PT96084A - Processo para a preparacao de ciclo-hexenos substituidos utilizados como agentes do sistema nervoso central - Google Patents
Processo para a preparacao de ciclo-hexenos substituidos utilizados como agentes do sistema nervoso centralInfo
- Publication number
- PT96084A PT96084A PT96084A PT9608490A PT96084A PT 96084 A PT96084 A PT 96084A PT 96084 A PT96084 A PT 96084A PT 9608490 A PT9608490 A PT 9608490A PT 96084 A PT96084 A PT 96084A
- Authority
- PT
- Portugal
- Prior art keywords
- nervous system
- central nervous
- agents
- preparation
- substituted cyclohexenes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Measurement Of Radiation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/446,950 US4975445A (en) | 1989-12-06 | 1989-12-06 | Substituted cyclohexenes as central nervous system agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT96084A true PT96084A (pt) | 1991-09-30 |
| PT96084B PT96084B (pt) | 1998-02-27 |
Family
ID=23774425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96084A PT96084B (pt) | 1989-12-06 | 1990-12-05 | Processo para a preparacao de ciclo-hexenos substituidos utilizados como agentes do sistema nervoso central |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4975445A (pt) |
| EP (1) | EP0431579B1 (pt) |
| JP (1) | JP3044790B2 (pt) |
| KR (1) | KR0166359B1 (pt) |
| AT (1) | ATE109136T1 (pt) |
| AU (1) | AU630770B2 (pt) |
| CA (1) | CA2031570C (pt) |
| DE (1) | DE69011054T2 (pt) |
| DK (1) | DK0431579T3 (pt) |
| ES (1) | ES2057341T3 (pt) |
| FI (1) | FI100240B (pt) |
| IE (1) | IE66117B1 (pt) |
| MY (1) | MY107354A (pt) |
| NO (1) | NO176097C (pt) |
| NZ (1) | NZ236336A (pt) |
| PH (1) | PH27326A (pt) |
| PT (1) | PT96084B (pt) |
| ZA (1) | ZA909774B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5314896A (en) * | 1991-11-20 | 1994-05-24 | Warner-Lambert Company | 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents |
| ZA929008B (en) * | 1991-12-13 | 1993-05-21 | Bristol Myers Squibb Co | Piperazinyl- and piperidinyl-cyclohexanols. |
| CA2091204C (en) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Antiischemic-piperazinyl and piperidinyl-cyclohexanes |
| CN1047594C (zh) * | 1993-01-02 | 1999-12-22 | 布里斯托尔-迈尔斯斯奎布公司 | 哌嗪基或哌啶基环己醇、其制法和用途 |
| GB9300194D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
| US5391570A (en) * | 1993-10-14 | 1995-02-21 | Bristol-Myers Squibb | Aminomethyl-benzodioxane and benzopyran serotonergic agents |
| WO2000040579A1 (en) * | 1999-01-07 | 2000-07-13 | American Home Products Corporation | New 1,4-disubstituted cyclohexane derivatives for the treatment of depression |
| US6200994B1 (en) | 1999-01-07 | 2001-03-13 | American Home Products Corp | 1,4-Disubstituted cyclohexane derivatives for the treatment of depression |
| AU771234B2 (en) | 1999-01-28 | 2004-03-18 | Bristol-Myers Squibb Company | Antidepressant heterocyclic compounds |
| US7985752B2 (en) * | 2008-05-29 | 2011-07-26 | Sk Holdings Co., Ltd. | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof |
| US7964605B2 (en) * | 2008-05-29 | 2011-06-21 | Sk Holdings Co., Ltd. | Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1327691A (en) * | 1970-08-31 | 1973-08-22 | Upjohn Co | Phenyl cyclohexenylamines and the preparation thereof |
| GB1311580A (en) * | 1970-08-31 | 1973-03-28 | Upjohn Co | 4-substituted phenyl cyclohexylamines and the preparation thereof |
| US4329353A (en) * | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
| GR73633B (pt) * | 1980-03-10 | 1984-03-26 | Janssen Pharmaceutica Nv | |
| US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| US5102889B1 (en) * | 1990-09-27 | 1993-05-11 | 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds |
-
1989
- 1989-12-06 US US07/446,950 patent/US4975445A/en not_active Expired - Lifetime
-
1990
- 1990-11-17 MY MYPI90002031A patent/MY107354A/en unknown
- 1990-12-03 PH PH41662A patent/PH27326A/en unknown
- 1990-12-03 FI FI905957A patent/FI100240B/fi not_active IP Right Cessation
- 1990-12-03 AU AU67701/90A patent/AU630770B2/en not_active Ceased
- 1990-12-04 NZ NZ236336A patent/NZ236336A/en unknown
- 1990-12-05 IE IE438590A patent/IE66117B1/en not_active IP Right Cessation
- 1990-12-05 PT PT96084A patent/PT96084B/pt not_active IP Right Cessation
- 1990-12-05 DK DK90123290.0T patent/DK0431579T3/da active
- 1990-12-05 EP EP90123290A patent/EP0431579B1/en not_active Expired - Lifetime
- 1990-12-05 JP JP2407444A patent/JP3044790B2/ja not_active Expired - Fee Related
- 1990-12-05 NO NO905254A patent/NO176097C/no unknown
- 1990-12-05 DE DE69011054T patent/DE69011054T2/de not_active Expired - Fee Related
- 1990-12-05 AT AT90123290T patent/ATE109136T1/de not_active IP Right Cessation
- 1990-12-05 KR KR1019900019932A patent/KR0166359B1/ko not_active IP Right Cessation
- 1990-12-05 ES ES90123290T patent/ES2057341T3/es not_active Expired - Lifetime
- 1990-12-05 CA CA002031570A patent/CA2031570C/en not_active Expired - Fee Related
- 1990-12-05 ZA ZA909774A patent/ZA909774B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69011054T2 (de) | 1994-12-08 |
| NO905254D0 (no) | 1990-12-05 |
| KR910011817A (ko) | 1991-08-07 |
| NO905254L (no) | 1991-06-07 |
| PH27326A (en) | 1993-06-08 |
| CA2031570A1 (en) | 1991-06-07 |
| EP0431579A2 (en) | 1991-06-12 |
| DE69011054D1 (de) | 1994-09-01 |
| DK0431579T3 (da) | 1994-10-31 |
| NO176097C (no) | 1995-02-01 |
| EP0431579B1 (en) | 1994-07-27 |
| PT96084B (pt) | 1998-02-27 |
| NZ236336A (en) | 1992-04-28 |
| AU630770B2 (en) | 1992-11-05 |
| EP0431579A3 (en) | 1991-12-11 |
| ATE109136T1 (de) | 1994-08-15 |
| FI905957A0 (fi) | 1990-12-03 |
| IE66117B1 (en) | 1995-12-13 |
| KR0166359B1 (ko) | 1999-01-15 |
| ZA909774B (en) | 1992-08-26 |
| ES2057341T3 (es) | 1994-10-16 |
| FI905957A (fi) | 1991-06-07 |
| FI100240B (fi) | 1997-10-31 |
| MY107354A (en) | 1995-11-30 |
| CA2031570C (en) | 2001-09-11 |
| JP3044790B2 (ja) | 2000-05-22 |
| NO176097B (no) | 1994-10-24 |
| IE904385A1 (en) | 1991-06-19 |
| US4975445A (en) | 1990-12-04 |
| AU6770190A (en) | 1991-06-13 |
| JPH03251576A (ja) | 1991-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910502 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19971118 |
|
| MM3A | Annulment or lapse |
Effective date: 20060518 |