DE69328969T2 - Verfahren zur stereospezifischen hydrolyse von piperidin-dion derivaten - Google Patents
Verfahren zur stereospezifischen hydrolyse von piperidin-dion derivatenInfo
- Publication number
- DE69328969T2 DE69328969T2 DE69328969T DE69328969T DE69328969T2 DE 69328969 T2 DE69328969 T2 DE 69328969T2 DE 69328969 T DE69328969 T DE 69328969T DE 69328969 T DE69328969 T DE 69328969T DE 69328969 T2 DE69328969 T2 DE 69328969T2
- Authority
- DE
- Germany
- Prior art keywords
- piperidine
- stereo
- specific hydrolysis
- dion derivatives
- dion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929209687A GB9209687D0 (en) | 1992-05-06 | 1992-05-06 | Novel process |
| PCT/GB1993/000721 WO1993022284A1 (en) | 1992-05-06 | 1993-04-06 | Process for stereospecific hydrolysis of piperidinedione derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69328969D1 DE69328969D1 (de) | 2000-08-10 |
| DE69328969T2 true DE69328969T2 (de) | 2000-12-07 |
Family
ID=10715029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69328969T Expired - Fee Related DE69328969T2 (de) | 1992-05-06 | 1993-04-06 | Verfahren zur stereospezifischen hydrolyse von piperidin-dion derivaten |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20010018205A1 (de) |
| EP (1) | EP0639180B1 (de) |
| JP (1) | JPH07507277A (de) |
| KR (1) | KR100287082B1 (de) |
| CN (2) | CN1059898C (de) |
| AP (1) | AP404A (de) |
| AT (1) | ATE194329T1 (de) |
| AU (1) | AU673166B2 (de) |
| BR (1) | BR9306326A (de) |
| CA (1) | CA2135169A1 (de) |
| CZ (1) | CZ283702B6 (de) |
| DE (1) | DE69328969T2 (de) |
| DK (1) | DK0639180T3 (de) |
| ES (1) | ES2147196T3 (de) |
| FI (1) | FI106855B (de) |
| GB (1) | GB9209687D0 (de) |
| GR (1) | GR3034034T3 (de) |
| HK (1) | HK1012374A1 (de) |
| HU (1) | HU215411B (de) |
| IL (1) | IL105162A (de) |
| MA (1) | MA22848A1 (de) |
| MX (1) | MX9301754A (de) |
| MY (1) | MY110188A (de) |
| NO (1) | NO944215L (de) |
| NZ (1) | NZ251404A (de) |
| PL (1) | PL172067B1 (de) |
| PT (1) | PT639180E (de) |
| RU (1) | RU2108393C1 (de) |
| SI (1) | SI9300158A (de) |
| SK (1) | SK281767B6 (de) |
| TW (1) | TW258732B (de) |
| WO (1) | WO1993022284A1 (de) |
| ZA (1) | ZA932212B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9325644D0 (en) * | 1993-12-15 | 1994-02-16 | Smithkline Beecham Plc | Novel formulation |
| EP0937152A2 (de) * | 1996-07-15 | 1999-08-25 | Smithkline Beecham Plc | Screening nach einer esterase und deren verwendung zur stereospezifischen auflösung |
| GB9618967D0 (en) * | 1996-09-11 | 1996-10-23 | Smithkline Beecham Plc | Pharmaceuticals |
| CA2293247C (en) * | 1997-06-10 | 2005-04-12 | Synthon B.V. | 4-phenylpiperidine compounds |
| CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
| IT1308629B1 (it) * | 1999-02-23 | 2002-01-09 | Recordati Chem Pharm | Processo per la produzione di paroxetina. |
| ES2161167B1 (es) * | 1999-09-24 | 2002-07-01 | Vita Invest Sa | Procedimiento de hidrolisis enzimatica de esteres del acido (3sr,4rs)-4-(4-fluorofenil)-6-oxopiperidin-3-carboxilico con biocatalizadores de lipasas o esterasas inmovilizadas. |
| WO2001085688A1 (en) | 2000-05-12 | 2001-11-15 | Synthon B.V. | TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS |
| WO2009005647A2 (en) * | 2007-06-27 | 2009-01-08 | Bioverdant, Inc. | Compounds and process to prepare chiral intermediates for synthesis of paroxetine |
