DE69413789T2 - 2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung - Google Patents

2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung

Info

Publication number
DE69413789T2
DE69413789T2 DE69413789T DE69413789T DE69413789T2 DE 69413789 T2 DE69413789 T2 DE 69413789T2 DE 69413789 T DE69413789 T DE 69413789T DE 69413789 T DE69413789 T DE 69413789T DE 69413789 T2 DE69413789 T2 DE 69413789T2
Authority
DE
Germany
Prior art keywords
amino
formula
oxo
compound
butyric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69413789T
Other languages
German (de)
English (en)
Other versions
DE69413789D1 (de
Inventor
Alberto I-20122 Milan Bianchetti
Massimo I-20020 Lainate Cini
Antonio I-27100 Pavia Giordani
Carmela I-20014 Nerviano Speciale
Mario I-20146 Milan Varasi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of DE69413789D1 publication Critical patent/DE69413789D1/de
Publication of DE69413789T2 publication Critical patent/DE69413789T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69413789T 1993-07-23 1994-07-12 2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung Expired - Fee Related DE69413789T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT93MI001649A IT1265101B1 (it) 1993-07-23 1993-07-23 Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
PCT/EP1994/002280 WO1995003271A1 (en) 1993-07-23 1994-07-12 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity

Publications (2)

Publication Number Publication Date
DE69413789D1 DE69413789D1 (de) 1998-11-12
DE69413789T2 true DE69413789T2 (de) 1999-05-06

Family

ID=11366678

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69413789T Expired - Fee Related DE69413789T2 (de) 1993-07-23 1994-07-12 2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung

Country Status (21)

Country Link
US (1) US20010008947A1 (cg-RX-API-DMAC10.html)
EP (1) EP0662948B1 (cg-RX-API-DMAC10.html)
JP (1) JPH08501805A (cg-RX-API-DMAC10.html)
KR (1) KR950703517A (cg-RX-API-DMAC10.html)
CN (1) CN1112786A (cg-RX-API-DMAC10.html)
AT (1) ATE171935T1 (cg-RX-API-DMAC10.html)
AU (1) AU678273B2 (cg-RX-API-DMAC10.html)
CA (1) CA2144521A1 (cg-RX-API-DMAC10.html)
DE (1) DE69413789T2 (cg-RX-API-DMAC10.html)
DK (1) DK0662948T3 (cg-RX-API-DMAC10.html)
ES (1) ES2123801T3 (cg-RX-API-DMAC10.html)
FI (1) FI951298A0 (cg-RX-API-DMAC10.html)
HU (1) HUT70478A (cg-RX-API-DMAC10.html)
IL (1) IL110365A (cg-RX-API-DMAC10.html)
IT (1) IT1265101B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ268896A (cg-RX-API-DMAC10.html)
PL (1) PL179857B1 (cg-RX-API-DMAC10.html)
RU (1) RU2139850C1 (cg-RX-API-DMAC10.html)
TW (1) TW268937B (cg-RX-API-DMAC10.html)
WO (1) WO1995003271A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA945425B (cg-RX-API-DMAC10.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519055A (en) * 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation
US5786508A (en) * 1994-07-15 1998-07-28 Pharmacia & Upjohn S.P.A. Substituted kynurenines and process for their preparation
GB9521486D0 (en) * 1995-10-20 1995-12-20 Pharmacia Spa Fluoro-substituted benzoylpropionic acid derivatives
GB9615441D0 (en) * 1996-07-23 1996-09-04 Pharmacia Spa Benzoylpropionic acid ester derivatives
EP0923569B1 (en) * 1996-08-16 2004-11-17 Warner-Lambert Company Llc Butyric acid matrix metalloproteinase inhibitors
GB9618349D0 (en) * 1996-09-03 1996-10-16 Pharmacia Spa N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity
GB9716103D0 (en) * 1997-07-30 1997-10-01 Pharmacia & Upjohn Spa Condensed heterocyclic compounds
GB9725055D0 (en) * 1997-11-26 1998-01-28 Pharmacia & Upjohn Spa 1,3,4-thiadiazoles compounds
GB9725141D0 (en) * 1997-11-27 1998-01-28 Pharmacia & Upjohn Spa Benzenesulfonamide compounds
DE69932414T2 (de) * 1998-02-23 2007-02-22 South Alabama Medical Science Foundation, Mobile Indol-3-propionsäure, salze und ester davon als arzneimittel #
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
PT1129066E (pt) * 1998-11-11 2005-05-31 Taito Co Producao de 2-amino-2-[2-(4-c2-20-alquil-fenil)etil]propano-1,3-diois
CN1144779C (zh) * 1999-03-11 2004-04-07 杭州中美华东制药有限公司 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物
EP1461323B1 (en) * 2001-06-12 2013-10-09 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
FR2827045B1 (fr) 2001-07-05 2007-08-10 Univ Pasteur Methodes et compositions pour la selection et le developpement de nouveaux agents pharmacologiques ou de nouveaux medicaments
FR2827859B1 (fr) 2001-07-30 2005-09-23 Lipha Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
CN1330774C (zh) * 2002-03-01 2007-08-08 国家人类基因组南方研究中心 犬尿氨酸水解酶多态性及其用途
ITMI20041626A1 (it) * 2004-08-06 2004-11-06 Roberto Pellicciari Inibitori della chinurenina-ammino-trasferasi
CN1309702C (zh) * 2005-10-28 2007-04-11 中国科学院上海有机化学研究所 犬尿氨酸酶的特异性抑制剂l－邻甲氧基苯甲酰基丙氨酸的合成方法
ES2536552T3 (es) 2008-03-19 2015-05-26 Novartis Ag Proceso para la preparación de 2-amino-2-[2-(4-alquil-C3-C21-fenil)etil]propano-1,3-dioles
AU2015321365B2 (en) * 2014-09-26 2021-05-20 The University Of British Columbia A combination of kynurenine and antigen presenting cells (APC) as therapeutics and methods for their use in immune modulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI96313C (fi) * 1990-11-28 1996-06-10 Daiichi Seiyaku Co Menetelmä terapeuttisesti käyttökelpoisten ja optisesti aktiivisten 10-(3-amino-4,4-dialkyyli-1-pyrrolidinyyli)-9-fluori-2,3-dihydro-3(S)-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojen valmistamiseksi
EP0501378B1 (en) * 1991-02-28 1995-01-11 Merrell Dow Pharmaceuticals Inc. NMDA Antagonists
US5495044A (en) * 1991-04-18 1996-02-27 University Of Georgia Research Foundation, Inc. Inhibitors of kynureninase
US5516936A (en) * 1991-04-18 1996-05-14 University Of Georgia Research Foundation, Inc. Inhibitors of kynureninase
GB9325360D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds

Also Published As

Publication number Publication date
IL110365A (en) 1998-06-15
ES2123801T3 (es) 1999-01-16
AU678273B2 (en) 1997-05-22
US20010008947A1 (en) 2001-07-19
ITMI931649A0 (it) 1993-07-23
TW268937B (cg-RX-API-DMAC10.html) 1996-01-21
CA2144521A1 (en) 1995-02-02
FI951298L (fi) 1995-03-20
FI951298A7 (fi) 1995-03-20
DK0662948T3 (da) 1999-06-21
PL308142A1 (en) 1995-07-24
PL179857B1 (pl) 2000-11-30
WO1995003271A1 (en) 1995-02-02
JPH08501805A (ja) 1996-02-27
KR950703517A (ko) 1995-09-20
IL110365A0 (en) 1994-10-21
DE69413789D1 (de) 1998-11-12
RU95111308A (ru) 1996-12-27
NZ268896A (en) 1997-01-29
HUT70478A (en) 1995-10-30
ATE171935T1 (de) 1998-10-15
CN1112786A (zh) 1995-11-29
EP0662948A1 (en) 1995-07-19
ZA945425B (en) 1995-03-01
HU9501146D0 (en) 1995-06-28
RU2139850C1 (ru) 1999-10-20
EP0662948B1 (en) 1998-10-07
ITMI931649A1 (it) 1995-01-23
FI951298A0 (fi) 1995-03-20
IT1265101B1 (it) 1996-10-30
AU7228594A (en) 1995-02-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee