DE69115682T2 - Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen - Google Patents

Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen

Info

Publication number
DE69115682T2
DE69115682T2 DE69115682T DE69115682T DE69115682T2 DE 69115682 T2 DE69115682 T2 DE 69115682T2 DE 69115682 T DE69115682 T DE 69115682T DE 69115682 T DE69115682 T DE 69115682T DE 69115682 T2 DE69115682 T2 DE 69115682T2
Authority
DE
Germany
Prior art keywords
liposomes
lipid
vesicles
lipids
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69115682T
Other languages
German (de)
English (en)
Other versions
DE69115682D1 (de
Inventor
Christian Guillot
Roland Hyacinthe
Bernard Lamy
Michel Schneider
Herve Tournier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of DE69115682D1 publication Critical patent/DE69115682D1/de
Publication of DE69115682T2 publication Critical patent/DE69115682T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69115682T 1990-12-11 1991-12-09 Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen Expired - Lifetime DE69115682T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90810969 1990-12-11
PCT/EP1991/002377 WO1992010166A1 (en) 1990-12-11 1991-12-09 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Publications (2)

Publication Number Publication Date
DE69115682D1 DE69115682D1 (de) 1996-02-01
DE69115682T2 true DE69115682T2 (de) 1996-05-15

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69115682T Expired - Lifetime DE69115682T2 (de) 1990-12-11 1991-12-09 Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen

Country Status (20)

