JPS646217A - Blood platelet protective agent for extracorporeal blood - Google Patents
Blood platelet protective agent for extracorporeal bloodInfo
- Publication number
- JPS646217A JPS646217A JP62160468A JP16046887A JPS646217A JP S646217 A JPS646217 A JP S646217A JP 62160468 A JP62160468 A JP 62160468A JP 16046887 A JP16046887 A JP 16046887A JP S646217 A JPS646217 A JP S646217A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- polypeptide
- protective agent
- mentioned
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE:To obtain a safe protective agent for extracorporeal blood, containing a polypeptide having a specific amino acid sequence in the structure as an active ingredient, having powerful inhibitory action on blood platelet agglutination and useful in extracorporeal circulation and preservation of blood. CONSTITUTION:A protective agent containing a polypeptide consisting of only Arg-Gly-Asp-Ser readily obtainable by a well-known method for synthesizing peptides or polypeptide having at least one above-mentioned amino acid sequence in part of the amino acid sequence of the afore-mentioned polypeptide chain as an active ingredient. The above-mentioned polypeptide has preferably a low molecular weight, e.g. about 400-600. Then does or amount of the afore- mentioned polypeptide blended varies with the amount of blood platelet, etc., flowing through artificial organs, but normally is 0.5-50mg/kg body weight, preferably 1-10mg/kg body weight. The above-mentioned protective agent is useful for protecting blood platelet from extracorporeal circulation of blood in using the artificial organic, etc.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62160468A JPS646217A (en) | 1987-06-26 | 1987-06-26 | Blood platelet protective agent for extracorporeal blood |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62160468A JPS646217A (en) | 1987-06-26 | 1987-06-26 | Blood platelet protective agent for extracorporeal blood |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS646217A true JPS646217A (en) | 1989-01-10 |
Family
ID=15715600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62160468A Pending JPS646217A (en) | 1987-06-26 | 1987-06-26 | Blood platelet protective agent for extracorporeal blood |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS646217A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04217700A (en) * | 1990-10-26 | 1992-08-07 | Fuji Photo Film Co Ltd | Cm-chitin derivative and its use |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6395873B1 (en) | 1990-04-06 | 2002-05-28 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
-
1987
- 1987-06-26 JP JP62160468A patent/JPS646217A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6395873B1 (en) | 1990-04-06 | 2002-05-28 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
JPH04217700A (en) * | 1990-10-26 | 1992-08-07 | Fuji Photo Film Co Ltd | Cm-chitin derivative and its use |
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