| CN104892491B (zh) * | 2015-05-06 | 2017-05-17 | 浙江海森药业有限公司 | 一种合成帕罗西汀手性中间体的方法 |
| KR102168129B1 (ko) | 2018-11-28 | 2020-10-20 | 장영선 | 넝쿨작물용 줄기 유인용 집게 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| DE3010104A1 (de) * | 1980-03-15 | 1981-10-01 | Basf Ag, 6700 Ludwigshafen | Aminoazoverbindungen |
| DE3680184D1 (de) * | 1985-08-10 | 1991-08-14 | Beecham Group Plc | Verfahren zur herstellung von arylpiperidincarbinol. |
| EP0223403B1 (de) * | 1985-10-25 | 1993-08-04 | Beecham Group Plc | Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel |
| DK716088D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Reduktion af piperidin-dion-derivater samt intermediat |
| US5258517A (en) * | 1992-08-06 | 1993-11-02 | Sepracor, Inc. | Method of preparing optically pure precursors of paroxetine |
-
1992
- 1992-05-06 GB GB929209687A patent/GB9209687D0/en active Pending
-
1993
- 1993-03-25 IL IL10516293A patent/IL105162A/en not_active IP Right Cessation
- 1993-03-25 AP APAP/P/1993/000501A patent/AP404A/en active
- 1993-03-29 MX MX9301754A patent/MX9301754A/es not_active IP Right Cessation
- 1993-03-29 ZA ZA932212A patent/ZA932212B/xx unknown
- 1993-03-31 MY MYPI93000567A patent/MY110188A/en unknown
- 1993-03-31 MA MA23143A patent/MA22848A1/fr unknown
- 1993-03-31 SI SI9300158A patent/SI9300158A/sl unknown
- 1993-04-01 CN CN93104523A patent/CN1059898C/zh not_active Expired - Fee Related
- 1993-04-06 DK DK93908004T patent/DK0639180T3/da active
- 1993-04-06 AU AU38999/93A patent/AU673166B2/en not_active Ceased
- 1993-04-06 DE DE69328969T patent/DE69328969T2/de not_active Expired - Fee Related
- 1993-04-06 CZ CZ942712A patent/CZ283702B6/cs not_active IP Right Cessation
- 1993-04-06 NZ NZ251404A patent/NZ251404A/en unknown
- 1993-04-06 JP JP5519022A patent/JPH07507277A/ja active Pending
- 1993-04-06 AT AT93908004T patent/ATE194329T1/de not_active IP Right Cessation
- 1993-04-06 ES ES93908004T patent/ES2147196T3/es not_active Expired - Lifetime
- 1993-04-06 BR BR9306326A patent/BR9306326A/pt not_active Application Discontinuation
- 1993-04-06 SK SK1315-94A patent/SK281767B6/sk unknown
- 1993-04-06 CA CA002135169A patent/CA2135169A1/en not_active Abandoned
- 1993-04-06 EP EP93908004A patent/EP0639180B1/de not_active Expired - Lifetime
- 1993-04-06 PT PT93908004T patent/PT639180E/pt unknown
- 1993-04-06 HU HU9403189A patent/HU215411B/hu not_active IP Right Cessation
- 1993-04-06 PL PL93305801A patent/PL172067B1/pl unknown
- 1993-04-06 RU RU94046012A patent/RU2108393C1/ru active
- 1993-04-06 WO PCT/GB1993/000721 patent/WO1993022284A1/en active IP Right Grant
- 1993-04-14 TW TW082102827A patent/TW258732B/zh active
-
1994
- 1994-11-04 NO NO944215A patent/NO944215L/no not_active Application Discontinuation
- 1994-11-04 FI FI945209A patent/FI106855B/fi active
- 1994-11-05 KR KR1019940703956A patent/KR100287082B1/ko not_active IP Right Cessation
-
1998
- 1998-12-16 HK HK98113575A patent/HK1012374A1/xx not_active IP Right Cessation
-
2000
- 2000-04-03 CN CN00104973A patent/CN1291653A/zh active Pending
- 2000-07-27 GR GR20000401724T patent/GR3034034T3/el not_active IP Right Cessation
-
2001
- 2001-03-21 US US09/813,755 patent/US20010018205A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |