DE69531515D1 - Verfahren und Vorrichtung zur Messung von Fluoreszenz-Resonanz-Energie-Übertragung - Google Patents

Verfahren und Vorrichtung zur Messung von Fluoreszenz-Resonanz-Energie-Übertragung

Info

Publication number
DE69531515D1
DE69531515D1 DE69531515T DE69531515T DE69531515D1 DE 69531515 D1 DE69531515 D1 DE 69531515D1 DE 69531515 T DE69531515 T DE 69531515T DE 69531515 T DE69531515 T DE 69531515T DE 69531515 D1 DE69531515 D1 DE 69531515D1
Authority
DE
Germany
Prior art keywords
energy transmission
resonance energy
fluorescence resonance
measuring fluorescence
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69531515T
Other languages
English (en)
Other versions
DE69531515T2 (de
Inventor
Akihiko Tsuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamamatsu Photonics KK
Original Assignee
Hamamatsu Photonics KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamamatsu Photonics KK filed Critical Hamamatsu Photonics KK
Publication of DE69531515D1 publication Critical patent/DE69531515D1/de
Application granted granted Critical
Publication of DE69531515T2 publication Critical patent/DE69531515T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • G01N2021/6421Measuring at two or more wavelengths
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
DE69531515T 1994-02-16 1995-02-16 Verfahren und Vorrichtung zur Messung von Fluoreszenz-Resonanz-Energie-Übertragung Expired - Fee Related DE69531515T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1950094 1994-02-16
JP01950094A JP3448090B2 (ja) 1994-02-16 1994-02-16 エネルギー移動検出法およびその装置

Publications (2)

Publication Number Publication Date
DE69531515D1 true DE69531515D1 (de) 2003-09-25
DE69531515T2 DE69531515T2 (de) 2004-06-17

Family

ID=12001101

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69531515T Expired - Fee Related DE69531515T2 (de) 1994-02-16 1995-02-16 Verfahren und Vorrichtung zur Messung von Fluoreszenz-Resonanz-Energie-Übertragung

Country Status (4)

