DE69426157D1 - 1,4-di(phenylalkyl)piperazinderivate - Google Patents
1,4-di(phenylalkyl)piperazinderivateInfo
- Publication number
- DE69426157D1 DE69426157D1 DE69426157T DE69426157T DE69426157D1 DE 69426157 D1 DE69426157 D1 DE 69426157D1 DE 69426157 T DE69426157 T DE 69426157T DE 69426157 T DE69426157 T DE 69426157T DE 69426157 D1 DE69426157 D1 DE 69426157D1
- Authority
- DE
- Germany
- Prior art keywords
- phenylalkyl
- different
- same
- represents lower
- piperazine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18583993 | 1993-07-28 | ||
PCT/JP1994/001220 WO1995004050A1 (fr) | 1993-07-28 | 1994-07-25 | Nouveau derive de 1,4-di(phenylalkyl)piperazine |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69426157D1 true DE69426157D1 (de) | 2000-11-23 |
DE69426157T2 DE69426157T2 (de) | 2001-05-17 |
Family
ID=16177784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69426157T Expired - Lifetime DE69426157T2 (de) | 1993-07-28 | 1994-07-25 | 1,4-di(phenylalkyl)piperazinderivate |
Country Status (11)
Country | Link |
---|---|
US (1) | US5736546A (de) |
EP (1) | EP0711763B1 (de) |
KR (1) | KR100299734B1 (de) |
CN (1) | CN1042029C (de) |
AT (1) | ATE197047T1 (de) |
CA (1) | CA2168264A1 (de) |
DE (1) | DE69426157T2 (de) |
ES (1) | ES2151930T3 (de) |
FI (1) | FI960364A (de) |
NO (1) | NO960270D0 (de) |
WO (1) | WO1995004050A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859295A (en) * | 1994-12-05 | 1999-01-12 | University Of Kentucky Research Foundation | Canavanine analogs and their use as chemotherapeutic agents |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
HUP9601331A3 (en) * | 1996-05-17 | 2000-06-28 | Egyt Gyogyszervegyeszeti Gyar | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them |
US5952349A (en) * | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
HUP9904622A3 (en) * | 1996-07-10 | 2001-07-30 | Schering Corp | 1,4-di-sustituted piperidines as muscarinic antagonists |
US5860391A (en) * | 1996-08-06 | 1999-01-19 | First Brands Corporation | Absorbents containing activated carbons |
US6713651B1 (en) * | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
EP1130018B1 (de) | 1998-11-09 | 2007-01-17 | Santen Pharmaceutical Co., Ltd. | Medikament gegen drogenabhängigkeit |
WO2001000604A1 (en) * | 1999-06-30 | 2001-01-04 | Santen Pharmaceutical Co., Ltd. | Brain sigma-1 receptor-binding ligand |
DE10050236A1 (de) * | 2000-10-11 | 2002-04-25 | Merck Patent Gmbh | Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen |
CN1181065C (zh) | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
CN1172919C (zh) | 2002-06-03 | 2004-10-27 | 上海医药工业研究院 | 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用 |
US7863272B2 (en) * | 2003-06-12 | 2011-01-04 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
WO2005028457A1 (en) * | 2003-09-23 | 2005-03-31 | Fermion Oy | Preparation of quetiapine |
DE102004061593A1 (de) | 2004-12-21 | 2006-06-22 | Abbott Gmbh & Co. Kg | Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung |
AU2006280203B2 (en) * | 2005-08-09 | 2010-06-17 | M's Science Corporation | Piperazine derivatives |
WO2008096189A2 (en) * | 2005-09-23 | 2008-08-14 | M's Science Corporation | Piperidine and piperazine derivatives |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
DE602007010236D1 (de) * | 2006-01-27 | 2010-12-16 | Ms Science Corp | Piperidin- und piperazin-derivate |
CA2642630A1 (en) * | 2006-02-15 | 2007-08-30 | M's Science Corporation | Piperazine derivatives |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | 5ht受容体介在性の神経新生 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
CA2668766A1 (en) * | 2006-11-13 | 2008-05-22 | M's Science Corporation | Sigma ligands for neuronal regeneration and functional recovery |
US8461389B2 (en) | 2008-04-18 | 2013-06-11 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8673920B2 (en) * | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2012058116A1 (en) | 2010-10-27 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2632464B1 (de) | 2010-10-29 | 2015-04-29 | Merck Sharp & Dohme Corp. | Inhibitoren des renalen kaliumkanals der äusseren medulla |
RU2014110401A (ru) | 2011-08-19 | 2015-09-27 | Мерк Шарп И Доум Корп. | Ингибиторы внешнего медуллярного калиевого канала почек |
WO2013039802A1 (en) | 2011-09-16 | 2013-03-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999990B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US8999991B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2773351B1 (de) | 2011-10-31 | 2017-08-23 | Merck Sharp & Dohme Corp. | Inhibitoren des renalen kaliumkanals der äusseren medulla |
WO2013066717A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9139585B2 (en) | 2011-10-31 | 2015-09-22 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
US9206199B2 (en) | 2011-12-16 | 2015-12-08 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
AR092031A1 (es) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | Inhibidores del canal de potasio medular externo renal |
EP2925322B1 (de) | 2012-11-29 | 2018-10-24 | Merck Sharp & Dohme Corp. | Inhibitoren des renalen kaliumkanals der äusseren medulla |
EP2934533B1 (de) | 2012-12-19 | 2017-11-15 | Merck Sharp & Dohme Corp. | Inhibitoren des kaliumkanals des äusseren nierenmarks |
EP2956142B1 (de) | 2013-02-18 | 2017-09-20 | Merck Sharp & Dohme Corp. | Inhibitoren des renalen kaliumkanals der äusseren medulla |
WO2014150132A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2015017305A1 (en) | 2013-07-31 | 2015-02-05 | Merck Sharp & Dohme Corp | Inhibitors of the renal outer medullary potassium channel |
WO2015065866A1 (en) | 2013-10-31 | 2015-05-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2016127358A1 (en) | 2015-02-12 | 2016-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of renal outer medullary potassium channel |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5583771A (en) * | 1978-12-20 | 1980-06-24 | Kanebo Ltd | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
JPS60155171A (ja) * | 1983-12-10 | 1985-08-15 | Wako Pure Chem Ind Ltd | ポリメトキシベンジルピペラジン誘導体 |
JPS6133827A (ja) * | 1984-07-27 | 1986-02-17 | Mitsubishi Electric Corp | 放電加工装置 |
JP2722250B2 (ja) * | 1989-05-30 | 1998-03-04 | 興和株式会社 | 新規なジアミン化合物及びこれを含有する脳機能障害改善剤 |
CA2071897A1 (en) * | 1989-12-28 | 1991-06-29 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
EP0566189A1 (de) * | 1992-04-13 | 1993-10-20 | Akzo N.V. | Psychotroop-Piperazinderivat |
US5428037A (en) * | 1993-04-09 | 1995-06-27 | Syntex Pharmaceuticals, Ltd. | Heterocyclic derivatives in the treatment of Ischaemia and related diseases |
-
1994
- 1994-07-25 CA CA002168264A patent/CA2168264A1/en not_active Abandoned
- 1994-07-25 CN CN94192903A patent/CN1042029C/zh not_active Expired - Fee Related
- 1994-07-25 WO PCT/JP1994/001220 patent/WO1995004050A1/ja active IP Right Grant
- 1994-07-25 US US08/586,661 patent/US5736546A/en not_active Expired - Lifetime
- 1994-07-25 AT AT94921809T patent/ATE197047T1/de active
- 1994-07-25 KR KR1019960700394A patent/KR100299734B1/ko not_active IP Right Cessation
- 1994-07-25 DE DE69426157T patent/DE69426157T2/de not_active Expired - Lifetime
- 1994-07-25 EP EP94921809A patent/EP0711763B1/de not_active Expired - Lifetime
- 1994-07-25 ES ES94921809T patent/ES2151930T3/es not_active Expired - Lifetime
-
1996
- 1996-01-23 NO NO960270A patent/NO960270D0/no unknown
- 1996-01-26 FI FI960364A patent/FI960364A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2168264A1 (en) | 1995-02-09 |
NO960270L (no) | 1996-01-23 |
WO1995004050A1 (fr) | 1995-02-09 |
EP0711763A4 (de) | 1996-06-12 |
DE69426157T2 (de) | 2001-05-17 |
CN1042029C (zh) | 1999-02-10 |
ATE197047T1 (de) | 2000-11-15 |
CN1128026A (zh) | 1996-07-31 |
EP0711763A1 (de) | 1996-05-15 |
EP0711763B1 (de) | 2000-10-18 |
FI960364A0 (fi) | 1996-01-26 |
NO960270D0 (no) | 1996-01-23 |
KR100299734B1 (ko) | 2002-01-09 |
ES2151930T3 (es) | 2001-01-16 |
FI960364A (fi) | 1996-01-26 |
US5736546A (en) | 1998-04-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
R082 | Change of representative |
Ref document number: 711763 Country of ref document: EP Representative=s name: PAUL & ALBRECHT PATENTANWALTSSOZIETAET, 41460 NEUS |