GB2345062B - Retroviral vectors - Google Patents

Retroviral vectors

Info

Publication number
GB2345062B
GB2345062B GB9929545A GB9929545A GB2345062B GB 2345062 B GB2345062 B GB 2345062B GB 9929545 A GB9929545 A GB 9929545A GB 9929545 A GB9929545 A GB 9929545A GB 2345062 B GB2345062 B GB 2345062B
Authority
GB
United Kingdom
Prior art keywords
retroviral vectors
retroviral
vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9929545A
Other versions
GB2345062A (en
GB9929545D0 (en
Inventor
Alan John Kingsman
Miles William Carroll
Jonathan Rohll
Kyriacos Mitrophanous
Narry Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Biomedica UK Ltd
Original Assignee
Oxford Biomedica UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9727135.7A external-priority patent/GB9727135D0/en
Priority claimed from GBGB9811037.2A external-priority patent/GB9811037D0/en
Application filed by Oxford Biomedica UK Ltd filed Critical Oxford Biomedica UK Ltd
Priority to GB9929545A priority Critical patent/GB2345062B/en
Publication of GB9929545D0 publication Critical patent/GB9929545D0/en
Publication of GB2345062A publication Critical patent/GB2345062A/en
Application granted granted Critical
Publication of GB2345062B publication Critical patent/GB2345062B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24144—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051—Methods of production or purification of viral material
    • C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15061—Methods of inactivation or attenuation
    • C12N2740/15062—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB9929545A 1997-12-22 1998-12-22 Retroviral vectors Expired - Lifetime GB2345062B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9929545A GB2345062B (en) 1997-12-22 1998-12-22 Retroviral vectors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9727135.7A GB9727135D0 (en) 1997-12-22 1997-12-22 Non-primate lentiviral vectors
GBGB9811037.2A GB9811037D0 (en) 1998-05-22 1998-05-22 Proretoviral vectors
GB9828387A GB2334257B (en) 1997-12-22 1998-12-22 Rectroviral vectors
GB9929545A GB2345062B (en) 1997-12-22 1998-12-22 Retroviral vectors

Publications (3)

Publication Number Publication Date
GB9929545D0 GB9929545D0 (en) 2000-02-09
GB2345062A GB2345062A (en) 2000-06-28
GB2345062B true GB2345062B (en) 2001-07-25

Family

ID=27269150

Family Applications (3)

Application Number Title Priority Date Filing Date
GB0024722A Expired - Lifetime GB2356200B (en) 1997-12-22 1998-12-22 Retroviral vectors
GB9828387A Expired - Lifetime GB2334257B (en) 1997-12-22 1998-12-22 Rectroviral vectors
GB9929545A Expired - Lifetime GB2345062B (en) 1997-12-22 1998-12-22 Retroviral vectors

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB0024722A Expired - Lifetime GB2356200B (en) 1997-12-22 1998-12-22 Retroviral vectors
GB9828387A Expired - Lifetime GB2334257B (en) 1997-12-22 1998-12-22 Rectroviral vectors

Country Status (1)

Country Link
GB (3) GB2356200B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0024550D0 (en) * 2000-10-06 2000-11-22 Oxford Biomedica Ltd
WO2002079482A2 (en) * 2000-11-16 2002-10-10 Rigel Pharmaceuticals, Inc. In vitro transcribed retroviral genomes, methods for their production and methods of use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997032983A1 (en) * 1996-03-05 1997-09-12 The Regents Of The University Of California Recombinant live feline immunodeficiency virus and proviral dna vaccines
WO1998039463A2 (en) * 1997-03-06 1998-09-11 Ueberla Klaus Lentivirus based vector and vector system
WO1998051810A1 (en) * 1997-05-13 1998-11-19 University Of North Carolina At Chapel Hill Lentivirus-based gene transfer vectors
WO1999015641A1 (en) * 1997-09-24 1999-04-01 The Regents Of The University Of California Non-primate lentiviral vectors and packaging systems
WO1999015683A1 (en) * 1997-09-25 1999-04-01 Oxford Biomedica (Uk) Limited Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631154A (en) * 1988-06-10 1997-05-20 Therion Biologics, Incorporated Self assembled, defective, non-self-propagating lentivirus particles
DE69029135T2 (en) * 1989-05-30 1997-05-28 Nippon Zeon Co METHOD FOR PRODUCING CORE STRUCTURES OF RETROVIRUS AND PARTICLES PRODUCED BY THIS
JP3034025B2 (en) * 1989-06-01 2000-04-17 アプライド・バイオテクノロジー・インコーポレーテツド Self-assembled deficient non-self-replicating virions
WO1991019803A1 (en) * 1990-06-19 1991-12-26 Applied Biotechnology, Incorporated Self assembled, defective, nonself-propagating viral particles
EP0652967B1 (en) * 1990-08-15 1998-02-04 Therion Biologics Corporation Self-assembling replication defective hybrid virus particles
CA2158977A1 (en) * 1994-05-09 1995-11-10 James G. Respess Retroviral vectors having a reduced recombination rate
US6300118B1 (en) * 1995-06-07 2001-10-09 American Home Products Corporation Plasmids comprising a genetically altered feline immunodeficiency virus genome
US7255862B1 (en) * 1996-11-14 2007-08-14 Connaught Technology Corporation ALVAC/FIV constructs
AT406376B (en) * 1998-01-16 2000-04-25 Immuno Ag CHIMEAN POXVIRUS CONTAINING A RETROVIRAL VECTOR COMPONENT

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997032983A1 (en) * 1996-03-05 1997-09-12 The Regents Of The University Of California Recombinant live feline immunodeficiency virus and proviral dna vaccines
WO1998039463A2 (en) * 1997-03-06 1998-09-11 Ueberla Klaus Lentivirus based vector and vector system
WO1998051810A1 (en) * 1997-05-13 1998-11-19 University Of North Carolina At Chapel Hill Lentivirus-based gene transfer vectors
WO1999015641A1 (en) * 1997-09-24 1999-04-01 The Regents Of The University Of California Non-primate lentiviral vectors and packaging systems
WO1999015683A1 (en) * 1997-09-25 1999-04-01 Oxford Biomedica (Uk) Limited Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site

Also Published As

Publication number Publication date
GB2356200A (en) 2001-05-16
GB2356200B (en) 2002-05-01
GB2345062A (en) 2000-06-28
GB9929545D0 (en) 2000-02-09
GB0024722D0 (en) 2000-11-22
GB2334257B (en) 2001-07-04
GB2334257A (en) 1999-08-18
GB9828387D0 (en) 1999-02-17

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20181221