DE3486438D1 - Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten - Google Patents

Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten

Info

Publication number
DE3486438D1
DE3486438D1 DE3486438T DE3486438T DE3486438D1 DE 3486438 D1 DE3486438 D1 DE 3486438D1 DE 3486438 T DE3486438 T DE 3486438T DE 3486438 T DE3486438 T DE 3486438T DE 3486438 D1 DE3486438 D1 DE 3486438D1
Authority
DE
Germany
Prior art keywords
fluoropropane
hydroxy
phenyl
derivatives
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3486438T
Other languages
English (en)
Other versions
DE3486438T2 (de
Inventor
Giancarlo Jommi
Dario Chiarino
Roberto Pagliarin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT21417/83A external-priority patent/IT1175919B/it
Priority claimed from IT22449/83A external-priority patent/IT1164388B/it
Priority claimed from IT19435/84A external-priority patent/IT1173213B/it
Application filed by Zambon SpA filed Critical Zambon SpA
Application granted granted Critical
Publication of DE3486438D1 publication Critical patent/DE3486438D1/de
Publication of DE3486438T2 publication Critical patent/DE3486438T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE3486438T 1983-06-02 1984-05-29 Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten Expired - Lifetime DE3486438T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT21417/83A IT1175919B (it) 1983-06-02 1983-06-02 Procedimento per preparare derivati dell'1-(fenil)-1-idrossi-2-ammino-3-fluoro-propano e loro intermedi
IT22449/83A IT1164388B (it) 1983-08-05 1983-08-05 Procedimento per preparare derivati dell'1-(fenil)-1-idrossi-2-ammino-3-fluoro-propano e loro derivati
IT19435/84A IT1173213B (it) 1984-02-03 1984-02-03 Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi

Publications (2)

Publication Number Publication Date
DE3486438D1 true DE3486438D1 (de) 1996-11-14
DE3486438T2 DE3486438T2 (de) 1998-08-13

Family

ID=27272965

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3486438T Expired - Lifetime DE3486438T2 (de) 1983-06-02 1984-05-29 Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten

Country Status (5)

Country Link
EP (3) EP0130633B1 (de)
JP (2) JPH0819085B2 (de)
AT (1) ATE143953T1 (de)
DE (1) DE3486438T2 (de)
ES (1) ES8505927A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5243056A (en) * 1983-06-02 1993-09-07 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
US5332835A (en) * 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US5153328A (en) * 1984-02-03 1992-10-06 Zambon S.P.A. 2 Hydrocarbyl-4 substituted methyl 5 (4 substituted phenyl)-oxazolines
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US5227494A (en) * 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
WO1990014434A1 (en) * 1989-05-15 1990-11-29 Schering Corporation Process for preparing antibacterial compounds and intermediates thereto
WO1991000923A2 (en) * 1989-07-07 1991-01-24 Schering Corporation Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates
IT1237798B (it) * 1989-10-20 1993-06-17 Zambon Spa Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
IT1240676B (it) * 1990-04-24 1993-12-17 Agrimont Spa Composizioni ad attivita' erbicida
SK281740B6 (sk) * 1990-10-25 2001-07-10 Schering Corporation Spôsob prípravy fluórfenikolu a jeho analógov
IT1249048B (it) 1991-02-21 1995-02-11 Zambon Spa Processo per la preparazione di trans-(5r)-2-ossazoline -2,4,5, trisostituite
US5663361A (en) * 1996-08-19 1997-09-02 Schering Corporation Process for preparing intermediates to florfenicol
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
US7601869B2 (en) * 2005-06-20 2009-10-13 Aurobindo Pharma Ltd. Process for the preparation of Florfenicol
CN101300227B (zh) * 2005-09-07 2013-07-03 谢尔英·普劳有限公司 制备酯*唑烷化合物及其转变成氟苯尼考的方法
CN103965085B (zh) * 2014-04-17 2016-02-24 上海恒晟药业有限公司 一种取代1,2-氨基醇药物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2820041A (en) * 1958-01-14 Preparation of nitrophenyloxazolines
AT179022B (de) * 1950-04-14 1954-07-10 Parke Davis & Co Verfahren zur Herstellung von neuen Oxazolinabkömmlingen
IT1065143B (it) 1976-08-05 1985-02-25 Clesa Spa Derivati del d-treo-1-fenil-2-trifluoroacetamido-1,3-propandiolo e processi per la loro preparazione
US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor

Also Published As

Publication number Publication date
JPH08295678A (ja) 1996-11-12
JPS6069072A (ja) 1985-04-19
EP0130633B1 (de) 1996-10-09
EP0678506A2 (de) 1995-10-25
JPH0819085B2 (ja) 1996-02-28
DE3486438T2 (de) 1998-08-13
ES533355A0 (es) 1985-06-16
EP0677511A2 (de) 1995-10-18
EP0677511A3 (de) 1996-07-24
ES8505927A1 (es) 1985-06-16
EP0130633A2 (de) 1985-01-09
JP2721959B2 (ja) 1998-03-04
EP0130633A3 (de) 1987-08-05
EP0678506A3 (de) 1996-07-24
ATE143953T1 (de) 1996-10-15

Similar Documents

Publication Publication Date Title
ATE415394T1 (de) Zwischeprodukte zur herstellung von retroviralen protease-hemmern
DE3486438D1 (de) Verfahren zur Herstellung von 1-(Phenyl)-1-hydroxy-2-amino-3-fluor-propan-Derivaten
ATE102181T1 (de) Zwischenprodukte zur herstellung von 1,2,4triazolo(1,5-a>pyrimidin-2-sulfonamiden.
DE69021530D1 (de) Neue Derivate von A-nor-3-Carboxysteroiden.
ATE71095T1 (de) Azolylmethyloxirane - ihre herstellung und verwendung als pflanzenschutzmittel.
ATE58529T1 (de) Verfahren zur herstellung von 2,2,6,6,-tetraalkyl-4-piperidylamine.
ATE47138T1 (de) Verfahren zur herstellung von 1,2-dithiolan-3pentans|ure (thioctsaeure).
ATE42273T1 (de) Verfahren zur herstellung von (z)-1-phenyl-1diethylaminocarbonyl-2-aminomethyl-cyclopropanhydrochlorid.
ATE60583T1 (de) Verfahren zur herstellung von 2,2,6,6-tetraalkyl- 4-piperidylaminen.
ATE104296T1 (de) Substituierte 1,2,4-triazindione, verfahren zu ihrer herstellung und ihre verwendung.
DE3484031D1 (de) Arylalkylimidazolium- und -triazoliumsalze, verfahren zu ihrer herstellung und ihre verwendung als mikrozide.
ATE46518T1 (de) Sialosylcerebroside und verfahren zu ihrer herstellung.
DE3775872D1 (de) Salicylsaeureamide, verfahren zu ihrer herstellung und ihre verwendung.
DE3885720D1 (de) Verfahren zur Herstellung von 4-Amino-1,2,4-triazol-5-onen.
ATE37534T1 (de) Arylethanolhydroxylamine, verfahren zu ihrer herstellung und ihre verwendung zur leistungsfoerderung.
ATE88476T1 (de) Verfahren zur herstellung von 7-aca-derivaten.
DE3650007D1 (de) Herstellung von Maleimid.
DE59905700D1 (de) N-phenylacetoacetamide und Verfahren zu ihrer Herstellung
ATE23993T1 (de) Verfahren zur herstellung von o,o'dithiobenzamiden.
DE3674027D1 (de) Methode zur herstellung von phenylbrenztraubensaeure.
DE3883433D1 (de) Verfahren zur Herstellung von Polybuten-1.
ATE121737T1 (de) Herstellung von enantiomeren des dropropizins.
ATE66921T1 (de) Verwendung von triazolylderivate zur bekaempfung von pilzen.
DE69109953D1 (de) Alfa-fluorocarbonsäurederivate als Zwischenprodukte zur Herstellung von Fungiziden.
ATE33837T1 (de) Azolylmethylcycloacetale, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING-PLOUTH LTD., LUZERN, CH