ATE168132T1 - Strukturgen von pneumokokken-protein - Google Patents

Strukturgen von pneumokokken-protein

Info

Publication number
ATE168132T1
ATE168132T1 AT92907062T AT92907062T ATE168132T1 AT E168132 T1 ATE168132 T1 AT E168132T1 AT 92907062 T AT92907062 T AT 92907062T AT 92907062 T AT92907062 T AT 92907062T AT E168132 T1 ATE168132 T1 AT E168132T1
Authority
AT
Austria
Prior art keywords
nucleic acid
pneumococcal protein
structure genes
pspa
genes
Prior art date
Application number
AT92907062T
Other languages
English (en)
Inventor
David E Briles
Janet L Yother
Larry S Mcdaniel
Original Assignee
Uab Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation filed Critical Uab Research Foundation
Application granted granted Critical
Publication of ATE168132T1 publication Critical patent/ATE168132T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT92907062T 1991-02-15 1992-02-12 Strukturgen von pneumokokken-protein ATE168132T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65677391A 1991-02-15 1991-02-15

Publications (1)

Publication Number Publication Date
ATE168132T1 true ATE168132T1 (de) 1998-07-15

Family

ID=24634503

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92907062T ATE168132T1 (de) 1991-02-15 1992-02-12 Strukturgen von pneumokokken-protein

Country Status (16)

Country Link
US (1) US5728387A (de)
EP (2) EP0786521A1 (de)
JP (3) JP3215109B2 (de)
AT (1) ATE168132T1 (de)
AU (1) AU692678C (de)
CA (1) CA2104014C (de)
DE (1) DE69226167T2 (de)
DK (1) DK0571538T5 (de)
ES (1) ES2118812T3 (de)
FI (1) FI933580A (de)
HK (1) HK1013629A1 (de)
IE (2) IE920479A1 (de)
IL (1) IL100946A0 (de)
NO (1) NO313999B1 (de)
WO (1) WO1992014488A1 (de)
ZA (1) ZA921025B (de)

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US6592876B1 (en) * 1993-04-20 2003-07-15 Uab Research Foundation Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
US6232116B1 (en) 1991-02-15 2001-05-15 University Of Alabama At Birmingham Research Foundation Oral administration of pneumococcal antigens
US6231870B1 (en) * 1995-06-02 2001-05-15 Uab Research Foundation Oral administration of pneumoccal antigens
US5980909A (en) * 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A
US5965141A (en) * 1991-02-15 1999-10-12 Uab Research Foundation Epitopic regions of pneumococcal surface protein a
CA2116261A1 (en) * 1993-04-20 1994-10-21 David E. Briles Epitopic regions of pneumococcal surface protein a
US5928900A (en) * 1993-09-01 1999-07-27 The Rockefeller University Bacterial exported proteins and acellular vaccines based thereon
AU734488B2 (en) * 1994-05-20 2001-06-14 Uab Research Foundation Mucosal administration of pneumococcal antigens
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US20020055101A1 (en) 1995-09-11 2002-05-09 Michel G. Bergeron Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US6004802A (en) * 1995-06-02 1999-12-21 University Of Alabama At Birmingham Oral administration of pneumococcal antigens
EP0871479A2 (de) * 1995-06-02 1998-10-21 The Uab Research Foundation Orale verabreichung von pneumokokken-antigenen
ZA964896B (en) 1995-06-07 1997-01-08 Connaught Lab Expression of lipoproteins
TR199701537T1 (xx) * 1995-06-07 1998-03-21 Biochem Vaccines Inc. HSP70 ailesinin streptokokal �s� �ok protein �yeleri.
EP1741718A3 (de) * 1995-06-07 2007-03-28 Sanofi Pasteur Inc. Expression von lipoproteinen
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US20100267012A1 (en) 1997-11-04 2010-10-21 Bergeron Michel G Highly conserved genes and their use to generate probes and primers for detection of microorganisms
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AU5523798A (en) * 1996-12-04 1998-06-29 University Of Alabama At Birmingham Compositions and methods for administering pneumococcal DNA
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CA2304128A1 (en) * 1997-09-18 1999-03-25 Robert Becker Improved method of production of pneumococcal surface proteins
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BR0014370A (pt) 1999-09-28 2002-11-05 Infectio Diagnostic Inc Genes altamente conservados e seu uso para gerar sondas de ácido nucléico e preparadores de amplificação especìficos em espécie, especìfico em gênero, especìficos em famìlia, especìficos em grupo e universais para rapidamente detectar e identificar microorganismos algais, amebianos, bacterianos, fúngicos e parasitas de espécimes clìnicos para diagnose
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US8691243B2 (en) 2002-04-02 2014-04-08 Ben-Gurion University Of The Negev Research And Development Authority Protein-based Streptococcus pneumoniae vaccine
WO2003082183A2 (en) * 2002-04-02 2003-10-09 Ben-Gurion University Of The Negev Research And Development Authority Protein-based streptococcus pneumoniae vaccines
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
LT3017827T (lt) 2005-12-22 2019-01-10 Glaxosmithkline Biologicals S.A. Pneumokokinė polisacharidinė konjuguota vakcina
ZA200805602B (en) 2006-01-17 2009-12-30 Arne Forsgren A novel surface exposed haemophilus influenzae protein (protein E; pE)
KR20100045445A (ko) 2007-06-26 2010-05-03 글락소스미스클라인 바이오로지칼즈 에스.에이. 스트렙토코쿠스 뉴모니애 캡슐 다당류 컨쥬게이트를 포함하는 백신
JP5749642B2 (ja) 2008-04-16 2015-07-15 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
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Also Published As

Publication number Publication date
ZA921025B (en) 1992-11-25
FI933580A0 (fi) 1993-08-13
IE920479A1 (en) 1992-08-26
HK1013629A1 (en) 1999-11-26
FI933580A (fi) 1993-10-13
IL100946A0 (en) 1992-11-15
EP0571538A1 (de) 1993-12-01
DE69226167D1 (de) 1998-08-13
AU1445392A (en) 1992-09-15
CA2104014A1 (en) 1992-08-16
US5728387A (en) 1998-03-17
EP0786521A1 (de) 1997-07-30
DK0571538T3 (da) 1999-04-19
AU692678B2 (en) 1998-06-11
CA2104014C (en) 2000-05-02
NO313999B1 (no) 2003-01-13
JPH09224680A (ja) 1997-09-02
AU692678C (en) 2002-08-29
EP0571538B1 (de) 1998-07-08
EP0571538A4 (en) 1994-08-24
IE20000062A1 (en) 2000-12-13
AU4798096A (en) 1996-06-27
JPH06504446A (ja) 1994-05-26
NO932890L (no) 1993-10-14
JP2001204482A (ja) 2001-07-31
ES2118812T3 (es) 1998-10-01
DE69226167T2 (de) 1998-11-12
JP3215109B2 (ja) 2001-10-02
WO1992014488A1 (en) 1992-09-03
DK0571538T5 (da) 2002-03-04
NO932890D0 (no) 1993-08-13
AU667668B2 (en) 1996-04-04

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