ES2118812T3 - Gen estructural de proteina pneumococica. - Google Patents

Gen estructural de proteina pneumococica.

Info

Publication number
ES2118812T3
ES2118812T3 ES92907062T ES92907062T ES2118812T3 ES 2118812 T3 ES2118812 T3 ES 2118812T3 ES 92907062 T ES92907062 T ES 92907062T ES 92907062 T ES92907062 T ES 92907062T ES 2118812 T3 ES2118812 T3 ES 2118812T3
Authority
ES
Spain
Prior art keywords
protein
pspa
pneumococica
structural gene
truncated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92907062T
Other languages
English (en)
Inventor
David E Briles
Janet L Yother
Larry S Mcdaniel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAB Research Foundation
Original Assignee
UAB Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UAB Research Foundation filed Critical UAB Research Foundation
Application granted granted Critical
Publication of ES2118812T3 publication Critical patent/ES2118812T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN PROTEINA A DE SUPERFICIE NEUMOCOCAL PURIFICADA (PSPA) COMPRENDE UNA FORMA TRUNCADA DE LA PROTEINA PSPA QUE ES INMUNOPROTECTORA Y CONTIENE LOS EPITOPES PROTECTORES DE PSPA. LA PROTEINA PSPA ES SOLUBLE EN UNA SOLUCION FISIOLOGICA Y CARECE AL MENOS DE REGION DE ANCLA DE MEMBRANA CELULAR DE TODA LA PROTEINA. LA PROTEINA ESTA FORMADA POR INSERCION-DUPLICACION DE MUTAGENESIS DE S.PNEUMONIAE CON EL GEN PSPA Y LA EXPRESION DE LA PROTEINA TRUNCADA EN EL MEDIO DE CRECIMIENTO.
ES92907062T 1991-02-15 1992-02-12 Gen estructural de proteina pneumococica. Expired - Lifetime ES2118812T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65677391A 1991-02-15 1991-02-15

Publications (1)

Publication Number Publication Date
ES2118812T3 true ES2118812T3 (es) 1998-10-01

Family

ID=24634503

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92907062T Expired - Lifetime ES2118812T3 (es) 1991-02-15 1992-02-12 Gen estructural de proteina pneumococica.

Country Status (16)

Country Link
US (1) US5728387A (es)
EP (2) EP0786521A1 (es)
JP (3) JP3215109B2 (es)
AT (1) ATE168132T1 (es)
AU (1) AU692678C (es)
CA (1) CA2104014C (es)
DE (1) DE69226167T2 (es)
DK (1) DK0571538T5 (es)
ES (1) ES2118812T3 (es)
FI (1) FI933580A (es)
HK (1) HK1013629A1 (es)
IE (2) IE920479A1 (es)
IL (1) IL100946A0 (es)
NO (1) NO313999B1 (es)
WO (1) WO1992014488A1 (es)
ZA (1) ZA921025B (es)

