DE3486438D1 - Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten - Google Patents
Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-DerivatenInfo
- Publication number
- DE3486438D1 DE3486438D1 DE3486438T DE3486438T DE3486438D1 DE 3486438 D1 DE3486438 D1 DE 3486438D1 DE 3486438 T DE3486438 T DE 3486438T DE 3486438 T DE3486438 T DE 3486438T DE 3486438 D1 DE3486438 D1 DE 3486438D1
- Authority
- DE
- Germany
- Prior art keywords
- fluoropropane
- hydroxy
- phenyl
- derivatives
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21417/83A IT1175919B (it) | 1983-06-02 | 1983-06-02 | Procedimento per preparare derivati dell'1-(fenil)-1-idrossi-2-ammino-3-fluoro-propano e loro intermedi |
IT22449/83A IT1164388B (it) | 1983-08-05 | 1983-08-05 | Procedimento per preparare derivati dell'1-(fenil)-1-idrossi-2-ammino-3-fluoro-propano e loro derivati |
IT19435/84A IT1173213B (it) | 1984-02-03 | 1984-02-03 | Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3486438D1 true DE3486438D1 (de) | 1996-11-14 |
DE3486438T2 DE3486438T2 (de) | 1998-08-13 |
Family
ID=27272965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3486438T Expired - Lifetime DE3486438T2 (de) | 1983-06-02 | 1984-05-29 | Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten |
Country Status (5)
Country | Link |
---|---|
EP (3) | EP0678506A3 (de) |
JP (2) | JPH0819085B2 (de) |
AT (1) | ATE143953T1 (de) |
DE (1) | DE3486438T2 (de) |
ES (1) | ES533355A0 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5243056A (en) * | 1983-06-02 | 1993-09-07 | Zambon S.P.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
US5332835A (en) * | 1984-02-03 | 1994-07-26 | Zambon S.P.A. | Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process |
US5153328A (en) * | 1984-02-03 | 1992-10-06 | Zambon S.P.A. | 2 Hydrocarbyl-4 substituted methyl 5 (4 substituted phenyl)-oxazolines |
US4876352A (en) * | 1988-09-14 | 1989-10-24 | Schering Corporation | Pressurized fluorination of hydroxy alkyl groups |
US5227494A (en) * | 1988-09-14 | 1993-07-13 | Schering Corporation | Process for preparing oxazoline compounds |
WO1990014434A1 (en) * | 1989-05-15 | 1990-11-29 | Schering Corporation | Process for preparing antibacterial compounds and intermediates thereto |
WO1991000923A2 (en) * | 1989-07-07 | 1991-01-24 | Schering Corporation | Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates |
IT1237798B (it) * | 1989-10-20 | 1993-06-17 | Zambon Spa | Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). |
IT1240676B (it) * | 1990-04-24 | 1993-12-17 | Agrimont Spa | Composizioni ad attivita' erbicida |
ATE115123T1 (de) * | 1990-10-25 | 1994-12-15 | Schering Corp | Verfahren zur herstellung von florfenicol, seine analoga und oxazolinzwischenprodukte. |
IT1249048B (it) | 1991-02-21 | 1995-02-11 | Zambon Spa | Processo per la preparazione di trans-(5r)-2-ossazoline -2,4,5, trisostituite |
US5663361A (en) * | 1996-08-19 | 1997-09-02 | Schering Corporation | Process for preparing intermediates to florfenicol |
US7126005B2 (en) | 2003-10-06 | 2006-10-24 | Aurobindo Pharma Limited | Process for preparing florfenicol |
EP1896403A1 (de) * | 2005-06-20 | 2008-03-12 | Aurobindo Pharma Limited | Verbessertes verfahren zur herstellung von florfenicol |
WO2007030405A2 (en) * | 2005-09-07 | 2007-03-15 | Schering-Plough Ltd. | A process for preparing ester oxazolidine compounds and their conversion to florfenicol |
CN103965085B (zh) * | 2014-04-17 | 2016-02-24 | 上海恒晟药业有限公司 | 一种取代1,2-氨基醇药物的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2820041A (en) * | 1958-01-14 | Preparation of nitrophenyloxazolines | ||
AT179022B (de) * | 1950-04-14 | 1954-07-10 | Parke Davis & Co | Verfahren zur Herstellung von neuen Oxazolinabkömmlingen |
IT1065143B (it) | 1976-08-05 | 1985-02-25 | Clesa Spa | Derivati del d-treo-1-fenil-2-trifluoroacetamido-1,3-propandiolo e processi per la loro preparazione |
US4235892A (en) | 1979-02-05 | 1980-11-25 | Schering Corporation, Patent Dept. | 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor |
-
1984
- 1984-05-29 EP EP95201523A patent/EP0678506A3/de not_active Withdrawn
- 1984-05-29 DE DE3486438T patent/DE3486438T2/de not_active Expired - Lifetime
- 1984-05-29 EP EP95201522A patent/EP0677511A3/de not_active Withdrawn
- 1984-05-29 EP EP84200772A patent/EP0130633B1/de not_active Expired - Lifetime
- 1984-05-29 AT AT84200772T patent/ATE143953T1/de not_active IP Right Cessation
- 1984-06-01 ES ES533355A patent/ES533355A0/es active Granted
- 1984-06-02 JP JP59113774A patent/JPH0819085B2/ja not_active Expired - Lifetime
-
1995
- 1995-09-29 JP JP7287772A patent/JP2721959B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES8505927A1 (es) | 1985-06-16 |
ES533355A0 (es) | 1985-06-16 |
EP0678506A3 (de) | 1996-07-24 |
DE3486438T2 (de) | 1998-08-13 |
JPS6069072A (ja) | 1985-04-19 |
EP0130633B1 (de) | 1996-10-09 |
EP0678506A2 (de) | 1995-10-25 |
ATE143953T1 (de) | 1996-10-15 |
JPH0819085B2 (ja) | 1996-02-28 |
EP0130633A2 (de) | 1985-01-09 |
JP2721959B2 (ja) | 1998-03-04 |
JPH08295678A (ja) | 1996-11-12 |
EP0130633A3 (de) | 1987-08-05 |
EP0677511A2 (de) | 1995-10-18 |
EP0677511A3 (de) | 1996-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SCHERING-PLOUTH LTD., LUZERN, CH |