EP0584066A4 - Anti-thrombotic peptide and pseudopeptide derivatives. - Google Patents

Anti-thrombotic peptide and pseudopeptide derivatives.

Info

Publication number
EP0584066A4
EP0584066A4 EP19910910671 EP91910671A EP0584066A4 EP 0584066 A4 EP0584066 A4 EP 0584066A4 EP 19910910671 EP19910910671 EP 19910910671 EP 91910671 A EP91910671 A EP 91910671A EP 0584066 A4 EP0584066 A4 EP 0584066A4
Authority
EP
European Patent Office
Prior art keywords
pseudopeptide derivatives
thrombotic
peptide
thrombotic peptide
pseudopeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910910671
Other languages
German (de)
French (fr)
Other versions
EP0584066A1 (en
Inventor
Scott I Klein
Bruce F Molino
Jeffrey M Dener
Mark Czekaj
Michael R Becker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Rorer International Holdings Inc
Original Assignee
Rhone Poulenc Rorer International Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer International Holdings Inc filed Critical Rhone Poulenc Rorer International Holdings Inc
Publication of EP0584066A1 publication Critical patent/EP0584066A1/en
Publication of EP0584066A4 publication Critical patent/EP0584066A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19910910671 1991-04-11 1991-04-11 Anti-thrombotic peptide and pseudopeptide derivatives. Withdrawn EP0584066A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1991/002471 WO1992018117A1 (en) 1991-04-11 1991-04-11 Anti-thrombotic peptide and pseudopeptide derivatives

Publications (2)

Publication Number Publication Date
EP0584066A1 EP0584066A1 (en) 1994-03-02
EP0584066A4 true EP0584066A4 (en) 1994-10-12

Family

ID=22225448

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910910671 Withdrawn EP0584066A4 (en) 1991-04-11 1991-04-11 Anti-thrombotic peptide and pseudopeptide derivatives.

Country Status (4)

Country Link
EP (1) EP0584066A4 (en)
JP (1) JPH08503920A (en)
AU (1) AU661659B2 (en)
WO (1) WO1992018117A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0677043A1 (en) * 1992-12-29 1995-10-18 Smithkline Beecham Corporation Platelet aggregation inhibiting compounds
PL310889A1 (en) * 1993-03-29 1996-01-08 Zeneca Ltd Heterocyclic derivatives as inhibitors of thrombocytes aggregation
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
ATE199727T1 (en) * 1993-10-15 2001-03-15 Rhone Poulenc Rorer Pharma ANTITHROMBOTIC AZACYCLOALKYL ALKANOYL PEPTIDES AND PSEUDOPEPTIDES

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319506A2 (en) * 1987-12-03 1989-06-07 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
EP0352249A1 (en) * 1988-07-20 1990-01-24 Monsanto Company Novel platelet-aggregation inhibitors
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
EP0445796A2 (en) * 1990-03-09 1991-09-11 F. Hoffmann-La Roche Ag Derivatives of acetic acid
EP0452257A2 (en) * 1990-04-05 1991-10-16 Ciba-Geigy Ag Novel platelet-aggregation inhibitors
US5086069A (en) * 1990-02-05 1992-02-04 Rorer Pharmaceutical Corporation Anti-thrombotic peptide and pseudopeptide derivatives
WO1992013552A1 (en) * 1991-02-05 1992-08-20 Smithkline Beecham Corporation Anti-aggregatory peptides containing an aromatic ester or amide
WO1992015607A2 (en) * 1991-03-06 1992-09-17 G.D. Searle & Co. Phenyl amidines derivatives useful as platelet aggregation inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
JPS5753446A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide derivative
US4634715A (en) * 1981-02-17 1987-01-06 Merck & Co., Inc. Aza analogs of carboxyalkyl dipeptide derivatives as antihypertensives
JPS606647A (en) * 1983-06-17 1985-01-14 Microbial Chem Res Found Alphamenine, its relating compound and their synthesis
ES2039213T3 (en) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation PROCEDURE FOR PRODUCING NEW COMPOUNDS RELATED TO SPERGUALINE.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319506A2 (en) * 1987-12-03 1989-06-07 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
EP0352249A1 (en) * 1988-07-20 1990-01-24 Monsanto Company Novel platelet-aggregation inhibitors
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
US5086069A (en) * 1990-02-05 1992-02-04 Rorer Pharmaceutical Corporation Anti-thrombotic peptide and pseudopeptide derivatives
EP0445796A2 (en) * 1990-03-09 1991-09-11 F. Hoffmann-La Roche Ag Derivatives of acetic acid
EP0452257A2 (en) * 1990-04-05 1991-10-16 Ciba-Geigy Ag Novel platelet-aggregation inhibitors
WO1992013552A1 (en) * 1991-02-05 1992-08-20 Smithkline Beecham Corporation Anti-aggregatory peptides containing an aromatic ester or amide
WO1992015607A2 (en) * 1991-03-06 1992-09-17 G.D. Searle & Co. Phenyl amidines derivatives useful as platelet aggregation inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9218117A1 *

Also Published As

Publication number Publication date
EP0584066A1 (en) 1994-03-02
JPH08503920A (en) 1996-04-30
AU8089691A (en) 1992-11-17
AU661659B2 (en) 1995-08-03
WO1992018117A1 (en) 1992-10-29

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Legal Events

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18D Application deemed to be withdrawn

Effective date: 19951101