DE69314253T3 - Mikropartikel-Zusammensetzung und Herstellung derselben - Google Patents

Mikropartikel-Zusammensetzung und Herstellung derselben

Info

Publication number
DE69314253T3
DE69314253T3 DE69314253T DE69314253T DE69314253T3 DE 69314253 T3 DE69314253 T3 DE 69314253T3 DE 69314253 T DE69314253 T DE 69314253T DE 69314253 T DE69314253 T DE 69314253T DE 69314253 T3 DE69314253 T3 DE 69314253T3
Authority
DE
Germany
Prior art keywords
water
soluble
organic acid
preparation
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69314253T
Other languages
English (en)
Other versions
DE69314253D1 (de
DE69314253T2 (de
Inventor
Yasaburo Akagi
Nobuyuki Takechi
Muneo Nonomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26358167&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69314253(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69314253D1 publication Critical patent/DE69314253D1/de
Application granted granted Critical
Publication of DE69314253T2 publication Critical patent/DE69314253T2/de
Publication of DE69314253T3 publication Critical patent/DE69314253T3/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE69314253T 1992-07-24 1993-07-22 Mikropartikel-Zusammensetzung und Herstellung derselben Expired - Fee Related DE69314253T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19824292 1992-07-24
JP2114293 1993-02-09

Publications (3)

Publication Number Publication Date
DE69314253D1 DE69314253D1 (de) 1997-11-06
DE69314253T2 DE69314253T2 (de) 1998-01-29
DE69314253T3 true DE69314253T3 (de) 2003-01-09

Family

ID=26358167

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69314253T Expired - Fee Related DE69314253T3 (de) 1992-07-24 1993-07-22 Mikropartikel-Zusammensetzung und Herstellung derselben

Country Status (9)

Country Link
US (1) US5723269A (de)
EP (1) EP0580428B2 (de)
KR (1) KR100297267B1 (de)
CN (1) CN1088092A (de)
AT (1) ATE158718T1 (de)
AU (1) AU4198793A (de)
CA (1) CA2101183C (de)
DE (1) DE69314253T3 (de)
HU (1) HUT67277A (de)

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* Cited by examiner, † Cited by third party
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CN1088092A (zh) 1994-06-22
AU4198793A (en) 1994-01-27
KR100297267B1 (ko) 2001-11-22
EP0580428B2 (de) 2002-05-29
HUT67277A (en) 1995-03-28
ATE158718T1 (de) 1997-10-15
EP0580428A1 (de) 1994-01-26
DE69314253D1 (de) 1997-11-06
HU9302137D0 (en) 1993-10-28
DE69314253T2 (de) 1998-01-29
US5723269A (en) 1998-03-03
CA2101183C (en) 2003-08-05
KR940005266A (ko) 1994-03-21
CA2101183A1 (en) 1994-01-25
EP0580428B1 (de) 1997-10-01

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