DE69219901D1 - Adenosinderivate, Verfahren zu deren Herstellung und pharmazeutische Mittel - Google Patents

Adenosinderivate, Verfahren zu deren Herstellung und pharmazeutische Mittel

Info

Publication number
DE69219901D1
DE69219901D1 DE69219901T DE69219901T DE69219901D1 DE 69219901 D1 DE69219901 D1 DE 69219901D1 DE 69219901 T DE69219901 T DE 69219901T DE 69219901 T DE69219901 T DE 69219901T DE 69219901 D1 DE69219901 D1 DE 69219901D1
Authority
DE
Germany
Prior art keywords
processes
preparation
pct
pharmaceutical agents
adenosine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69219901T
Other languages
English (en)
Other versions
DE69219901T2 (de
Inventor
Nicole Bru-Magniez
Timur Gungor
Jean-Marie Teulon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNION PHARMA SCIENT APPL
UPSA SAS
Original Assignee
UNION PHARMA SCIENT APPL
UPSA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNION PHARMA SCIENT APPL, UPSA SAS filed Critical UNION PHARMA SCIENT APPL
Application granted granted Critical
Publication of DE69219901D1 publication Critical patent/DE69219901D1/de
Publication of DE69219901T2 publication Critical patent/DE69219901T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69219901T 1992-01-08 1992-12-29 Adenosinderivate, Verfahren zu deren Herstellung und pharmazeutische Mittel Expired - Lifetime DE69219901T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9200138A FR2685918B1 (fr) 1992-01-08 1992-01-08 Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
PCT/FR1992/001241 WO1993014102A1 (fr) 1992-01-08 1992-12-29 Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
DE69219901D1 true DE69219901D1 (de) 1997-06-26
DE69219901T2 DE69219901T2 (de) 1997-11-13

Family

ID=9425478

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69219901T Expired - Lifetime DE69219901T2 (de) 1992-01-08 1992-12-29 Adenosinderivate, Verfahren zu deren Herstellung und pharmazeutische Mittel

Country Status (25)

Country Link
US (2) US5229505A (de)
EP (1) EP0623138B1 (de)
JP (1) JP3224542B2 (de)
KR (1) KR100232672B1 (de)
AT (1) ATE153342T1 (de)
AU (1) AU661894B2 (de)
CA (1) CA2127472C (de)
CZ (1) CZ289047B6 (de)
DE (1) DE69219901T2 (de)
DK (1) DK0623138T3 (de)
EE (1) EE03087B1 (de)
ES (1) ES2105285T3 (de)
FI (1) FI106205B (de)
FR (1) FR2685918B1 (de)
GE (1) GEP19981357B (de)
GR (1) GR3024386T3 (de)
HU (1) HU221304B1 (de)
LV (1) LV11899B (de)
MD (1) MD502G2 (de)
NZ (1) NZ246904A (de)
RU (1) RU2129560C1 (de)
SK (1) SK282205B6 (de)
TW (1) TW254945B (de)
UA (1) UA44221C2 (de)
WO (1) WO1993014102A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685918B1 (fr) * 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
FR2714907B1 (fr) * 1994-01-07 1996-03-29 Union Pharma Scient Appl Nouveaux dérivés de l'Adénosine, leurs procédés de préparation, compositions pharmaceutiques les contenant.
WO1995018817A1 (fr) * 1994-01-07 1995-07-13 Laboratoires Upsa Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
FR2772271B1 (fr) * 1997-12-11 2000-09-01 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
JP3933870B2 (ja) 1998-06-23 2007-06-20 グラクソ グループ リミテッド ２−（プリン−９−イル）−テトラヒドロフラン−３，４−ジオール誘導体
JP2002173427A (ja) * 1998-09-01 2002-06-21 Yamasa Shoyu Co Ltd 眼疾患治療用医薬組成物
DE19924818A1 (de) 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
EP1229901B1 (de) * 1999-11-17 2009-03-18 Boston Scientific Limited Miniaturisierte vorrichtungen zur abgabe von molekülen in einer trägerflüssigkeit
WO2002020539A1 (fr) * 2000-09-08 2002-03-14 Toa Eiyo Ltd. Derives d'adenosine et leur utilisation
EP1352910A1 (de) * 2002-04-10 2003-10-15 Grünenthal GmbH Neue Analoga von Nitrobenzylthioinosine
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
US4167565A (en) * 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
US5310731A (en) * 1984-06-28 1994-05-10 Whitby Research, Inc. N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
JPH0696534B2 (ja) * 1986-04-25 1994-11-30 ヘキストジヤパン株式会社 抗痴呆剤
WO1988003148A2 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Heteroaromatic derivatives of adenoside
WO1988003147A1 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Selected n6-substituted adenosines having selective a2 binding activity
EP0267878A1 (de) * 1986-11-14 1988-05-18 Ciba-Geigy Ag N9-Cyclopentylsubstituierte Adeninderivate
SU1661367A1 (ru) * 1988-11-01 1991-07-07 Всесоюзный научно-исследовательский институт по креплению скважин и буровым растворам Способ гидрофобизации тампонажных материалов
WO1992005177A1 (en) * 1990-09-25 1992-04-02 Rhone-Poulenc Rorer International (Holdings) Inc. Compounds having antihypertensive and anti-ischemic properties
FR2685918B1 (fr) * 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
AU3455093A (en) 1993-08-03
SK81894A3 (en) 1995-04-12
RU2129560C1 (ru) 1999-04-27
CZ289047B6 (cs) 2001-10-17
US5480983A (en) 1996-01-02
GR3024386T3 (en) 1997-11-28
ATE153342T1 (de) 1997-06-15
LV11899B (lv) 1998-03-20
JPH07502738A (ja) 1995-03-23
HU221304B1 (en) 2002-09-28
FR2685918B1 (fr) 1995-06-23
CZ164394A3 (en) 1995-02-15
MD502F1 (en) 1996-03-29
HU9402040D0 (en) 1994-09-28
GEP19981357B (en) 1998-08-25
FR2685918A1 (fr) 1993-07-09
EP0623138B1 (de) 1997-05-21
DE69219901T2 (de) 1997-11-13
ES2105285T3 (es) 1997-10-16
FI943222A (fi) 1994-08-18
EP0623138A1 (de) 1994-11-09
MD502G2 (ro) 1996-11-30
DK0623138T3 (da) 1997-12-15
KR100232672B1 (ko) 1999-12-01
RU94039545A (ru) 1997-04-27
SK282205B6 (sk) 2001-12-03
TW254945B (de) 1995-08-21
UA44221C2 (uk) 2002-02-15
HUT68095A (en) 1995-05-29
WO1993014102A1 (fr) 1993-07-22
LV11899A (lv) 1997-12-20
EE03087B1 (et) 1998-04-15
FI943222A0 (fi) 1994-07-06
NZ246904A (en) 1995-04-27
AU661894B2 (en) 1995-08-10
FI106205B (fi) 2000-12-15
CA2127472C (en) 2003-11-18
CA2127472A1 (en) 1993-07-22
JP3224542B2 (ja) 2001-10-29
US5229505A (en) 1993-07-20

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