DE69715049T2 - Tranilast enthaltendes externum und verfahren zu dessen herstellung - Google Patents

Tranilast enthaltendes externum und verfahren zu dessen herstellung

Info

Publication number
DE69715049T2
DE69715049T2 DE69715049T DE69715049T DE69715049T2 DE 69715049 T2 DE69715049 T2 DE 69715049T2 DE 69715049 T DE69715049 T DE 69715049T DE 69715049 T DE69715049 T DE 69715049T DE 69715049 T2 DE69715049 T2 DE 69715049T2
Authority
DE
Germany
Prior art keywords
tranilast
active ingredient
aqueous base
solubilizer
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69715049T
Other languages
English (en)
Other versions
DE69715049D1 (de
Inventor
Masao Mori
Noriyasu Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Lead Chemical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Lead Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd, Lead Chemical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Publication of DE69715049D1 publication Critical patent/DE69715049D1/de
Application granted granted Critical
Publication of DE69715049T2 publication Critical patent/DE69715049T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69715049T 1996-02-07 1997-02-06 Tranilast enthaltendes externum und verfahren zu dessen herstellung Expired - Fee Related DE69715049T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4549396 1996-02-07
PCT/JP1997/000283 WO1997028793A1 (fr) 1996-02-07 1997-02-06 Preparation a usage externe comprenant du tranilast et processus de production de cette preparation

Publications (2)

Publication Number Publication Date
DE69715049D1 DE69715049D1 (de) 2002-10-02
DE69715049T2 true DE69715049T2 (de) 2003-04-03

Family

ID=12720933

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0974350T Pending DE974350T1 (de) 1996-02-07 1997-02-06 Tranilast enthaltendes externum und verfahren zu dessen herstellung
DE69715049T Expired - Fee Related DE69715049T2 (de) 1996-02-07 1997-02-06 Tranilast enthaltendes externum und verfahren zu dessen herstellung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0974350T Pending DE974350T1 (de) 1996-02-07 1997-02-06 Tranilast enthaltendes externum und verfahren zu dessen herstellung

Country Status (12)

Country Link
US (1) US6239177B1 (de)
EP (1) EP0974350B1 (de)
JP (1) JP4154621B2 (de)
KR (1) KR100449939B1 (de)
CN (1) CN1081030C (de)
AT (1) ATE222759T1 (de)
DE (2) DE974350T1 (de)
DK (1) DK0974350T3 (de)
ES (1) ES2151464T3 (de)
HK (1) HK1018218A1 (de)
PT (1) PT974350E (de)
WO (1) WO1997028793A1 (de)

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EP0894496A4 (de) * 1996-02-15 2001-01-03 Kissei Pharmaceutical Hemmer der gefässneubildung
JP4865958B2 (ja) * 2001-05-23 2012-02-01 株式会社トクホン 鎮痛抗炎症局所作用型の貼付剤
ATE497764T1 (de) * 2002-11-05 2011-02-15 Lead Chem Co Ltd Perkutane absorptionszubereitungen mit 3-methyl-1-phenyl-2-pyrazolin-5-on
JP2004307364A (ja) * 2003-04-03 2004-11-04 Yuutoku Yakuhin Kogyo Kk 経皮吸収貼付剤
CA2546064C (en) * 2003-11-12 2011-06-21 Lead Chemical Co., Ltd. Percutaneous absorption type cerebral protective agent
US20050106230A1 (en) * 2003-11-17 2005-05-19 Young Janel E. Drug-enhanced adhesion prevention
US9066912B2 (en) * 2003-11-17 2015-06-30 Ethicon, Inc. Drug-enhanced adhesion prevention
US20050239892A1 (en) * 2003-11-21 2005-10-27 Trustees Of Tufts College Therapeutic avenathramide compounds
US7105263B2 (en) * 2003-12-30 2006-09-12 Samsung Electronics Company Dry toner comprising encapsulated pigment, methods and uses
JP4590224B2 (ja) * 2004-07-20 2010-12-01 株式会社日本点眼薬研究所 トラニラストまたは薬理学的に許容される塩を含有する懸濁性医薬組成物
JP4843824B2 (ja) * 2004-08-18 2011-12-21 株式会社 メドレックス 外用剤
US7473738B2 (en) * 2004-09-30 2009-01-06 Johnson & Johnson Vision Care, Inc. Lactam polymer derivatives
US20080009519A1 (en) * 2004-11-17 2008-01-10 Lawrence Steinman Method of modulating t cell functioning
ZA200704871B (en) * 2004-11-17 2008-09-25 Angiogen Pharmaceuticals Pty L A method of modulating B cell functioning
JP2007051089A (ja) * 2005-08-18 2007-03-01 Medorekkusu:Kk 外用剤
EP1946753A4 (de) * 2005-10-21 2009-05-13 Medrx Co Ltd Zubereitung zur topischen applikation mit einem salz eines mastzellen-degranulationshemmers mit einer carboxy-gruppe mit organischem amin
JP4959991B2 (ja) * 2006-03-03 2012-06-27 株式会社日本点眼薬研究所 トラニラストまたはその薬理学的に許容される塩を含有する懸濁性医薬組成物
AU2007271734B2 (en) 2006-07-05 2012-03-29 Certa Therapeutics Pty. Ltd. Therapeutic compounds
US8668703B2 (en) * 2006-12-01 2014-03-11 Wake Forest University Health Sciences Medical devices incorporating collagen inhibitors
EP2030617A1 (de) * 2007-08-17 2009-03-04 Sygnis Bioscience GmbH & Co. KG Verwendungen von Tranilast und Derivaten daraus zur Behandlung neurologischer Leiden
CN101152164B (zh) * 2007-09-14 2011-04-06 李世荣 含有抗肥大细胞类药物的抗瘢痕外用贴膜及其制备方法
CN101152163B (zh) * 2007-09-14 2010-05-26 李世荣 含有激素类药物的抗瘢痕外用贴膜及其制备方法
US9062076B2 (en) 2009-10-22 2015-06-23 Fibrotech Therapeutics Pty Ltd Fused ring analogues of anti-fibrotic agents
KR101593339B1 (ko) * 2011-06-20 2016-02-11 히사미쓰 세이야꾸 가부시키가이샤 리도카인 함유 파프제
JP6096021B2 (ja) * 2013-03-22 2017-03-15 ファイテン株式会社 顎関節症用外用剤
JP6558117B2 (ja) * 2014-08-19 2019-08-14 大正製薬株式会社 皮膚用剤
MA41266A (fr) * 2014-12-22 2017-10-31 Hisamitsu Pharmaceutical Co Cataplasme
EP3263097B1 (de) 2015-02-24 2021-08-25 Hisamitsu Pharmaceutical Co., Inc. Haftender hautwickel
CN104784101A (zh) * 2015-03-05 2015-07-22 中国药科大学制药有限公司 一种曲尼司特凝胶和软膏剂的处方及制备方法
KR101691472B1 (ko) 2015-07-06 2017-01-09 이광재 배낭에 탈착이 용이한 스틱 걸이
EP3503884B1 (de) * 2016-08-23 2021-07-21 Neurim Pharmaceuticals Ltd. Pharmazeutische zusammensetzung zur verwendung bei der behandlung von pruritus und/oder juckreiz
CN110546133A (zh) 2017-02-03 2019-12-06 塞尔塔治疗有限公司 抗纤维化化合物
CN108324724A (zh) * 2018-04-10 2018-07-27 苏州芝宇生物科技有限公司 一种克立硼罗可溶性膜制剂的制法及其应用
CN113423394A (zh) 2019-02-14 2021-09-21 久光制药株式会社 泥罨剂