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US6232116B1 (en) 1991-02-15 2001-05-15 University Of Alabama At Birmingham Research Foundation Oral administration of pneumococcal antigens
US6231870B1 (en) * 1995-06-02 2001-05-15 Uab Research Foundation Oral administration of pneumoccal antigens
US5980909A (en) * 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A
US5965141A (en) * 1991-02-15 1999-10-12 Uab Research Foundation Epitopic regions of pneumococcal surface protein a
CA2116261A1 (en) * 1993-04-20 1994-10-21 David E. Briles Epitopic regions of pneumococcal surface protein a
US5928900A (en) * 1993-09-01 1999-07-27 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
AU734488B2 (en) * 1994-05-20 2001-06-14 Uab Research Foundation Mucosal administration of pneumococcal antigens
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US20020055101A1 (en) 1995-09-11 2002-05-09 Michel G. Bergeron Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US6004802A (en) * 1995-06-02 1999-12-21 University Of Alabama At Birmingham Oral administration of pneumococcal antigens
EP0871479A2 (en) * 1995-06-02 1998-10-21 The Uab Research Foundation Oral administration of pneumococcal antigens
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EP1741718A3 (en) * 1995-06-07 2007-03-28 Sanofi Pasteur Inc. Expression of lipoproteins
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US5994066A (en) * 1995-09-11 1999-11-30 Infectio Diagnostic, Inc. Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US7078042B2 (en) 1995-09-15 2006-07-18 Uab Research Foundation Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
US5949537A (en) 1996-04-18 1999-09-07 American Air Liquide Inc. In-line cell for absorption spectroscopy
US6165989A (en) 1996-05-14 2000-12-26 Smithkline Beecham Corporation Era of Streptococcus pneumoniae
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US5882896A (en) * 1996-09-24 1999-03-16 Smithkline Beecham Corporation M protein
US5928895A (en) * 1996-09-24 1999-07-27 Smithkline Beecham Corporation IgA Fc binding protein
US20100267012A1 (en) 1997-11-04 2010-10-21 Bergeron Michel G Highly conserved genes and their use to generate probes and primers for detection of microorganisms
US20030049636A1 (en) 1999-05-03 2003-03-13 Bergeron Michel G. Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
AU5523798A (en) * 1996-12-04 1998-06-29 University Of Alabama At Birmingham Compositions and methods for administering pneumococcal DNA
KR19980067137A (ko) * 1997-01-31 1998-10-15 박원훈 알긴산염 초미세과립구를 이용한 폐렴구균 감연중에 대한 백신
CA2304128A1 (en) * 1997-09-18 1999-03-25 Robert Becker Improved method of production of pneumococcal surface proteins
US6224882B1 (en) 1997-11-07 2001-05-01 Protein Science Corp. Insect cells or fractions as adjuvant for antigens
US20010016200A1 (en) * 1998-04-23 2001-08-23 Briles David E. Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
BR0014370A (pt) 1999-09-28 2002-11-05 Infectio Diagnostic Inc Genes altamente conservados e seu uso para gerar sondas de ácido nucléico e preparadores de amplificação especìficos em espécie, especìfico em gênero, especìficos em famìlia, especìficos em grupo e universais para rapidamente detectar e identificar microorganismos algais, amebianos, bacterianos, fúngicos e parasitas de espécimes clìnicos para diagnose
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
AT410412B (de) 2000-11-10 2003-04-25 Inteco Int Techn Beratung Verfahren zum elektroschlacke umschmelzen von metallen
US8691243B2 (en) 2002-04-02 2014-04-08 Ben-Gurion University Of The Negev Research And Development Authority Protein-based Streptococcus pneumoniae vaccine
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Also Published As

Publication number Publication date
ZA921025B (en) 1992-11-25
ATE168132T1 (de) 1998-07-15
FI933580A0 (fi) 1993-08-13
IE920479A1 (en) 1992-08-26
HK1013629A1 (en) 1999-11-26
FI933580A (fi) 1993-10-13
IL100946A0 (en) 1992-11-15
EP0571538A1 (en) 1993-12-01
DE69226167D1 (de) 1998-08-13
AU1445392A (en) 1992-09-15
CA2104014A1 (en) 1992-08-16
US5728387A (en) 1998-03-17
EP0786521A1 (en) 1997-07-30
DK0571538T3 (da) 1999-04-19
AU692678B2 (en) 1998-06-11
CA2104014C (en) 2000-05-02
NO313999B1 (no) 2003-01-13
JPH09224680A (ja) 1997-09-02
AU692678C (en) 2002-08-29
EP0571538B1 (en) 1998-07-08
EP0571538A4 (en) 1994-08-24
IE20000062A1 (en) 2000-12-13
AU4798096A (en) 1996-06-27
JPH06504446A (ja) 1994-05-26
NO932890L (no) 1993-10-14
JP2001204482A (ja) 2001-07-31
DE69226167T2 (de) 1998-11-12
JP3215109B2 (ja) 2001-10-02
WO1992014488A1 (en) 1992-09-03
DK0571538T5 (da) 2002-03-04
NO932890D0 (no) 1993-08-13
AU667668B2 (en) 1996-04-04

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