DE69635874D1 - Verfahren zur Herstellung von optisch aktiven Alkoholen - Google Patents
Verfahren zur Herstellung von optisch aktiven AlkoholenInfo
- Publication number
- DE69635874D1 DE69635874D1 DE69635874T DE69635874T DE69635874D1 DE 69635874 D1 DE69635874 D1 DE 69635874D1 DE 69635874 T DE69635874 T DE 69635874T DE 69635874 T DE69635874 T DE 69635874T DE 69635874 D1 DE69635874 D1 DE 69635874D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- optically active
- active alcohols
- alcohols
- optically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0237—Amines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0239—Quaternary ammonium compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0252—Nitrogen containing compounds with a metal-nitrogen link, e.g. metal amides, metal guanidides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0255—Phosphorus containing compounds
- B01J31/0267—Phosphines or phosphonium compounds, i.e. phosphorus bonded to at least one carbon atom, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, the other atoms bonded to phosphorus being either carbon or hydrogen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0271—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds also containing elements or functional groups covered by B01J31/0201 - B01J31/0231
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
- B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/821—Ruthenium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP31830495 | 1995-12-06 | ||
JP7318303A JP2962668B2 (ja) | 1995-12-06 | 1995-12-06 | 光学活性アルコール類の製造方法 |
JP7318304A JP2912572B2 (ja) | 1995-12-06 | 1995-12-06 | 光学活性アミン類の製造方法 |
JP31830395 | 1995-12-06 | ||
JP28423396 | 1996-10-25 | ||
JP8284233A JP3040353B2 (ja) | 1996-10-25 | 1996-10-25 | ルテニウム−ジアミン錯体及びこれを触媒とする光学活性アルコール類の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69635874D1 true DE69635874D1 (de) | 2006-05-04 |
DE69635874T2 DE69635874T2 (de) | 2006-12-14 |
Family
ID=27337070
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69634639T Expired - Lifetime DE69634639T2 (de) | 1995-12-06 | 1996-12-06 | Verfahren zur herstellung optische aktive verbindungen |
DE69635874T Expired - Lifetime DE69635874T2 (de) | 1995-12-06 | 1996-12-06 | Verfahren zur Herstellung von optisch aktiven Alkoholen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69634639T Expired - Lifetime DE69634639T2 (de) | 1995-12-06 | 1996-12-06 | Verfahren zur herstellung optische aktive verbindungen |
Country Status (4)
Country | Link |
---|---|
US (1) | US6184381B1 (de) |
EP (2) | EP1300381B1 (de) |
DE (2) | DE69634639T2 (de) |
WO (1) | WO1997020789A1 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6187961B1 (en) | 1997-11-06 | 2001-02-13 | Roche Vitamins Inc. | Process for the preparation of trans-(R,R)-actinol |
EP1050525B1 (de) * | 1998-01-19 | 2005-08-31 | Takara Bio Inc. | Substanzen, welche apoptose einleiten können |
NL1009346C2 (nl) * | 1998-06-09 | 1999-12-10 | Dsm Nv | Asymmetrische transferhydrogenering. |
EP1146037B1 (de) * | 1999-01-18 | 2006-06-21 | Nippon Soda Co., Ltd. | Verfahren zur herstellung von optisch aktiven amino-alkoholen |
TW519537B (en) | 1999-03-26 | 2003-02-01 | Asahi Chemical Ind | Process for the preparation of tricylic amino-alcohol derivatives |
SK19372001A3 (sk) * | 1999-07-01 | 2002-04-04 | Merck & Co., Inc. | Spôsob výroby (R)-1-(3,5-bis(trifluórmetyl)fenyl)etan-1-olu a spôsob jeho čistenia |
FR2796938B1 (fr) * | 1999-07-29 | 2004-04-02 | Ppg Sipsy | Nouveaux derives chiraux n-substitues de la norephedrine, leur preparation et leur utilisation pour la synthese de composes fonctionnalises optiquement actifs par transfert d'hydrogene |
AU6596800A (en) * | 1999-09-03 | 2001-04-10 | Asahi Kasei Kabushiki Kaisha | Processes for the preparation of tricyclic amino alcohol derivatives |
EP1132372A3 (de) * | 2000-03-06 | 2003-11-19 | Solvias AG | Bicyclische 1,3-Aminoalcoholen, Komplexe mit d8-Metallen und Verfahren zur Hydrierung |
NL1015313C2 (nl) | 2000-05-26 | 2001-11-27 | Dsm Nv | Werkwijze voor de bereiding van enantiomeer verrijkte esters en alcoholen. |
CA2415738A1 (en) * | 2000-07-24 | 2002-01-31 | Julian Paul Henschke | Ruthenium complexes and their use in asymmetric hydrogenation |
AU2001280028A1 (en) | 2000-09-13 | 2002-03-26 | Firmenich S.A. | Catalytic hydrogenation processes |
US6271193B1 (en) | 2000-10-11 | 2001-08-07 | International Flavors & Fragrances Inc. | Carbon containing functional group substituted 4,5,6,7-tetrahydro-polyalkylated-4-indanes, isomers thereof, processes for preparing same and uses thereof |
WO2002051781A1 (fr) | 2000-12-25 | 2002-07-04 | Ajinomoto Co., Inc. | Procede permettant de preparer un compose d'halohydrine optiquement actif |
US7166754B2 (en) * | 2001-03-12 | 2007-01-23 | California Institute Of Technology | Methods and compositions for enantioselective oxidation reactions |
JP4015450B2 (ja) | 2001-05-18 | 2007-11-28 | 高砂香料工業株式会社 | 光学活性アルコールの製造方法 |
US6462206B1 (en) * | 2001-06-20 | 2002-10-08 | E. I. Du Pont De Nemours And Company | Catalytic reduction of ketones and aldehydes using organometallic ruthenium complexes |
EP1409125B1 (de) | 2001-07-12 | 2016-04-20 | Reaxa Limited | Mikroverkapselter katalysator, sein herstellungsverfahren sowie verwendung |
US6867302B2 (en) * | 2001-07-13 | 2005-03-15 | Board Of Trustees Of Michigan State University | Process for the catalytic synthesis of biaryls and polymers from aryl compounds |
JP3504254B2 (ja) | 2001-10-31 | 2004-03-08 | 関東化学株式会社 | 光学活性アミノアルコールおよびその中間体の製造方法 |
GB0204129D0 (en) * | 2002-02-21 | 2002-04-10 | Novartis Ag | Process for the manufacture of organic compounds |
GB0210234D0 (en) | 2002-05-03 | 2002-06-12 | Novartis Ag | Process for the manufacture of organic compounds |
KR100583810B1 (ko) * | 2002-05-07 | 2006-05-26 | 윤혜숙 | 신규 테트라하이드로이소퀴놀린계 거울상 이성질체 화합물및 그의 약학적으로 허용되는 염, 그 제조방법 및 이를포함하는 약학적 조성물 |
DE10225352A1 (de) * | 2002-06-07 | 2003-12-18 | Bayer Ag | Verfahren zur stereoselektiven Reduktion von 4-Aryl-4-oxobutansäure-derivaten |
ES2331911T3 (es) * | 2002-06-17 | 2010-01-20 | Saltigo Gmbh | Procedimiento para la preparacion de diaminas mono-n-sulfoniladas. |
GB0215526D0 (en) * | 2002-07-05 | 2002-08-14 | Univ Edinburgh | Anticancer compounds |
GB0221438D0 (en) * | 2002-09-16 | 2002-10-23 | Avecia Ltd | Processes and compounds |
US8461072B2 (en) * | 2002-10-25 | 2013-06-11 | Exxonmobil Chemical Patents Inc. | Late transition metal catalysts for olefin oligomerizations |
NZ543184A (en) * | 2003-04-30 | 2008-03-28 | Univ Edinburgh | Ruthenium (II) complexes suitable for use in the treatment of cancer |
WO2004096735A2 (en) * | 2003-05-02 | 2004-11-11 | Kamaluddin Abdur-Rashid | Transfer hydrogenation processes and catalysts |
GB0322559D0 (en) * | 2003-09-18 | 2003-10-29 | Avecia Ltd | Process |
AU2005250077B2 (en) | 2004-03-01 | 2011-06-09 | Idorsia Pharmaceuticals Ltd | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
ITPD20040115A1 (it) * | 2004-05-04 | 2004-08-04 | Univ Degli Studi Udine | Complessi di rutenio con 2-(amminometil)piridine e fosfine, loro preparazione ed uso come catalizzatori |
EP1781615A1 (de) * | 2004-07-23 | 2007-05-09 | Pliva Istrazivanje i Razvoj d.o.o. | Neue form eines benzolsulfonamidderivats |
GB0424000D0 (en) * | 2004-10-29 | 2004-12-01 | Avecia Ltd | Process |
MX2007005170A (es) * | 2004-10-29 | 2007-07-04 | Avecia Pharmaceuticals Ltd | Composiciones catalizadoras y su uso en el desenriquecimiento de substratos enantiomericamente enriquecidos. |
JP2008519798A (ja) * | 2004-11-11 | 2008-06-12 | ディーエスエム アイピー アセッツ ビー.ブイ. | 不斉移動水素化のための触媒として適したキラル化合物 |
GB0425320D0 (en) | 2004-11-17 | 2004-12-22 | Johnson Matthey Plc | Diamines |
DE102004063443A1 (de) * | 2004-12-30 | 2006-07-13 | Bayer Cropscience Gmbh | Verfahren zur Herstellung von optisch aktiven cyclischen Aminen |
GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
US20070208183A1 (en) * | 2006-03-02 | 2007-09-06 | Haan Rene J | Hydrogenation process for the conversion of a carboxylic acid or an ester having a carbonyl group |
JP4807574B2 (ja) * | 2006-04-19 | 2011-11-02 | 住友化学株式会社 | 光学フィルム及びその製造方法 |
US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
DE102006026329A1 (de) * | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Verfahren zur Herstellung von enantiomerenangereicherten Hydroxylaminderivaten |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
JP5330706B2 (ja) * | 2007-02-23 | 2013-10-30 | 川研ファインケミカル株式会社 | 光学活性3−キヌクリジノールの製造方法 |
AU2008207580B2 (en) * | 2007-05-04 | 2011-04-14 | SpecGx LLC | Improved process for the preparation of 6-alpha-hydroxy-N-alkylated opiates |
WO2009005024A1 (ja) | 2007-07-03 | 2009-01-08 | Hamari Chemicals, Ltd. | 光学活性アミンの製造方法 |
ITPD20070237A1 (it) | 2007-07-11 | 2009-01-12 | Univ Degli Studi Udine | Nuovi leganti della classe della benzo[h]chinolina e complessi di metalli di transizione che li contengono e uso di tali complessi come catalizzatori |
NZ582668A (en) * | 2007-07-17 | 2012-02-24 | Mallinckrodt Llc | Preparation of n-alkylated opiates by reductive amination |
US20090163601A1 (en) * | 2007-12-21 | 2009-06-25 | The Regents Of The University Of California | (r)-2-methyl-(2,5-dimethylphenyl)propanol and (s)-(2-methyl-2,5-dimethylphenyl)propanol |
CN101917853B (zh) | 2007-12-27 | 2014-03-19 | 无限药品股份有限公司 | 立体选择性还原的方法 |
KR101579992B1 (ko) | 2007-12-28 | 2015-12-23 | 액테리온 파마슈티칼 리미티드 | 삼치환된 3,4-디하이드로-1h-이소퀴놀린 화합물, 상기 화합물의 제조 공정 및 상기 화합물의 용도 |
WO2009130056A1 (en) * | 2008-04-25 | 2009-10-29 | Synthon B.V. | Process for making montelukast intermediates |
NZ607842A (en) * | 2008-09-30 | 2013-12-20 | Mallinckrodt Llc | Processes for the selective amination of ketomorphinans |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
JP5727127B2 (ja) * | 2009-04-10 | 2015-06-03 | 関東化学株式会社 | 不斉触媒およびこれを用いた光学活性アルコール類の製造方法 |
ES2465066T3 (es) * | 2009-06-11 | 2014-06-05 | Mallinckrodt Llc | Aminación reductora de 6-ceto-normorfinanos por transferencia de hidrógeno catalítica |
PL2440562T3 (pl) * | 2009-06-11 | 2017-07-31 | Mallinckrodt Llc | Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru |
JP6141015B2 (ja) | 2009-08-05 | 2017-06-07 | インフィニティ ファーマスーティカルズ、インク. | シクロパミン類似体の酵素によるアミノ基転移 |
CN102574803A (zh) | 2009-10-09 | 2012-07-11 | 帝斯曼知识产权资产管理有限公司 | 用于制备孟鲁司特的光学活性中间体的合成 |
JP5680878B2 (ja) | 2010-05-13 | 2015-03-04 | 関東化学株式会社 | 光学活性アルコールの製造方法 |
EP2390245A1 (de) * | 2010-05-26 | 2011-11-30 | Nabriva Therapeutics AG | Enantiomerisch reine Amine |
EP2402322A1 (de) | 2010-07-02 | 2012-01-04 | Actelion Pharmaceuticals Ltd. | 1,2,3,4-Tetrahydroisochinolin-Derivat und seine Verwendung als Orexin Rezeptor Antagonist |
US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
MX2013013634A (es) | 2011-06-09 | 2013-12-12 | Mallinckrodt Llc | Aminacion reductiva de 6-ceto-morfinanos por transfrencia catalitica de hidrogeno. |
JP2014526467A (ja) | 2011-09-08 | 2014-10-06 | マリンクロッド エルエルシー | 中間体の単離なしでのアルカロイドの調製 |
EP2772476B1 (de) | 2011-10-25 | 2017-01-11 | Hamari Chemicals, Ltd. | Verfahren zur herstellung eines optisch aktiven alkohols |
CN103073492A (zh) * | 2013-02-04 | 2013-05-01 | 中国科学院上海有机化学研究所 | 2-[3-(s)-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-羟基丙基]苯甲酸酯的合成方法 |
EP3586835B1 (de) | 2013-09-09 | 2023-11-22 | Peloton Therapeutics, Inc. | Pharmazeutische zusammensetzungen enthaltend arylether |
US9884843B2 (en) | 2013-12-16 | 2018-02-06 | Peloton Therapeutics, Inc. | Cyclic sulfone and sulfoximine analogs and uses thereof |
US10155726B2 (en) | 2015-03-11 | 2018-12-18 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
US10278942B2 (en) | 2015-03-11 | 2019-05-07 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
WO2016196928A1 (en) | 2015-06-04 | 2016-12-08 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
WO2023097678A1 (zh) * | 2021-12-03 | 2023-06-08 | 广东莱佛士制药技术有限公司 | 一种合成(R)-5-(2,2-二甲基-4H-苯并[d][1,3]二恶英-6-基)恶唑烷-2-酮的方法 |
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US3883580A (en) * | 1972-02-09 | 1975-05-13 | Monsanto Co | Asymmetric reduction of ketones to form optically active alcohols |
DE2312924A1 (de) * | 1972-03-16 | 1973-09-27 | Monsanto Co | Verfahren zur asymmetrischen reduktion von ketonen unter bildung optisch aktiver alkohole |
DE3774172D1 (de) * | 1986-05-16 | 1991-12-05 | Ciba Geigy Ag | Iridiumkomplexe und deren verwendung. |
JPS632935A (ja) * | 1986-06-20 | 1988-01-07 | Sumitomo Chem Co Ltd | 光学活性アルコ−ル類の製造方法 |
ATE66666T1 (de) * | 1986-08-04 | 1991-09-15 | Ciba Geigy Ag | Verfahren zur herstellung von optisch aktiven sekundaeren arylaminen. |
JPS63152337A (ja) * | 1986-08-27 | 1988-06-24 | Takasago Corp | 光学活性アルコ−ルの製法 |
JPH064544B2 (ja) * | 1987-06-19 | 1994-01-19 | 高砂香料工業株式会社 | 光学活性アルコ−ルの製造方法 |
US5011995A (en) * | 1987-07-28 | 1991-04-30 | Ciba-Geigy Corporation | Process for the preparation of optically active secondary amines |
DE69232443T2 (de) * | 1991-08-26 | 2002-10-31 | Research Corp. Technologies, Inc. | Herstellung von epoxchromanen mit einem chiralen katalysator |
JPH06247793A (ja) * | 1993-02-22 | 1994-09-06 | Sumitomo Electric Ind Ltd | 単結晶ダイヤモンドおよび製造法 |
JP2734457B2 (ja) * | 1994-02-23 | 1998-03-30 | 日産化学工業株式会社 | 不斉エポキシ化反応 |
JP2731377B2 (ja) * | 1994-12-07 | 1998-03-25 | 科学技術振興事業団 | 光学活性アルコール類の製造方法 |
JP3976357B2 (ja) * | 1995-03-31 | 2007-09-19 | 三井化学株式会社 | 光学活性アルコールの製造方法 |
JP3716460B2 (ja) * | 1995-09-01 | 2005-11-16 | 日産化学工業株式会社 | 不斉シクロプロパン化反応 |
-
1996
- 1996-12-06 EP EP02025508A patent/EP1300381B1/de not_active Expired - Lifetime
- 1996-12-06 US US09/077,787 patent/US6184381B1/en not_active Expired - Lifetime
- 1996-12-06 EP EP96941186A patent/EP0916637B1/de not_active Expired - Lifetime
- 1996-12-06 DE DE69634639T patent/DE69634639T2/de not_active Expired - Lifetime
- 1996-12-06 DE DE69635874T patent/DE69635874T2/de not_active Expired - Lifetime
- 1996-12-06 WO PCT/JP1996/003573 patent/WO1997020789A1/ja active IP Right Grant
Also Published As
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EP0916637B1 (de) | 2005-04-20 |
EP0916637A1 (de) | 1999-05-19 |
DE69635874T2 (de) | 2006-12-14 |
WO1997020789A1 (fr) | 1997-06-12 |
EP1300381B1 (de) | 2006-03-08 |
EP0916637A4 (de) | 2000-05-03 |
US6184381B1 (en) | 2001-02-06 |
DE69634639D1 (de) | 2005-05-25 |
DE69634639T2 (de) | 2006-03-02 |
EP1300381A1 (de) | 2003-04-09 |
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