DE69226167D1 - Strukturgen von pneumokokken-protein - Google Patents
Strukturgen von pneumokokken-proteinInfo
- Publication number
- DE69226167D1 DE69226167D1 DE69226167T DE69226167T DE69226167D1 DE 69226167 D1 DE69226167 D1 DE 69226167D1 DE 69226167 T DE69226167 T DE 69226167T DE 69226167 T DE69226167 T DE 69226167T DE 69226167 D1 DE69226167 D1 DE 69226167D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- protein
- pneumokokken
- structures
- pspa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 108010040473 pneumococcal surface protein A Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65677391A | 1991-02-15 | 1991-02-15 | |
PCT/US1992/000857 WO1992014488A1 (en) | 1991-02-15 | 1992-02-12 | Structural gene of pneumococcal protein |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69226167D1 true DE69226167D1 (de) | 1998-08-13 |
DE69226167T2 DE69226167T2 (de) | 1998-11-12 |
Family
ID=24634503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69226167T Expired - Fee Related DE69226167T2 (de) | 1991-02-15 | 1992-02-12 | Strukturgen von pneumokokken-protein |
Country Status (16)
Country | Link |
---|---|
US (1) | US5728387A (de) |
EP (2) | EP0786521A1 (de) |
JP (3) | JP3215109B2 (de) |
AT (1) | ATE168132T1 (de) |
AU (1) | AU692678C (de) |
CA (1) | CA2104014C (de) |
DE (1) | DE69226167T2 (de) |
DK (1) | DK0571538T5 (de) |
ES (1) | ES2118812T3 (de) |
FI (1) | FI933580A (de) |
HK (1) | HK1013629A1 (de) |
IE (2) | IE920479A1 (de) |
IL (1) | IL100946A0 (de) |
NO (1) | NO313999B1 (de) |
WO (1) | WO1992014488A1 (de) |
ZA (1) | ZA921025B (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6231870B1 (en) * | 1995-06-02 | 2001-05-15 | Uab Research Foundation | Oral administration of pneumoccal antigens |
US6027734A (en) * | 1991-02-15 | 2000-02-22 | Uab Research Foundation | Mucosal administration of pneumococcal antigens |
US6232116B1 (en) | 1991-02-15 | 2001-05-15 | University Of Alabama At Birmingham Research Foundation | Oral administration of pneumococcal antigens |
US5980909A (en) * | 1991-02-15 | 1999-11-09 | Uab Research Foundation | Epitopic regions of pneumococcal surface protein A |
US6592876B1 (en) * | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
US5965141A (en) * | 1991-02-15 | 1999-10-12 | Uab Research Foundation | Epitopic regions of pneumococcal surface protein a |
CA2116261A1 (en) * | 1993-04-20 | 1994-10-21 | David E. Briles | Epitopic regions of pneumococcal surface protein a |
US5928900A (en) * | 1993-09-01 | 1999-07-27 | The Rockefeller University | Bacterial exported proteins and acellular vaccines based thereon |
AU734488B2 (en) * | 1994-05-20 | 2001-06-14 | Uab Research Foundation | Mucosal administration of pneumococcal antigens |
US20020055101A1 (en) | 1995-09-11 | 2002-05-09 | Michel G. Bergeron | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
US6001564A (en) * | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
CA2222965A1 (en) * | 1995-06-02 | 1996-12-12 | Uab Research Foundation | Oral administration of pneumococcal antigens |
US6004802A (en) * | 1995-06-02 | 1999-12-21 | University Of Alabama At Birmingham | Oral administration of pneumococcal antigens |
JPH11507214A (ja) * | 1995-06-07 | 1999-06-29 | バイオケム ヴァシーンズ インク. | Hsp70ファミリーに属する連鎖球菌の熱ショック蛋白質メンバー |
US6251405B1 (en) | 1995-06-07 | 2001-06-26 | Connaught Laboratories, Inc. | Immunological combination compositions and methods |
PT832093E (pt) * | 1995-06-07 | 2006-12-29 | Sanofi Pasteur Inc | Expressão de lipoproteínas |
