DE69432596D1 - Zusammensetzungen für verabreichung von osteogenen proteinen - Google Patents

Zusammensetzungen für verabreichung von osteogenen proteinen

Info

Publication number
DE69432596D1
DE69432596D1 DE69432596T DE69432596T DE69432596D1 DE 69432596 D1 DE69432596 D1 DE 69432596D1 DE 69432596 T DE69432596 T DE 69432596T DE 69432596 T DE69432596 T DE 69432596T DE 69432596 D1 DE69432596 D1 DE 69432596D1
Authority
DE
Germany
Prior art keywords
administration
compositions
disclosed
osteogenic proteins
osteogenic protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69432596T
Other languages
English (en)
Other versions
DE69432596T2 (de
Inventor
Kalvin W K Yim
Michael C Huberty
Northey, Jr
Richard A Kenley
Jay A Schrier
Jennifer L Smith
John J Steckert
C Michael Philbrook
Patrick Joseph Desouza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of DE69432596D1 publication Critical patent/DE69432596D1/de
Application granted granted Critical
Publication of DE69432596T2 publication Critical patent/DE69432596T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/84Bones; tendons; teeth; cartilage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69432596T 1993-09-10 1994-09-02 Zusammensetzungen für verabreichung von osteogenen proteinen Expired - Fee Related DE69432596T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US119772 1993-09-10
US08/119,772 US5385887A (en) 1993-09-10 1993-09-10 Formulations for delivery of osteogenic proteins
PCT/US1994/009870 WO1995007108A2 (en) 1993-09-10 1994-09-02 Formulations for delivery of osteogenic proteins

Publications (2)

Publication Number Publication Date
DE69432596D1 true DE69432596D1 (de) 2003-06-05
DE69432596T2 DE69432596T2 (de) 2004-03-18

Family

ID=22386293

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432596T Expired - Fee Related DE69432596T2 (de) 1993-09-10 1994-09-02 Zusammensetzungen für verabreichung von osteogenen proteinen

Country Status (14)

Country Link
US (1) US5385887A (de)
EP (1) EP0724459B1 (de)
JP (1) JPH09502368A (de)
KR (1) KR100329408B1 (de)
AT (1) ATE238819T1 (de)
AU (1) AU695374B2 (de)
CA (1) CA2169362C (de)
DE (1) DE69432596T2 (de)
DK (1) DK0724459T3 (de)
ES (1) ES2196033T3 (de)
FI (1) FI961037A (de)
NO (1) NO960905D0 (de)
PT (1) PT724459E (de)
WO (1) WO1995007108A2 (de)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620406B1 (en) 1994-03-08 2003-09-16 Genetics Institute, Llc. Methods for treatment of periodontal diseases and lesions using bone morphogenetic proteins
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US20060280774A1 (en) * 1995-06-02 2006-12-14 Allergan, Inc. Compositions and methods for treating glaucoma
US6369116B1 (en) 1995-06-02 2002-04-09 Oculex Pharmaceuticals, Inc. Composition and method for treating glaucoma
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5674292A (en) * 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
JP4344404B2 (ja) * 1996-02-09 2009-10-14 アムジェン インコーポレイテッド インターロイキン―1インヒビターおよび制御放出ポリマーを含む組成物
EP0852951A1 (de) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
EP0957943B2 (de) * 1997-02-07 2008-11-26 Stryker Corporation Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
AU779278B2 (en) * 1997-02-07 2005-01-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US6071982A (en) * 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
AU7260598A (en) * 1997-04-28 1998-11-24 Trustees Of The University Of Pennsylvania, The Method for promoting myogenesis using osteogenic proteins
US6391336B1 (en) * 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US20080050367A1 (en) * 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6787523B1 (en) * 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US7790856B2 (en) * 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US20050059802A1 (en) * 1998-04-07 2005-03-17 Neuralab Ltd Prevention and treatment of amyloidogenic disease
WO2000020021A1 (en) * 1998-10-06 2000-04-13 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
US7371408B1 (en) 1999-06-07 2008-05-13 Wright Medical Technology, Inc. Bone graft substitute composition
US7687462B2 (en) * 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
US7884066B2 (en) * 1999-10-05 2011-02-08 The Regents Of The University Of California NELL-1 enhanced bone mineralization
US7052856B2 (en) * 1999-10-05 2006-05-30 The Regents Of The University Of California NELL-1 enhanced bone mineralization
US20090060988A1 (en) * 1999-10-05 2009-03-05 Kang Ting Nell-1 enhanced bone mineralization
EP1155704A1 (de) * 2000-01-13 2001-11-21 Chih-I Lin Orthopädisches Füllmaterial und Verfahren zu dessen Verwendung
US6630153B2 (en) * 2001-02-23 2003-10-07 Smith & Nephew, Inc. Manufacture of bone graft substitutes
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
US20080233165A1 (en) * 2000-08-07 2008-09-25 Biolok International, Inc. Time release calcium sulfate and growth factor matrix for bone augmentation
DE60114229T2 (de) 2000-11-29 2006-07-06 Allergan, Inc., Irvine Verhinderung von transplantatabstossung im auge
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
TWI255272B (en) * 2000-12-06 2006-05-21 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
EP1492475B1 (de) * 2001-04-16 2011-12-21 Wright Medical Technology, Inc. Dichte/poröse strukturen zur verwendung als knochenersatz
US20070254009A1 (en) * 2001-07-13 2007-11-01 Flow Focusing, Inc. Antibiotic/bone morphogenic protein formulation and method of treatment
US20060263401A1 (en) * 2001-07-13 2006-11-23 Flow Focusing, Inc. Formulation and Method for Preventing Infection
US20050129732A1 (en) * 2001-07-13 2005-06-16 Flow Focusing, Inc. Biodegradable, antibiotic, controlled release tape
US20070254008A1 (en) * 2001-07-13 2007-11-01 Flow Focusing, Inc. Antibiotic formulation and method of treatment
US7371409B2 (en) * 2001-09-06 2008-05-13 Wright Medical Technology, Inc. Bone graft substitute composition
BR0214275A (pt) * 2001-11-19 2004-09-21 Scil Technology Gmbh Dispositivo tendo propriedades osteocondutora e osteoindutora
AU2003209071B2 (en) * 2002-02-08 2008-08-14 The University Of Erlangen-Nuremberg Formulation comprising bioactive agents and method of using same
MY139983A (en) * 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
AU2003258172B2 (en) 2002-03-29 2008-02-28 Wright Medical Technolgy, Inc. Bone graft substitute composition
US6652887B1 (en) 2002-06-24 2003-11-25 Wright Medical Technology, Inc. Bone graft substitute composition
US7291179B2 (en) * 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
US20040002770A1 (en) * 2002-06-28 2004-01-01 King Richard S. Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
US7029006B2 (en) * 2002-08-29 2006-04-18 Canon Kabushiki Kaisha Sheet feeding apparatus and image forming apparatus
US8986737B2 (en) * 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
US7763270B2 (en) * 2002-09-10 2010-07-27 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
KR20050084550A (ko) * 2002-09-13 2005-08-26 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Nell-1 향상 골 무기질화
US7164005B2 (en) * 2002-10-17 2007-01-16 Alkermes, Inc. Microencapsulation and sustained release of biologically active polypeptides
US20050048099A1 (en) * 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
