DE69411900T2 - Heterozyklische derivate als plätchenaggregationsinhibitoren - Google Patents

Heterozyklische derivate als plätchenaggregationsinhibitoren

Info

Publication number
DE69411900T2
DE69411900T2 DE69411900T DE69411900T DE69411900T2 DE 69411900 T2 DE69411900 T2 DE 69411900T2 DE 69411900 T DE69411900 T DE 69411900T DE 69411900 T DE69411900 T DE 69411900T DE 69411900 T2 DE69411900 T2 DE 69411900T2
Authority
DE
Germany
Prior art keywords
formula
compound
pyridyl
alkylene
piperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69411900T
Other languages
German (de)
English (en)
Other versions
DE69411900D1 (de
Inventor
Andrew George Macclesfield Cheshire Sk10 5Qu Brewster
Peter William Rodney Macclesfield Cheshire Sk10 1Lx Caulkett
Alan Wellington Macclesfield Cheshire Sk10 5La Faull
Stuart Dennett Macclesfield Cheshire Sk11 9Rd Mills
Robert James Wilmslow Cheshire Sk9 5Ja Pearce
John Wall Stockport Cheshire Sk7 6Ns Rayner
Richard Eden Macclesfield Cheshire Sk10 3Af Shute
Michael James Macclesfield Cheshire Sk11 8Lt Smithers
Michael Garth Stoke On Trent Staffs St8 7Tb Wayne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939306453A external-priority patent/GB9306453D0/en
Priority claimed from GB939325605A external-priority patent/GB9325605D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DE69411900D1 publication Critical patent/DE69411900D1/de
Publication of DE69411900T2 publication Critical patent/DE69411900T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Electroluminescent Light Sources (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69411900T 1993-03-29 1994-03-28 Heterozyklische derivate als plätchenaggregationsinhibitoren Expired - Fee Related DE69411900T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939306453A GB9306453D0 (en) 1993-03-29 1993-03-29 Heterocyclic derivatives
GB939325605A GB9325605D0 (en) 1993-12-15 1993-12-15 Heterocyclic derivatives
PCT/GB1994/000647 WO1994022834A1 (en) 1993-03-29 1994-03-28 Heterocyclic derivatives as platelet aggregation inhibitors

Publications (2)

Publication Number Publication Date
DE69411900D1 DE69411900D1 (de) 1998-08-27
DE69411900T2 true DE69411900T2 (de) 1998-12-10

Family

ID=26302668

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69411900T Expired - Fee Related DE69411900T2 (de) 1993-03-29 1994-03-28 Heterozyklische derivate als plätchenaggregationsinhibitoren
DE69427548T Expired - Fee Related DE69427548T2 (de) 1993-03-29 1994-03-28 Heterozyklische Derivate als Plätchenaggregationsinhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69427548T Expired - Fee Related DE69427548T2 (de) 1993-03-29 1994-03-28 Heterozyklische Derivate als Plätchenaggregationsinhibitoren

Country Status (26)

Country Link
US (1) US5556977A (ref)
EP (2) EP0825184B1 (ref)
JP (1) JPH08508291A (ref)
KR (1) KR100231089B1 (ref)
CN (1) CN1120334A (ref)
AT (2) ATE202345T1 (ref)
AU (1) AU692438B2 (ref)
BR (1) BR9406613A (ref)
CA (1) CA2156070A1 (ref)
CZ (1) CZ250995A3 (ref)
DE (2) DE69411900T2 (ref)
DK (2) DK0691959T3 (ref)
ES (2) ES2119184T3 (ref)
FI (1) FI954616A7 (ref)
GB (1) GB9406143D0 (ref)
GR (2) GR3027751T3 (ref)
HU (2) HUT72088A (ref)
IL (1) IL109144A (ref)
NO (1) NO305244B1 (ref)
NZ (1) NZ262941A (ref)
PL (1) PL310889A1 (ref)
PT (1) PT825184E (ref)
SK (1) SK120895A3 (ref)
TW (1) TW276254B (ref)
WO (1) WO1994022834A1 (ref)
ZW (1) ZW4294A1 (ref)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
PL321003A1 (en) * 1994-12-23 1997-11-24 Thomae Gmbh Dr K Derivatives of piperasine, drugs containing them, their application and methods of obtaining them
US5700801A (en) * 1994-12-23 1997-12-23 Karl Thomae, Gmbh Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
FR2734818B1 (fr) * 1995-06-01 1998-07-10 Zeneca Ltd Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant
WO1996038416A1 (en) * 1995-06-01 1996-12-05 Zeneca Limited (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor
DE19524765A1 (de) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
ES2184893T3 (es) * 1995-11-17 2003-04-16 Warner Lambert Co Inhibidores de sulfonamida de lasd metaloproteinasas matricales.
GB9525620D0 (en) 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
US6313127B1 (en) * 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2246756A1 (en) * 1996-02-28 1997-09-04 Merck & Co., Inc. Fibrinogen receptor antagonists
AU2044297A (en) * 1996-03-29 1997-10-22 Meiji Seika Kaisha Ltd. Novel heterocyclic compounds having platelet aggregation inhibitory effects
WO1998000134A1 (en) * 1996-06-28 1998-01-08 Merck & Co., Inc. Fibrinogen receptor antagonists
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2257937A1 (en) * 1996-06-28 1998-01-08 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5932582A (en) * 1996-06-28 1999-08-03 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5990107A (en) * 1996-06-28 1999-11-23 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
GB9821483D0 (en) 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US5945545A (en) * 1996-12-13 1999-08-31 Merck & Co., Inc. Fibrinogen receptor antagonists
US6391880B1 (en) 1997-02-13 2002-05-21 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
US6440972B1 (en) 1997-02-13 2002-08-27 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
US6451827B2 (en) 1998-05-12 2002-09-17 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6221902B1 (en) 1998-05-12 2001-04-24 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en) 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
CN1308604A (zh) 1998-05-12 2001-08-15 美国家用产品公司 用于治疗胰岛素抗性和高血糖的2,3,5－取代的联苯化合物
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) * 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en) 1998-05-12 2004-03-02 Wyeth Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
JP2002521444A (ja) 1998-07-31 2002-07-16 イーライ・リリー・アンド・カンパニー 複素環スルホンアミド誘導体
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
WO2000063161A1 (en) * 1999-04-19 2000-10-26 Coelacanth Corporation Ppar-(gamma) agonists as agents for the treatment of type ii diabetes
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
EP3684767B1 (en) 2017-09-22 2024-04-24 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
WO2019077631A1 (en) 2017-10-18 2019-04-25 Jubilant Biosys Limited IMIDAZO-PYRIDINE COMPOUNDS FOR USE AS PAD INHIBITORS
BR112020008851A2 (pt) 2017-11-06 2020-10-20 Jubilant Prodel LLC composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas
SG11202004537UA (en) 2017-11-24 2020-06-29 Jubilant Episcribe Llc Heterocyclic compounds as prmt5 inhibitors
BR112020018610A2 (pt) 2018-03-13 2020-12-29 Jubilant Prodel LLC Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3875165A (en) * 1973-02-22 1975-04-01 Wyeth John & Brother Ltd (4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines
GB1474296A (en) * 1975-01-23 1977-05-18 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
JPS57183738A (en) * 1981-05-06 1982-11-12 Yamanouchi Pharmaceut Co Ltd Aromatic carboxylic acid derivative
ZA825719B (en) * 1981-09-03 1983-06-29 Recordati Chem Pharm Alkanoylanilides
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4613598A (en) * 1984-03-13 1986-09-23 Mitsubishi Chemical Industries Limited Piperazine derivatives and their acid addition salts