Country Link
US (1) US5393530A (cg-RX-API-DMAC7.html)
EP (1) EP0514523B1 (cg-RX-API-DMAC7.html)
JP (1) JP3241720B2 (cg-RX-API-DMAC7.html)
KR (1) KR0137783B1 (cg-RX-API-DMAC7.html)
AT (1) ATE131724T1 (cg-RX-API-DMAC7.html)
AU (1) AU635456B2 (cg-RX-API-DMAC7.html)
CA (1) CA2072559C (cg-RX-API-DMAC7.html)
DE (1) DE69115682T2 (cg-RX-API-DMAC7.html)
DK (1) DK0514523T3 (cg-RX-API-DMAC7.html)
ES (1) ES2081605T3 (cg-RX-API-DMAC7.html)
GR (1) GR3018506T3 (cg-RX-API-DMAC7.html)
HU (1) HUT62458A (cg-RX-API-DMAC7.html)
IE (1) IE72163B1 (cg-RX-API-DMAC7.html)
IL (1) IL99835A (cg-RX-API-DMAC7.html)
IN (1) IN172269B (cg-RX-API-DMAC7.html)
IS (1) IS1685B (cg-RX-API-DMAC7.html)
MX (1) MX9102516A (cg-RX-API-DMAC7.html)
NZ (1) NZ240817A (cg-RX-API-DMAC7.html)
WO (1) WO1992010166A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA918489B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
JPH08505312A (ja) * 1992-10-16 1996-06-11 ザックセ，アンドレアス 液状分散系を製造する方法及び装置
US5869305A (en) * 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US6217849B1 (en) 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
CN1148812A (zh) * 1994-03-28 1997-04-30 尼科梅德成像有限公司 “脂质体”
EP0759785B1 (en) * 1995-02-24 2001-10-31 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
JP2001507207A (ja) 1996-05-01 2001-06-05 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 化合物を細胞に送達する方法
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US20010051131A1 (en) * 1996-06-19 2001-12-13 Evan C. Unger Methods for delivering bioactive agents
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
GB9624918D0 (en) * 1996-11-29 1997-01-15 Nycomed Imaging As Particulate components
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
WO1998044910A1 (en) 1997-04-09 1998-10-15 Philipp Lang NEW TECHNIQUE TO MONITOR DRUG DELIVERY NONINVASIVELY $i(IN VIVO)
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
US6306432B1 (en) * 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
DE69841598D1 (de) 1997-09-18 2010-05-20 Pacira Pharmaceuticals Inc Retardierte freisetzung liposmaler anesthetischer zusammensetzungen.
AU752802C (en) 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19813773A1 (de) * 1998-03-27 1999-09-30 Clemens Unger Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen
JP2002520120A (ja) 1998-07-17 2002-07-09 スカイファーマ インコーポレーテッド 封入物質の制御放出のための生分解性組成物
US6511676B1 (en) 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
CA2410887C (en) 2000-06-02 2012-07-24 Bracco Research Usa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
WO2002096368A2 (en) * 2001-05-31 2002-12-05 Skyepharma Inc. Encapsulation of nanosuspensions in liposomes and microspheres
JP3990880B2 (ja) * 2001-07-10 2007-10-17 キヤノン株式会社 ポリヒドロキシアルカノエート被覆リポソームの製造方法
US7615233B2 (en) * 2001-07-10 2009-11-10 Canon Kabushiki Kaisha Particulate construct comprising polyhydroxyalkanoate and method for producing it
US20030129224A1 (en) * 2001-11-13 2003-07-10 Paul Tardi Lipid carrier compositions and methods for improved drug retention
WO2003041681A2 (en) * 2001-11-13 2003-05-22 Celator Technologies, Inc. Lipid carrier compositions with enhanced blood stability
ATE373466T1 (de) * 2001-11-13 2007-10-15 Celator Pharmaceuticals Inc Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung
US20050129750A1 (en) * 2003-12-15 2005-06-16 Yu-Fang Hu Process for producing liposome suspension and product containing liposome suspension produced thereby
EP1547580A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Loading of a camptothecin drug into colloidal nanoparticles
EP1547582A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Method of producing lipid complexed camptothecin-carboxylate
ES2313352T3 (es) 2004-06-03 2009-03-01 Bracco Research S.A. Ensamblaje de liposomas para uso terapeutico y/o diagnostico.
ATE401057T1 (de) * 2004-10-08 2008-08-15 Alza Corp Verfahren zur einführung eines lipid-verknüpften teils in eine vorgeformte lipidanordnung mit mikrowellen
CA2595731A1 (en) * 2005-01-26 2006-08-03 Celator Pharmaceuticals, Inc. Lipid carrier compositions with reduced polydispersity
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
ES2275443B1 (es) 2005-11-30 2008-06-01 Italfarmaco, S.A. Procedimiento de preparacion de liposomas.
JP5080779B2 (ja) * 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
US20090136937A1 (en) * 2007-05-09 2009-05-28 Coleman Matthew A Methods and systems for monitoring production of a target protein in a nanolipoprotein particle
US9040079B2 (en) * 2007-11-19 2015-05-26 Biolitec Pharma Marketing Ltd Pegylated compounds for age-related macular degeneration
US8907061B2 (en) 2008-01-11 2014-12-09 Lawrence Livermore National Security, Llc. Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification
US9303273B2 (en) 2008-05-09 2016-04-05 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
US8883729B2 (en) * 2008-05-22 2014-11-11 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions, methods and systems
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
US9192685B2 (en) 2008-10-07 2015-11-24 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same
EP2184054A1 (en) * 2008-11-08 2010-05-12 Lipoxen Technologies Limited Small Interfering RNA Delivery
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
CA2781527C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes
US10736844B2 (en) 2011-01-13 2020-08-11 Variation Biotechnologies Inc. Compositions and methods for treating viral infections
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
WO2013104995A2 (en) 2012-01-12 2013-07-18 Variation Biotechnologies, Inc. Compositions and methods for treating viral infections
CN104244984B (zh) * 2012-01-27 2020-03-31 变异生物技术公司 用于治疗剂的方法和组合物
WO2015068020A2 (en) * 2013-11-05 2015-05-14 García-Sánchez Gustavo A Immunosuppressive treatments, formulations and methods
WO2015166987A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
HRP20202030T1 (hr) 2014-04-30 2021-02-19 Fujifilm Corporation Liposomska kompozicija i postupak za njeno dobivanje
WO2016049061A1 (en) 2014-09-22 2016-03-31 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide co-factor dependent target reduction, and related methods and systems
WO2016109400A2 (en) 2014-12-31 2016-07-07 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
US11376218B2 (en) 2015-05-04 2022-07-05 Versantis AG Method for preparing transmembrane pH-gradient vesicles
US12226529B2 (en) 2015-08-25 2025-02-18 Lawrence Livermore National Security, Llc Stable nanolipoprotein particles and related compositions methods and systems
US11279749B2 (en) 2015-09-11 2022-03-22 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
WO2017078009A1 (ja) * 2015-11-02 2017-05-11 富士フイルム株式会社 リポソーム組成物およびその製造方法
WO2017192910A2 (en) 2016-05-04 2017-11-09 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3493790A4 (en) 2016-08-02 2020-03-25 Curirx Inc. LIPOSOME PREPARATION METHODS
WO2018204495A1 (en) 2017-05-02 2018-11-08 Synthetic Genomics, Inc. Nanolipoprotein particles and related compositions methods and systems for loading rna
WO2018204421A2 (en) 2017-05-02 2018-11-08 Lawrence Livermore National Security, Llc Momp telonanoparticles, and related compositions, methods and systems
FI3811949T3 (fi) 2018-06-20 2024-09-13 Fujifilm Corp Liposomikoostumukseen kapseloitua gemsitabiinia ja immuunitarkistuspistesalpaajaa käsittävä yhdistelmälääke
ES3049663T3 (en) * 2019-06-28 2025-12-17 Univ Texas Method of reconstituting liposomal annamycin
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
WO2023064464A1 (en) 2021-10-14 2023-04-20 Pacira Pharmaceuticals, Inc. Bupivacaine multivesicular liposome formulations and uses thereof
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251468B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12246092B1 (en) 2024-05-20 2025-03-11 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
CA1270198C (en) * 1984-08-08 1990-06-12 Marcel B Bally ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES
JPS6150912A (ja) * 1984-08-16 1986-03-13 Shionogi & Co Ltd リポソ−ム製剤の製造法
JPS63211222A (ja) * 1987-02-27 1988-09-02 Terumo Corp リポソ−ムの製法
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
CH672733A5 (cg-RX-API-DMAC7.html) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
US4870160A (en) * 1987-08-19 1989-09-26 Regents Of The University Of Minnesota Polypeptides with laminin activity
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
CA1330199C (en) * 1987-12-22 1994-06-14 Thomas D. Madden Spontaneous vesiculation of multilamellar liposomes
ATE108651T1 (de) * 1988-05-20 1994-08-15 Liposome Co Inc Aktives mittel: lipid-komplex mit hohem verhältnis.
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung

Also Published As

Publication number Publication date
IS1685B (is) 1998-02-24
ATE131724T1 (de) 1996-01-15
DK0514523T3 (da) 1996-01-29
IE914289A1 (en) 1992-06-17
ES2081605T3 (es) 1996-03-16
ZA918489B (en) 1992-07-29
CA2072559A1 (en) 1992-06-12
KR0137783B1 (ko) 1998-05-15
HUT62458A (en) 1993-05-28
JPH05504150A (ja) 1993-07-01
WO1992010166A1 (en) 1992-06-25
CA2072559C (en) 1997-03-18
IE72163B1 (en) 1997-03-26
MX9102516A (es) 1992-06-01
EP0514523B1 (en) 1995-12-20
NZ240817A (en) 1993-01-27
JP3241720B2 (ja) 2001-12-25
IS3773A7 (is) 1992-06-12
IN172269B (cg-RX-API-DMAC7.html) 1993-05-29
IL99835A (en) 1995-11-27
IL99835A0 (en) 1992-08-18
KR920703014A (ko) 1992-12-17
AU9062991A (en) 1992-07-08
EP0514523A1 (en) 1992-11-25
DE69115682D1 (de) 1996-02-01
GR3018506T3 (en) 1996-03-31
AU635456B2 (en) 1993-03-18
US5393530A (en) 1995-02-28

Similar Documents

Publication Publication Date Title
DE69115682T2 (de) Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen
DE69935435T2 (de) Mittels Ammoniumsulfatgradient hergestellte liposomale analgetische Zusammensetzungen
DE68915001T2 (de) Liposome.
DE68919321T2 (de) Ladung und gesteuerte Abgabe von Molekülen zu und von Liposomen.
DE2629100C3 (de) Dispersion von Kügelchen und Verfahren zu ihrer Herstellung
DE69713615T2 (de) Ionophorenvermitteltes aufladen von liposomen mit schwach basischen arzneistoffen
DE3874485T2 (de) Injizierbare, opazifizierende liposomzusammensetzung.
DE69426884T2 (de) Verfahren zum kontrollieren der liposomengrösse
DE3786555T2 (de) Vermehrte herstellung von mit liposomen eingekapseltem hämoglobin.
DE3689056T2 (de) Verfahren und Zusammensetzung zur Herstellung von Liposomen.
DE69432320T2 (de) Fusogene liposomen und verfahren zu deren herstellung und verwendung
DE60012693T2 (de) Verfahren zur kontrolle der liposomengrösse
DE69828624T2 (de) Biologisch aktive verbindungen enthaltende multilamellare koaleszenzvesikel (mlcv)
DE69429511T2 (de) Reduzierung von durch liposome induzierte physiologischen gegenreaktionen
DD201973A5 (de) Verfahren zur herstellung von liposomalen arzneimitteln
EP0665756A1 (de) Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme
DE60222580T2 (de) Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung
EP0707847A1 (de) Ketoprofen Liposomen
DE69123568T2 (de) Interdigitation-fusionsliposomen und gele
EP0478727B1 (de) Verfahren zur herstellung von wirkstoffhaltigen wässrigen liposomensuspensionen
DE4038075C1 (en) Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
DE69122810T2 (de) Liposomen
DE68916956T2 (de) Aktives mittel: lipid-komplex mit hohem verhältnis.
DE69616453T2 (de) Liposomensuspensionen als blut-pool-kontrastmittel
DE69209830T2 (de) Hemmung der aggregaton arzneistoffhaltiger partikeln

Legal Events

Date Code Title Description
8364 No opposition during term of opposition