BRPI0407058A (pt) * 2003-02-01 2006-01-17 Neuralab Ltd Métodos de profilaxia e de tratamento de uma doença, composição farmacêutica, e, uso de um fragmento
US7507257B2 (en) * 2003-02-04 2009-03-24 Wright Medical Technology, Inc. Injectable resorbable bone graft material, powder for forming same and methods relating thereto for treating bone defects
CN101018562A (zh) * 2003-02-07 2007-08-15 加州大学董事会 Nell肽表达系统和nell肽的骨形成活性
PE20050627A1 (es) * 2003-05-30 2005-08-10 Wyeth Corp Anticuerpos humanizados que reconocen el peptido beta amiloideo
CA2529503A1 (en) * 2003-06-20 2004-12-29 Royer Biomedical, Inc. Drug polymer complexes
US20040262809A1 (en) * 2003-06-30 2004-12-30 Smith Todd S. Crosslinked polymeric composite for orthopaedic implants
EP2441474B1 (de) 2003-10-17 2015-08-05 Joslin Diabetes Center, Inc. Verfahren und Zusammensetzungen zur Modulation der Adipozytfunktion
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20060141049A1 (en) * 2003-11-12 2006-06-29 Allergan, Inc. Triamcinolone compositions for intravitreal administration to treat ocular conditions
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
WO2005065396A2 (en) * 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US7691607B2 (en) * 2004-02-09 2010-04-06 The Regents Of The University Of California Expression system of NELL peptide
US8377904B2 (en) * 2004-02-09 2013-02-19 Hill's Pet Nutrition, Inc. Composition and method for use in cartilage affecting conditions
MXPA06011924A (es) * 2004-04-15 2007-06-11 Alkermes Inc Dispositivo de liberacion continua base polimeros.
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US20050244471A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
US20050244465A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US20050244466A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Photodynamic therapy in conjunction with intraocular implants
US8512738B2 (en) 2004-04-30 2013-08-20 Allergan, Inc. Biodegradable intravitreal tyrosine kinase implants
US8147865B2 (en) 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US20050244462A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US20050244461A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
US20050244478A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Anti-excititoxic sustained release intraocular implants and related methods
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
WO2005110374A1 (en) * 2004-04-30 2005-11-24 Allergan, Inc. Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US20050244469A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US8591885B2 (en) * 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US7384430B2 (en) * 2004-06-30 2008-06-10 Depuy Products, Inc. Low crystalline polymeric material for orthopaedic implants and an associated method
WO2006017347A2 (en) * 2004-07-12 2006-02-16 Allergan, Inc. Opthalmic compositions and methods for treating ophthalmic conditions
EP3698780A1 (de) * 2004-08-09 2020-08-26 Enrique Melendez Hevia Glycin als nahrungergänzungsmittel zur vorbeugung und/oder behandlung einer durch einen virus in einem der kollagen bedürfenden menschen collagensynthese bedarf verursachten infektionskrankheit
WO2006043965A1 (en) * 2004-10-14 2006-04-27 Allergan, Inc. Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods
US7250550B2 (en) * 2004-10-22 2007-07-31 Wright Medical Technology, Inc. Synthetic bone substitute material
US20060257396A1 (en) * 2004-12-15 2006-11-16 Jacobsen Jack S Abeta antibodies for use in improving cognition
US8916165B2 (en) * 2004-12-15 2014-12-23 Janssen Alzheimer Immunotherapy Humanized Aβ antibodies for use in improving cognition
ES2396555T3 (es) * 2004-12-15 2013-02-22 Janssen Alzheimer Immunotherapy Anticuerpos que reconocen péptido beta amiloide
US7896921B2 (en) * 2004-12-30 2011-03-01 Depuy Products, Inc. Orthopaedic bearing and method for making the same
US7879275B2 (en) * 2004-12-30 2011-02-01 Depuy Products, Inc. Orthopaedic bearing and method for making the same
US7883653B2 (en) 2004-12-30 2011-02-08 Depuy Products, Inc. Method of making an implantable orthopaedic bearing
RU2007124933A (ru) * 2005-01-28 2009-03-10 Вайет (Us) Стабилизированные жидкие полипептидные составы
GT200600031A (es) * 2005-01-28 2006-08-29 Formulacion anticuerpo anti a beta
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP1851237A4 (de) 2005-02-16 2009-01-07 Univ California Pharmazeutische zusammensetzungen zur behandlung oder prävention von knochenerkrankungen
WO2006089380A1 (fr) * 2005-02-24 2006-08-31 Roland Dricot Implant osseux
US20100150885A1 (en) * 2005-06-01 2010-06-17 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
US20060286171A1 (en) * 2005-06-17 2006-12-21 Tianhong Zhou Bone morphogenetic protein formulations
DK1933892T3 (da) 2005-09-09 2013-03-25 Agnovos Healthcare Llc Sammensat knoglegrafterstatningscement og artikler fremstillet deraf
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
US8911759B2 (en) * 2005-11-01 2014-12-16 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US20070178138A1 (en) * 2006-02-01 2007-08-02 Allergan, Inc. Biodegradable non-opthalmic implants and related methods
WO2009017467A1 (en) 2007-07-27 2009-02-05 Elan Pharma International Limited Treatment of amyloidogenic diseases
