DE69125035D1 - Verfahren zur herstellung von interferon-alpha-2 kristallen - Google Patents

Verfahren zur herstellung von interferon-alpha-2 kristallen

Info

Publication number
DE69125035D1
DE69125035D1 DE69125035T DE69125035T DE69125035D1 DE 69125035 D1 DE69125035 D1 DE 69125035D1 DE 69125035 T DE69125035 T DE 69125035T DE 69125035 T DE69125035 T DE 69125035T DE 69125035 D1 DE69125035 D1 DE 69125035D1
Authority
DE
Germany
Prior art keywords
crystals
interferon alpha
producing interferon
producing
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69125035T
Other languages
English (en)
Other versions
DE69125035T2 (de
Inventor
Paul Reichert
Gerald Hammond
Hung Le
Tattanahalli Nagabhushan
Paul Trotta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69125035D1 publication Critical patent/DE69125035D1/de
Application granted granted Critical
Publication of DE69125035T2 publication Critical patent/DE69125035T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69125035T 1990-06-04 1991-06-03 Verfahren zur herstellung von interferon-alpha-2 kristallen Expired - Fee Related DE69125035T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53322590A 1990-06-04 1990-06-04
PCT/US1991/003660 WO1991018927A1 (en) 1990-06-04 1991-06-03 Method for preparing interferon alpha-2 crystals

Publications (2)

Publication Number Publication Date
DE69125035D1 true DE69125035D1 (de) 1997-04-10
DE69125035T2 DE69125035T2 (de) 1997-07-10

Family

ID=24125036

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69125035T Expired - Fee Related DE69125035T2 (de) 1990-06-04 1991-06-03 Verfahren zur herstellung von interferon-alpha-2 kristallen

Country Status (24)

Country Link
US (2) US5460956A (de)
EP (1) EP0597851B1 (de)
JP (1) JPH0749440B2 (de)
CN (2) CN1033035C (de)
AT (1) ATE149523T1 (de)
AU (1) AU636043B2 (de)
CA (1) CA2084406A1 (de)
DE (1) DE69125035T2 (de)
ES (1) ES2098358T3 (de)
FI (1) FI925515A (de)
HU (1) HUT63185A (de)
IE (1) IE911892A1 (de)
IL (1) IL98354A0 (de)
MX (1) MX9203319A (de)
MY (1) MY107450A (de)
NO (1) NO924672D0 (de)
NZ (1) NZ238384A (de)
OA (1) OA09720A (de)
PL (1) PL166045B1 (de)
PT (1) PT97849A (de)
SG (1) SG45207A1 (de)
TW (1) TW342395B (de)
WO (1) WO1991018927A1 (de)
ZA (1) ZA914200B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912015A (en) * 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
SE9302278D0 (sv) * 1992-10-28 1993-07-02 Kabi Pharmacia Ab Growth hormone
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
AU706180B2 (en) * 1994-07-25 1999-06-10 Alkermes Controlled Therapeutics, Inc. Controlled release of metal cation-stabilized interferon
JP2000507912A (ja) * 1995-08-31 2000-06-27 アルカームズ コントロールド セラピューティックス，インコーポレイテッド 作用剤の徐放性組成物
US5972331A (en) * 1995-12-22 1999-10-26 Schering Corporation Crystalline interferon alpha for pulmonary delivery and method for producing the same
US6392069B2 (en) 1996-01-08 2002-05-21 Canji, Inc. Compositions for enhancing delivery of nucleic acids to cells
US20100251425A9 (en) * 1998-05-15 2010-09-30 University Of Central Florida Expression of human interferon in transgenic chloroplasts
US6281337B1 (en) 1998-11-12 2001-08-28 Schering Corporation Methods for conversion of protein isoforms
DE19859876A1 (de) 1998-12-23 2000-06-29 Fraunhofer Ges Forschung Verfahren zur Kristallisation aus Lösungen
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
CN1578664A (zh) * 2001-10-30 2005-02-09 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
CA2512001A1 (en) * 2002-12-31 2004-07-22 Altus Pharmaceuticals Inc. Complexes of protein crystals and ionic polymers
DK1581251T3 (da) 2002-12-31 2016-06-27 Althea Tech Inc Krystaller af humant væksthormon og fremgangsmåder til fremstilling deraf
WO2005074546A2 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human growth hormone polypeptides and their uses
US8679472B1 (en) 2006-10-05 2014-03-25 Merck, Sharp & Dohme Corp. Crystal of human interferon alpha 2B in complex with zinc
CA2712606A1 (en) 2008-02-08 2009-08-13 Ambrx, Inc. Modified leptin polypeptides and their uses
US20110027229A1 (en) 2009-07-31 2011-02-03 Medtronic, Inc. Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
US2822203A (en) * 1955-02-17 1958-02-04 Gen Motors Corp Door latch and control means
US4315852A (en) * 1980-11-26 1982-02-16 Schering Corporation Extraction of interferon from bacteria
US4672108A (en) * 1981-12-07 1987-06-09 Hoffmann-La Roche Inc. Crystalline human leukocyte interferon
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals

Also Published As

Publication number Publication date
HUT63185A (en) 1993-07-28
CN1033035C (zh) 1996-10-16
ES2098358T3 (es) 1997-05-01
NO924672L (no) 1992-12-03
CA2084406A1 (en) 1991-12-05
SG45207A1 (en) 1998-01-16
EP0597851B1 (de) 1997-03-05
CN1058022A (zh) 1992-01-22
JPH0749440B2 (ja) 1995-05-31
OA09720A (en) 1993-08-30
ATE149523T1 (de) 1997-03-15
AU7955291A (en) 1991-12-31
TW342395B (en) 1998-10-11
IE911892A1 (en) 1991-12-04
MY107450A (en) 1995-12-30
CN1132212A (zh) 1996-10-02
JPH05503292A (ja) 1993-06-03
ZA914200B (en) 1992-03-25
EP0597851A1 (de) 1994-05-25
NO924672D0 (no) 1992-12-03
NZ238384A (en) 1992-11-25
US5741485A (en) 1998-04-21
FI925515A0 (fi) 1992-12-04
PT97849A (pt) 1992-03-31
WO1991018927A1 (en) 1991-12-12
US5460956A (en) 1995-10-24
CN1044709C (zh) 1999-08-18
IL98354A0 (en) 1992-07-15
PL166045B1 (pl) 1995-03-31
DE69125035T2 (de) 1997-07-10
MX9203319A (es) 1992-07-31
HU9203828D0 (en) 1993-03-29
AU636043B2 (en) 1993-04-08
FI925515A (fi) 1992-12-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee