CA2084406A1 - Method for preparing interferon alpha-2 crystals - Google Patents

Method for preparing interferon alpha-2 crystals

Info

Publication number
CA2084406A1
CA2084406A1 CA002084406A CA2084406A CA2084406A1 CA 2084406 A1 CA2084406 A1 CA 2084406A1 CA 002084406 A CA002084406 A CA 002084406A CA 2084406 A CA2084406 A CA 2084406A CA 2084406 A1 CA2084406 A1 CA 2084406A1
Authority
CA
Canada
Prior art keywords
interferon alpha
crystals
alpha
solution
sulfate salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002084406A
Other languages
English (en)
French (fr)
Inventor
Paul Reichert
Gerald Hammond
Hung Le
Tattanahalli Nagabhushan
Paul Trotta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2084406A1 publication Critical patent/CA2084406A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002084406A 1990-06-04 1991-06-03 Method for preparing interferon alpha-2 crystals Abandoned CA2084406A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53322590A 1990-06-04 1990-06-04
US533,225 1990-06-04

Publications (1)

Publication Number Publication Date
CA2084406A1 true CA2084406A1 (en) 1991-12-05

Family

ID=24125036

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002084406A Abandoned CA2084406A1 (en) 1990-06-04 1991-06-03 Method for preparing interferon alpha-2 crystals

Country Status (24)

Country Link
US (2) US5460956A (de)
EP (1) EP0597851B1 (de)
JP (1) JPH0749440B2 (de)
CN (2) CN1033035C (de)
AT (1) ATE149523T1 (de)
AU (1) AU636043B2 (de)
CA (1) CA2084406A1 (de)
DE (1) DE69125035T2 (de)
ES (1) ES2098358T3 (de)
FI (1) FI925515A (de)
HU (1) HUT63185A (de)
IE (1) IE911892A1 (de)
IL (1) IL98354A0 (de)
MX (1) MX9203319A (de)
MY (1) MY107450A (de)
NO (1) NO924672D0 (de)
NZ (1) NZ238384A (de)
OA (1) OA09720A (de)
PL (1) PL166045B1 (de)
PT (1) PT97849A (de)
SG (1) SG45207A1 (de)
TW (1) TW342395B (de)
WO (1) WO1991018927A1 (de)
ZA (1) ZA914200B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
SE9302278D0 (sv) * 1992-10-28 1993-07-02 Kabi Pharmacia Ab Growth hormone
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
AU706180B2 (en) * 1994-07-25 1999-06-10 Alkermes Controlled Therapeutics, Inc. Controlled release of metal cation-stabilized interferon
WO1997007788A2 (en) * 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
US5972331A (en) * 1995-12-22 1999-10-26 Schering Corporation Crystalline interferon alpha for pulmonary delivery and method for producing the same
US6392069B2 (en) 1996-01-08 2002-05-21 Canji, Inc. Compositions for enhancing delivery of nucleic acids to cells
US20100251425A9 (en) * 1998-05-15 2010-09-30 University Of Central Florida Expression of human interferon in transgenic chloroplasts
US6281337B1 (en) 1998-11-12 2001-08-28 Schering Corporation Methods for conversion of protein isoforms
DE19859876A1 (de) 1998-12-23 2000-06-29 Fraunhofer Ges Forschung Verfahren zur Kristallisation aus Lösungen
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
CN101912367A (zh) * 2001-10-30 2010-12-15 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
ES2343518T3 (es) * 2002-09-09 2010-08-03 Hanall Biopharma Co., Ltd. Polipeptidos interferon alfa modificados resistentes a proteasas.
NZ554885A (en) * 2002-12-31 2009-07-31 Altus Pharmaceuticals Inc Complexes of hgh crystals and protamine polymers
EP1581251B1 (de) 2002-12-31 2016-03-16 Althea Technologies, Inc. Menschliche wachstumshormonkristalle und herstellungsverfahren dafür
JP4896745B2 (ja) 2004-02-02 2012-03-14 アンブレツクス・インコーポレイテツド 修飾されたヒトインターフェロンポリペプチドおよびこれらの使用
US8679472B1 (en) 2006-10-05 2014-03-25 Merck, Sharp & Dohme Corp. Crystal of human interferon alpha 2B in complex with zinc
EP2247743B1 (de) 2008-02-08 2016-04-06 Ambrx, Inc. Modifizierte leptin-polypeptide und deren verwendungen
US20110027229A1 (en) 2009-07-31 2011-02-03 Medtronic, Inc. Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients
EP3079668A1 (de) 2013-12-09 2016-10-19 Durect Corporation Pharmazeutisch aktive wirkstoffkomplexe, polymerkomplexe und zusammensetzungen und verfahren damit

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
US2822203A (en) * 1955-02-17 1958-02-04 Gen Motors Corp Door latch and control means
US4315852A (en) * 1980-11-26 1982-02-16 Schering Corporation Extraction of interferon from bacteria
US4672108A (en) * 1981-12-07 1987-06-09 Hoffmann-La Roche Inc. Crystalline human leukocyte interferon
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals

Also Published As

Publication number Publication date
EP0597851B1 (de) 1997-03-05
SG45207A1 (en) 1998-01-16
JPH0749440B2 (ja) 1995-05-31
NO924672L (no) 1992-12-03
ATE149523T1 (de) 1997-03-15
EP0597851A1 (de) 1994-05-25
FI925515A0 (fi) 1992-12-04
FI925515A (fi) 1992-12-04
HUT63185A (en) 1993-07-28
DE69125035D1 (de) 1997-04-10
OA09720A (en) 1993-08-30
ES2098358T3 (es) 1997-05-01
AU7955291A (en) 1991-12-31
PL166045B1 (pl) 1995-03-31
CN1132212A (zh) 1996-10-02
PT97849A (pt) 1992-03-31
ZA914200B (en) 1992-03-25
TW342395B (en) 1998-10-11
MX9203319A (es) 1992-07-31
IL98354A0 (en) 1992-07-15
CN1033035C (zh) 1996-10-16
HU9203828D0 (en) 1993-03-29
IE911892A1 (en) 1991-12-04
DE69125035T2 (de) 1997-07-10
US5741485A (en) 1998-04-21
CN1044709C (zh) 1999-08-18
US5460956A (en) 1995-10-24
WO1991018927A1 (en) 1991-12-12
MY107450A (en) 1995-12-30
JPH05503292A (ja) 1993-06-03
NZ238384A (en) 1992-11-25
CN1058022A (zh) 1992-01-22
AU636043B2 (en) 1993-04-08
NO924672D0 (no) 1992-12-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued