JPS646217A - Blood platelet protective agent for extracorporeal blood - Google Patents

Blood platelet protective agent for extracorporeal blood

Info

Publication number
JPS646217A
JPS646217A JP62160468A JP16046887A JPS646217A JP S646217 A JPS646217 A JP S646217A JP 62160468 A JP62160468 A JP 62160468A JP 16046887 A JP16046887 A JP 16046887A JP S646217 A JPS646217 A JP S646217A
Authority
JP
Japan
Prior art keywords
blood
polypeptide
protective agent
mentioned
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62160468A
Other languages
Japanese (ja)
Inventor
Takehisa Matsuda
Eisuke Tatsumi
Hisateru Takano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Priority to JP62160468A priority Critical patent/JPS646217A/en
Publication of JPS646217A publication Critical patent/JPS646217A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE:To obtain a safe protective agent for extracorporeal blood, containing a polypeptide having a specific amino acid sequence in the structure as an active ingredient, having powerful inhibitory action on blood platelet agglutination and useful in extracorporeal circulation and preservation of blood. CONSTITUTION:A protective agent containing a polypeptide consisting of only Arg-Gly-Asp-Ser readily obtainable by a well-known method for synthesizing peptides or polypeptide having at least one above-mentioned amino acid sequence in part of the amino acid sequence of the afore-mentioned polypeptide chain as an active ingredient. The above-mentioned polypeptide has preferably a low molecular weight, e.g. about 400-600. Then does or amount of the afore- mentioned polypeptide blended varies with the amount of blood platelet, etc., flowing through artificial organs, but normally is 0.5-50mg/kg body weight, preferably 1-10mg/kg body weight. The above-mentioned protective agent is useful for protecting blood platelet from extracorporeal circulation of blood in using the artificial organic, etc.
JP62160468A 1987-06-26 1987-06-26 Blood platelet protective agent for extracorporeal blood Pending JPS646217A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62160468A JPS646217A (en) 1987-06-26 1987-06-26 Blood platelet protective agent for extracorporeal blood

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62160468A JPS646217A (en) 1987-06-26 1987-06-26 Blood platelet protective agent for extracorporeal blood

Publications (1)

Publication Number Publication Date
JPS646217A true JPS646217A (en) 1989-01-10

Family

ID=15715600

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62160468A Pending JPS646217A (en) 1987-06-26 1987-06-26 Blood platelet protective agent for extracorporeal blood

Country Status (1)

Country Link
JP (1) JPS646217A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04217700A (en) * 1990-10-26 1992-08-07 Fuji Photo Film Co Ltd Cm-chitin derivative and its use
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6395873B1 (en) 1990-04-06 2002-05-28 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6395873B1 (en) 1990-04-06 2002-05-28 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
JPH04217700A (en) * 1990-10-26 1992-08-07 Fuji Photo Film Co Ltd Cm-chitin derivative and its use

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