ES2151930T3 - Nuevos derivados de 1,4-(difenilalquil)piperazina. - Google Patents
Nuevos derivados de 1,4-(difenilalquil)piperazina.Info
- Publication number
- ES2151930T3 ES2151930T3 ES94921809T ES94921809T ES2151930T3 ES 2151930 T3 ES2151930 T3 ES 2151930T3 ES 94921809 T ES94921809 T ES 94921809T ES 94921809 T ES94921809 T ES 94921809T ES 2151930 T3 ES2151930 T3 ES 2151930T3
- Authority
- ES
- Spain
- Prior art keywords
- difenilalquil
- piperazina
- new derivatives
- sup
- equal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN COMPUESTO NOVEDOSO REPRESENTADO POR LA FORMULA GENERAL [I], DONDE R{SUP,1} Y R{SUP,2} PUEDEN SER IGUALES O DIFERENTES ENTRE SI Y REPRESENTA CADA UNA ALCOXI BAJO; Y A Y B PUEDEN SER IGUALES O DIFERENTES ENTRE SI Y CADA UNA REPRESENTA ALQUILENO BAJO. POSEE UNA AFINIDAD {SI} RECEPTORA Y ES UTIL COMO REMEDIO PARA ENFERMEDADES QUE ACOMPAÑAN A LOS DESORDENES DE LA FUNCION DEL NERVIO CRANIAL, TALES COMO DEMENCIA, DEPRESION, ESQUIZOFRENIA Y ANSIEDAD, INMUNOPATIA Y CRIPTORREA, Y ULCERA DIGESTIVA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18583993 | 1993-07-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2151930T3 true ES2151930T3 (es) | 2001-01-16 |
Family
ID=16177784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94921809T Expired - Lifetime ES2151930T3 (es) | 1993-07-28 | 1994-07-25 | Nuevos derivados de 1,4-(difenilalquil)piperazina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5736546A (es) |
EP (1) | EP0711763B1 (es) |
KR (1) | KR100299734B1 (es) |
CN (1) | CN1042029C (es) |
AT (1) | ATE197047T1 (es) |
CA (1) | CA2168264A1 (es) |
DE (1) | DE69426157T2 (es) |
ES (1) | ES2151930T3 (es) |
FI (1) | FI960364A (es) |
NO (1) | NO960270D0 (es) |
WO (1) | WO1995004050A1 (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859295A (en) * | 1994-12-05 | 1999-01-12 | University Of Kentucky Research Foundation | Canavanine analogs and their use as chemotherapeutic agents |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
HUP9601331A3 (en) * | 1996-05-17 | 2000-06-28 | Egyt Gyogyszervegyeszeti Gyar | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them |
DK0912515T3 (da) * | 1996-07-10 | 2003-03-10 | Schering Corp | 1,4-Disubstituerede piperidiner som muscarinantagonister |
US5952349A (en) * | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
US5860391A (en) * | 1996-08-06 | 1999-01-19 | First Brands Corporation | Absorbents containing activated carbons |
US6713651B1 (en) * | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
CN1131221C (zh) * | 1998-11-09 | 2003-12-17 | 参天制药株式会社 | 药物依赖症的治疗剂 |
AU5569800A (en) * | 1999-06-30 | 2001-01-31 | Santen Pharmaceutical Co. Ltd. | Brain sigma-1 receptor-binding ligand |
DE10050236A1 (de) * | 2000-10-11 | 2002-04-25 | Merck Patent Gmbh | Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen |
CN1181065C (zh) * | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
CN1172919C (zh) * | 2002-06-03 | 2004-10-27 | 上海医药工业研究院 | 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用 |
WO2004110387A2 (en) * | 2003-06-12 | 2004-12-23 | Agy Therapeutics, Inc. | Sigma ligands for neuronal regeneration and functional recovery |
WO2005028457A1 (en) * | 2003-09-23 | 2005-03-31 | Fermion Oy | Preparation of quetiapine |
DE102004061593A1 (de) | 2004-12-21 | 2006-06-22 | Abbott Gmbh & Co. Kg | Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung |
WO2007021545A2 (en) * | 2005-08-09 | 2007-02-22 | M's Science Corporation | Piperazine derivatives |
PL1978959T3 (pl) * | 2005-09-23 | 2012-04-30 | Ms Science Corp | Pochodne piperydyny i piperazyny |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
WO2007089462A2 (en) | 2006-01-27 | 2007-08-09 | M's Science Corporation | Piperidine and piperazine derivatives |
AU2007218086A1 (en) * | 2006-02-15 | 2007-08-30 | M's Science Corporation | Piperazine derivatives |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
CA2668766A1 (en) * | 2006-11-13 | 2008-05-22 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
US8461389B2 (en) | 2008-04-18 | 2013-06-11 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9073882B2 (en) | 2010-10-27 | 2015-07-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2012058134A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
CN103874493A (zh) | 2011-08-19 | 2014-06-18 | 默沙东公司 | 肾外髓质钾通道的抑制剂 |
US9527830B2 (en) | 2011-09-16 | 2016-12-27 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2771004B1 (en) | 2011-10-25 | 2016-05-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999990B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013066718A2 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2773199B1 (en) | 2011-10-31 | 2019-04-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9108947B2 (en) | 2011-10-31 | 2015-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
WO2013090271A1 (en) | 2011-12-16 | 2013-06-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
AR092031A1 (es) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | Inhibidores del canal de potasio medular externo renal |
EP2925322B1 (en) | 2012-11-29 | 2018-10-24 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2934533B1 (en) | 2012-12-19 | 2017-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9604998B2 (en) | 2013-02-18 | 2017-03-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2014150132A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9951052B2 (en) | 2013-10-31 | 2018-04-24 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2016127358A1 (en) | 2015-02-12 | 2016-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of renal outer medullary potassium channel |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5583771A (en) * | 1978-12-20 | 1980-06-24 | Kanebo Ltd | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
JPS60155171A (ja) * | 1983-12-10 | 1985-08-15 | Wako Pure Chem Ind Ltd | ポリメトキシベンジルピペラジン誘導体 |
JPS6133827A (ja) * | 1984-07-27 | 1986-02-17 | Mitsubishi Electric Corp | 放電加工装置 |
JP2722250B2 (ja) * | 1989-05-30 | 1998-03-04 | 興和株式会社 | 新規なジアミン化合物及びこれを含有する脳機能障害改善剤 |
CA2071897A1 (en) * | 1989-12-28 | 1991-06-29 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
EP0566189A1 (en) * | 1992-04-13 | 1993-10-20 | Akzo N.V. | Psychotropic piperazine derivative |
US5428037A (en) * | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
-
1994
- 1994-07-25 ES ES94921809T patent/ES2151930T3/es not_active Expired - Lifetime
- 1994-07-25 WO PCT/JP1994/001220 patent/WO1995004050A1/ja active IP Right Grant
- 1994-07-25 KR KR1019960700394A patent/KR100299734B1/ko not_active IP Right Cessation
- 1994-07-25 CN CN94192903A patent/CN1042029C/zh not_active Expired - Fee Related
- 1994-07-25 CA CA002168264A patent/CA2168264A1/en not_active Abandoned
- 1994-07-25 EP EP94921809A patent/EP0711763B1/en not_active Expired - Lifetime
- 1994-07-25 AT AT94921809T patent/ATE197047T1/de active
- 1994-07-25 DE DE69426157T patent/DE69426157T2/de not_active Expired - Lifetime
- 1994-07-25 US US08/586,661 patent/US5736546A/en not_active Expired - Lifetime
-
1996
- 1996-01-23 NO NO960270A patent/NO960270D0/no unknown
- 1996-01-26 FI FI960364A patent/FI960364A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI960364A0 (fi) | 1996-01-26 |
EP0711763B1 (en) | 2000-10-18 |
NO960270L (no) | 1996-01-23 |
WO1995004050A1 (fr) | 1995-02-09 |
DE69426157D1 (de) | 2000-11-23 |
EP0711763A1 (en) | 1996-05-15 |
ATE197047T1 (de) | 2000-11-15 |
FI960364A (fi) | 1996-01-26 |
KR100299734B1 (ko) | 2002-01-09 |
NO960270D0 (no) | 1996-01-23 |
CA2168264A1 (en) | 1995-02-09 |
DE69426157T2 (de) | 2001-05-17 |
CN1128026A (zh) | 1996-07-31 |
US5736546A (en) | 1998-04-07 |
EP0711763A4 (es) | 1996-06-12 |
CN1042029C (zh) | 1999-02-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2151930T3 (es) | Nuevos derivados de 1,4-(difenilalquil)piperazina. | |
MX9203338A (es) | Nuevos derivados del oxico a_nor-esteroide-3-carboxilico. | |
ATE45942T1 (de) | Diarylacetylene, ihre herstellung und verwendung. | |
DE3576331D1 (de) | Tetralin-derivate, ihre herstellung und verwendung. | |
DE3582689D1 (de) | Instrumente zum chirurgischen ersetzen von ligamenten. | |
FI870113A0 (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten 4,5,6-substioitujenN-(substituoitu-fenyyli)-2-pyrimidiiniamiinien valmistamiseksi | |
ES2159714T3 (es) | Hidroximetil-imidazodiazepinas y sus esteres. | |
ES545882A0 (es) | Procedimiento para preparar nuevos derivados de acidos feni-laceticos | |
AU2911489A (en) | Quinoline derivatives as antagonists of leukotriene d4 | |
ES2150150T3 (es) | Derivados de lactona de derivados de 17-beta-carboxi, carbonato y amida androstano. | |
ES2000368A6 (es) | Un procedimiento para preparar di-t-butilfenoles sustituidos | |
FI881877A0 (fi) | 17 -(cyklopropylamino) androst-5 -en-3 -ol och naerstaoende foereningar, som aer anvaendbara som c17-20-lyas-inhibitorer. | |
GB2083459B (en) | New substituted heterocyclic benzamides and their production | |
EP0326023A3 (en) | Benzamide against cognitive disorders | |
EP0330041A3 (de) | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung und ihre Verwendung | |
ATE67495T1 (de) | 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2thiazolamine und 4-(hexahydro-1-alkyl-3pyridinyl)-2-thiazolamine. | |
ATE39694T1 (de) | (pyrrol-1-yl)-phenyl-dihydropyridazinone, ihre herstellung und verwendung. | |
PT96084A (pt) | Processo para a preparacao de ciclo-hexenos substituidos utilizados como agentes do sistema nervoso central | |
AR013844A1 (es) | Compuestos derivados de 3-oxo-pirido[1,2-a] bencimidazol-4-carboxamida sustituidos en posicion 5 con alquilo que contiene heteroatomo,- y composiciones farmaceuticas que los comprenden. | |
ATE51229T1 (de) | Oxa- und thiadiazolylderivate und ihre verwendung. | |
IL65597A (en) | Preparation of 1alpha,24,25-trihydroxy-and 24,25-dihydroxy-cholesterol and certain novel intermediates used therein | |
ES2053478T3 (es) | Proceso mejorado para preparar 2,4-quinazolinodiaminas 5,6-substituidas y nuevos intermedios. | |
ATE121737T1 (de) | Herstellung von enantiomeren des dropropizins. | |
ES8307711A1 (es) | "procedimiento para la preparacion de un nuevo derivado de alquilenodiamina". | |
EP0405376A3 (en) | Characterization of viruses |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 711763 Country of ref document: ES |