ZA964896B (en) | 1995-06-07 | 1997-01-08 | Connaught Lab | Expression of lipoproteins |
US5994066A (en) * | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
US7078042B2 (en) | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
US5949537A (en) | 1996-04-18 | 1999-09-07 | American Air Liquide Inc. | In-line cell for absorption spectroscopy |
US6165989A (en) * | 1996-05-14 | 2000-12-26 | Smithkline Beecham Corporation | Era of Streptococcus pneumoniae |
EP0979101B1 (de) | 1996-07-03 | 2010-10-27 | Merial, Inc. | Rekombinanter hunde-adenovirus 2 (cav2), welcher exogene dna enthält |
US5882896A (en) * | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
US5928895A (en) * | 1996-09-24 | 1999-07-27 | Smithkline Beecham Corporation | IgA Fc binding protein |
US20100267012A1 (en) | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
US20030049636A1 (en) | 1999-05-03 | 2003-03-13 | Bergeron Michel G. | Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories |
CA2274095A1 (en) * | 1996-12-04 | 1998-06-11 | University Of Alabama At Birmingham | Compositions and methods for administering pneumococcal dna |
KR19980067137A (ko) * | 1997-01-31 | 1998-10-15 | 박원훈 | 알긴산염 초미세과립구를 이용한 폐렴구균 감연중에 대한 백신 |
CA2304128A1 (en) * | 1997-09-18 | 1999-03-25 | Robert Becker | Improved method of production of pneumococcal surface proteins |
US6224882B1 (en) | 1997-11-07 | 2001-05-01 | Protein Science Corp. | Insect cells or fractions as adjuvant for antigens |
US20010016200A1 (en) * | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
EP1246935B1 (de) | 1999-09-28 | 2013-08-14 | Geneohm Sciences Canada Inc. | Konservierte gene und dessen benutzung für die herstellung von sonden und primern für mikroorganismen nachweis |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
AT410412B (de) | 2000-11-10 | 2003-04-25 | Inteco Int Techn Beratung | Verfahren zum elektroschlacke umschmelzen von metallen |
US8691243B2 (en) | 2002-04-02 | 2014-04-08 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based Streptococcus pneumoniae vaccine |
EP2275123B1 (de) * | 2002-04-02 | 2012-12-05 | Ben Gurion University Of The Negev Research And Development Authority | Streptococcus-pneumoniae-Vakzine auf Proteinbasis |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
JO2813B1 (en) | 2005-12-22 | 2014-09-15 | جلاكسو سميث كلاين بايولوجيكالز اس.ايه | A vaccine with multiple pneumococcal saccharides |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
MY150105A (en) | 2006-01-17 | 2013-11-29 | Forsgren Arne | A novel surface exposed haemophilus influenzae protein (protein e; pe) |
PT2167121E (pt) | 2007-06-26 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vacina compreendendo conjugados de polissacáridos capsulares de streptococcus pneumoniae |
AU2009237647A1 (en) | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
CN102170903B (zh) | 2008-05-02 | 2016-04-06 | 亮点医疗有限公司 | 用于刺激免疫反应的产品和方法 |
GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
WO2011110953A2 (en) | 2010-03-09 | 2011-09-15 | Artemev, Timur | Polyepitope constructs and methods for their preparation and use |
CA2798331C (en) | 2010-05-14 | 2022-03-15 | Baxter International Inc. | Ospa chimeras and use thereof in vaccines |
US9109007B2 (en) | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
US20140072622A1 (en) | 2011-05-17 | 2014-03-13 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
KR20150038380A (ko) | 2012-07-27 | 2015-04-08 | 백스터 인터내셔널 인코포레이티드 | 키메라 ospa 분자를 포함하는 조성물 및 이의 사용 방법 |
CN109289045A (zh) | 2012-09-19 | 2019-02-01 | 国立大学法人大阪大学 | 含有肺炎球菌表面蛋白a的肺炎球菌疫苗 |
US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
CN110381992A (zh) * | 2016-12-03 | 2019-10-25 | Uab研究基金会 | 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗 |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
CN110499375B (zh) * | 2019-08-28 | 2023-03-28 | 首钢医院有限公司 | 结合多交叉置换扩增和金纳米检测肺炎链球菌的方法 |
WO2023240124A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
WO2023240109A1 (en) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Multispecific molecules for modulating t-cell activity, and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4673574A (en) * | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4496538A (en) * | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
-
1992
- 1992-02-12 JP JP50675592A patent/JP3215109B2/ja not_active Expired - Fee Related
- 1992-02-12 EP EP96119668A patent/EP0786521A1/de not_active Ceased
- 1992-02-12 AT AT92907062T patent/ATE168132T1/de not_active IP Right Cessation
- 1992-02-12 EP EP92907062A patent/EP0571538B1/de not_active Expired - Lifetime
- 1992-02-12 ES ES92907062T patent/ES2118812T3/es not_active Expired - Lifetime
- 1992-02-12 DE DE69226167T patent/DE69226167T2/de not_active Expired - Fee Related
- 1992-02-12 DK DK92907062T patent/DK0571538T5/da active
- 1992-02-12 WO PCT/US1992/000857 patent/WO1992014488A1/en active IP Right Grant
- 1992-02-12 CA CA002104014A patent/CA2104014C/en not_active Expired - Fee Related
- 1992-02-12 ZA ZA921025A patent/ZA921025B/xx unknown
- 1992-02-14 IE IE047992A patent/IE920479A1/en not_active IP Right Cessation
- 1992-02-14 IE IE20000062A patent/IE20000062A1/en not_active IP Right Cessation
- 1992-02-14 IL IL100946A patent/IL100946A0/xx unknown
-
1993
- 1993-08-13 NO NO19932890A patent/NO313999B1/no not_active IP Right Cessation
- 1993-08-13 FI FI933580A patent/FI933580A/fi not_active Application Discontinuation
-
1994
- 1994-03-17 US US08/214,164 patent/US5728387A/en not_active Expired - Lifetime
-
1996
- 1996-03-08 AU AU47980/96A patent/AU692678C/en not_active Ceased
- 1996-07-02 JP JP8172110A patent/JPH09224680A/ja active Pending
-
1998
- 1998-12-23 HK HK98115032A patent/HK1013629A1/xx not_active IP Right Cessation
-
2000
- 2000-12-18 JP JP2000383712A patent/JP2001204482A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IE920479A1 (en) | 1992-08-26 |
NO932890D0 (no) | 1993-08-13 |
JP2001204482A (ja) | 2001-07-31 |
US5728387A (en) | 1998-03-17 |
AU692678B2 (en) | 1998-06-11 |
EP0571538B1 (de) | 1998-07-08 |
AU692678C (en) | 2002-08-29 |
AU667668B2 (en) | 1996-04-04 |
JP3215109B2 (ja) | 2001-10-02 |
DE69226167T2 (de) | 1998-11-12 |
IL100946A0 (en) | 1992-11-15 |
CA2104014C (en) | 2000-05-02 |
HK1013629A1 (en) | 1999-11-26 |
DK0571538T5 (da) | 2002-03-04 |
EP0571538A1 (de) | 1993-12-01 |
DK0571538T3 (da) | 1999-04-19 |
AU1445392A (en) | 1992-09-15 |
FI933580A (fi) | 1993-10-13 |
NO932890L (no) | 1993-10-14 |
AU4798096A (en) | 1996-06-27 |
WO1992014488A1 (en) | 1992-09-03 |
JPH09224680A (ja) | 1997-09-02 |
FI933580A0 (fi) | 1993-08-13 |
ES2118812T3 (es) | 1998-10-01 |
JPH06504446A (ja) | 1994-05-26 |
NO313999B1 (no) | 2003-01-13 |
ZA921025B (en) | 1992-11-25 |
CA2104014A1 (en) | 1992-08-16 |
EP0571538A4 (en) | 1994-08-24 |
ATE168132T1 (de) | 1998-07-15 |
IE20000062A1 (en) | 2000-12-13 |
EP0786521A1 (de) | 1997-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |