| EP0951565B1 (en) | 2003-03-05 |
| ATE233826T1 (de) | 2003-03-15 |
| US20020102592A1 (en) | 2002-08-01 |
| CA2252817A1 (en) | 1997-11-06 |
| JP2000508920A (ja) | 2000-07-18 |
| WO1997041254A1 (en) | 1997-11-06 |
| SE9601676D0 (sv) | 1996-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LANDEGREN GENE TECHNOLOGY AB, UPPSALA, SE |
|
| 8381 | Inventor (new situation) |
Inventor name: LANDEGREN, ULF, 756 45 UPPSALA, SE |
|
| 8364 | No opposition during term of opposition |