AU5428686A (en) * 1985-03-12 1986-09-18 Smith Kline & French Laboratories Limited Imidazolinone and thiazolinone derivatives
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
EP0264883A3 (en) * 1986-10-21 1990-04-04 Banyu Pharmaceutical Co., Ltd. Substituted pyridine derivatives
MY104343A (en) * 1987-11-23 1994-03-31 Janssen Pharmaceutica Nv Novel pyridizinamine deravatives
GB8819307D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
DE4134467A1 (de) * 1991-10-18 1993-04-22 Thomae Gmbh Dr K Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
JP3065659B2 (ja) * 1989-07-25 2000-07-17 ファルマシア・アンド・アップジョン・カンパニー 抗不整脈性第三級アミン―アルケニル―フェニル―アルカンスルホンアミド
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
GB9007751D0 (en) * 1990-04-05 1990-06-06 Ciba Geigy Ag Novel platelet-aggregation inhibitors
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5264420A (en) * 1990-09-27 1993-11-23 Merck & Co., Inc. Fibrinogen receptor antagonists
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0570507A4 (en) * 1991-02-05 1994-09-21 Smithkline Beecham Corp Anti-aggregatory peptides containing an aromatic ester or amide
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
UA39849C2 (uk) * 1991-03-26 2001-07-16 Ф.Хоффманн-Ля Рош Аг ПОХІДНІ N-АЦИЛ-<font face="Symbol">a</font>-АМІНОКИСЛОТИ АБО ЇХ ФІЗІОЛОГІЧНО ПРИЙНЯТНІ СОЛІ, ПРОСТІ АБО СКЛАДНІ ЕФІРИ, АМІДИ АБО ЇХ ГІДРАТИ ЯК ФАРМАЦЕВТИЧНО АКТИВНІ РЕЧОВИНИ
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
EP0584066A4 (en) * 1991-04-11 1994-10-12 Rhone Poulenc Rorer Int Anti-thrombotic peptide and pseudopeptide derivatives.
US5321034A (en) * 1991-05-07 1994-06-14 Merck & Co., Inc. Fibrinogen receptor antagonists
HUT68769A (en) * 1991-05-07 1995-07-28 Merck & Co Inc FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
EP0513675B1 (en) * 1991-05-13 1996-09-11 Fujisawa Pharmaceutical Co., Ltd. New peptide compound and a process for the preparation thereof
JPH05213884A (ja) * 1991-06-14 1993-08-24 Upjohn Co:The 新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
AU646966B2 (en) * 1991-08-23 1994-03-10 Takeda Chemical Industries Ltd. 2-piperazinone compounds, their production and use
EP0630366B1 (en) * 1991-10-15 2003-01-02 G.D. Searle &amp; Co. Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5254573A (en) * 1991-10-15 1993-10-19 Monsanto Company Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
GB9122016D0 (en) * 1991-10-16 1991-11-27 Glaxo Group Ltd Chemical compounds
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
TW221996B (ref) * 1991-11-14 1994-04-01 Glaxo Group Ltd
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
JPH07503459A (ja) * 1992-01-21 1995-04-13 グラクソ、グループ、リミテッド 酢酸誘導体
US5264457A (en) * 1992-02-14 1993-11-23 G. D. Searle & Co. Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
HUT63609A (en) * 1992-03-10 1993-09-28 Sandoz Ag Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
GB9208740D0 (en) * 1992-04-23 1992-06-10 Glaxo Group Ltd Chemical compounds
DE4213634A1 (de) * 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
DE4219158A1 (de) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO1994014775A1 (en) * 1992-12-29 1994-07-07 Smithkline Beecham Corporation Platelet aggregation inhibiting compounds
TW301607B (ref) * 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
ZW4294A1 (en) 1994-12-21
HU211336A9 (en) 1995-11-28
EP0825184B1 (en) 2001-06-20
FI954616A0 (fi) 1995-09-28
GB9406143D0 (en) 1994-05-18
CN1120334A (zh) 1996-04-10
ES2159798T3 (es) 2001-10-16
PL310889A1 (en) 1996-01-08
EP0691959B1 (en) 1998-07-22
GR3027751T3 (en) 1998-11-30
FI954616L (fi) 1995-09-28
HUT72088A (en) 1996-03-28
CZ250995A3 (en) 1996-01-17
BR9406613A (pt) 1996-02-06
SK120895A3 (en) 1996-06-05
IL109144A0 (en) 1994-06-24
EP0825184A1 (en) 1998-02-25
WO1994022834A1 (en) 1994-10-13
FI954616A7 (fi) 1995-09-28
NO953837L (no) 1995-09-28
DE69427548D1 (de) 2001-07-26
ATE202345T1 (de) 2001-07-15
IL109144A (en) 2000-02-29
DK0825184T3 (da) 2001-09-10
DK0691959T3 (da) 1999-04-26
AU6288994A (en) 1994-10-24
US5556977A (en) 1996-09-17
NO953837D0 (no) 1995-09-28
JPH08508291A (ja) 1996-09-03
DE69427548T2 (de) 2002-04-18
GR3036640T3 (en) 2001-12-31
NZ262941A (en) 1997-07-27
EP0691959A1 (en) 1996-01-17
ES2119184T3 (es) 1998-10-01
PT825184E (pt) 2001-11-30
KR100231089B1 (ko) 1999-11-15
ATE168678T1 (de) 1998-08-15
AU692438B2 (en) 1998-06-11
NO305244B1 (no) 1999-04-26
TW276254B (ref) 1996-05-21
HU9502290D0 (en) 1995-10-30
CA2156070A1 (en) 1994-10-13
DE69411900D1 (de) 1998-08-27

Similar Documents

Publication Publication Date Title
DE69411900T2 (de) Heterozyklische derivate als plätchenaggregationsinhibitoren
AU692439B2 (en) Heterocyclic compounds as platelet aggregation inhibitors
DE69730490T2 (de) Aminoheterocyclische verbindungen als antithrombotisches oder antikoagulierendes mittel
DE69023928T2 (de) DIAMINVERBINDUNGEN UND ARZNEIMITTEL GEGEN CEREBRALE STöRUNGEN DIE DIESE ENTHALTEN.
CA2493660A1 (en) Process for preparing quinolin antibiotic intermediates
US20140309192A1 (en) Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
CA2369103A1 (en) Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same
DE3530046C2 (de) Äthylendiaminmonoamid-Derivate
RU2327688C2 (ru) Основные непептидные антагонисты брадикинина и их фармацевтические композиции
DE69408580T2 (de) 2-amino-1,2,3,4-tetrahydronaphthalenderivate mit cardiovaskulärer wirkung
DE68905845T2 (de) Tetrazolverbindungen als antagonisten der excitatorischen aminosaeurerezeptoren.
JPS62149662A (ja) Ｎ−含有複素環化合物
DE69110828T2 (de) Heterozyklische Aminderivate, deren Herstellung und deren Verwendung.
US5750754A (en) Heterocyclic compounds
DE69329385T2 (de) Thiazolin-derivate
US5753659A (en) Heterocyclic compouds
DE69405815T2 (de) Acylharnstoffe
US5728701A (en) Heterocyclic derivatives
DE69402471T2 (de) 1,2-Diacylierte Hydrazin-Derivate und ihre Verwendung als Zelladhäsion-Inhibitoren
DE60113406T2 (de) N-substituierte peptidylnitrile als cystein-cathepsin-inhibitoren
RU2142944C1 (ru) Производные пиридина и их фармацевтически приемлемые соли, фармацевтическая композиция на их основе и промежуточные вещества
DE69405816T2 (de) Allophansäure Derivate
EP2563762B1 (de) Verfahren zur herstellung substituierter pyridin- 2 - one

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB

8339 Ceased/non-payment of the annual fee