DE69426157T2 - 1,4-di(phenylalkyl)piperazinderivate - Google Patents

1,4-di(phenylalkyl)piperazinderivate

Info

Publication number
DE69426157T2
DE69426157T2 DE69426157T DE69426157T DE69426157T2 DE 69426157 T2 DE69426157 T2 DE 69426157T2 DE 69426157 T DE69426157 T DE 69426157T DE 69426157 T DE69426157 T DE 69426157T DE 69426157 T2 DE69426157 T2 DE 69426157T2
Authority
DE
Germany
Prior art keywords
compound
compounds
pharmaceutically acceptable
acceptable salt
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69426157T
Other languages
German (de)
English (en)
Other versions
DE69426157D1 (de
Inventor
Heiko Hirano
Yoichi Kawashima
Junzo Matsumoto
Kiyoshi Matsuno
Toshihiko Senda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of DE69426157D1 publication Critical patent/DE69426157D1/de
Application granted granted Critical
Publication of DE69426157T2 publication Critical patent/DE69426157T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69426157T 1993-07-28 1994-07-25 1,4-di(phenylalkyl)piperazinderivate Expired - Lifetime DE69426157T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18583993 1993-07-28
PCT/JP1994/001220 WO1995004050A1 (en) 1993-07-28 1994-07-25 Novel 1,4-di(phenylalkyl)piperazine derivative

Publications (2)

Publication Number Publication Date
DE69426157D1 DE69426157D1 (de) 2000-11-23
DE69426157T2 true DE69426157T2 (de) 2001-05-17

Family

ID=16177784

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426157T Expired - Lifetime DE69426157T2 (de) 1993-07-28 1994-07-25 1,4-di(phenylalkyl)piperazinderivate

Country Status (11)

Country Link
US (1) US5736546A (OSRAM)
EP (1) EP0711763B1 (OSRAM)
KR (1) KR100299734B1 (OSRAM)
CN (1) CN1042029C (OSRAM)
AT (1) ATE197047T1 (OSRAM)
CA (1) CA2168264A1 (OSRAM)
DE (1) DE69426157T2 (OSRAM)
ES (1) ES2151930T3 (OSRAM)
FI (1) FI960364L (OSRAM)
NO (1) NO960270L (OSRAM)
WO (1) WO1995004050A1 (OSRAM)

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US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
HUP9601331A3 (en) * 1996-05-17 2000-06-28 Egyt Gyogyszervegyeszeti Gyar Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them
US5952349A (en) * 1996-07-10 1999-09-14 Schering Corporation Muscarinic antagonists for treating memory loss
NZ333513A (en) * 1996-07-10 2000-04-28 Schering Corp 1,4-di-substituted piperidines and medicaments useful as muscarinic antagonists
US5860391A (en) * 1996-08-06 1999-01-19 First Brands Corporation Absorbents containing activated carbons
US6713651B1 (en) * 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
KR100700347B1 (ko) * 1998-11-09 2007-03-29 산텐 세이야꾸 가부시키가이샤 약물 의존증 치료제
WO2001000604A1 (fr) * 1999-06-30 2001-01-04 Santen Pharmaceutical Co., Ltd. Ligand de liaison avec le recepteur sigma-1 du cerveau
DE10050236A1 (de) * 2000-10-11 2002-04-25 Merck Patent Gmbh Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen
CN1181065C (zh) 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
US20050032827A1 (en) * 2003-06-12 2005-02-10 Donna Oksenberg Sigma ligands for neuronal regeneration and functional recovery
WO2005028457A1 (en) * 2003-09-23 2005-03-31 Fermion Oy Preparation of quetiapine
DE102004061593A1 (de) * 2004-12-21 2006-06-22 Abbott Gmbh & Co. Kg Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung
CA2617346A1 (en) * 2005-08-09 2007-02-22 M's Science Corporation Piperazine derivatives
JP2009528976A (ja) * 2005-09-23 2009-08-13 株式会社エムズサイエンス ピペリジン誘導体及びピペラジン誘導体
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
DE602007010236D1 (de) * 2006-01-27 2010-12-16 Ms Science Corp Piperidin- und piperazin-derivate
CA2642630A1 (en) * 2006-02-15 2007-08-30 M's Science Corporation Piperazine derivatives
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008060271A1 (en) * 2006-11-13 2008-05-22 M's Science Corporation Sigma ligands for neuronal regeneration and functional recovery
EP2291181B9 (en) 2008-04-18 2013-09-11 University College Dublin National University Of Ireland, Dublin Captodiamine for the treatment of depression symptoms
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8673920B2 (en) * 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058116A1 (en) 2010-10-27 2012-05-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058134A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9062070B2 (en) 2011-08-19 2015-06-23 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TW201317213A (zh) 2011-09-16 2013-05-01 Merck Sharp & Dohme 腎外髓質鉀通道抑制劑
WO2013062900A1 (en) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2771005B1 (en) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9108947B2 (en) 2011-10-31 2015-08-18 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
WO2013066718A2 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9139585B2 (en) 2011-10-31 2015-09-22 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
US9206199B2 (en) 2011-12-16 2015-12-08 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
EP2925322B1 (en) 2012-11-29 2018-10-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2934533B1 (en) 2012-12-19 2017-11-15 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2956142B1 (en) 2013-02-18 2017-09-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2968288B1 (en) 2013-03-15 2018-07-04 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP3027625B1 (en) 2013-07-31 2018-05-30 Merck Sharp & Dohme Corp. Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure
WO2015065866A1 (en) 2013-10-31 2015-05-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2016127358A1 (en) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibitors of renal outer medullary potassium channel

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5583771A (en) * 1978-12-20 1980-06-24 Kanebo Ltd N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt
JPS60155171A (ja) * 1983-12-10 1985-08-15 Wako Pure Chem Ind Ltd ポリメトキシベンジルピペラジン誘導体
JPS6133827A (ja) * 1984-07-27 1986-02-17 Mitsubishi Electric Corp 放電加工装置
JP2722250B2 (ja) * 1989-05-30 1998-03-04 興和株式会社 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
WO1991009594A1 (en) * 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof
EP0566189A1 (en) * 1992-04-13 1993-10-20 Akzo N.V. Psychotropic piperazine derivative
US5428037A (en) * 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases

Also Published As

Publication number Publication date
EP0711763A4 (OSRAM) 1996-06-12
KR100299734B1 (ko) 2002-01-09
ES2151930T3 (es) 2001-01-16
NO960270D0 (no) 1996-01-23
ATE197047T1 (de) 2000-11-15
DE69426157D1 (de) 2000-11-23
US5736546A (en) 1998-04-07
NO960270L (no) 1996-01-23
WO1995004050A1 (en) 1995-02-09
EP0711763B1 (en) 2000-10-18
CN1042029C (zh) 1999-02-10
FI960364A0 (fi) 1996-01-26
EP0711763A1 (en) 1996-05-15
FI960364A7 (fi) 1996-01-26
CN1128026A (zh) 1996-07-31
FI960364L (fi) 1996-01-26
CA2168264A1 (en) 1995-02-09

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