BR0009771A - Utilização de derivados de bisindóis indigóides capazes de penetrarem na membrana de células - Google Patents

Utilização de derivados de bisindóis indigóides capazes de penetrarem na membrana de células

Info

Publication number
BR0009771A
BR0009771A BR0009771-3A BR0009771A BR0009771A BR 0009771 A BR0009771 A BR 0009771A BR 0009771 A BR0009771 A BR 0009771A BR 0009771 A BR0009771 A BR 0009771A
Authority
BR
Brazil
Prior art keywords
derivatives
cell membrane
penetrating
indigoid
bisindoles
Prior art date
Application number
BR0009771-3A
Other languages
English (en)
Inventor
Gerhard Eisenbrand
Heinz Herbert Fiebig
Ralph Hoessel
Doris Marko
Weici Tang
Original Assignee
Gerhard Eisenbrand
Heinz Herbert Fiebig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gerhard Eisenbrand, Heinz Herbert Fiebig filed Critical Gerhard Eisenbrand
Publication of BR0009771A publication Critical patent/BR0009771A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"<UM>UTILIZAçãO DE DERIVADOS DE BISINDóIS INDIGóIDES CAPAZES DE PENETRAREM NA MEMBRANA DE CéLULAS<MV>". A presente invenção refere-se ao uso de derivados de bisindóis indigóides capazes de penetrarem na membrana de células, para a manufatura de um medicamento adequado para o tratamento de canceres sólidos humanos.
BR0009771-3A 1999-04-12 2000-04-11 Utilização de derivados de bisindóis indigóides capazes de penetrarem na membrana de células BR0009771A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99106206 1999-04-12
EP99107474 1999-04-29
PCT/EP2000/003210 WO2000061124A2 (en) 1999-04-12 2000-04-11 Use off cell membrane penetrating indigoid bisindole derivatives

Publications (1)

Publication Number Publication Date
BR0009771A true BR0009771A (pt) 2002-01-08

Family

ID=26152939

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009771-3A BR0009771A (pt) 1999-04-12 2000-04-11 Utilização de derivados de bisindóis indigóides capazes de penetrarem na membrana de células

Country Status (11)

Country Link
US (1) US6664285B1 (pt)
EP (1) EP1218004B1 (pt)
JP (1) JP2002541189A (pt)
CN (1) CN1378447A (pt)
AT (1) ATE427746T1 (pt)
AU (1) AU775633B2 (pt)
BR (1) BR0009771A (pt)
CA (1) CA2369626C (pt)
DE (1) DE60041974D1 (pt)
MX (1) MXPA01010436A (pt)
WO (1) WO2000061124A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125763A1 (de) * 2001-05-17 2002-11-28 Schering Ag Verwendung selektiver Indirubinderivate als VEGF-R Inhibitoren
US20050154046A1 (en) 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
AU2002357191A1 (en) * 2001-12-13 2003-06-30 Natrogen Therapeutics, Inc. Derivatives of isoindigo, indigo and indirubin and use in treating cancer
US8563525B2 (en) 2004-01-12 2013-10-22 Natrogen Therapeutics International, Inc. Methods of treating an inflammatory-related disease
US7582670B2 (en) 2001-12-13 2009-09-01 Natrogen Therapeutics, Inc. Methods of treating an inflammatory-related disease
EP1340745A1 (en) * 2002-02-20 2003-09-03 Gerhard Prof. Dr. Eisenbrand Indirubin derivatives and their use for the treatment of cancer
KR100588803B1 (ko) * 2004-01-27 2006-06-12 학교법인조선대학교 암세포주에 항암활성을 지닌 인디루빈 유도체
FR2952819A1 (fr) * 2009-11-23 2011-05-27 Oreal Composition contenant au moins un precurseur de coloration derive d'oxindole et au moins un colorant indoline dione
AU2013234955A1 (en) 2012-03-23 2014-11-13 Dennis Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
CN103333161B (zh) * 2013-05-28 2015-09-30 滁州市洛达生物科技有限公司 1’-氧代靛玉红的制备和用途
CN103274987A (zh) * 2013-06-07 2013-09-04 华东师范大学 3,3-二取代氧化吲哚衍生物及其合成方法和应用
CN103342674B (zh) * 2013-07-05 2015-08-19 华东师范大学 一类光学活性吡咯衍生物及其合成方法
KR101493324B1 (ko) 2013-07-11 2015-02-16 연세대학교 산학협력단 인디루빈 유도체를 포함하는 골길이 성장 촉진용 조성물
CN110305056A (zh) * 2019-05-22 2019-10-08 西北大学 靛玉红新衍生物及其药用用途
CN114533755B (zh) * 2022-03-23 2024-05-03 遵义医科大学 一种绞股蓝多糖与靛玉红在抗黑色素瘤药物上的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS609022B2 (ja) * 1981-06-19 1985-03-07 イスクラ産業株式会社 インジルビン誘導体およびそれを含有する抗腫瘍剤
JPS609023B2 (ja) * 1981-06-19 1985-03-07 イスクラ産業株式会社 インジルビン誘導体およびそれを含有する抗腫瘍剤
JPS617254A (ja) * 1984-06-20 1986-01-13 Isukura Sangyo Kk ビスインドリノンおよびそれを主成分とする制癌剤
US5935581A (en) * 1996-07-24 1999-08-10 Kapadia; Govind J. Inhibitory effects of synthetic and natural colorants on carcinogenesis
CA2333661A1 (en) * 1998-05-29 1999-12-09 Cnrs (Centre National De Recherche Scientifique) France Innovation Scien Tifique Et Transfernt Use of indigoid bisindole derivatives for the manufacture of a medicament to inhibit cyclin dependent kinases
CN1207924A (zh) * 1998-08-07 1999-02-17 刘克贤 治疗口腔、咽喉、食道疾病的药物及其制备方法
SK14272001A3 (sk) 1999-04-12 2002-05-09 Gerhard Eisenbrand Indigoidné bisindolové deriváty

Also Published As

Publication number Publication date
DE60041974D1 (de) 2009-05-20
US6664285B1 (en) 2003-12-16
MXPA01010436A (es) 2002-09-18
CA2369626C (en) 2009-01-13
CN1378447A (zh) 2002-11-06
WO2000061124A2 (en) 2000-10-19
WO2000061124A3 (en) 2002-05-02
AU4294900A (en) 2000-11-14
EP1218004B1 (en) 2009-04-08
EP1218004A2 (en) 2002-07-03
JP2002541189A (ja) 2002-12-03
CA2369626A1 (en) 2000-10-19
ATE427746T1 (de) 2009-04-15
AU775633B2 (en) 2004-08-05

Similar Documents

Publication Publication Date Title
BR0009770A (pt) Derivados de bisindóis indigóides capazes de penetrarem na membrana de células, formulação farmacêutica e utilização da mesma
BR0009771A (pt) Utilização de derivados de bisindóis indigóides capazes de penetrarem na membrana de células
EP0974350A4 (en) EXTERNAL CONTAINING TRANILAST AND METHOD FOR THE PRODUCTION THEREOF
AR052921A1 (es) Uso de ranolazina para la preparacion de una composicion farmaceutica y composicion farmaceutica
BR0113643A (pt) Compostos de guanidinobenzamidas como agonistas de mc4-r e seus usos
ES2161085T3 (es) Formulaciones que contienen oxaliplatino.
TR200101339T2 (tr) Potasyum kanal modülatörleri olarak 3-yer-alanlı-4-arilkinolin-2-on türevleri, 3,4-okzadiazolon türevleri
SV2002000245A (es) Oxazolidinonas substituidas y su uso ref. lea 34122-sv
BR0111358A (pt) Compostos de tioacetamida e seu uso
BR9914638A (pt) Composto, método para a preparação do mesmo, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio ou doença de um corpo de animal vivo
UY26082A1 (es) Derivados de 1,4-diazabiciclo [3.2.2] nonan-4-carboxilato y -carboxamidas, su preparacion y su aplicacion en terapeutica
DE69921318D1 (de) Tensid für äusserlich anzuwendende hautpräparate und diese beinhaltende äusserlich anzuwendende hautpräparate
TR200000576T1 (tr) Lipozomal kapsüllenmiş taksan uygulanması için bir yöntem
FR2784294B1 (fr) Composition cosmetique et/ou dermatologique renfermant au moins un extrait de murier, au moins un extrait de scutellaire et au moins un derive d&#39;acide salicylique
BRPI0111639B8 (pt) uso de uma molécula de ácido oligodeoxinucléico imunoestimulatório e composição farmacêutica.
CA2356310A1 (en) External preparations containing a basic drug
EA200100154A1 (ru) Бензоциклогептены, способ их получения, содержащие их фармацевтические препараты и их применение для получения лекарственных средств
ATE370730T1 (de) Pharmazeutische zubereitungen, die chelatbildner/sequestriermittel enthalten und deren dermatologische verwendung
BR9704554B1 (pt) utilizaÇço de lipÍdios complexos como adiÇÕes de estabilizaÇço para composiÇÕes farmacÊuticas de misturas de enzimas de digestço, composiÇÕes farmacÊuticas soléveis em Água e kit para preparaÇço de soluÇÕes aquosas.
TR200103819T2 (tr) kanser tedavisinde ET743 terkipleri ve kullanımları
HN1999000146A (es) Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
DE59902270D1 (de) Feuchtigkeitsaktivierbares therapeutisches system
EA200401111A1 (ru) Биполярные соли транс-каротиноидов и их применение
PT998287E (pt) Utilizacao de levobupivacaina
BR9916575A (pt) Composição farmacêutica de liberação controlada com mesilato de tilidina como substância-ativa

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: A61K 31/00

Ipc: A61K 31/404 (2009.01), A61P 35/00 (2009.01)

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11 E 13 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.