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US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
JPS62169723A (ja) * 1986-01-22 1987-07-25 Teisan Seiyaku Kk 徐放化製剤
JPS63238024A (ja) * 1987-03-26 1988-10-04 Towa Yakuhin Kk 水難溶性薬物を含有する外用ゲル組成物
EP0303445A1 (de) * 1987-08-13 1989-02-15 Walton S.A. Pflaster zur transdermalen Applikation von Cleboprid
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
JPH01294620A (ja) * 1988-05-19 1989-11-28 Kissei Pharmaceut Co Ltd 水溶液製剤およびその製造方法
JPH07116029B2 (ja) * 1989-04-04 1995-12-13 キッセイ薬品工業株式会社 トラニラスト水溶液製剤
JPH0794378B2 (ja) 1989-08-18 1995-10-11 久光製薬株式会社 エアゾール剤
JP3243564B2 (ja) * 1990-08-20 2002-01-07 リードケミカル株式会社 外用貼付剤
JPH05178763A (ja) * 1991-02-19 1993-07-20 Nippon Saafuakutanto Kogyo Kk 難溶解性薬物溶解剤組成物
JPH05163222A (ja) * 1991-12-18 1993-06-29 Kissei Pharmaceut Co Ltd コラーゲン過剰合成疾患治療剤
US5989586A (en) * 1992-10-05 1999-11-23 Cygnus, Inc. Two-phase matrix for sustained release drug delivery device
JPH06128153A (ja) * 1992-10-16 1994-05-10 Kissei Pharmaceut Co Ltd トラニラスト軟膏組成物およびその製造方法
AU667161B2 (en) * 1993-04-28 1996-03-07 Daiichi Pharmaceutical Co., Ltd. Butyrophenone transdermal compositions
PT698393E (pt) * 1993-05-19 2002-10-31 Hisamitsu Pharmaceutical Co Agente de solubilizacao e preparacao para uso externo contendo o mesmo
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Also Published As

Publication number Publication date
JP4154621B2 (ja) 2008-09-24
DE69715049D1 (de) 2002-10-02
KR19990082254A (ko) 1999-11-25
ES2151464T1 (es) 2001-01-01
CN1210462A (zh) 1999-03-10
HK1018218A1 (en) 1999-12-17
US6239177B1 (en) 2001-05-29
CN1081030C (zh) 2002-03-20
EP0974350A4 (de) 2000-01-26
EP0974350A1 (de) 2000-01-26
WO1997028793A1 (fr) 1997-08-14
ES2151464T3 (es) 2002-12-16
KR100449939B1 (ko) 2004-11-20
DK0974350T3 (da) 2002-11-25
DE974350T1 (de) 2001-01-25
ATE222759T1 (de) 2002-09-15
PT974350E (pt) 2002-12-31
EP0974350B1 (de) 2002-08-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee