DE69535669D1 - Retrovirale vektoren mit verminderter rekombinationsrate - Google Patents

Retrovirale vektoren mit verminderter rekombinationsrate

Info

Publication number
DE69535669D1
DE69535669D1 DE69535669T DE69535669T DE69535669D1 DE 69535669 D1 DE69535669 D1 DE 69535669D1 DE 69535669 T DE69535669 T DE 69535669T DE 69535669 T DE69535669 T DE 69535669T DE 69535669 D1 DE69535669 D1 DE 69535669D1
Authority
DE
Germany
Prior art keywords
pol
gag
expression cassettes
env
ltr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535669T
Other languages
English (en)
Other versions
DE69535669T2 (de
Inventor
James G Respess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Biomedica UK Ltd
Original Assignee
Oxford Biomedica UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Biomedica UK Ltd filed Critical Oxford Biomedica UK Ltd
Application granted granted Critical
Publication of DE69535669D1 publication Critical patent/DE69535669D1/de
Publication of DE69535669T2 publication Critical patent/DE69535669T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13051—Methods of production or purification of viral material
    • C12N2740/13052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
DE69535669T 1994-05-09 1995-05-09 Retrovirale vektoren mit verminderter rekombinationsrate Expired - Lifetime DE69535669T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24003094A 1994-05-09 1994-05-09
US240030 1994-05-09
PCT/US1995/005789 WO1995030763A2 (en) 1994-05-09 1995-05-09 Retroviral vectors having a reduced recombination rate

Publications (2)

Publication Number Publication Date
DE69535669D1 true DE69535669D1 (de) 2008-01-31
DE69535669T2 DE69535669T2 (de) 2008-12-04

Family

ID=22904813

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535669T Expired - Lifetime DE69535669T2 (de) 1994-05-09 1995-05-09 Retrovirale vektoren mit verminderter rekombinationsrate

Country Status (8)

Country Link
EP (2) EP1881075B1 (de)
JP (1) JP4303315B2 (de)
AT (1) ATE381624T1 (de)
AU (1) AU2585395A (de)
CA (1) CA2158977A1 (de)
DE (1) DE69535669T2 (de)
ES (1) ES2297831T3 (de)
WO (1) WO1995030763A2 (de)

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CA2158977A1 (en) 1995-11-10
WO1995030763A3 (en) 1996-04-04
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EP1881075A1 (de) 2008-01-23
ES2297831T3 (es) 2008-05-01
EP0772689B1 (de) 2007-12-19
WO1995030763A2 (en) 1995-11-16
ATE381624T1 (de) 2008-01-15
AU2585395A (en) 1995-11-29

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