Country Link
US (2) US5776782A (de)
EP (1) EP0668498B1 (de)
JP (1) JP3448090B2 (de)
DE (1) DE69531515T2 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
AU4321497A (en) * 1996-09-27 1998-04-17 Laboratory Of Molecular Biophotonics Probes for detecting polynucleotides and detection method
AT405103B (de) * 1996-10-16 1999-05-25 Avl Verbrennungskraft Messtech Sensorschicht zur quantitativen bestimmung zumindest einer chemischen komponente einer gasförmigen oder flüssigen probe
DE19722630C2 (de) * 1997-05-30 1999-09-16 Stiftung Fuer Lasertechnologie Verfahren zur in situ Messung mitochondrialer Stoffwechselprodukte
DE19737562A1 (de) * 1997-08-28 1999-05-06 Otogene Biotechnologische Fors Verfahren zur Identifizierung von Wechselwirkungen zwischen Proteinen bzw. Peptiden
JPH1189598A (ja) * 1997-09-18 1999-04-06 Hitachi Software Eng Co Ltd 蛍光標識プローブ及びハイブリダイゼーション検出方法
DE19811730A1 (de) * 1998-03-18 1999-09-23 November Ag Molekulare Medizin Verfahren und Vorrichtung zum Identifizieren einer Markierung
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
JP2003524754A (ja) * 1998-05-16 2003-08-19 ピーイー コーポレイション (エヌワイ) Dnaのポリメラーゼ連鎖反応をモニタする装置
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
GB9811483D0 (en) * 1998-05-29 1998-07-29 Photonic Research Systems Limi Luminescence assay using cyclical excitation wavelength sequence
DE19829495A1 (de) * 1998-07-02 2000-01-05 Jacques Paysan Reagenzien und deren Anwendung zur Untersuchung von Wechselwirkungen zwischen zellulären Molekülen und deren Lokalisation in Zellen
US6558945B1 (en) * 1999-03-08 2003-05-06 Aclara Biosciences, Inc. Method and device for rapid color detection
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6528258B1 (en) 1999-09-03 2003-03-04 Lifebeam Technologies, Inc. Nucleic acid sequencing using an optically labeled pore
EP1089068A1 (de) * 1999-09-28 2001-04-04 Norbert Graf Verfahren und Vorrichtung zur Bestimmung von Kontaminationen
AU783767B2 (en) 1999-10-14 2005-12-01 Takara Bio Usa, Inc. Anthozoa derived chromophores/fluorophores and methods for using the same
US6426505B1 (en) 2000-01-19 2002-07-30 University Of Maryland Biotechnology Institute Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier
JP3460673B2 (ja) * 2000-02-04 2003-10-27 浜松ホトニクス株式会社 特定の遺伝子を発現した生細胞の選択的分離方法
US6844154B2 (en) 2000-04-04 2005-01-18 Polygenyx, Inc. High throughput methods for haplotyping
FR2809817B1 (fr) * 2000-06-02 2003-08-15 Cis Bio Int Procede de detection de presence d'un liquide dans un melange
JP4593739B2 (ja) * 2000-07-27 2010-12-08 独立行政法人科学技術振興機構 多光子励起蛍光寿命画像化システム
US7125660B2 (en) * 2000-09-13 2006-10-24 Archemix Corp. Nucleic acid sensor molecules and methods of using same
US6927246B2 (en) 2001-02-15 2005-08-09 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs and methods for making them
CA2440754A1 (en) * 2001-03-12 2002-09-19 Stephen Quake Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
US20030010931A1 (en) * 2001-07-16 2003-01-16 Pittaro Richard J. Methods for analyzing arrays
DE10144435B4 (de) * 2001-09-06 2005-03-24 EuroPhoton GmbH Gesellschaft für optische Sensorik Verfahren zur Charakterisierung der Eigenschaften von fluoreszierenden Proben, insbesondere lebenden Zellen und Geweben, in multi-well, in in-vitro Fluoreszenz-Assays, in DNA-Chips, Vorrichtungen zur Durchführung des Verfahrens und deren Verwendung
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
US6867005B2 (en) * 2001-10-24 2005-03-15 Beckman Coulter, Inc. Method and apparatus for increasing the dynamic range and accuracy of binding assays
US6696690B2 (en) * 2001-12-17 2004-02-24 The Boeing Company Method and apparatus to correct for the temperature sensitivity of pressure sensitive paint
ATE439368T1 (de) * 2001-12-19 2009-08-15 Univ Chicago Schnellreifende fluoreszierende proteine und verfahren zu deren anwendung
DE03779067T1 (de) 2002-11-12 2006-06-22 Zakrytoe Aktsionernoe Obschestvo "Evrogen" Fluoreszenzproteine und chromoproteine aus nicht-aequorea-hydrozoa-spezies sowie verfahren zur verwendung davon
EP1576157B1 (de) 2002-12-26 2010-07-21 Zakrytoe Aktsionernoe Obschestvo " Evrogen" Fluoreszenzproteine aus copepoda-spezies und verfahren zur verwendung davon
DE10337108B3 (de) * 2003-08-11 2005-05-04 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Photochromes relaxationskinetisches Verfahren
US20050084867A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Hybridization and scanning apparatus
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
EP2248911A1 (de) 2004-02-19 2010-11-10 Helicos Biosciences Corporation Verfahren und Zusammensetzungen zur Analyse von Polynukleotidsequenzen
EP1732944B1 (de) * 2004-04-07 2012-09-05 The University of Chicago Monomere, rotfluoreszierende proteine
WO2006014494A2 (en) * 2004-07-07 2006-02-09 Corcoran Timothy C Multiple-label fluorescence imaging using excitation-emission matrices
GB2416945A (en) * 2004-08-04 2006-02-08 Imp College Innovations Ltd Imaging system for generating output images from a sequence of component images
JP4704052B2 (ja) * 2005-01-24 2011-06-15 オリンパス株式会社 蛍光寿命測定装置
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
AU2006291054B2 (en) 2005-09-12 2011-10-13 The Brigham And Women's Hospital, Inc. Recurrent gene fusions in prostate cancer
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
RU2412250C2 (ru) * 2005-11-04 2011-02-20 Закрытое акционерное общество "ЕВРОГЕН" Модифицированные зеленые флуоресцентные белки и способы их использования
US20090305248A1 (en) * 2005-12-15 2009-12-10 Lander Eric G Methods for increasing accuracy of nucleic acid sequencing
WO2007085923A2 (en) 2006-01-25 2007-08-02 Evrogen, Ip Novel fluorescent proteins and methods for using same
US8563703B2 (en) 2006-01-25 2013-10-22 Evrogen IP Joint Stock Company Fluorescent proteins and methods for using same
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
WO2008094316A2 (en) * 2006-09-22 2008-08-07 Stowers Institute Of Medical Research Novel branchiostoma derived fluorescent proteins
JP2010508855A (ja) * 2006-11-08 2010-03-25 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌マーカーとしてのspink1およびその使用
ES2376509T3 (es) 2007-07-06 2012-03-14 The Regents Of The University Of Michigan Reordenamientos de genes mipol 1-etv1.
EP2196795A4 (de) * 2007-08-30 2014-04-02 Mitsui Shipbuilding Eng Fret-nachweisverfahren und -vorrichtung
US8614099B2 (en) 2007-08-30 2013-12-24 Mitsui Engineering & Shipbuilding Co., Ltd. FRET detection method and device
JP5124216B2 (ja) * 2007-09-14 2013-01-23 オリンパス株式会社 光シグナル観察方法および光シグナル観察システム
US8679749B2 (en) * 2007-11-01 2014-03-25 The University Of Chicago Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
JP2009229387A (ja) * 2008-03-25 2009-10-08 Kobelco Kaken:Kk 非定常発光体の分光解析方法およびその装置
CN102712953A (zh) * 2009-09-17 2012-10-03 密歇根大学董事会 前列腺癌中的复发性基因融合物
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
CN102175657A (zh) * 2011-01-04 2011-09-07 西南科技大学 废水资源化处理关键过程产物在线检测仪
SE535980C2 (sv) * 2011-05-16 2013-03-12 Andreas Ehn Förfarande och anordning för bestämning av avklingningstider för pulsstimulerande signaler.
EP3492604B1 (de) 2011-11-04 2021-01-06 Gen-Probe Incorporated Molekulartestreagenzien und -verfahren
WO2013144673A1 (en) * 2012-03-29 2013-10-03 University Of Calcutta Chiral determination using half-frequency spectral signatures
DE102012219136A1 (de) * 2012-10-19 2014-05-28 Leica Microsystems Cms Gmbh Mikroskop und ein Verfahren zur Untersuchung einer Probe mit einem Mikroskop
WO2014168734A1 (en) * 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
JP6247530B2 (ja) * 2013-12-27 2017-12-13 キヤノン株式会社 撮像装置
US10564088B2 (en) 2014-10-09 2020-02-18 Kinetic River Corp. Particle analysis and sorting apparatus and methods
US11740174B2 (en) 2014-10-09 2023-08-29 Kinetic River Corp. Apparatus and methods for particle analysis and autofluorescence discrimination
US9658148B2 (en) * 2014-10-09 2017-05-23 Kinetic River Corp. Particle analysis and sorting apparatus and methods
JP6425242B2 (ja) * 2014-12-16 2018-11-21 国立大学法人静岡大学 変調光検出のsn比を向上する方法
EP3159676B1 (de) * 2015-10-23 2018-04-04 Abberior Instruments GmbH Verfahren und vorrichtung zum hochauflösenden abbilden einer mit fluoreszenzmarkern markierten struktur einer probe
WO2017173315A1 (en) 2016-04-01 2017-10-05 Black Light Surgical, Inc. Systems, devices, and methods for time-resolved fluorescent spectroscopy
JP7064315B2 (ja) * 2017-11-07 2022-05-10 オリンパス株式会社 光検出装置およびレーザ走査型顕微鏡
WO2023135485A1 (en) 2022-01-13 2023-07-20 Oslo Universitetssykehus Hf Prostate cancer markers and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095822B (en) * 1981-03-30 1984-10-10 Ramley Engineering Co Ltd Identifying objects by detecting decaying phosphorescence from phosphor coating thereon
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US4822746A (en) * 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5254477A (en) * 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
US4861727A (en) * 1986-09-08 1989-08-29 C. R. Bard, Inc. Luminescent oxygen sensor based on a lanthanide complex
US4791310A (en) * 1986-10-02 1988-12-13 Syracuse University Fluorescence microscopy

Also Published As

Publication number Publication date
EP0668498A2 (de) 1995-08-23
US5911952A (en) 1999-06-15
EP0668498B1 (de) 2003-08-20
DE69531515T2 (de) 2004-06-17
EP0668498A3 (de) 1995-10-25
JPH07229835A (ja) 1995-08-29
JP3448090B2 (ja) 2003-09-16
US5776782A (en) 1998-07-07

Similar Documents

Publication Publication Date Title
DE69531515D1 (de) Verfahren und Vorrichtung zur Messung von Fluoreszenz-Resonanz-Energie-Übertragung
DE69532091D1 (de) Verfahren und Vorrichtung zur Durchführung von Messungen
DE69530563D1 (de) Verfahren und Vorrichtung zur Messung der Chemilumineszenz
DE59610818D1 (de) Verfahren und vorrichtung zur messung von lichtbündeln
DE69535165D1 (de) Verfahren und Vorrichtung zur Bohrlochuntersuchung
DE69635150D1 (de) Verfahren und Vorrichtung zur Verwaltung von Reagenzien
DE69528558T2 (de) Vorrichtung und Verfahren zur Identifizierung von mehreren Transpondern
DE69623248D1 (de) Verfahren und Vorrichtung zur Entfernungsmessung
DE69629098D1 (de) Verfahren und Vorrichtung zur Belastungsprüfung
DE69510587D1 (de) Verfahren und Vorrichtung zur Ermittlung der Fahrbahnsteigung
DE69511276T2 (de) Vorrichtung zur messung von schwerefeldern
DE69501878T2 (de) Verfahren und vorrichtung zur förderung und messung von flüssigkeiten
DE69928465D1 (de) Vorrichtung und Verfahren zur simultanen Messung von unterschiedlichen Strahlungsarten
DE69009109T2 (de) Vorrichtung und Verfahren zur Lichtmessung.
DE59302962D1 (de) Verfahren und Vorrichtung zur Abstandsmessung
DE69937858D1 (de) Verfahren und Vorrichtung zur Messung von Vibrationswellen
DE69727520D1 (de) Vorrichtung und Verfahren zur Flüssigkeitsstandsmessung
DE69819227D1 (de) Vorrichtung und Verfahren zur Trübungsmessung
DE4497995T1 (de) Vorrichtung und Verfahren zur Frequenzmessung
DE69532841D1 (de) Vorrichtung und Verfahren zur Messung von Gasabsorptionseigenschaften
DE69520760D1 (de) Vorrichtung und Verfahren zur Messung von Crimphöhe
ATE261119T1 (de) Verfahren und vorrichtung zur messung der oktanzahl
DE59303589D1 (de) Vermessungsverfahren für seilkernbohrungen und vorrichtung zur durchführung
DE59502277D1 (de) Verfahren und vorrichtung zur elektrooptischen entfernungsmessung
DE59609675D1 (de) Verfahren und Vorrichtung zur Abstandsmessung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee