ATE121737T1 - Herstellung von enantiomeren des dropropizins. - Google Patents
Herstellung von enantiomeren des dropropizins.Info
- Publication number
- ATE121737T1 ATE121737T1 AT89201651T AT89201651T ATE121737T1 AT E121737 T1 ATE121737 T1 AT E121737T1 AT 89201651 T AT89201651 T AT 89201651T AT 89201651 T AT89201651 T AT 89201651T AT E121737 T1 ATE121737 T1 AT E121737T1
- Authority
- AT
- Austria
- Prior art keywords
- enantiomers
- preparation
- dropropicine
- dropropizine
- phenylpiperazine
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- PTVWPYVOOKLBCG-UHFFFAOYSA-N 3-(4-phenyl-1-piperazinyl)propane-1,2-diol Chemical compound C1CN(CC(O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-UHFFFAOYSA-N 0.000 abstract 2
- 229960004722 dropropizine Drugs 0.000 abstract 2
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8801622A NL8801622A (nl) | 1988-06-25 | 1988-06-25 | Bereiding van enantiomeren van dropropizine. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE121737T1 true ATE121737T1 (de) | 1995-05-15 |
Family
ID=19852523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89201651T ATE121737T1 (de) | 1988-06-25 | 1989-06-22 | Herstellung von enantiomeren des dropropizins. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0349066B1 (de) |
| AT (1) | ATE121737T1 (de) |
| DE (1) | DE68922344T2 (de) |
| ES (1) | ES2072288T3 (de) |
| NL (1) | NL8801622A (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1226570B (it) * | 1988-08-01 | 1991-01-24 | Bidachem Spa | Procedimento di preparazione della levo- e destro-dropropizina |
| IT1231158B (it) * | 1989-07-20 | 1991-11-19 | Dompe Farmaceutici Spa | Procedimento per la risoluzione ottica della dropropizina. |
| IT1254452B (it) * | 1992-02-14 | 1995-09-25 | Dompe Farmaceutici Spa | N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli |
| IT1254993B (it) * | 1992-06-24 | 1995-10-11 | Procedimento per la preparazione degli enantiomeri della dropropizina | |
| IT1318650B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-diossolani ad attivita' antitosse. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE601394A (de) * | ||||
| IT1203721B (it) * | 1983-12-29 | 1989-02-23 | Dompe Farmaceutici Spa | Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono |
-
1988
- 1988-06-25 NL NL8801622A patent/NL8801622A/nl not_active Application Discontinuation
-
1989
- 1989-06-22 EP EP89201651A patent/EP0349066B1/de not_active Revoked
- 1989-06-22 ES ES89201651T patent/ES2072288T3/es not_active Expired - Lifetime
- 1989-06-22 DE DE68922344T patent/DE68922344T2/de not_active Revoked
- 1989-06-22 AT AT89201651T patent/ATE121737T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE68922344D1 (de) | 1995-06-01 |
| DE68922344T2 (de) | 1995-12-14 |
| NL8801622A (nl) | 1990-01-16 |
| ES2072288T3 (es) | 1995-07-16 |
| EP0349066A1 (de) | 1990-01-03 |
| EP0349066B1 (de) | 1995-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |