ATE233826T1 - Verbesserte erkennung von spezifischen nukleinsäuren - Google Patents

Verbesserte erkennung von spezifischen nukleinsäuren

Info

Publication number
ATE233826T1
ATE233826T1 AT97921072T AT97921072T ATE233826T1 AT E233826 T1 ATE233826 T1 AT E233826T1 AT 97921072 T AT97921072 T AT 97921072T AT 97921072 T AT97921072 T AT 97921072T AT E233826 T1 ATE233826 T1 AT E233826T1
Authority
AT
Austria
Prior art keywords
nucleic acids
specific nucleic
improved detection
target
sequence
Prior art date
Application number
AT97921072T
Other languages
English (en)
Inventor
Ulf Landegren
Original Assignee
Ulf Landegren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulf Landegren filed Critical Ulf Landegren
Application granted granted Critical
Publication of ATE233826T1 publication Critical patent/ATE233826T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT97921072T 1996-04-30 1997-04-30 Verbesserte erkennung von spezifischen nukleinsäuren ATE233826T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9601676A SE9601676D0 (sv) 1996-04-30 1996-04-30 Improved probing of specific mucleic acids
PCT/SE1997/000737 WO1997041254A1 (en) 1996-04-30 1997-04-30 Improved probing of specific nucleic acids

Publications (1)

Publication Number Publication Date
ATE233826T1 true ATE233826T1 (de) 2003-03-15

Family

ID=20402429

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97921072T ATE233826T1 (de) 1996-04-30 1997-04-30 Verbesserte erkennung von spezifischen nukleinsäuren

Country Status (8)

Country Link
US (2) US20010007742A1 (de)
EP (1) EP0951565B1 (de)
JP (1) JP2000508920A (de)
AT (1) ATE233826T1 (de)
CA (1) CA2252817C (de)
DE (1) DE69719557T2 (de)
SE (1) SE9601676D0 (de)
WO (1) WO1997041254A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) * 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
EP1572974A2 (de) * 2002-11-19 2005-09-14 Applera Corporation Polynukleotidsequenznachweistests und-analyse
AU2003295745A1 (en) * 2002-11-19 2004-06-15 Applera Corporation Polynucleotide sequence detection assays
EP1641936B1 (de) 2003-06-17 2010-08-04 Human Genetic Signatures PTY Ltd. Verfahren zur genomamplifikation
CA2537810C (en) * 2003-09-04 2012-12-18 Human Genetic Signatures Pty Ltd Nucleic acid detection assay
US8168777B2 (en) 2004-04-29 2012-05-01 Human Genetic Signatures Pty. Ltd. Bisulphite reagent treatment of nucleic acid
EP1756307A1 (de) * 2004-05-20 2007-02-28 Trillion Genomics Limited Verwendung massenmarkierter sonden zum nachweis von zielnukleinsäuren mittels massenspektrometrie
JP4980219B2 (ja) 2004-09-10 2012-07-18 ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド インターカレート型擬似ヌクレオチド(ipn)を含有するインターカレーティング核酸(ina)を含む増幅ブロッカー
KR101293713B1 (ko) 2004-12-03 2013-08-12 휴먼 제네틱 시그너처스 피티와이 엘티디 시토신의 화학적 변형에 의한 미생물 핵산의 단순화 방법
CN101203618B (zh) 2005-05-26 2013-03-13 人类遗传标记控股有限公司 使用含有非常规碱基的引物的等温链置换扩增
CN101292046B (zh) 2005-09-14 2013-03-13 人类遗传标记控股有限公司 健康状态的测定法
EP1879377A3 (de) * 2006-07-13 2010-06-16 Panasonic Corporation Tragbare Vorrichtung
CN101918595A (zh) 2007-11-27 2010-12-15 人类遗传标记控股有限公司 用于扩增和复制亚硫酸氢盐修饰的核酸的酶
WO2009121021A1 (en) * 2008-03-28 2009-10-01 Life Technologies Corporation Degradable arrays for preventing reuse
SG177252A1 (en) 2008-12-01 2012-03-29 Lab Corp America Holdings METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95
EP2387711B1 (de) 2009-01-15 2015-04-22 Laboratory Corporation of America Holdings Verfahren zur bestimmung von patientenreaktionen durch her-3-messung
WO2010083463A1 (en) * 2009-01-15 2010-07-22 Laboratory Corporation Of America Holdings Methods of determining patient response by measurement of her-2 expression
EP2425240A4 (de) 2009-04-30 2012-12-12 Good Start Genetics Inc Verfahren und zusammensetzung zur bewertung genetischer marker
WO2011066476A1 (en) * 2009-11-25 2011-06-03 Quantalife, Inc. Methods and compositions for detecting genetic material
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
EP3940084A1 (de) 2011-02-09 2022-01-19 Bio-Rad Laboratories, Inc. Analyse von nukleinsäuren
CA2827497C (en) 2011-02-15 2014-12-02 Leica Biosystems Newcastle Ltd. Method for localized in situ detection of mrna
US9556473B2 (en) 2011-02-15 2017-01-31 Leica Biosystems Newcastle Ltd Methods for identifying nucleic acid sequences
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
US8932819B2 (en) 2011-07-06 2015-01-13 Affymetrix, Inc. Assays for affinity profiling of nucleic acid binding proteins
US9732375B2 (en) 2011-09-07 2017-08-15 Human Genetic Signatures Pty. Ltd. Molecular detection assay using direct treatment with a bisulphite reagent
WO2013058907A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
CA2904181A1 (en) 2013-03-13 2014-10-09 Anahit Aghvanyan Sandwich immunoassay comprising anchoring reagent
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
EP2970631B1 (de) 2013-03-15 2017-05-03 Lubrizol Advanced Materials, Inc. Schwermetallfreie, chlorierte pvc zusammensetzungen
WO2014197377A2 (en) 2013-06-03 2014-12-11 Good Start Genetics, Inc. Methods and systems for storing sequence read data
WO2015013681A1 (en) 2013-07-25 2015-01-29 Bio-Rad Laboratories, Inc. Genetic assays
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
EP3143401A4 (de) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Verbesserte testverfahren
CA2949732C (en) 2014-06-13 2023-01-17 Q-Linea Ab Method for detecting and characterising a microorganism
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
US10429399B2 (en) 2014-09-24 2019-10-01 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
EP4098753A1 (de) 2014-10-23 2022-12-07 Ricardo Mancebo Reagenzien und verfahren für eine isothermische kettenreaktion
WO2016112073A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
GB201507026D0 (en) 2015-04-24 2015-06-10 Linea Ab Q Medical sample transportation container
ES2745556T3 (es) 2015-07-29 2020-03-02 Progenity Inc Acidos nucleicos y métodos para detectar anomalías cromosómicas
CN108779487A (zh) 2015-11-16 2018-11-09 普罗格尼迪公司 用于检测甲基化状态的核酸和方法
GB2554767A (en) 2016-04-21 2018-04-11 Q Linea Ab Detecting and characterising a microorganism
JP2020514746A (ja) 2016-12-01 2020-05-21 ノーティラス バイオテクノロジー インコーポレイテッド タンパク質をアッセイする方法
CA3056650A1 (en) 2017-03-30 2018-10-04 Pioneer Hi-Bred International, Inc. Methods of identifying and characterizing gene editing variations in nucleic acids
JP7348603B2 (ja) 2018-04-02 2023-09-21 エニュメラ・モレキュラー・インコーポレイテッド 核酸分子を計数するための方法、システム、および組成物
EP3931201A1 (de) 2019-03-01 2022-01-05 Meso Scale Technologies, LLC Elektrochemilumineszente markierte sonden zur verwendung in immunoassay-verfahren, verfahren mit verwendung davon und kits damit
EP3947718A4 (de) 2019-04-02 2022-12-21 Enumera Molecular, Inc. Verfahren, systeme und zusammensetzungen zum zählen von nukleinsäuremolekülen
EP4231174A3 (de) 2020-06-11 2023-11-01 Nautilus Subsidiary, Inc. Verfahren und syteme zur rechnerischen decodierung biologischer, chemischer und physikalischer einheiten
JP2023543424A (ja) 2020-09-21 2023-10-16 ビオラ・セラピューティクス・インコーポレイテッド 無細胞dnaを単離するための組成物および方法
CA3203106A1 (en) 2021-01-20 2022-07-28 Parag Mallick Systems and methods for biomolecule quantitation
CA3203535A1 (en) 2021-01-21 2022-07-28 Gregory KAPP Systems and methods for biomolecule preparation
IL305336A (en) 2021-03-11 2023-10-01 Nautilus Subsidiary Inc Systems and methods for the preservation of biomolecules
AU2022352593A1 (en) 2021-09-22 2024-02-15 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US20230314324A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023212490A1 (en) 2022-04-25 2023-11-02 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US20240094215A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5643724A (en) * 1994-06-06 1997-07-01 Roche Molecular Systems, Inc. Methods and reagents for Glycophorin A typing
GB9414934D0 (en) * 1994-07-25 1994-09-14 Raggio Italgene Spa Method and reagents for the detection of target nuceic acid sequences
NZ298494A (en) 1995-07-11 1999-09-29 Forfas Trading As Bioresearch Glycosylase mediated detection of nucleotide sequences at candidate loci

Also Published As

Publication number Publication date
US20010007742A1 (en) 2001-07-12
JP2000508920A (ja) 2000-07-18
US20020102592A1 (en) 2002-08-01
US7351528B2 (en) 2008-04-01
EP0951565B1 (de) 2003-03-05
DE69719557D1 (de) 2003-04-10
CA2252817A1 (en) 1997-11-06
DE69719557T2 (de) 2004-02-26
WO1997041254A1 (en) 1997-11-06
CA2252817C (en) 2009-07-07
SE9601676D0 (sv) 1996-04-30
EP0951565A1 (de) 1999-10-27

Similar Documents

Publication Publication Date Title
ATE233826T1 (de) Verbesserte erkennung von spezifischen nukleinsäuren
DK56091A (da) Nucleinsyreprober indeholdende en forbedret molekylaer omskifter samt analyser og kits, hvori disse indgaar
ES2109226T3 (es) Deteccion de secuencias de acidos nucleicos usando polarizacion de fluorescencia.
SE0000538D0 (sv) Methods and kits for proximity probing
DE68901285D1 (de) Verfahren zum nachweis von nukleotid-sequenzen.
ATE141956T1 (de) Verfahren zur vervielfältigung von nukleinsäuresequenzen
DE69506393T2 (de) Hybridisation-ligitation-verfahren zum nachweis von spezifischen dns sequenzen
DE69637726D1 (de) Gruppen zum einfangen von nukleinsäuren
ES2177590T3 (es) Deteccion de amplificacion de acidos nucleicos.
ATE515693T1 (de) Nachweis einer zielsubstanz in einer probe
DK0407789T3 (da) Fremgangsmåde til detektering af nukleinsyrer
DE59107797D1 (de) Verfahren zum Nachweis von phosphoryliertes Tyrosin enthaltenden Proteinen
KR930002371A (ko) 핵산의 고정화 방법
DE69630517D1 (de) Sonde zur anwendung in der analyse von nukleinsaüren und verfahren der detektion basierend auf excimer-fluoreszenz
ATE449868T1 (de) Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
DE69632826D1 (de) Nukleinsaeure erkennung von hepatitis gb virus
EP1008658A4 (de) Festphase zur erkennung von nukleinsäuren und verfahren zu deren erkennung
DE60132335D1 (de) Verfahren zur Detektion von Nukleinsäure-Zielmolekülen bei dem Enzym verbundenen Sonde Einfangtest sowie geeignetes Testsystem
ATE158815T1 (de) Hippurikasegen
DE69010243T2 (de) DNS-Probe zum Nachweis von Lactobacillus delbrueckii.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties