DE69320875T2 - Fumarsäuresalze von Chinolinderivaten zur Aufhebung von vielfacher Drogenresistenz in der Krebsbehandlung - Google Patents

Fumarsäuresalze von Chinolinderivaten zur Aufhebung von vielfacher Drogenresistenz in der Krebsbehandlung

Info

Publication number
DE69320875T2
DE69320875T2 DE69320875T DE69320875T DE69320875T2 DE 69320875 T2 DE69320875 T2 DE 69320875T2 DE 69320875 T DE69320875 T DE 69320875T DE 69320875 T DE69320875 T DE 69320875T DE 69320875 T2 DE69320875 T2 DE 69320875T2
Authority
DE
Germany
Prior art keywords
elimination
fumaric acid
acid salts
drug resistance
cancer treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69320875T
Other languages
English (en)
Other versions
DE69320875D1 (de
Inventor
Nobuyuki Fukazawa
Tuneji Suzuki
Kengo Otsuka
Osamu Yano
Daiji Iwata
Yukichi Kawai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Application granted granted Critical
Publication of DE69320875D1 publication Critical patent/DE69320875D1/de
Publication of DE69320875T2 publication Critical patent/DE69320875T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE69320875T 1992-06-18 1993-06-17 Fumarsäuresalze von Chinolinderivaten zur Aufhebung von vielfacher Drogenresistenz in der Krebsbehandlung Expired - Fee Related DE69320875T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP04159318A JP3076672B2 (ja) 1992-06-18 1992-06-18 キノリン誘導体のフマル酸塩

Publications (2)

Publication Number Publication Date
DE69320875D1 DE69320875D1 (de) 1998-10-15
DE69320875T2 true DE69320875T2 (de) 1999-04-08

Family

ID=15691180

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69320875T Expired - Fee Related DE69320875T2 (de) 1992-06-18 1993-06-17 Fumarsäuresalze von Chinolinderivaten zur Aufhebung von vielfacher Drogenresistenz in der Krebsbehandlung

Country Status (5)

Country Link
US (1) US5434155A (de)
EP (1) EP0575890B1 (de)
JP (1) JP3076672B2 (de)
CN (1) CN1037266C (de)
DE (1) DE69320875T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643909A (en) * 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
US6025359A (en) * 1996-06-17 2000-02-15 Eli Lilly And Company Drug resistance and multidrug resistance modulators
KR20000057157A (ko) * 1996-11-22 2000-09-15 피터 지. 스트링거 약물 내성 및 복합 약물 내성 조절제
JP2000290181A (ja) * 1999-04-01 2000-10-17 Mitsui Chemicals Inc 脳疾患治療薬脳内移行増強剤
KR20030015655A (ko) * 2001-08-17 2003-02-25 한미약품공업 주식회사 항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
US7462718B2 (en) 2003-05-06 2008-12-09 Schering Ag Process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate and high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate
DE10321255B4 (de) * 2003-05-06 2006-09-28 Schering Ag Verfahren zur Herstellung von reinstem rac-1{4-[2- Hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarat und reinstes rac-1{4-[2-Hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2
MX2013007295A (es) 2010-12-23 2013-08-26 Merck Sharp & Dohme Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2.
WO2012087872A1 (en) * 2010-12-23 2012-06-28 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
US4965271A (en) * 1986-12-31 1990-10-23 Hoechst Roussel Pharmaceuticals, Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5204348A (en) * 1988-10-06 1993-04-20 Mitsui Toatsu Chemicals Inc. Heterocyclic compounds and anticancer-drug potentiaters conaining them as effective components
CA1340821C (en) * 1988-10-06 1999-11-16 Nobuyuki Fukazawa Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components
US5039666A (en) * 1990-10-30 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside

Also Published As

Publication number Publication date
JP3076672B2 (ja) 2000-08-14
EP0575890B1 (de) 1998-09-09
EP0575890A1 (de) 1993-12-29
CN1083476A (zh) 1994-03-09
US5434155A (en) 1995-07-18
CN1037266C (zh) 1998-02-04
DE69320875D1 (de) 1998-10-15
JPH061768A (ja) 1994-01-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

8339 Ceased/non-payment of the annual fee