DE69132288T2 - Verfahren zur steigerung der blut-hirn-schranken-durchlässigkeit - Google Patents

Verfahren zur steigerung der blut-hirn-schranken-durchlässigkeit

Info

Publication number
DE69132288T2
DE69132288T2 DE69132288T DE69132288T DE69132288T2 DE 69132288 T2 DE69132288 T2 DE 69132288T2 DE 69132288 T DE69132288 T DE 69132288T DE 69132288 T DE69132288 T DE 69132288T DE 69132288 T2 DE69132288 T2 DE 69132288T2
Authority
DE
Germany
Prior art keywords
blood
pencility
brain barrier
blood brain
increasing blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132288T
Other languages
English (en)
Other versions
DE69132288D1 (de
Inventor
Bernard Malfroy-Camine
L Smart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Publication of DE69132288D1 publication Critical patent/DE69132288D1/de
Application granted granted Critical
Publication of DE69132288T2 publication Critical patent/DE69132288T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69132288T 1990-04-23 1991-04-23 Verfahren zur steigerung der blut-hirn-schranken-durchlässigkeit Expired - Fee Related DE69132288T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/512,913 US5112596A (en) 1990-04-23 1990-04-23 Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
PCT/US1991/002772 WO1991016355A1 (en) 1990-04-23 1991-04-23 Method for increasing blood-brain barrier permeability

Publications (2)

Publication Number Publication Date
DE69132288D1 DE69132288D1 (de) 2000-08-10
DE69132288T2 true DE69132288T2 (de) 2000-12-14

Family

ID=24041129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132288T Expired - Fee Related DE69132288T2 (de) 1990-04-23 1991-04-23 Verfahren zur steigerung der blut-hirn-schranken-durchlässigkeit

Country Status (11)

Country Link
US (1) US5112596A (de)
EP (1) EP0528891B1 (de)
JP (1) JPH05506859A (de)
AT (1) ATE194289T1 (de)
AU (1) AU650020B2 (de)
CA (1) CA2081308A1 (de)
DE (1) DE69132288T2 (de)
DK (1) DK0528891T3 (de)
ES (1) ES2147722T3 (de)
GR (1) GR3034351T3 (de)
WO (1) WO1991016355A1 (de)

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