US8784810B2 (en) * 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
WO2007136664A2 (en) * 2006-05-16 2007-11-29 Flow Focusing, Inc. Antibiotic formulation and method of treatment
US8802128B2 (en) * 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20070298073A1 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
CA2657819C (en) * 2006-07-21 2014-05-20 Genera Doo Whole blood-derived coagulum device for treating bone defects
JP2009544411A (ja) * 2006-07-26 2009-12-17 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 骨形成増進組成物
US20080051796A1 (en) * 2006-08-01 2008-02-28 Warsaw Orthopedic, Inc. Graft retention tack
PL2359808T3 (pl) 2006-08-09 2013-10-31 Intarcia Therapeutics Inc Osmotyczne systemy dostawcze i zespoły tłokowe
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
DE102006060958A1 (de) * 2006-12-20 2008-06-26 Jennissen, Herbert P., Prof. Dr. Verfahren zur Herstellung einer Polymermatrix, daraus bestehende Implantate sowie deren Verwendung
JP2010522196A (ja) * 2007-03-22 2010-07-01 アルカームズ,インコーポレイテッド コアセルベーション工程
US8003097B2 (en) * 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
AU2008242648B2 (en) * 2007-04-18 2013-09-12 Janssen Alzheimer Immunotherapy Prevention and treatment of cerebral amyloid angiopathy
US7911053B2 (en) * 2007-04-19 2011-03-22 Marvell World Trade Ltd. Semiconductor packaging with internal wiring bus
CA2683610C (en) 2007-04-23 2013-01-08 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
EP2144624A1 (de) * 2007-05-15 2010-01-20 Stryker Corporation Konzentrierte proteinpräparate aus knochenmorphogenetischen proteinen und verfahren zu ihrer verwendung
WO2008157495A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Bone matrix compositions and methods
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
CA3062443C (en) * 2007-06-15 2022-03-15 Warsaw Orthopedic, Inc. Method of treating tissue
WO2008157492A2 (en) * 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
US9358113B2 (en) * 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
US8058237B2 (en) * 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
JO3076B1 (ar) * 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2211921B1 (de) 2007-10-19 2013-12-25 Warsaw Orthopedic, Inc. Demineralisierte knochenmatrix-zusammensetzungen und verfahren
DE102007051914A1 (de) * 2007-10-29 2009-05-07 Herbert Prof. Dr. Jennissen Verfahren zur Herstellung von mit Wachstumsfaktoren beladenen Partikeln sowie die so erhaltenen Partikel
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
CN102026619A (zh) * 2008-04-14 2011-04-20 先进科技及再生医学有限责任公司 液体缓冲的gdf-5制剂
US9616153B2 (en) * 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
CA2725208A1 (en) * 2008-05-06 2009-11-12 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
US9492375B2 (en) * 2008-07-23 2016-11-15 Warsaw Orthopedic, Inc. Foam carrier for bone grafting
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
WO2010093955A1 (en) 2009-02-12 2010-08-19 Osteotech,Inc. Segmented delivery system
US9409963B2 (en) 2009-05-26 2016-08-09 The Regents Of The University Of California Fibromodulin peptide
KR101823699B1 (ko) 2009-09-28 2018-01-30 인타르시아 세라퓨틱스 인코포레이티드 실질 항정상태 약물 전달의 신속 확립 및/또는 종결
SG10201805840WA (en) 2009-11-09 2018-08-30 Allergan Inc Compositions and methods for stimulating hair growth
WO2011086788A1 (ja) * 2010-01-15 2011-07-21 国立大学法人島根大学 骨セメント
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
WO2011137231A1 (en) * 2010-04-29 2011-11-03 Warsaw Orthopedic, Inc. Flowable ceramic putty
CA3048850A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
EP2606121B1 (de) 2010-08-19 2016-05-11 The Regents of The University of California Zusammensetzung mit perivaskulären stammzellen und nell-1-protein
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
RU2017134806A (ru) 2011-04-11 2019-02-07 Индьюс Байолоджикс Инк. Система и способ многофазного высвобождения факторов роста
US8765189B2 (en) 2011-05-13 2014-07-01 Howmedica Osteonic Corp. Organophosphorous and multivalent metal compound compositions and methods
JP6318143B2 (ja) 2012-04-11 2018-04-25 インデュース バイオロジクス インコーポレイテッドInduce Biologics Inc. 成長因子の多相性放出のためのシステムおよび方法
CA2901280A1 (en) 2013-02-15 2014-08-21 Allergan, Inc. Sustained drug delivery implant
US10294107B2 (en) 2013-02-20 2019-05-21 Bone Support Ab Setting of hardenable bone substitute
TWI651103B (zh) 2013-12-13 2019-02-21 萊特醫技股份有限公司 多相骨移植替代材料
JP6587675B2 (ja) 2014-03-20 2019-10-09 ステイブル セラピューティクス アーベー 椎間板性疼痛の治療での使用のための組成物
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CA2977625A1 (en) * 2014-12-29 2016-07-07 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
MX2017015504A (es) 2015-06-03 2018-05-15 Intarcia Therapeutics Inc Sistemas de colocacion y remoción de implante.
CN108601864A (zh) 2015-10-30 2018-09-28 佰欧维恩图斯有限责任公司 用于增强骨修复中骨诱导分子的递送的基质
AU2017268161B2 (en) 2016-05-16 2020-03-12 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
EP3468626A1 (de) 2016-06-10 2019-04-17 Bioventus LLC Proteinfreisetzung mit poröser metallischer struktur
AU2018206539A1 (en) 2017-01-03 2019-07-18 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
US11103618B2 (en) 2018-02-22 2021-08-31 Warsaw Orthopedic, Inc. Demineralized bone matrix having improved handling characteristics

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2093348B (en) * 1981-02-23 1984-09-12 Leo Pharm Prod Ltd Pharmaceutical composition for implantation
AU581177B2 (en) * 1983-05-31 1989-02-16 Choong-Gook Jang Dry direct compression compositions for controlled release dosage forms
US4526909A (en) * 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
US4619655A (en) * 1984-01-26 1986-10-28 University Of North Carolina Plaster of Paris as a bioresorbable scaffold in implants for bone repair
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5108436A (en) * 1988-09-29 1992-04-28 Collagen Corporation Implant fixation
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
WO1991000252A1 (en) * 1989-06-30 1991-01-10 United States Gypsum Company Calcium sulfate hemihydrate composition having utility in the presence of blood
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
WO1993000050A1 (en) * 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
CA2119090A1 (en) * 1993-03-26 1994-09-27 Wayne R. Gombotz Compositions for controlled release of biologically active tgf-.beta.

Also Published As

Publication number Publication date
EP0724459A1 (de) 1996-08-07
ES2196033T3 (es) 2003-12-16
KR960704587A (ko) 1996-10-09
WO1995007108A2 (en) 1995-03-16
EP0724459B1 (de) 2003-05-02
AU7953794A (en) 1995-03-27
WO1995007108A3 (en) 1995-06-15
AU695374B2 (en) 1998-08-13
NO960905L (no) 1996-03-06
US5385887A (en) 1995-01-31
DK0724459T3 (da) 2003-10-27
CA2169362C (en) 2000-05-02
NO960905D0 (no) 1996-03-06
JPH09502368A (ja) 1997-03-11
FI961037A0 (fi) 1996-03-06
ATE238819T1 (de) 2003-05-15
FI961037A (fi) 1996-03-06
DE69432596T2 (de) 2004-03-18
KR100329408B1 (ko) 2002-09-26
PT724459E (pt) 2003-08-29

Similar Documents

Publication Publication Date Title
DE69432596D1 (de) Zusammensetzungen für verabreichung von osteogenen proteinen
ATE189611T1 (de) Zusammensetzungen, die eine blutgerinnselpolymermatrix zur verabreichung von osteogenen proteinen enthalten
ES2088006T3 (es) Composiciones farmaceuticas osteoinductivas.
KR950031103A (ko) 단백질 함유의 안정한 동결-건조 제제
ATE142693T1 (de) Herstellung des vaskulären endothelialen zellwachstumsfaktors
DK0591392T3 (da) Farmaceutiske formuleringer af osteogene proteiner
EP1686172A3 (de) Herztransplantate und dafür nützliche Zellzusammensetzungen
DE60016614D1 (de) Zusammensetzungen zur abgabe osteogener proteine
UA26855C2 (uk) Фармацевтичhа композиція, яка регулює гематопоез
NO993709D0 (no) Stabilisert blanding omfattende fibrinogen
DK1017413T3 (da) Flydende formulering af interferon-beta
PT97539A (pt) Estabilizacao de somatotropinas e outras proteinas por modificacao dos residuos sw cisteina
HUP9900506A2 (hu) Protrombinszármazékok
ATE281155T1 (de) Medikamentöse verabreichung von proteinen aus polymergemischen
ATE188129T1 (de) Ipriflavone enthaltende pharmazeutische zubereitungen und deren verwendung zur ersetzung von knochendefekten
TR199900748A2 (xx) Osteinduktif protein ve dorsalize faktörünün kombinasyonunun kullanılması.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee